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  1. The high HIV prevalence in South Africa may potentially be shaping the local adverse drug reaction (ADR) burden. We aimed to describe the prevalence and characteristics of serious ADRs at admission, and during...

    Authors: Johannes P. Mouton, Melony C. Fortuin-de Smidt, Nicole Jobanputra, Ushma Mehta, Annemie Stewart, Reneé de Waal, Karl-Günter Technau, Andrew Argent, Max Kroon, Christiaan Scott and Karen Cohen

    Citation: BMC Pediatrics 2020 20:3

    Content type: Research article

    Published on:

  2. Early diagnosis and treatment are improving significantly the quality of life of patients with cystic fibrosis (CF). This recessive disease is caused by a great variability of mutations in the CF transmembrane...

    Authors: Joana Rosa, Patrícia Gaspar-Silva, Paula Pacheco, Conceição Silva, Cláudia C. Branco, Barbara S. Vieira, Alexandra Carreiro, Juan Gonçalves and Luisa Mota-Vieira

    Citation: BMC Pediatrics 2020 20:2

    Content type: Research article

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  3. Choice of insulin delivery for type 1 diabetes can be difficult for many parents and children. We evaluated decision coaching using a patient decision aid for helping youth with type 1 diabetes and parents dec...

    Authors: Margaret L. Lawson, Allyson L. Shephard, Bryan Feenstra, Laura Boland, Nadia Sourial and Dawn Stacey

    Citation: BMC Pediatrics 2020 20:1

    Content type: Research article

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  4. Positional deformities (PD) are common during early infancy. Severe cases may result in facial abnormalities and be associated with delayed neurological development in infants. The earlier the detection of PD,...

    Authors: Wang Yang, Jianping Chen, Wenzhi Shen, Chengju Wang, Zhifeng Wu, Qing Chang, Wenzao Li, Kuilin Lv, Qiuming Pan, Hongxia Li, Duyao Ha and Yuping Zhang

    Citation: BMC Pediatrics 2019 19:520

    Content type: Research article

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  5. Bacterial meningitis (BM) is a serious, life-threatening infectious disease of the central nervous system that often occurs in young children. The most common severe to moderate sequelae following BM are senso...

    Authors: O. El Tahir, R. C. J. de Jonge, S. Ouburg, S. A. Morré and A. M. van Furth

    Citation: BMC Pediatrics 2019 19:519

    Content type: Study protocol

    Published on:

  6. Undernutrition poses a serious health challenge in developing countries and Tanzania has the highest undernutrition burden of Eastern and Southern Africa. Poor infant and young child feeding practices have bee...

    Authors: Ahmed Gharib Khamis, Akwilina Wendelin Mwanri, Julius Edward Ntwenya and Katharina Kreppel

    Citation: BMC Pediatrics 2019 19:518

    Content type: Research article

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  7. Given its narrow therapeutic range, digoxin’s pharmacokinetic parameters in infants are difficult to predict due to variation in birth weight and gestational age, especially for critically ill newborns. There ...

    Authors: Shu-Hui Yao, Hsiang-Te Tsai, Wen-Lin Lin, Yu-Chieh Chen, Chiahung Chou and Hsiang-Wen Lin

    Citation: BMC Pediatrics 2019 19:517

    Content type: Research article

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  9. Gynecomastia develops due to the reversed estradiol-to-Testosterone ratio in adolescence, and symptoms typically improve within 2 years. The causes vary widely, including estrogen excess and tumors, and surgic...

    Authors: Jung-Eun Moon, Cheol Woo Ko, Jung Dug Yang and Joon Seok Lee

    Citation: BMC Pediatrics 2019 19:515

    Content type: Case report

    Published on:

  10. A healthy migrant effect on birth outcomes has been reported, however, whether this protective effect persists throughout childhood is unknown. The effect of urbanicity on child health among an immigrant popul...

    Authors: Ya-Ting Chang, Huei-Shyong Wang, Jia-Rou Liu, Chi-Nan Tseng, I-Jun Chou, Shue-Fen Luo, Chang-Fu Kuo and Lai-Chu See

    Citation: BMC Pediatrics 2019 19:514

    Content type: Research article

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  11. Spinal cord injury without radiographic abnormality (SCIWORA) is defined as having “clinical symptoms of traumatic myelopathy with no radiographic or computed tomographic features of spinal fracture or instabi...

    Authors: Qin Chuan Liang, Bo Yang, Yun Hai Song, Pin Pin Gao, Ze Yang Xia and Nan Bao

    Citation: BMC Pediatrics 2019 19:513

    Content type: Case report

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  12. Natural vegetable oils are widely used for newborn massage in many low resource settings. Animal models indicated that sunflower seed oil (SSO) can accelerate skin barrier recovery following damage, while othe...

    Authors: Aimee Summers, Marty O. Visscher, Subarna K. Khatry, Jeevan B. Sherchand, Steven C. LeClerq, Joanne Katz, James M. Tielsch and Luke C. Mullany

    Citation: BMC Pediatrics 2019 19:512

    Content type: Research article

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  13. In developed economies, obesity prevalence is high within children from some culturally and linguistically diverse (CALD) backgrounds. This study aims to identify whether CALD groups in Victoria, Australia, ar...

    Authors: Breanna Scott, Kristy A. Bolton, Claudia Strugnell, Steven Allender and Jennifer Marks

    Citation: BMC Pediatrics 2019 19:511

    Content type: Research article

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  14. Isolated sulfite oxidase deficiency (ISOD) is an autosomal recessive disorder caused by a deficiency of sulfite oxidase, which is encoded by the sulfite oxidase gene (SUOX). Clinically, the disorder is classified...

    Authors: Maoqiang Tian, Yi Qu, Lingyi Huang, Xiaojuan Su, Shiping Li, Junjie Ying, Fengyan Zhao and Dezhi Mu

    Citation: BMC Pediatrics 2019 19:510

    Content type: Case report

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  15. For every newborn who dies within the first month, as many as eight more suffer life-threatening complications but survive (termed ‘neonatal near-misses’ (NNM)). However, there is no universally agreed-upon de...

    Authors: Ashura Bakari, April J. Bell, Samuel A. Oppong, Yemah Bockarie, Priscilla Wobil, Gyikua Plange-Rhule, Bamenla Q. Goka, Cyril M. Engmann, Richard M. Adanu and Cheryl A. Moyer

    Citation: BMC Pediatrics 2019 19:509

    Content type: Research article

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  16. Increasing studies have focused on motor function/dysfunction in PICU survivors; however, most studies have focused on adults and older children. This study investigated gross motor developmental function outc...

    Authors: Chun-Feng Yang, Yang Xue, Jun-Yan Feng, Fei-Yong Jia, Yu Zhang and Yu-Mei Li

    Citation: BMC Pediatrics 2019 19:508

    Content type: Research article

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  17. Maternal obesity and high gestational weight gain (GWG) disproportionally affect low-income populations and may be associated with child neurodevelopment in a sex-specific manner. We examined sex-specific asso...

    Authors: Elizabeth M. Widen, Amy R. Nichols, Linda G. Kahn, Pam Factor-Litvak, Beverly J. Insel, Lori Hoepner, Sara M. Dube, Virginia Rauh, Frederica Perera and Andrew Rundle

    Citation: BMC Pediatrics 2019 19:507

    Content type: Research article

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  18. Neonatal jaundice is a common finding in newborns in Asia, including Indonesia. In some cases, the serum total bilirubin levels exceeds the 95th percentile for hours of life (neonatal hyperbilirubinemia). Seve...

    Authors: Dewi A. Wisnumurti, Yunia Sribudiani, Robert M. Porsch, Ani M. Maskoen, Sri E. Rahayuningsih, Eni K. Asni, Frank Sleutels, Wilfred F. J. van Ijcken, Abdurachman Sukadi and Tri H. Achmad

    Citation: BMC Pediatrics 2019 19:506

    Content type: Research article

    Published on:

  19. Cleft lip and/or palate is among the most prevalent congenital birth defects, and negatively affects maternal psychological status and may consequently result in higher prevalence of child maltreatment. Howeve...

    Authors: Shinobu Tsuchiya, Masahiro Tsuchiya, Haruki Momma, Takeyoshi Koseki, Kaoru Igarashi, Ryoichi Nagatomi, Takahiro Arima and Nobuo Yaegashi

    Citation: BMC Pediatrics 2019 19:505

    Content type: Research article

    Published on:

  20. Relatively little is known about weight management programs targeted toward young children with obesity. Using data from the Early Lifestyles Intervention program, we report outcomes from a referral-based, mul...

    Authors: Eric E. Wickel, Lamiaa Ali, Hollie Hawkins and Eden Hemming

    Citation: BMC Pediatrics 2019 19:504

    Content type: Research article

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  21. The aim of this study was to determine whether physical activity volume and intensity in mid-childhood and early adolescence were associated with cardiometabolic risk factors at 13.5 years.

    Authors: Sarah H. Kehoe, Ghattu V. Krishnaveni, Sargoor Veena, Krishnarajasagara N. Kiran, Samuel C. Karat, Asha Dhubey, Patsy Coakley and Caroline H. D. Fall

    Citation: BMC Pediatrics 2019 19:503

    Content type: Research article

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  22. Pulmonary arterial hypertension (PAH) caused by congenital heart disease (CHD) is very common in clinics. Some studies have shown that PAH is related to the number of endothelial progenitor cells (EPCs), but t...

    Authors: Hong-Xiao Sun, Guo-Ju Li, Zhan-Hui Du, Zhen Bing, Zhi-Xian Ji, Gang Luo and Si-Lin Pan

    Citation: BMC Pediatrics 2019 19:502

    Content type: Research article

    Published on:

  23. Helicobacter pylori infection is known to alter growth-related hormones and affect growth in young children. However, it is still unknown whether maternal H. pylori infection has an impact on the levels of cord b...

    Authors: Fu-Ping Lai, Yi-Fang Tu, Bor-Shyang Sheu and Yao-Jong Yang

    Citation: BMC Pediatrics 2019 19:501

    Content type: Research article

    Published on:

  24. The rapid triage and treatment system for paediatrics (RETTS-p) has been used by the emergency medical services (EMS) in the west of Sweden since 2014. The performance of the RETTS-p in the pre-hospital settin...

    Authors: Carl Magnusson, Johan Herlitz, Thomas Karlsson, Maria Jiménez-Herrera and Christer Axelsson

    Citation: BMC Pediatrics 2019 19:500

    Content type: Research article

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  25. The neonatal period is the most vulnerable time for child survival. The declines in the neonatal mortality rate have been slower than the post-neonatal under-five mortality rate in the majority of countries. T...

    Authors: Abera Mersha, Agegnehu Bante and Shitaye Shibiru

    Citation: BMC Pediatrics 2019 19:499

    Content type: Research article

    Published on:

  26. Fetal alcohol spectrum disorder (FASD) is a highly prevalent lifelong disorder with high rates of comorbid neurodevelopmental disorders. Individuals with FASD are often exposed to abuse, neglect and foster hom...

    Authors: Cassondra Kambeitz, Marilyn G. Klug, Jacob Greenmyer, Svetlana Popova and Larry Burd

    Citation: BMC Pediatrics 2019 19:498

    Content type: Research article

    Published on:

  27. It is critically important to assess the prognostic value of NT-proBNP in the form of repeated measures among children undergoing surgery for congenital heart defects (CHD). The aim of the present study is to ...

    Authors: Fangqin Lin, Lingling Zheng, Yanqin Cui, Weidan Chen, Ramit Kumar Gupta, Huixian Li, Xinxin Chen, Huimin Xia and Huiying Liang

    Citation: BMC Pediatrics 2019 19:497

    Content type: Research article

    Published on:

  28. There is a high global burden of neonatal mortality, with many newborn babies dying of preventable and treatable conditions, particularly in low and middle-income countries. Improving quality of newborn care c...

    Authors: Christiane Horwood, Lyn Haskins, Silondile Luthuli and Neil McKerrow

    Citation: BMC Pediatrics 2019 19:496

    Content type: Research article

    Published on:

  29. This study aims to investigate the application value of three-dimensional arterial spin labeling (3DASL) in investigating cerebral blood flow dynamics in full-term neonates.

    Authors: Jia-Ning Wang, Jia Li, Huai-Jun Liu, Xiao-Ping Yin, Huan Zhou, Ya-Ting Zheng, Na An, Si Liang and Zuo-Jun Geng

    Citation: BMC Pediatrics 2019 19:495

    Content type: Research article

    Published on:

  31. Recently, pathogenic alleles within ubiquitin N-recognin domain-containing E3 ligase 4 (UBR4) gene have been shown to be associated with Hirschsprung disease (HSCR). We determined the UBR4 expressions in Indonesi...

    Authors: Gunadi, Alvin Santoso Kalim, Estelita Liana, Aditya Rifqi Fauzi, Dian Nirmala Sirait, Dwiki Afandy, Sagita Mega Sekar Kencana, Eko Purnomo, Kristy Iskandar and Akhmad Makhmudi

    Citation: BMC Pediatrics 2019 19:493

    Content type: Research article

    Published on:

  32. Colon stenosis and acute appendicitis are rare diseases among premature babies. To the best of our knowledge, no study has identified both the conditions in preterm babies.

    Authors: Takuto Naito, Hiromu Teramen, Hiroaki Hayashi, Mai Takegawa, Haruko Sakamoto, Toshihide Shimada, Koichi Ohno and Misao Yoshii

    Citation: BMC Pediatrics 2019 19:492

    Content type: Case report

    Published on:

  33. Earlier studies evaluated the physiological responses to video games in children with different clinical conditions; however, no study has compared active video games with an incremental field test in healthy ...

    Authors: Cristiane A. Moran, Simone Dal Corso, Maria Teresa Bombig, Andrey Jorge Serra, Silvana Alves Pereira and Maria Stella Peccin

    Citation: BMC Pediatrics 2019 19:491

    Content type: Research article

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  34. The objective of the study was to evaluate data on early-onset neonatal invasive infections in western Sweden for the period 1997–2017. To identify changes in incidence, etiology and mortality and compare to p...

    Authors: Margrét Johansson Gudjónsdóttir, Anders Elfvin, Elisabet Hentz, Ingegerd Adlerberth, Ingemar Tessin and Birger Trollfors

    Citation: BMC Pediatrics 2019 19:490

    Content type: Research article

    Published on:

  35. There is increasing evidence that intrauterine environment and, consequently, growth in utero have both immediate and far-reaching consequences for health. Neonatal body composition might be a more sensitive m...

    Authors: Cornelia Wiechers, Sara Kirchhof, Christoph Maas, Christian F. Poets and Axel R. Franz

    Citation: BMC Pediatrics 2019 19:489

    Content type: Research article

    Published on:

    The Research article to this article has been published in BMC Pediatrics 2019 19:488

  36. During pregnancy, a variety of factors can influence fetal growth and development. Intrauterine growth may impact on later life and health. Neonatal body composition may be a more sensitive marker for the intr...

    Authors: Cornelia Wiechers, Sara Kirchhof, Lena Balles, Vanessa Avelina, Romy Weber, Christoph Maas, Jan Pauluschke-Fröhlich, Manfred Hallschmid, Hubert Preißl, Andreas Fritsche, Christian F. Poets and Axel R. Franz

    Citation: BMC Pediatrics 2019 19:488

    Content type: Research article

    Published on:

    The Research article to this article has been published in BMC Pediatrics 2019 19:489

  38. Problems arising from medicines usage are recognised as a key patient safety issue. Children are a particular concern, given that they are more likely than adults to experience medication-related harm. While p...

    Authors: Adam Sutherland, Denham L. Phipps, Stephen Tomlin and Darren M. Ashcroft

    Citation: BMC Pediatrics 2019 19:486

    Content type: Research Article

    Published on:

  40. Handwriting difficulties are common in children with attention deficient hyperactive disorder (ADHD). The aim of our study was to find distinctive characteristics of handwriting in children with ADHD by using ...

    Authors: Rony Cohen, Batia Cohen-Kroitoru, Ayelet Halevy, Sharon Aharoni, Irena Aizenberg and Avinoam Shuper

    Citation: BMC Pediatrics 2019 19:484

    Content type: Research article

    Published on:

  41. Childhood obesity is rising in developed and developing countries, while childhood underweight is rising mainly in developing countries. Childhood underweight has been shown to increase a child’s risk of rapid...

    Authors: Saad Al-Lahham, Nidal Jaradat, Mohammad Altamimi, Ola Anabtawi, Alma Irshid, Malik AlQub, Majdi Dwikat, Fouad Nafaa, Lama Badran, Rawan Mohareb, Reema Haji, Tareq Aqqad, Sadeq Jayyab, Budour Abu Ghosh, Rina Taher and Hamzeh Al Zabadi

    Citation: BMC Pediatrics 2019 19:483

    Content type: Research article

    Published on:

  42. Globally pneumonia is the leading cause of under-five child mortality. Several risk factors for pneumonia mortality have been identified, including delay in seeking health care. For successful reduction of del...

    Authors: Getasew Mulat Bantie, Zemene Meseret, Melkamu Bedimo and Abebayehu Bitew

    Citation: BMC Pediatrics 2019 19:482

    Content type: Research article

    Published on:

  43. Dental problems are the most prevalent chronic disease worldwide, with up to half of all kindergarten children having tooth decay. However, there is a lack of evidence of whether unaddressed dental needs (UDNs...

    Authors: Magdalena Janus, Caroline Reid-Westoby, Catherine Lee, Marni Brownell and Jonathon L. Maguire

    Citation: BMC Pediatrics 2019 19:481

    Content type: Research article

    Published on:

  44. Passive transferred antibodies to the fetus play an essential role on protecting neonates and young infants until infant vaccination is more efficacious. However, very little is known about the discrepancy of ...

    Authors: Qinghong Meng, Qinghui Qian, Li Li, Dandan Liu, Wei Gao, Lin Yuan and Kaihu Yao

    Citation: BMC Pediatrics 2019 19:480

    Content type: Research article

    Published on:

  45. Allergic diseases, such as asthma, dermatitis, rhinitis, and eczema, are highly prevalent in Chinese school children. Environmental factors, including air pollution and automobile exhaust, play an important ro...

    Authors: Bolan Yu, Lijuan Dai, Juanjuan Chen, Wen Sun, Jingsi Chen, Lili Du, Nali Deng and Dunjin Chen

    Citation: BMC Pediatrics 2019 19:479

    Content type: Research article

    Published on:

  46. Despite advances in the field of pediatric oncology, cancer remains a leading cause of death in children. The delays in cancer diagnosis may occur throughout the diagnostic pathway. Diagnosis of childhood canc...

    Authors: Alemseged Berhane, Tadele Hailu and Afework Mulugeta

    Citation: BMC Pediatrics 2019 19:478

    Content type: Research article

    Published on:

  47. Nutritive sucking is a complex activity, the biomechanical components of which may vary in relation to respiratory phase, swallow-rate per minute, suck-swallow ratio, and swallow non-inspiratory flow (SNIF). Q...

    Authors: M. L. J. Lagarde, N. van Alfen, S. A. F. de Groot, A. C. H. Geurts and L. van den Engel-Hoek

    Citation: BMC Pediatrics 2019 19:477

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Pediatrics 2020 20:44

  48. Recent guidelines recommend a cranial ultrasound (CU) in neonates born at < 30 weeks gestation, admitted to the neonatal intensive care unit (NICU), or with a CU indication. Here, we addressed the need to exte...

    Authors: Judith Weise, Matthias Heckmann, Hagen Bahlmann, Till Ittermann, Heike Allenberg, Grzegorz Domanski and Anja Erika Lange

    Citation: BMC Pediatrics 2019 19:476

    Content type: Research article

    Published on:

  49. Family dissolution has become more common and one third of the child population in most Western countries now experience family dissolution. Studies show that children from dissolved families have lower levels...

    Authors: Line Lund Laursen, Kathrine Bang Madsen, Carsten Obel and Lena Hohwü

    Citation: BMC Pediatrics 2019 19:449

    Content type: Research article

    Published on:

  50. The purpose of this study was to examine differences in attitudes to feeding in neonates with Gastroschisis between clinical groups and to develop a standardized feeding protocol. Confusion, inconsistencies in...

    Authors: Donna Hobson, Kaye Spence, Amit Trivedi and Gordon Thomas

    Citation: BMC Pediatrics 2019 19:475

    Content type: Research article

    Published on:

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