- Research article
- Open Access
Effects of minimally invasive and traditional surgeries on the quality of life of children with congenital heart disease: a retrospective propensity score-matched study
BMC Pediatrics volume 21, Article number: 522 (2021)
The focus of clinical care after treating congenital heart disease (CHD) has shifted from saving patients’ lives to improving their quality of life. This study aimed to examine the influence of minimally invasive and traditional surgeries on the quality of life of children with CHD.
This was a retrospective cross-sectional study. A total of 459 children aged 2–18 years with CHD treated at Second Xiangya Hospital of Central South University from July 2016 to June 2017 were enrolled, among whom 219 underwent minimally invasive surgery and 240 traditional surgery. The quality of life of children with CHD after surgery was reported by the patients’ parents. We applied propensity score matching to correct for confounding factors and conducted multiple linear regression analysis to examine the related effects of minimally invasive and traditional surgeries on the quality of life of children with CHD.
The scores of problems related to perceived physical appearance in children undergoing minimally invasive surgery was higher than those in those undergoing traditional surgery (p = 0.004). Different treatment modes were independent influencing factors for problems related to perceived physical appearance in children with CHD. There was no significant difference in average treatment effect scores of children undergoing different surgical procedures in other quality of life dimensions (problems related to cardiac symptoms and their treatment, drug treatment, anxiety regarding treatment, cognitive psychology, and communication), suggesting that different operation modes were not independent influencing factors for these related problems.
Compared with traditional surgery, minimally invasive surgery can significantly improve the physical appearance perception scores of children with CHD after surgery. Therefore, minimally invasive surgery can improve the quality of life of children with CHD.
The prevalence of congenital heart disease (CHD) has been increasing with approximately 1.35 million newborns suffering from CHD globally each year  and 150 thousand children in China. The overall prevalence rate of CHD in neonates is approximately 0.91%, the most common heart disease in this population . With continuous progress in early diagnosis and surgical techniques, the life expectancy of children with CHD has shown considerable improvement . Currently, 90% of patients with CHD who underwent heart surgery during childhood enter adulthood, indicating that there may be more adult than pediatric patients with CHD [3,4,5]. Traditional indicators for treatment outcomes, such as survival and mortality rates, reflect the treatment outcomes of children with CHD from the medical perspective. With the changes in health concepts and medical care modes, the goal of medical care is not only to maintain life and improve organ function but also to improve the quality of life (QOL), which has become another recognized evaluation index of treatment success [1, 6]. Under such circumstances, the health-related QOL of children with CHD has attracted widespread attention from scholars. Some research shows that children and adolescents with CHD have a lower QOL than do healthy individuals . Research has shown that children and adolescents with CHD exhibit more behavioral and emotional problems than children from the general population, irrespective of the severity of the disease [8,9,10,11]. Landolt and Spijkerboer et al. found that children with CHD had worse motor cognition, and social and emotional functions than did healthy children [12,13,14]. However, the findings of Teixeira and Culbert et al. contradict those of previous studies [15, 16]. Their research revealed that the QOL of adolescents with CHD was higher than that of the general population, especially regarding environmental and social relations. The difference in these research results may be attributed to differences in methods or country of residence . At present, the research on the influences of different surgical procedures on the QOL of children with CHD is still very limited. This study aimed to examine the influences of minimally invasive and traditional surgeries on the postoperative QOL of children with CHD.
This was a cross-sectional study that examined the influences of minimally invasive and traditional surgeries on the postoperative QOL of children with CHD.
Data and sample collection
From July 2016 to June 2017, all pediatric patients who underwent minimally invasive or traditional surgical treatment in the Department of Pediatric Cardiovascular Surgery that satisfied the inclusion criteria were invited to participate in this study. The inclusion criteria were as follows: left-to-right shunting without complications as confirmed by echocardiography and diagnosed by a doctor; patients were aged 2–18 years; patients reported no neurodevelopmental complications according to past medical history; patients received minimally invasive or traditional surgical treatment; and informed consent had been obtained from the parents. If either the child or parent had impediments in reading or understanding, or had inadequate communication skills, they were excluded. The parents of 459 children aged 2–18 years were followed up with a questionnaire (Supplement 1, 2, 3, 4, 5, 6, 7). Of them, 230 (50.1%) filled out.
questionnaires on-site at the Department of Pediatric Cardiovascular Surgery of the Second Xiangya Hospital of Central South University, and the remaining 229 questionnaires were completed through telephone follow-up (49.9%). Forty-three children were lost to follow-up because their parents could not be reached by telephone, whereas the parents of 16 children refused to complete the questionnaire survey because they were working away from home and did not know the condition of their child (n = 9) or because of time constraints (n = 7). The final analysis included a total of 400 participants, including 183 cases in the minimally invasive surgery group and 217 in the traditional surgery group. Consent to this study was obtained from the parents, and the questionnaire results were obtained from all subjects. Medical diagnoses were transcribed from inpatient medical records.
The parents of children with CHD completed a general information questionnaire that included sex, age, disease type, and time since the operation.
The QOL of children was investigated using the parents’ report section of the Pediatric Quality of Life Inventory Measurement Models, Cardiac Module Version 3.0 (PedsQL™ 3.0) [18,19,20]. The use of this scale was authorized by Mapi Research Trust. The parents’ report scale corresponded to the contents of the self-assessment questionnaire for children of corresponding age groups (2–4 years, 5–7 years, 8–12 years, and 13–18 years) and was expressed in third-person. There were 22 items in the scale that were divided into five dimensions: heart problems and symptoms, perception of physical appearance, anxiety regarding treatment, cognitive psychology, and communication problems. In addition, problems related to drug treatment were added for children who were taking medication.
The development of the PedsQL was initiated by Professor James W. Varni of the United States in 1987 and includes a universal module and disease-specific module with a mature scale system, and PedsQL has been applied in many countries and regions . The disease-specific module, PedsQL 3.0, is a commonly used scale for measuring the QOL of children with heart disease in various countries [22,23,24,25]. It has been repeatedly evaluated and applied, and has been proven to have good reliability and validity. Every item in the PedsQL 3.0 scale questions the frequency of events in the previous month. The PedsQL 3.0 is scored on a 5-point scale (0–4). The total score and scores in all aspects are between 0 and 100, and higher scores indicate a higher QOL (Supplement 8).
General information on the children, such as demographics, were presented as frequencies, percentages, means, and standard deviation. The χ2 or two-sample independent t-tests were used to compare the differences in baseline characteristics between the two treatment groups. The children’s QOL scores did not conform to a normal distribution. Median and polar distance were used for descriptive analysis, and the Wilcoxon rank sum test was used to compare the differences in QOL score between the traditional and minimally invasive surgery groups. Traditional surgery was performed through a full median sternotomy and under cardiopulmonary bypass. Minimally invasive surgery was performed through a mini-sternotomy and the defect was occluded with a metal occluder delivered through the surface of the heart. Figures 1 and 2 show the scars after the two different surgeries. The difference in QOL score between children undergoing the two treatment modes were analyzed and compared according to age (2–4 years, 5–7 years, 8–12 years, and 13–18 years) and postoperative time (≤1 month, 1–6 months, 6–12 months, 12–36 months, and > 36 months). Considering the unbalanced baseline conditions of children in different treatment groups, propensity score matching (PSM) was used to control for confounding factors. After matching, the standardized mean difference (SMD) of general information was controlled within 10%, and the covariates were age, sex, body mass index (BMI), CHD type, and postoperative time. The average treatment effect (ATE) of matched samples was analyzed and tested. Multiple linear regression was used to analyze the independent factors influencing the children’s QOL for the matched samples, and the dependent variables were the logarithmic values of QOL scores for these dimensions. SAS 9.4 and R 3.5.3 software were used for statistical analysis.
The minimally invasive group comprised 72 males and 111 females. The average age of patients in the minimally invasive group was 6.5 ± 3.5 years, and there were 20 patients with ventricular septal defects (VSDs), 144 with atrial septal defects (ASDs), and 19 with other conditions. The traditional surgery group comprised 112 males and 105 females. The average age of patients in the traditional surgery group was 5.4 ± 3.1 years, and there were 42 patients with VSDs, 173 with ASDs, and 2 with other conditions (Table 1).
There were significant differences in the scores of children’s problems related to cardiac symptoms and their treatment (p = 0.0069), drug treatment (p = 0.0395), and perception of physical appearance (p = 0.0150) between the traditional and minimally invasive surgery groups. Subgroup analysis by age showed significant differences in scores of problems related to cardiac symptoms and their treatment (p = 0.0366), and perception of physical appearance (p = 0.0089) among children aged 5–7 years, and cardiac symptoms and their treatment (p = 0.0396), drug treatment (p = 0.0095), perception of physical appearance (p = 0.0228), anxiety regarding treatment (p = 0.0072), and communication (p = 0.0017) among children aged 8–12 years (p < 0.05) (Table 2).
There was no difference in the scores for various dimensions between the minimally invasive and traditional surgery groups at 1 month (p = 0.5946), 1–6 months, and 6–12 months after surgery (p > 0.05). At 12–36 months after the operation, the scores of problems related to perceived physical appearance in the minimally invasive surgery group were higher than those in the traditional surgery group (p = 0.0399). After > 36 months, the scores of problems related to cardiac symptoms and their treatment (p = 0.0260), drug treatment (p = 0.0216), anxiety regarding treatment (p = 0.0489), cognitive psychology (p = 0.0120), and communication (p = 0.0009) in the minimally invasive surgery group were higher than those in the traditional surgery group (p < 0.05) (Table 3).
After PSM of the children’s QOL scores, 136 children from each group were successfully matched. After matching, the SMD values of the two groups were below 10% except for the postoperative time, and the matching status was acceptable. The demographic clinical characteristics are shown in Table 4.
Comparing the QOL average treatment effect on the treated (ATT) scores of children with CHD between the minimally invasive and traditional surgery groups after matching, the ATT scores of children who underwent minimally invasive surgery was higher than that of those who underwent traditional surgery (p = 0.0043). There were no significant differences in ATT scores of children with different surgical procedures in other QOL dimensions including problems related to cardiac symptoms and their treatment (p = 0.1009), drug treatment (p = 0.2334), anxiety regarding treatment (p = 0.1243), cognitive psychology (p = 0.7924), and communication (p = 0.5939) (Table 5).
Multiple linear regression analysis found that different treatment modes (p = 0.003) and ages (p < 0.001) were independent influencing factors of problems related to children’s perceived physical appearance reported by their parents. Different treatment modes were not independent influencing factors of scores of other QOL dimensions including male sex (reference = female) (p = 0.229), BMI (p = 0.099), time since the operation (p = 0.730), problems related to communication (p = 0.701), VSDs (reference = ASDs) (p = 0.072), or other types of diseases (reference = ASDs) (p = 0.591) (Table 6).
Multiple studies have been conducted on postoperative QOL of patients with CHD, but results are inconsistent. Patients with CHD score similar to or better than their healthy peers in QOL questionnaires [26,27,28], but some studies argue that QOL might be compromised [15, 29] The disagreement may have arisen from heterogeneity in subject demographics, the questionnaire used, specific CHD, or country of origin. Our study is the first to focus on the impact of different surgical methods on CHD repair. Our results demonstrated that the QOL of children in the minimally invasive surgery group was higher than that of those in the traditional surgery group with respect to the scores of problems related to cardiac symptoms and their treatment, drug treatment, and perception of physical appearance (< 0.05). This may be related to traditional surgical procedures that use median sternotomy and cardiopulmonary bypass, which can cause more complications and leave a long scar after the operation, whereas minimally invasive surgery is characterized by less trauma, quick recovery time, and no large incision of a median sternotomy, cardiopulmonary bypass, and vascular-related injuries [30,31,32].
There were no significant differences in the scores of problems related to anxiety regarding treatment, cognitive psychology, or communication between the two groups. Some results are consistent with those from the study by Sarrechia et al. . Although the cardiovascular malformation of children with CHD had been corrected by surgery, their psychological and social problems had not disappeared following the correction of malformation, and these problems continued to affect children with CHD. This result is similar to that obtained by Wang and Li et al. [34, 35]. This emphasizes the need for psychological assessment of children with CHD by clinical medical staff to identify psychological and social problems as soon as possible and provide targeted intervention measures. In addition, it is necessary to provide health education to parents on the psychological and social aspects of CHD.
Our study showed no differences in QOL scores between children with CHD treated with minimally invasive or traditional surgery at 1 month, 1–6 months, and 6–12 months after surgery. Children with CHD and their parents may have mainly considered whether the cardiac malformation was corrected and whether the symptoms of CHD were improved at the early stages after the operation. Both minimally invasive and traditional surgical treatments can achieve ideal treatment outcomes for improving children’s hemodynamics [32, 33]. At 12–36 months after the operation, children in the minimally invasive surgery group scored higher than those in the traditional surgery group (p < 0.05), indicating that with the correction of cardiac malformation and recovery of cardiac function, the focus of children with CHD and their parents’ perception of their QOL began to shift toward their physical appearance, and permanent scarring was an important factor affecting the QOL at this stage. Children in the minimally invasive surgery group scored higher than those in the traditional surgery group, reflecting the advantage of minimally invasive surgery. However, after 36 months the scores of problems related to cardiac symptoms and their treatment, drug treatment, anxiety regarding treatment, cognitive psychology, and communication in the minimally invasive surgery group were higher than those in the traditional surgery group (p < 0.05). This suggests that the QOL of children with CHD in different periods was dynamic. After 36 months, the QOL of children with CHD treated with minimally invasive surgery was higher in the physiological and psychosocial aspects than that of those treated with traditional surgery, and this difference showed a continuous increasing trend with time, indicating a clear treatment effect of minimally invasive treatment in the medium- and long-term [12, 13, 31].
The multiple linear regression analysis results in this study revealed that different treatment modes were independent influencing factors for problems related to the perception of physical appearance in children with CHD but were not independent influencing factors for other dimensions of their QOL. This result suggests that the advantage of less trauma in the minimally invasive surgery group was related to the increased demands of children with CHD and their parents regarding physical appearance-related problems after the correction of cardiac malformation. This emphasizes the need for attention to wound management for children with CHD who have undergone traditional surgery. To ensure surgical safety, the length of the incision should be minimized as much as possible; wound management should be strengthened after surgery to include extensive health education on wound care at home and encouraging children with CHD to visit physicians at the dermatology and cosmetology department. Attention should be paid to the aesthetics of wounds in children with CHD to reduce the negative impact of permanent scars on the QOL of children with CHD.
Our study has several limitations. Firstly, as this study is a cross-sectional study, we cannot assess any fluctuations of QOL over time, thus future studies including long-term follow-up is required. Secondly, the dropout rate was as high as 14.8%, thus potential bias could not be ignored. Thirdly, our data were completely obtained from parental reports, which need to be further studied in combination with self-reported data from children. Lastly, because this study is not a randomized controlled study, although PSM was adopted, the influence of confounding factors could not be completely ruled out.
The results of our study show that problems related to the perception of physical appearance were an important factor influencing the postoperative QOL of children with CHD. Compared with traditional surgery, minimally invasive surgery can significantly improve the score of perceived physical appearance and improve the postoperative QOL of children with CHD. For children with CHD who are not eligible for minimally invasive surgery, medical staff should strengthen wound management to reduce the negative impact of permanent scars on the QOL. Furthermore, these findings highlight the need for future studies with larger sample sizes and long-term continuous follow-up to help formulate more targeted nursing interventions to improve the QOL of children with CHD.
Availability of data and materials
The dataset necessary to interpret, replicate and build upon the findings reported in the article will be made available on reasonable request and can be obtained by contacting the corresponding author.
Body mass index
Atrial septal defect
Ventricular septal defect
Congenital heart disease
Quality of Life
Average treatment effect on the treated
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Thanks to Dr. Yifeng Yang, Dr. Weizhi Zhang and RN Rong Xu of Cardiovascular Surgery Department of the Second Xiangya Hospital of Central South University for their support and guidance to conduct the study. Special thanks to all nurses in the fourth and fifth wards of the Department of Cardiovascular Surgery of the Second Xiangya Hospital of Central South University for their help.
This work was funded by the Key Project of the Chinese Academy of Medical Sciences (No.2017YFC1310802). The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Ethics approval and consent to participate
The study was approved by the ethics of the Second Xiangya Hospital of Central South University (No. 2020–800). All participants and all parents or guardians of participants under the age of 14 agreed to participate and written informed consent obtained.
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The patients’ parents gave their written informed consent for the publication of this report.
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Cite this article
Tan, H., Huang, E., Deng, X. et al. Effects of minimally invasive and traditional surgeries on the quality of life of children with congenital heart disease: a retrospective propensity score-matched study. BMC Pediatr 21, 522 (2021). https://doi.org/10.1186/s12887-021-02978-5
- Congenital heart disease
- Minimally invasive operation
- Traditional surgery
- Quality of life