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  1. Content type: Research article

    There is increasing recognition of the value of “real-world evidence” in evaluating health care services. Registry-based, observational studies conducted in clinical settings represent a relevant model to achi...

    Authors: Katherine M. Morrison, Geoff D. C. Ball, Josephine Ho, Pam Mackie, Annick Buchholz, Jean-Pierre Chanoine, Jill Hamilton, Anne-Marie Laberge, Laurent Legault, Lehana Thabane, Mark Tremblay and Ian Zenlea

    Citation: BMC Pediatrics 2018 18:237

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  2. Content type: Study protocol

    Globally one out of four children under 5 years is affected by linear growth delay (stunting). This syndrome has severe long-term sequelae including increased risk of illness and mortality and delayed psychomotor...

    Authors: Pascale Vonaesch, Rindra Randremanana, Jean-Chrysostome Gody, Jean-Marc Collard, Tamara Giles-Vernick, Maria Doria, Inès Vigan-Womas, Pierre-Alain Rubbo, Aurélie Etienne, Emilson Jean Andriatahirintsoa, Nathalie Kapel, Eric Brown, Kelsey E. Huus, Darragh Duffy, B.Brett Finlay, Milena Hasan…

    Citation: BMC Pediatrics 2018 18:236

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  3. Content type: Study protocol

    Nutrition and environmental factors are essential for the education of the neonatal immune system. Epidemiological evidence has shown that malnutrition and allergic diseases that occur during early childhood s...

    Authors: Fui Chee Woon, Yit Siew Chin, Intan Hakimah Ismail, Yoke Mun Chan, Marijka Batterham, Amir Hamzah Abdul Latiff, Wan Ying Gan and Geeta Appannah

    Citation: BMC Pediatrics 2018 18:233

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  4. Content type: Study protocol

    Adolescents with chronic illness (CI) and parents of a child with CI are at risk for psychosocial problems. Psychosocial group interventions may prevent these problems. With the use of cognitive-behavioral the...

    Authors: Miriam Douma, Linde Scholten, Heleen Maurice-Stam and Martha A. Grootenhuis

    Citation: BMC Pediatrics 2018 18:235

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  5. Content type: Research article

    Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infan...

    Authors: Abhishek Chopra, Anup Thakur, Pankaj Garg, Neelam Kler and Kanwal Gujral

    Citation: BMC Pediatrics 2018 18:234

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  6. Content type: Study protocol

    A child’s first years of life are crucial for cognitive development and future health. Studies show that a varied diet with a high intake of vegetables is positive for both weight and cognitive development. Th...

    Authors: Eli Anne Myrvoll Blomkvist, Sissel Heidi Helland, Elisabet Rudjord Hillesund and Nina Cecilie Øverby

    Citation: BMC Pediatrics 2018 18:232

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  7. Content type: Study protocol

    Children with congenital heart disease (CHD) are at increased risk for behavioral, emotional, and cognitive problems. They often have reduced exercise capacity and participate less in sports, which is associat...

    Authors: Malindi van der Mheen, Ingrid M. van Beynum, Karolijn Dulfer, Jan van der Ende, Eugène van Galen, Jorieke Duvekot, Lisette E. Rots, Tabitha P. L. van den Adel, Ad J. J. C. Bogers, Christopher G. McCusker, Frank A. Casey, Willem A. Helbing and Elisabeth M. W. J. Utens

    Citation: BMC Pediatrics 2018 18:230

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  8. Content type: Research article

    To investigate the unique features of inflammatory bowel disease (IBD) in children, we wanted to identify whether there might be a strong correlation between the disease phenotype and its prognosis at various ...

    Authors: Xin-Qiong Wang, Yuan Xiao, Xu Xu, Yi Yu, Cheng-Yan Shan, Yan Guo, Ling Gong, Tong Zhou, Shen-Shen Gao, Yao-Zong Yuan, Xiao-Jin Wang and Chun-Di Xu

    Citation: BMC Pediatrics 2018 18:229

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  9. Content type: Case report

    Lesch-Nyhan syndrome is a rare inborn error of purine metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). Inherited as an X-linked recessive genetic ...

    Authors: Lisa B. E. Shields, Dennis S. Peppas and Eran Rosenberg

    Citation: BMC Pediatrics 2018 18:231

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  10. Content type: Research article

    It was unclear how and to what extent the “Child Care” intervention (CCI) in rural Primary Health Care Program affected the prevalence of childhood diarrhea in rural western China.

    Authors: Wenlong Gao, Guirong Li, Xiaoning Liu and Hong Yan

    Citation: BMC Pediatrics 2018 18:228

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  11. Content type: Research article

    Measurement of transcutaneous bilirubin (TcB) is a quick, reliable and painless method to guide management of hyperbilirubinemia. Studies in term and late preterm infants have found that TcB measurements from ...

    Authors: Vidit Bhargava, Daniel Tawfik, Bruce Niebuhr and Sunil K. Jain

    Citation: BMC Pediatrics 2018 18:227

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  12. Content type: Study protocol

    The greatest opportunity for lifelong impact of genomic sequencing is during the newborn period. The “BabySeq Project” is a randomized trial that explores the medical, behavioral, and economic impacts of integ...

    Authors: Ingrid A. Holm, Pankaj B. Agrawal, Ozge Ceyhan-Birsoy, Kurt D. Christensen, Shawn Fayer, Leslie A. Frankel, Casie A. Genetti, Joel B. Krier, Rebecca C. LaMay, Harvey L. Levy, Amy L. McGuire, Richard B. Parad, Peter J. Park, Stacey Pereira, Heidi L. Rehm, Talia S. Schwartz…

    Citation: BMC Pediatrics 2018 18:225

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  13. Content type: Research article

    Various intervention programs exist for parents of preterm babies and some systematic reviews (SRs) have synthesised the evidence of their effectiveness. These reviews are, however, limited to specific interve...

    Authors: Shuby Puthussery, Muhammad Chutiyami, Pei-Ching Tseng, Lesley Kilby and Jogesh Kapadia

    Citation: BMC Pediatrics 2018 18:223

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  14. Content type: Study protocol

    HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) ...

    Authors: R. Chingono, H. Mebrahtu, Z. Mupambireyi, V. Simms, H. A. Weiss, P. Ndlovu, F. Charasika, M. Tomlinson, L.D. Cluver, F. M. Cowan and L. Sherr

    Citation: BMC Pediatrics 2018 18:222

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  16. Content type: Correction

    After publication of the original article [1], the corresponding author noticed the given names and family names of the members included in the Swiss Neonatal End-of-Life Study Group were incorrectly reverted.

    Authors: Hans Ulrich Bucher, Sabine D. Klein, Manya J. Hendriks, Ruth Baumann-Hölzle, Thomas M. Berger, Jürg C. Streuli and Jean-Claude Fauchère

    Citation: BMC Pediatrics 2018 18:226

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    The original article was published in BMC Pediatrics 2018 18:81

  17. Content type: Study protocol

    Initial studies suggest pharmaceutical grade cannabidiol (CBD) can reduce the frequency of convulsive seizures and lead to improvements in quality of life in children affected by epileptic encephalopathies. Wi...

    Authors: Darren Reithmeier, Richard Tang-Wai, Blair Seifert, Andrew W. Lyon, Jane Alcorn, Bryan Acton, Scott Corley, Erin Prosser-Loose, Darrell D. Mousseau, Hyun J. Lim, Jose Tellez-Zenteno, Linda Huh, Edward Leung, Lionel Carmant and Richard J. Huntsman

    Citation: BMC Pediatrics 2018 18:221

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  18. Content type: Study protocol

    Babies born at moderate-late preterm gestations account for > 80% of all preterm births. Although survival is excellent, these babies are at increased risk of adverse neurodevelopmental outcomes. They also are...

    Authors: Frank H. Bloomfield, Jane E. Harding, Michael P. Meyer, Jane M. Alsweiler, Yannan Jiang, Clare R. Wall and Tanith Alexander

    Citation: BMC Pediatrics 2018 18:220

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  19. Content type: Study protocol

    Bronchiolitis is the most common reason for admission to hospital for infants less than one year of age. Although management is well defined, there is substantial variation in practice, with infants receiving ...

    Authors: Libby Haskell, Emma J. Tavender, Catherine Wilson, Sharon O’Brien, Franz E. Babl, Meredith L. Borland, Liz Cotterell, Tibor Schuster, Francesca Orsini, Nicolette Sheridan, David Johnson, Ed Oakley and Stuart R. Dalziel

    Citation: BMC Pediatrics 2018 18:218

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  21. Content type: Research article

    We previously reported that perinatal dioxin exposure increased autistic traits in children living in dioxin-contaminated areas of Vietnam. In the present study, we investigated the impact of dioxin exposure o...

    Authors: Anh Thi Nguyet Nguyen, Muneko Nishijo, Tai The Pham, Nghi Ngoc Tran, Anh Hai Tran, Luong Van Hoang, Hitomi Boda, Yuko Morikawa, Yoshikazu Nishino and Hisao Nishijo

    Citation: BMC Pediatrics 2018 18:213

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  22. Content type: Case report

    Generalized Arterial Calcification of Infancy (GACI) is a heritable ectopic mineralization disorder resulting in diffuse arterial calcifications and/or stenosis, mostly caused by mutations in the ENPP1 gene. Here...

    Authors: Iole Brunod, Barthélémy Tosello, Sophie Hassid, Catherine Gire, Laurent Thomachot and Michel Panuel

    Citation: BMC Pediatrics 2018 18:217

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  23. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is complicated disease and increasing worldwide. Previously, many studies of NALFD prevalences have used alanine aminotransferase (ALT) of > 40 U/L to define NAFLD, al...

    Authors: Yunkoo Kang, Sowon Park, Seung Kim and Hong Koh

    Citation: BMC Pediatrics 2018 18:215

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  24. Content type: Research article

    Acute respiratory infection (ARI) is the leading cause of morbidity and mortality in pediatric patients worldwide and imposes an intense pressure on health care facilities. Data on the epidemiology profiles of...

    Authors: Jiayi Chen, Pengwei Hu, Tao Zhou, Tianli Zheng, Lingxu Zhou, Chunping Jiang and Xiaofang Pei

    Citation: BMC Pediatrics 2018 18:216

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  25. Content type: Case report

    Human milk is fundamental for its nutritional properties and to protect newborns, but it is not sterile and can sometime transmit bacteria. Few anecdotal cases suggest that breast milk could be a possible sour...

    Authors: Giangiacomo Nicolini, Martina Borellini, Vitaliana Loizzo, Roberta Creti, Luigi Memo and Alberto Berardi

    Citation: BMC Pediatrics 2018 18:214

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  26. Content type: Research article

    Exploring the osteogenic effect of different bone-loading sports is particular relevant to understand the interaction between skeletal muscle and bone health during growth. This study aimed to compare total an...

    Authors: João Valente-dos-Santos, Óscar M. Tavares, João P. Duarte, Paulo M. Sousa-e-Silva, Luís M. Rama, José M. Casanova, Carlos A. Fontes-Ribeiro, Elisa A. Marques, Daniel Courteix, Enio R. V. Ronque, Edilson S. Cyrino, Jorge Conde and Manuel J. Coelho-e-Silva

    Citation: BMC Pediatrics 2018 18:212

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  27. Content type: Research article

    Newborn weight change (NWC) in the first 4 days represents short-term adaptations to external environment. It may be a key developmental period for future cardio-metabolic health, but this has not been explore...

    Authors: Maria João Fonseca, Milton Severo, Debbie A. Lawlor, Henrique Barros and Ana Cristina Santos

    Citation: BMC Pediatrics 2018 18:211

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  28. Content type: Case report

    Renal hypouricemia is a rare heterogeneous inherited disorder characterized by impaired tubular uric acid transport, reabsorption insufficiency and /or acceleration of secretion. The affected individuals are p...

    Authors: Dinesha Maduri Vidanapathirana, Subashinie Jayasena, Eresha Jasinge and Blanka Stiburkova

    Citation: BMC Pediatrics 2018 18:210

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  29. Content type: Research article

    Chinese immigrants are the third largest immigrant group in Australia. Recent qualitative evidence from Victorian Maternal and Child Health nurses indicate that infants of Chinese parents commonly have rapid g...

    Authors: Kristy A. Bolton, Peter Kremer, Kylie D. Hesketh, Rachel Laws, Konsita Kuswara and Karen J. Campbell

    Citation: BMC Pediatrics 2018 18:209

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  30. Content type: Research article

    Neonatal sepsis, one of the leading causes of mortality in neonatal intensive care units (NICU) of developing countries like Nepal, is often not extensively studied. In order to decrease the morbidity and mort...

    Authors: Bhishma Pokhrel, Tapendra Koirala, Ganesh Shah, Suchita Joshi and Pinky Baral

    Citation: BMC Pediatrics 2018 18:208

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  31. Content type: Research article

    Adverse childhood experiences (ACEs) negatively impact health throughout the life course. For children exposed to ACEs, resilience may be particularly important. However, the literature regarding resilience, p...

    Authors: Nia Heard-Garris, Matthew M. Davis, Moira Szilagyi and Kristin Kan

    Citation: BMC Pediatrics 2018 18:204

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  32. Content type: Research article

    Very preterm birth (24 to < 32 week’s gestation) is a major public health issue due to its prevalence, the clinical and ethical questions it raises and the associated costs. It raises two major clinical and et...

    Authors: Isabelle Aujoulat, Séverine Henrard, Anne Charon, Anne-Britt Johansson, Jean-Paul Langhendries, Anne Mostaert, Danièle Vermeylen and Gaston Verellen

    Citation: BMC Pediatrics 2018 18:206

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  33. Content type: Research article

    Emergency Department (ED) revisits have often been used as an indicator of medical care quality. This study aimed to quantify the frequency of ED revisits within 72 h of discharge and identify its factors amon...

    Authors: Anwar E. Ahmed, Bashayr I. ALMuqbil, Manair N. Alrajhi, Hend R. Almazroa, Doaa A. AlBuraikan, Monirah A. Albaijan, Maliha Nasim, Majid A. Alsalamah, Donna K. McClish and Hamdan AL-Jahdali

    Citation: BMC Pediatrics 2018 18:205

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  34. Content type: Case report

    Whilst hypocalcemic complications from vitamin D deficiency are considered rare in high-income countries, they are highly prevalent among Black, Asian and Minority Ethnic (BAME) group with darker skin. To date...

    Authors: Suma Uday, Nadja Fratzl-Zelman, Paul Roschger, Klaus Klaushofer, Ashish Chikermane, Vrinda Saraff, Ted Tulchinsky, Tom D. Thacher, Tamas Marton and Wolfgang Högler

    Citation: BMC Pediatrics 2018 18:183

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  35. Content type: Research article

    Fluid overload (FO) is associated with unfavorable outcomes in critically ill children. Clinicians are encouraged to avoid FO; however, strategies to avoid FO are not well-described in pediatrics. Our aim was ...

    Authors: Franco Díaz, María José Nuñez, Pablo Pino, Benjamín Erranz and Pablo Cruces

    Citation: BMC Pediatrics 2018 18:207

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  37. Content type: Research article

    We aimed to compare the antipyretic efficacy, safety, and tolerability between oral dexibuprofen and intravenous propacetamol in children with upper respiratory tract infection (URTI) presenting with fever.

    Authors: Seung Jun Choi, Sena Moon, Ui Yoon Choi, Yoon Hong Chun, Jung Hyun Lee, Jung Woo Rhim, Jin Lee, Hwang Min Kim and Dae Chul Jeong

    Citation: BMC Pediatrics 2018 18:201

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  38. Content type: Research article

    Neonatal hyperbilirubinaemia is one of the commonest causes of hospital visit in the neonatal period. When severe, it is a leading cause of irreversible neurological and musculoskeletal disability. Prompt reco...

    Authors: Chidiebere D. I. Osuorah, Uchenna Ekwochi and Isaac N. Asinobi

    Citation: BMC Pediatrics 2018 18:202

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  39. Content type: Research article

    Measuring adolescents’ preferences for health states can play an important role in evaluating the delivery of pediatric healthcare. However, formal evaluation of the common direct preference elicitation method...

    Authors: R. Trafford Crump, Ryan Lau, Elizabeth Cox, Gillian Currie and Julie Panepinto

    Citation: BMC Pediatrics 2018 18:199

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  40. Content type: Study protocol

    Kawasaki disease (KD) is an acute febrile systemic vasculitis most commonly seen in children under 5 years old. High-dose aspirin is often administered, but the duration of such treatment varies. Many centers ...

    Authors: Ho-Chang Kuo, Mindy Ming-Huey Guo, Mao-Hung Lo, Kai-Sheng Hsieh and Ying-Hsien Huang

    Citation: BMC Pediatrics 2018 18:200

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  41. Content type: Case report

    Hemolytic streptococcus gangrene is a life threatening invasive bacterial infection. Hemolytic streptococcus gangrene in the danger triangle of the face is too lethal to operate. A case of the confirmed hemolytic...

    Authors: Xiao-ling Jia, Janak L. Pathak, Jin-fa Tong and Ji-mei Su

    Citation: BMC Pediatrics 2018 18:198

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  43. Content type: Research article

    Low vitamin D levels have been linked to the risk of sleep-disordered breathing (SDB) in children. Although adenotonsillar hypertrophy (ATH) is the major contributor to childhood SDB, the relationship between ...

    Authors: Ji-Hyeon Shin, Byung-Guk Kim, Boo Young Kim, Soo Whan Kim, Sung Won Kim and Hojong Kim

    Citation: BMC Pediatrics 2018 18:196

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  45. Content type: Research article

    Fever phobia is still a major issue in paediatrics. We report knowledge of a sample of Italian paediatricians performed six years after the release of the Italian guidelines for the management of fever in chil...

    Authors: Elena Chiappini, Antonina Marta Cangelosi, Paolo Becherucci, Monica Pierattelli, Luisa Galli and Maurizio de Martino

    Citation: BMC Pediatrics 2018 18:194

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  46. Content type: Research article

    Fibroblast growth factor 23 (FGF23) and insulin-like growth factor binding protein 7 (IGFBP-7) are suggested to be biomarkers for predicting acute kidney injury (AKI). We compared them with proposed AKI biomar...

    Authors: Zhenjiang Bai, Fang Fang, Zhong Xu, Chunjiu Lu, Xueqin Wang, Jiao Chen, Jian Pan, Jian Wang and Yanhong Li

    Citation: BMC Pediatrics 2018 18:192

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  47. Content type: Research article

    Preterm birth leads to multiple morbidities affecting the health of a child. Lack of information on the health impact of prematurity hinders the possibility of any effective public health interventions in this...

    Authors: Hemali Jayakody, Upul Senarath and Deepika Attygalle

    Citation: BMC Pediatrics 2018 18:193

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  48. Content type: Case report

    Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, atrophic gastritis, antibodies to parietal cell antigens and intrins...

    Authors: Youyou Luo, Jie Chen, Youhong Fang, Jingan Lou and Jindan Yu

    Citation: BMC Pediatrics 2018 18:191

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  49. Content type: Research article

    Indirect neonatal hyperbilirubinemia (INH) is a common neonatal disorder worldwide which can remain benign if prompt management is available. However there is a higher morbidity and mortality risk in settings ...

    Authors: L. Thielemans, M. Trip-Hoving, J. Landier, C. Turner, T. J. Prins, E. M. N. Wouda, B. Hanboonkunupakarn, C. Po, C. Beau, M. Mu, T. Hannay, F. Nosten, B. Van Overmeire, R. McGready and V. I. Carrara

    Citation: BMC Pediatrics 2018 18:190

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  50. Content type: Research article

    Erythema migrans (EM) is the most common manifestation of Lyme borreliosis (LB), caused by the spirochete Borrelia burgdorferi sensu lato. The infection can disseminate into the nervous system and cause Lyme neur...

    Authors: Kesia Backman and Barbro H. Skogman

    Citation: BMC Pediatrics 2018 18:189

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