Positional treatment without mechanical ventilation in a very preterm infant with unilateral pulmonary interstitial emphysema: case report and review of the literature

Table 1 The Clinical Parameters of this Case: From Birth to Discharge

	Before LISA (0-35 min)	The first day after LISA	2nd-5th day	Onset PIE (5th day)	Begin positioning therapy	5th–9th day	10th - 35th day	To discharge
Ventilation	n CPAP	n CPAP	n CPAP	n CPAP	HFNC	HFNC	HFNC	No
Target SpO₂%	89–94	89–94	89–94	89–94	89–92	89–92	90–95	92–99
FiO₂%	0.4	0.21	0.21	0.28	0.4	From 0.4 to 0.25	From 0.25 to 0.21	air
Silverman Score	3	1–2	0–1	3–4	1–3	1–2	0–1	0–1
pCO₂ mmHg	35	40	40–50	53	60	40–55	45–55	40–55
Pressure mbar	6.5	6.5–6.0	5.5	5.5	3–4 (calc)	3–4(calc)	2–3(calc)	None

CPAP continuous positive airway pressure, HFNC High Flow Nasal Cannula, LISA less invasive surfactant application, PIE pulmonary interstitial emphysema