Skip to main content

Positional treatment without mechanical ventilation in a very preterm infant with unilateral pulmonary interstitial emphysema: case report and review of the literature

Abstract

Background

Pulmonary interstitial emphysema (PIE) in very low birth weight infants is a rare but severe complication. Although most of these air leaks develop in mechanically ventilated infants, they have also been reported in infants exposed only to nasal continuous positive airway pressure (CPAP). The optimal treatment for PIE is still under discussion and includes different approaches such as unilateral intubation, high frequency oscillation ventilation and even surgical lobectomy. However, as yet, there has been no report on complete resolution of unilateral PIE by positioning therapy without mechanical ventilation.

Case presentation

We report the case of a 28+1gestational week twin, 990 g birth weight, Apgar 9–10-10. After stabilization with nasal CPAP the baby received surfactant by less invasive surfactant application (LISA) technique in the delivery room after 35 min of life, and continued respiratory support with nasal CPAP. At day 5 X-ray presented unilateral PIE, while pCO2 increased from 40 mmHg to 55 mmHg and FiO2 from 0.21 to 0.28 to achieve SpO2 in the target range of 89–94%. The baby was treated by strict positioning on the affected hemithorax in a special splint while spontaneously breathing on High Flow Nasal Cannula (HFNC). Complete resolution of the unilateral PIE was observed after 96 h. No chronic lung disease developed.

Conclusion

For unilateral PIE in very preterm infants, positioning on the affected hemithorax without mechanical ventilation is a therapeutic option.

Peer Review reports

Background

Pulmonary interstitial emphysema (PIE) is a well known and severe complication in very premature newborns with respiratory distress syndrome (RDS) receiving invasive mechanical ventilation. However, few PIE cases - unilateral or bilateral - have been reported in premature babies exposed to nasal continuous positive airway pressure (nCPAP) [1,2,3,4,5,6,7]. So far, there is no standard treatment for unilateral PIE, and several treatment approaches have been reported in literature, including selective unilateral intubation and ventilation [8,9,10,11,12], High Frequency Oscillation Ventilation (HFOV) and High Frequency Jet Ventilation (HJFV) [12,13,14,15,16], Neurally Adjusted Ventilatory Assist (NAVA) [17, 18], and even surgical lobectomy [19,20,21]. Positioning of the baby on the affected side is considered an adjunct to these therapies [12, 15, 22, 23]. However, as yet, there is no report on complete resolution of unilateral PIE by positioning therapy without mechanical ventilation.

We report on a very low birth weight (VLBW) infant who developed unilateral PIE secondary to nasal CPAP. The baby was treated by a strict positioning on the affected hemithorax in a special splint while spontaneously breathing on high-flow nasal cannula (HFNC). PIE completely resolved in 96 h. Considering the reported interventions in literature, our aim is to add to the available knowledge on therapy concepts for unilateral PIE.

Case presentation

Second twin, born after 28+ 1 weeks of gestation, 990 g-birth weight, Apgar 9–10-10. Steroid prophylaxis was given to the mother 96 h before C-Section was performed due to onset of labour and premature rupture of the membranes. No clinical symptoms, laboratory, or histological signs of chorioamnionitis were detected. After stabilization with nasal CPAP (FiO2 0.4, Silverman score 4) the baby received surfactant by less invasive surfactant application (LISA) procedure in the delivery room 35 min of after birth. Initial X-ray (one hour after LISA) showed RDS 1° (Fig. 1). After good response to surfactant, respiratory support with nasal CPAP (5.5 to 6.5 mbar) was continued for the following 5 days with FiO2 0.21 for SpO2 89–94%. PCO2 ranged between 40 and 50 mmHg and the Silverman Score was 1–2. The pressure levels of nasal CPAP were 6.5 mbar for the first 8 h after LISA, followed by 6.0 mbar for another 12 h and 5.5 mbar from 2nd to 5th day. A second X-ray at the age of 24 h showed regression of RDS and bilateral symmetrical ventilation of the lung, without signs of over-distension or air leak. Thus, unilateral surfactant delivery could be ruled out.

Fig. 1
figure1

Initial X-ray chest: respiratory distress syndrome grade 1°. One hour after LISA. Nasal CPAP settings: 6.5 mbar, FiO2 0.21

At day 5, pCO2 increased from 40 to 55 mmHg and FiO2 from 0.21 to 0.28 for SpO2 89–94% was needed, while apnea–bradycardia syndrome was more pronounced (minimal heart rate 75/min). The Silverman Score rose to 3–4. A sepsis was ruled out by negative Il-6 and CRP, and blood pressure measurements were normal. X-ray indicated severe left unilateral PIE, shifting the mediastinum to the right (Fig. 2). We changed nasal CPAP to High-Flow Nasal Cannula (HFNC) with flow 6 l/min, used a 1 mm bi-nostril prong-interface and a small pacifier to keep the mouth close, by calculated pressure 3.0–4.0 mbar and performed a strict positioning therapy in a splint (Fig. 3a and b) on the affected left hemithorax. This stiff, but pliant padded plastic splint is normally used for the stabilization of forearm bone-fractures in the Emergency Room. Mild hypercapnia (paCO2 60 mmHg) occurred and FiO2 was needed up to 0.4 to reach target SpO2 of 88–92%. Following unilateral positioning in the splint, the respiratory status improved, FiO2 was gradually decreased from 0.4 to 0.25, and complete resolution of PIE was demonstrated by X-ray after 96 h (Fig. 4). We continued HFNC with FiO2 between 0.21 and 0.25 up to day 35 (33+ 2 gestational week). When the baby was discharged after 10 weeks, SpO2 was 99% (Table 1). Though a few bilateral central opaque zones were visible, significant signs of bronchopulmonary dysplasia (BPD) were not detectable on X-ray (Fig. 5). Several ultrasound examinations of the brain were performed including one at discharge. We never detected any signs of Intraventricular Haemorrhage (IVH) or any stages of periventricular Leukomalacia (PVL).

Fig. 2
figure2

X ray chest day 5 of life: Severe left unilateral pulmonary interstitial emphysema. Left-sided diffuse pulmonary interstitial emphysema, mild mediastinal shift to the right. Nasal nCPAP settings: 5.5 mbar, FiO2 0.28

Fig. 3
figure3

a The splint used for Positioning Therapy. b Positioning Therapy in the splint

Fig. 4
figure4

X ray chest day 9 Resolved Unilateral Pulmonary Interstitial Emphysema. No cysts are presented in the left lung, mediastinal shift recovered. High-flow nasal cannula settings: Flow 6 L/min, FiO2 0.21–0.25

Table 1 The Clinical Parameters of this Case: From Birth to Discharge
Fig. 5
figure5

X ray chest 10 weeks of life: No significant signs of bronchopulmonary dysplasia 10 weeks after birth. Bilateral central opaque zones are visible, the baby didn’t need oxygen or any respiratory support for SpO2 > 92%

Discussion and conclusions

This case demonstrates that unilateral PIE developed in a spontaneously breathing baby, may resolve by positioning the baby on the affected hemithorax in a special splint without mechanical ventilation.

PIE is a life-threatening form of air leak syndrome in very premature infants with RDS. It also occurs in Meconium-Aspiration-Syndrome in term-infants. Its pathophysiology was firstly discussed by Macklin [24] in 1939. When infants are exposed to positive pressure ventilation, especially - but not exclusively - while intubated and mechanically ventilated, potential loss of the epithelial integrity of the small airways, sacculi or immature alveoli permits entering air into the perivascular tissue of the pulmonary interstitium. By spreading into the bronchovascular bundles, it may result in pneumothorax, pneumomediastinum, pneumopericardium, pneumoperitoneum, subcutaneous emphysema, and terminally massive air embolism [24, 25]. The entrapment of air can initiate compression of functional lung tissue and vascular structures, resulting in adjacent atelectasis, leading to severe impairment of lung function and increased respiratory distress of the baby.

Prematurity, meconium aspiration resuscitation, and hyperoxia are known to be risk factors for PIE [26,27,28]. A high risk for air leaks including PIE seems to be surfactant deficiency in mechanical ventilated very premature babies not treated with surfactant [27, 29]. A study from the pre-surfactant era, the incidence of PIE in ventilated preterm infants is reported up to 32% [27]. Technical risk factors include use of high peak inspiratory pressure (PIP) and/or high positive end expiratory pressure (PEEP) in mechanical ventilation, high (FiO2), long inspiratory time and large tidal volumes [1, 25,26,27, 30]. Malpositioning of the tube in one bronchus may also be responsible for unilateral PIE [30].

In our case, the baby received LISA followed by nasal CPAP, exposed to widely accepted pressure levels in the delivery room, avoiding mask or mechanical ventilation. This case is consistent with a previous study that indicates the incidence of PIE reaches 11.5% in cases receiving nasal CPAP only and/or non-invasive ventilation in delivery room management [1]. The X-ray on the first day (Fig. 1) shows symmetrical lung ventilation ruling out the main differential diagnoses unilateral surfactant delivery, adenocystic lung malformation and congenital lobe emphysema.

When PIE is treated successfully, secondary serious complications can be prevented. In older reports, fatality rates of premature infants with PIE reach 80% [31] and recent data still show a high risk of death (37%) [28]. In survivors, high proportions of adverse outcomes with significant morbidity such as IVH (54%) and BPD (77%) are reported [1, 32].

The generally accepted treatment strategy for PIE includes maintaining low levels of peak inspiratory pressure, mean airway pressure and low tidal volumes, accepting high FiO2 and moderate hypercapnia. Regarding our case, unilateral PIE resolved completely by positional treatment and reduction of the calculated airway pressure. Previous studies from the 1980’s [22, 23] reported that positioning the baby laterally on the affected hemithorax for several hours, while ventilating with low airway pressure achieved ideal results in neonates with unilateral PIE.

In 1988, Gortner et al. [15] reported on a concept of positioning therapy combined with HFOV which proved remarkable successful. By positioning the baby on the affected side, the mediastinum, following gravity, can compress the lung of the underlying hemithorax, while the unaffected lung is still ventilated. To keep the baby in the right position we used a splint as described above. The soft, padded surface protects the vulnerable skin of the baby. Fixing spontaneously breathing premature infants without sedation in a lateral position may be challenging, so the splint provides an effective significant support. We here demonstrate that positioning therapy can be successful for babies receiving HFNC also.

Using a three-dimensionally printed airway model a recent study [33] demonstrated that, while the baby’s mouth closed, a flow of 6 l/min in HFNC can achieve pressures of approximately 4.0 mbar in preterm infants. HFNC also provides active CO2 out-washing from the nasopharynx [33]. In view of these potential advantages we selected this mode during positioning therapy. It should be emphasized, that there are no data available comparing HFNC versus nCPAP in unilateral PIE. Thus, the mode of gas delivery may not have been as important as the positioning therapy in our case.

The challenge in the treatment of unilateral PIE is to find the balance between beneficial therapeutic approaches for the affected lung and the potential harmful side effects for the contralateral lung. Selective ventilation of the non-affected lung has been advocated as it provides the possibility of reabsorption of interstitial air by reducing the alveolar pressure of the affected lung to zero. Atelectasis and ventilator-induced lung injury of the ventilated lung were reported as the limitations of selective ventilation [8]. High frequency ventilation has also been used for PIE to attain an adequate gas exchange with lower mean airway pressures and volume than conventional ventilation [13]. However, HFOV itself contributes to PIE [25] and the low volume strategy induce alveolar hypoventilation of the unaffected lung, leading to severe hypercapnia and dependency on high FiO2.

In our case, strictly performed positioning on the affected hemithorax, combined with HFNC, seems to be a successful alternative to more invasive strategies in the treatment of unilateral PIE. The use of a flexible splint provides the possibility to maintain the baby in the required position. This approach may offer a good chance to reduce invasive ventilation, and if tolerated, it should be considered to be the first line treatment. However, it must be emphasised that infants who continue to have respiratory acidosis and/or significant work of breathing will require other types of respiratory support.

Availability of data and materials

All the important information of this case are included in the manuscript.

Abbreviations

BPD:

Bronchopulmonary dysplasia

CPAP:

Continuous positive airway pressure

HFJV:

High Frequency Jet Ventilation

HFNC:

High Flow Nasal Cannula

HFOV:

High Frequency Oscillation Ventilation

IVH:

Intraventricular haemorrhage

LISA:

Less invasive surfactant application

NAVA:

Neurally Adjusted Assist Ventilation

PEEP:

Positive end-expiratory pressure

PIE:

Pulmonary interstitial emphysema

PIP:

Peak inspiratory pressure

PVL:

Periventricular leucomalacia

RDS:

Respiratory distress syndrome

References

  1. 1.

    Hummler HD, Parys E, Mayer B, Essers J, Fuchs H, Schmid M. Risk indicators for air leaks in preterm infants exposed to restrictive use of endotracheal intubation. Neonatology. 2015;108:1–7.

    Article  Google Scholar 

  2. 2.

    Morley CJ, Davis PG, Doyle LW, Brion LP, Hascoet JM, Carlin JB, et al. Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med. 2008;358:700–8.

    CAS  Article  Google Scholar 

  3. 3.

    Gürakan B, Tarcan A, Arda IS, Coşkun M. Persistent pulmonary interstitial emphysema in an unventilated neonate. Pediatr Pulmonol. 2002;34:409–11.

    Article  Google Scholar 

  4. 4.

    Crosswell HE, Stewart DL. Special feature: radiological case of the month. Pulmonary interstitial emphysema in a nonventilated preterm infant. Arch Pediatr Adolesc Med. 2001;155:615–6.

    CAS  Article  Google Scholar 

  5. 5.

    Dembinski J, Heep A, Kau N, Knopfle G, Bartmann P. CT imaging of pulmonary lobar interstitial emphysema in a spontaneous breathing preterm infant. Am J Perinatol. 2002;19:285–90.

    CAS  Article  Google Scholar 

  6. 6.

    Gessler P, Toenz M, Gugger M, Pfenninger J. Lobar pulmonary interstitial emphysema in a premature infant on continuous positive airway pressure using nasal prongs. Eur J Pediatr. 2001;160:263–4.

    CAS  Article  Google Scholar 

  7. 7.

    Bawa P, Soontarapornchai K, Perenyi A, Goldfisher R, Amodio J. Development of localized pulmonary interstitial emphysema in a late preterm infant without mechanical ventilation. Case Rep Pediatr. 2014;2014:429797.

    PubMed  PubMed Central  Google Scholar 

  8. 8.

    Oliver JE, Smith IJ. Treatment of severe localized pulmonary interstitial emphysema by selective bronchial intubation. Postgrad Med J. 1984;60:58–9.

    CAS  Article  Google Scholar 

  9. 9.

    Chalak LF, Kaiser JR, Arrington RW. Resolution of pulmonary interstitial emphysema following selective left main stem intubation in a premature newborn: an old procedure revisited. Paediatr Anaesth. 2007;17:183–6.

    Article  Google Scholar 

  10. 10.

    O’Donovan D, Wearden M, Adams J. Unilateral pulmonary interstitial emphysema following pneumonia in a preterm infant successfully treated with prolonged selective bronchial intubation. Am J Perinatol. 1999;16:327–31.

    Article  Google Scholar 

  11. 11.

    Joseph LJ, Bromiker R, Toker O, Schimmel MS, Goldberg S, Picard E. Unilateral lung intubation for pulmonary air leak syndrome in neonates: a case series and a review of the literature. Am J Perinatol. 2011;28:151–6.

    Article  Google Scholar 

  12. 12.

    Filho LV, Rossi FD, Deutsch AD, Yagui AC, Timenetsky K, Rebello CD. Persistence of ventilatory defect after resolution of pulmonary interstitial emphysema in a preterm baby. J Matern-Fetal Neo M. 2010;23:712–6.

    Article  Google Scholar 

  13. 13.

    Cools F, Henderson-Smart DJ, Offringa M, Askie LM. Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants. Cochrane Database Syst Rev. 2009;8:CD000104.

    Google Scholar 

  14. 14.

    Squires KA, De Paoli AG, Williams C, Dargaville PA. High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema. Neonatology. 2013;104:243–9.

    Article  Google Scholar 

  15. 15.

    Gortner L, Pohlandt F, Bartmann P. Treatment of unilateral space-occupying pulmonary interstitial emphysema with positioning measures and high-frequency ventilation. Monatsschr Kinderheilkd. 1988;136:432–5.

    CAS  PubMed  Google Scholar 

  16. 16.

    Keszler M, Donn SM, Bucciarelli RL, Alverson DC, Hart M, Lunyong V, et al. Multicenter controlled trial comparing high-frequency jet ventilation and conventional mechanical ventilation in newborn infants with pulmonary interstitial emphysema. J Pediatr. 1991;119:85–93.

    CAS  Article  Google Scholar 

  17. 17.

    Lee SR. Application of selective bronchial intubation versus Neurally adjusted Ventilatory assist in the Management of Unilateral Pulmonary Interstitial Emphysema: an illustrative case and the literature review. Ajp Rep. 2017;7:e101–5.

    Article  Google Scholar 

  18. 18.

    Lee SR, Shek CC. Resolution of localized pulmonary interstitial emphysema in two neonates - why does neurally adjusted ventilatory assist work? J Clin Neonatol. 2015;4:115–8.

    Article  Google Scholar 

  19. 19.

    Matta R, Matta J, Hage P, Nassif Y, Mansour N, Diab N. Diffuse persistent interstitial pulmonary emphysema treated by lobectomy. Ann Thorac Surg. 2011;92:73–5.

    Article  Google Scholar 

  20. 20.

    Castillo BTD, Gordillo I, García ER, Lafever SN, Cortés RG, Villaescusa JU, et al. Diffuse persistent pulmonary interstitial emphysema secondary to mechanical ventilation in bronchiolitis. BMC Pulm Med. 2016;16:139.

    Article  Google Scholar 

  21. 21.

    Messineo A, Fusaro F, Mognato G, Sabatti M, D'Amore ES, Guglielmi M. Lung volume reduction surgery in lieu of pneumonectomy in an infant with severe unilateral pulmonary interstitial emphysema. Pediatr Pulmonol. 2001;31:389–93.

    CAS  Article  Google Scholar 

  22. 22.

    Cohen RS, Smith DW, Stevenson DK, Moskowitz PS, Graham CB. Lateral decubitus position as therapy for persistent focal pulmonary interstitial emphysema in neonates: a preliminary report. J Pediatr. 1984;104:441.

    CAS  Article  Google Scholar 

  23. 23.

    Schwartz AN, Graham CB. Neonatal tension pulmonary interstitial emphysema in bronchopulmonary dysplasia: treatment with lateral decubitus positioning. Radiology. 1986;161:351–4.

    CAS  Article  Google Scholar 

  24. 24.

    Macklin CC. Transport of air along sheaths of pulmonic blood vessels from alveoli to mediastinum: clinical implications. Arch Intern Med. 1939;64:913–26.

    Article  Google Scholar 

  25. 25.

    Gummalla P, Mundakel G, Agaronov M, Lee H. Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review. Case Reports in Pediatr. 2017;2017:6907329.

    Article  Google Scholar 

  26. 26.

    Nunez-Ramiro A, Aguar M, Cernada M, Parra-Llorca A, Vento M. Oxygen needs during resuscitation and surfactant to achieve stabilisation were independent risks factors for pulmonary interstitial emphysema in preterm infants. Acta Paediatr. 2018;107(1):28.

    CAS  Article  Google Scholar 

  27. 27.

    Hart SM, McNair M, Gamsu HR, Price JF. Pulmonary interstitial emphysema in very low birthweight infants. Arch Dis Child. 1983;58(8):612–5.

    CAS  Article  Google Scholar 

  28. 28.

    Verma RP, Chandra S, Niwas R, Komaroff E. Risk factors and clinical outcomes of pulmonary interstitial emphysema in extremely low birth weight infants. J Perinatol. 2006 Mar.;26(3):197–200.

    CAS  Article  Google Scholar 

  29. 29.

    BahadueFL SR. Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev. 2012;11:CD 001456.

    Google Scholar 

  30. 30.

    Greenough A, Dixon AK, Roberton NR. Pulmonary interstitial emphysema. Arch Dis Child. 1984;59(11):1046–51.

    CAS  Article  Google Scholar 

  31. 31.

    Gaylord MS, Thieme RE, Woodall DL, Quissell BJ. Predicting mortality in low-birth-weight infants with pulmonary interstitial emphysema. Pediatrics. 1985 Aug.;76(2):219–24.

    CAS  PubMed  Google Scholar 

  32. 32.

    Laughon M, O'Shea MT, Allred EN, Bose C, Kuban K, Van Marter LJ, et al. Chronic lung disease and developmental delay at 2 years of age in children born before 28 weeks' gestation. Pediatrics. 2009;124(2):637–48.

    Article  Google Scholar 

  33. 33.

    Nielsen KR, Ellington LE, Gray AJ, Stanberry LI, Smith LS, DiBlasi RM. Effect of high-flow nasal cannula on expiratory pressure and ventilation in infant, pediatric, and adult models. Respir Care. 2018;63(2):147–57.

    Article  Google Scholar 

Download references

Acknowledgements

Professor Christoph Haertel and Professor Giles Vince for reviewing the Manuscript.

Funding

The present report did not receive any forms of funding.

Author information

Affiliations

Authors

Contributions

XL wrote the first draft of the manuscript and was the leading author. OS designed the device for position treatment. KS, CB and RC reviewed the literatures and critically revised the manuscript. CW was in charge of the treatment and was the senior author. All authors approved the final version.

Corresponding author

Correspondence to Christian Wieg.

Ethics declarations

Ethics approval and consent to participate

This case report using de-identified medical records is approved by Ethical Committee of the Bavarian Board of Physicians .

Consent for publication

A informed consent was written by the parents for publication of this manuscript.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Lei, X., Stangl, O., Bösche, C. et al. Positional treatment without mechanical ventilation in a very preterm infant with unilateral pulmonary interstitial emphysema: case report and review of the literature. BMC Pediatr 19, 267 (2019). https://doi.org/10.1186/s12887-019-1640-2

Download citation

Keywords

  • Pulmonary interstitial emphysema
  • Non-invasive treatment
  • Prematurity