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  1. Severe fatal human adenoviral (HAdV) pneumonia is associated with significant mortality and no effective drug is available for clinical therapy. We evaluated the association and safety of high titer neutralizi...

    Authors: Hongyan Peng, Feiyan Chen, Yunlong Zuo, Bolun Huang, Yiyu Yang and Run Dang
    Citation: BMC Pediatrics 2022 22:151
  2. Acute lymphoblastic leukemia (ALL) is the most common type of cancer in the age range of under 15 years old and accounts for 25–30% of all childhood cancers. Although conventional chemotherapy regimens are use...

    Authors: Omid Reza Zekavat, Elham Nikpendar, Sezaneh Haghpanah, Negin Shokrgozar, Seyed Javad Dehghani and Nargess Arandi
    Citation: BMC Pediatrics 2022 22:149
  3. Since Ethiopia has been implemented the Community-Led Total Sanitation and Hygiene (CLTSH) approach to control incidence of diarrhea, few studies have compared the prevalence of diarrhea and associated factors...

    Authors: Gezahegn Mernie, Helmut Kloos and Metadel Adane
    Citation: BMC Pediatrics 2022 22:148
  4. The objective of this study was to assess if children aged 0–23 months in a conflict-affected state of South Sudan were on track with their immunization schedule and to identify predisposing factors that affec...

    Authors: Israel Oluwaseyidayo Idris, Janet Tapkigen, Germaine Kabutaulaka, Gabriel Omoniyi Ayeni, Francis Ifeanyi Ayomoh and Justin Geno Obwoya
    Citation: BMC Pediatrics 2022 22:147
  5. The Peripheral Arterial Tonometry (PAT) technique measured by Endo-PAT™, is recently introduced for peripheral vascular assessment in youth, primarily benefits from its easy and non-invasive operation. However...

    Authors: Wennan He, Yi Zhang, Xuesong Li, Kai Mu, Yalan Dou, Ying Ye, Fang Liu and Weili Yan
    Citation: BMC Pediatrics 2022 22:146
  6. Hydrocephalus (HCP) is a common disorder of cerebral spinal fluid (CSF) physiology resulting in abnormal expansion of the cerebral ventricles. Infants commonly present with progressive macrocephaly whereas chi...

    Authors: Blein Mulugeta, Girma Seyoum, Abebe Mekonnen and Elbet Ketema
    Citation: BMC Pediatrics 2022 22:145
  7. Research and development of pediatric drug faces many difficulties and pediatric clinical trials remain a challenge. Since 2011, a series of measures have been taken to encourage research, development of drugs...

    Authors: Lin Song, Yuntao Jia, Sujuan Ran, Bin Li, Jin Xu, Bennian Huo, Nange Yin, Maolin Ai and Yao Liu
    Citation: BMC Pediatrics 2022 22:144
  8. During puberty, changes in body composition due to sex hormones are associated with lung mechanics. However, little is known about the mediation effect of sex differences in body composition during puberty wit...

    Authors: Ju Hee Kim, Jin Ah Kim, Eun Kyo Ha, Hye Mi Jee, Seung Won Lee, Mo Kyung Jung, Sanghoo Lee, Yoon Ho Shin, Eun-Gyong Yoo and Man Yong Han
    Citation: BMC Pediatrics 2022 22:143
  9. Noonan syndrome (NS) is a relatively rare inherited disease. Typical clinical presentation is important for the diagnosis of NS. But the initial presentation of NS could be significant variant individually whi...

    Authors: Xiujun Tang, Zheng Chen, Xiaoxia Shen, Tian Xie, Xiaohong Wang, Taixiang Liu and Xiaolu Ma
    Citation: BMC Pediatrics 2022 22:142
  10. The relationship between physical activity and health care costs among adolescents is not yet clear in the literature.

    Authors: Wésley Torres, Lucas Gabriel de Moraes Chagas, Rômulo Araújo Fernandes, Monique Yndawe Castanho Araujo, Jacqueline Bexiga Urban, Santiago Maillane-Vanegas, Bruna Camilo Turi-Lynch, Jamile Sanches Codogno and Nana Kwame Anokye
    Citation: BMC Pediatrics 2022 22:141
  11. Bacterial infection (BI), both community-acquired (CA-BI) and hospital-acquired (HAI), might present as a severe complication in patients with bronchiolitis. This study aimed to describe BI in children with se...

    Authors: Carmina Guitart, Carme Alejandre, Sara Bobillo-Perez, Monica Girona-Alarcon, Anna Sole-Ribalta, Francisco Jose Cambra, Monica Balaguer and Iolanda Jordan
    Citation: BMC Pediatrics 2022 22:140
  12. Congenital mesoblastic nephromas mainly present as asymptomatic abdominal masses, but some present hematuria, hypertension or hypercalcemia. Neonatal dyspnea in an early-birth neonate due to rapid tumor growth...

    Authors: Hirotaka Kato, Yasuyuki Mitani, Taro Goda and Hiroki Yamaue
    Citation: BMC Pediatrics 2022 22:139
  13. To assess the outcome of extracorporeal membrane oxygenation (ECMO) for severe adenovirus (Adv) pneumonia with refractory hypoxic respiratory failure (RHRF) in paediatric patients.

    Authors: Yun Cui, Jingyi Shi, Yiping Zhou, Jiaying Dou, Xi Xiong, Ting Sun, Yijun Shan, Tingting Xu, Ye Lu and Yucai Zhang
    Citation: BMC Pediatrics 2022 22:138
  14. Neonatal acute kidney injury (AKI) has been associated with unfavorable outcomes, including increased mortality. We aimed to describe the clinical course and outcomes during the first 7 days after diagnosis in...

    Authors: O. C. Pantoja-Gómez, S. Realpe, Ginna Cabra-Bautista, J. M. Restrepo, O. L. Prado, A. M. Velasco, G. E. Martínez, S. Leal, A. Vallejo and Jose Andrés Calvache
    Citation: BMC Pediatrics 2022 22:136
  15. Strokes in the paediatric age group have their own epidemiology and aetiology and are frequently misdiagnosed. As in the adult population, they present some risk factors that must be identified. Cerebral arter...

    Authors: Víctor González-Maestro, Einés Monteagudo-Vilavedra, Jorge Rodríguez-Antuña, Marta Lendoiro-Fuentes, María Soledad Brage Gómez and Elena Maside Miño
    Citation: BMC Pediatrics 2022 22:135
  16. The purpose of this study was to evaluate the utility of endoscopic retrograde cholangiopancreatography (ERCP) in pediatric patients with pancreaticobiliary diseases.

    Authors: Satoshi Makita, Hizuru Amano, Hiroki Kawashima, Akinari Hinoki, Chiyoe Shirota, Takahisa Tainaka, Wataru Sumida, Kazuki Yokota, Masamune Okamoto, Aitaro Takimoto, Akihiro Yasui, Yoichi Nakagawa and Hiroo Uchida
    Citation: BMC Pediatrics 2022 22:134
  17. Functional exercises is very essential to the recovery of patients with fracture. We aimed to evaluate the compliance of functional exercises in school-age children with limb fracture, to provide evidence to t...

    Authors: Hui Liu, Yun Wang, Mengya Li, Dan Chen and Yuping Tang
    Citation: BMC Pediatrics 2022 22:133
  18. Kawasaki disease (KD) is an acute, febrile, systemic vasculitis of unknown etiology that primarily affects the coronary arteries and generally occurs at around 1 year of age. Although the diagnosis of KD is ge...

    Authors: Yoshiki Kawamura, Hiroki Miura, Kazuyoshi Saito, Takayuki Kanno, Tadafumi Yokoyama, Yuta Aizawa and Tetsushi Yoshikawa
    Citation: BMC Pediatrics 2022 22:132
  19. Homozygous familial hypercholesterolemia (hoFH) is a rare genetic disorder leading to extremely increased LDL-cholesterol (LDL-C), resulting in high cardiovascular risk in early childhood. Lipid apheresis (LA)...

    Authors: Julia Lischka, Klaus Arbeiter, Charlotte de Gier, Andrea Willfort-Ehringer, Nina-Katharina Walleczek, Renata Gellai, Michael Boehm, Albert Wiegman and Susanne Greber-Platzer
    Citation: BMC Pediatrics 2022 22:131
  20. Patient-level predictors of enrollment in pediatric biorepositories are poorly described. Especially in pandemic settings, understanding who is likely to enroll in a biorepository is critical to interpreting a...

    Authors: Anne M. Neilan, Anisha Tyagi, Yao Tong, Eva J. Farkas, Madeleine D. Burns, Allison Fialkowski, Grace Park, Margot Hardcastle, Elizabeth Gootkind, Ingrid V. Bassett, Fatma M. Shebl and Lael M. Yonker
    Citation: BMC Pediatrics 2022 22:130
  21. Maternal dietary intake during pregnancy plays an important role in fetal development and birth outcomes. The aim of the present study was to determine maternal dietary diversity and Nutritional adequacy in re...

    Authors: Tahereh Karimi, Hassan Eini-Zinab, Arezoo Rezazadeh and Zeinab Moslemi
    Citation: BMC Pediatrics 2022 22:129
  22. Early essential newborn care (EENC) was introduced to medical practice in China in 2016, but the number of medical institutions that have put EENC into practice remains low due to insufficient clinical evidenc...

    Authors: Chuanya Huang, Lei Hu, Jingjing He and Biru Luo
    Citation: BMC Pediatrics 2022 22:127
  23. In this case report, we described the past history, clinical manifestations, genetic characteristics and cognitive evaluation of a boy with congenital insensitivity to pain with anhidrosis (CIPA) who developed...

    Authors: Mi Zhang, Xueqin Cao, Ningbo Li, Guangyou Duan and Xianwei Zhang
    Citation: BMC Pediatrics 2022 22:126
  24. Early infantile epileptic encephalopathy is a severe form of epilepsy that is genetically extremely heterogeneous and characterized by seizures or spasms at the beginning of infancy. Homozygous or compound het...

    Authors: Sepideh Gholami Yarahmadi and Saeid Morovvati
    Citation: BMC Pediatrics 2022 22:125
  25. Acute respiratory tract infection (ARI) is one of the leading causes of illness and mortality in children under the age of five worldwide. Pneumonia, which is caused by a respiratory tract infection, kills abo...

    Authors: Amanuel Merera, Tilahun Asena and Mebratu Senbeta
    Citation: BMC Pediatrics 2022 22:123
  26. Although blood lead levels (BLLs) in children are gradually decreasing, low-concentration lead exposure can still exert adverse effects. We studied the factors that affect BLLs in children in Shenyang, China.

    Authors: Xiao-Jun Cheng, Guang-Bo Li, Shuang-Shuang Zhang, Ying Liu, Yi-Chen Dong and Xue-Ning-Li
    Citation: BMC Pediatrics 2022 22:122
  27. Within Europe, the Netherlands has one of the lowest antibiotic consumption rates. We aimed to gain insight into attitudes of Dutch physicians and parents towards information provided during discharge conversa...

    Authors: Daphne Peeters, Lars M. A. van Scheppingen, Gertjan J. A. Driessen and Lilly M. Verhagen
    Citation: BMC Pediatrics 2022 22:121
  28. Bottle feeding is associated with diarrheal disease morbidity and mortality and risk of pyloric stenosis, especially in developing countries. Even though, World Health Organization (WHO) recommended avoiding b...

    Authors: Daniel Gashaneh Belay, Mihret Getnet, Yonas Akalu, Mengistie Diress, Yibeltal Yismaw Gela, Amare Belete Getahun, Desalegn Anmut Bitew, Bewuketu Terefe and Yitayeh Belsti
    Citation: BMC Pediatrics 2022 22:120
  29. Coats plus syndrome, cerebroretinal microangiopathy with calcifications and cysts, is a rare disease with autosomal recessive pattern occurring due to a mutation in CTC1, encoding conserved telomere maintenanc...

    Authors: Selcen Bozkurt, Ayse Merve Usta, Nafiye Urganci, Nida Gulderen Kalay, Gulsen Kose and Evrim Ozmen
    Citation: BMC Pediatrics 2022 22:119
  30. Smart infusion pumps with dose error reduction software can be used to prevent harmful medication errors. The aim of this study was to develop a method for defining and assessing optimal dosing limits in a neo...

    Authors: Sini Kuitunen, Krista Kärkkäinen, Carita Linden-Lahti, Lotta Schepel and Anna-Riia Holmström
    Citation: BMC Pediatrics 2022 22:118
  31. Autism spectrum disorders (ASD) are a set of developmental, psychological, and neurological disorders that occur in early childhood. The most important characteristic of individuals with autism is difficulty i...

    Authors: Hedieh Piraneh, Mahdia Gholami, Katayoun Sargeran and Ahmad Reza Shamshiri
    Citation: BMC Pediatrics 2022 22:116
  32. Anemia is one of the common hematological problems among HIV-infected children. It impairs physical functioning, affects the quality of life, increases HIV progression, and decreases survival of HIV-infected c...

    Authors: Gashaw Kerebeh, Yeneneh Ayalew, Demewoz Kefale, Ermias Sisay Chanie, Natnael Moges Misganaw, Dejen Getaneh Feleke, Amare Kassaw, Agimasie Tigabu, Berihun Bantie, Mahlet Tamirat, Teshale Mengesha, Molla Azmeraw and Aklilu Endalamaw
    Citation: BMC Pediatrics 2022 22:115
  33. Even though treatment failure is higher among TB and HIV infected children in a resource-limited setting, there is no prior evidence in general and in the study area in particular. Hence, this study was aimed ...

    Authors: Ermias Sisay Chanie, Achenef Asmamaw Muche, Mengistu Berhanu Gobeza, Eshetie Molla Alemu, Wondimnew Desalegn Addis, Melkalem Mamuye Azanaw, Alemayehu Digssie Gebremariam, Desalegn Tesfa, Melaku Tadege Engidaw, Getaneh Atikilit, Sofonyas AbebawTiruneh and Getachew Arage
    Citation: BMC Pediatrics 2022 22:114
  34. Retinopathy of prematurity (ROP) remains a leading cause of childhood blindness worldwide. This study aimed to investigate whether supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) in parenteral n...

    Authors: Rongqiang Yang, Hao Ding, Jing Shan, Xiaole Li, Jian Zhang, Guanghui Liu, Hong Zheng, Yu Su, Hongyang Yao and Kemin Qi
    Citation: BMC Pediatrics 2022 22:113
  35. With accumulating evidence suggesting that CVD has its origins in childhood obesity. The purpose of this study was to determine the effect of a real-world school-based high-intensity interval training interven...

    Authors: Cao Meng, Tang Yucheng, Li Shu and Zou Yu
    Citation: BMC Pediatrics 2022 22:112
  36. Pancreaticobiliary maljunction is a congenital anatomical abnorma l junction of the pancreatic duct and bile duct into a common channel outside the duodenal wall. Pancreas divisum is also a congenital anatomic...

    Authors: Waiun Lei, Jiayu Yan, Tingchong Zhang, Lu Liu and Yajun Chen
    Citation: BMC Pediatrics 2022 22:110
  37. There is a growing body of literature on the increasing prevalence of obesity in adolescents of Sub-Saharan African ancestry. However, limited data is available on the impact of obesity on pulmonary function. ...

    Authors: Godwill Azeh Engwa, Chungag Anye and Benedicta Ngwenchi Nkeh-Chungag
    Citation: BMC Pediatrics 2022 22:109
  38. Studies assessing the association between short birth interval, a birth-to-birth interval of less than 33 months, and under-five undernutrition have produced inconclusive results. This study aimed to assess th...

    Authors: Desalegn Markos Shifti, Catherine Chojenta, Elizabeth G. Holliday and Deborah Loxton
    Citation: BMC Pediatrics 2022 22:108
  39. Melatonin’s effectiveness as an anxiolytic medication has been confirmed in adults; however, its efficacy in a paediatric population is unclear. A number of small studies have assessed its use in children as a...

    Authors: Katie Mellor, Diana Papaioannou, Anna Thomason, Robert Bolt, Chris Evans, Matthew Wilson and Chris Deery
    Citation: BMC Pediatrics 2022 22:107
  40. Inhibitory control develops rapidly during the preschool stage, and development of inhibitory control in this period is significant for the healthy growth of the future. However, most studies paid more attenti...

    Authors: Yiyan Li, Tang Zhou, Yanhua Lu, Menghao Sang, Jiajia Liu, Xiaolong He and Minghui Quan
    Citation: BMC Pediatrics 2022 22:106
  41. Congenital central hypoventilation syndrome (CCHS) is a rare condition caused by mutations in the Paired-Like Homeobox 2B (PHOX2B) gene. It causes alveolar hypoventilation and autonomic dysregulation. This rep...

    Authors: Prakarn Tovichien, Krittin Rattananont, Narathorn Kulthamrongsri, Mongkol Chanvanichtrakool and Buranee Yangthara
    Citation: BMC Pediatrics 2022 22:105
  42. The COVID-2019 pandemic has placed extensive pressure on health systems and posed a severe public health challenge worldwide. Lockdown measures implemented in many countries have delayed virus spread. However,...

    Authors: Jinyue Yu, Mingyue Gao, Zhuang Wei, Jonathan C. K. Wells and Mary Fewtrell
    Citation: BMC Pediatrics 2022 22:104
  43. Assessing health-related quality of life (HRQOL) and its determinants in children may provide a comprehensive view of child health. The study aimed to assess the HRQOL in Indonesian children and its determinants.

    Authors: Mei Neni Sitaresmi, Braghmandita Widya Indraswari, Nisrina Maulida Rozanti, Zena Sabilatuttaqiyya and Abdul Wahab
    Citation: BMC Pediatrics 2022 22:103
  44. Oculo-auriculo-vertebral spectrum is a heterogeneous group of genetic disorder, also known as Goldenhar Syndrome, which has several phenotypic features including craniofacial anomalies, cardiac, vertebral and ...

    Authors: İsmail Balaban, Meltem Ceyhan Bilgici and Kemal Baysal
    Citation: BMC Pediatrics 2022 22:102
  45. The Syrian conflict has had a massive impact on the dental health of refugees. Dental extraction is a good indicator of socioeconomic position and degree of oral hygiene, however there is a scarcity of evidenc...

    Authors: Nesreen A Salim, Faleh A Sawair, Fatima Hafedh Meyad, Julian D Satterthwaite, Ashraf Abukaraky and Samiha Sartawi
    Citation: BMC Pediatrics 2022 22:100

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