World Health Organization. Physical Activity: WHO; [Available from: http://www.who.int/dietphysicalactivity/pa/en//.
Tremblay MS, Warburton DE, Janssen I, Paterson DH, Latimer AE, Rhodes RE, et al. New Canadian physical activity guidelines. Appl Physiol Nutr Metab. 2011;36(1):36–46 7-58.
Article
PubMed
Google Scholar
Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–59.
Article
PubMed
Google Scholar
World Health Organization. Global Recommendations on Physical Activity for Health. Geneva: World Health Organization; 2010.
Google Scholar
Tremblay MS, Carson V, Chaput JP, Connor Gorber S, Dinh T, Duggan M, et al. Canadian 24-hour movement guidelines for children and youth: an integration of physical activity, sedentary behaviour, and sleep. Appl Physiol Nutr Metab. 2016;41(6 Suppl 3):S311–27.
Article
PubMed
Google Scholar
Janssen I, Leblanc AG. Systematic review of the health benefits of physical activity and fitness in school-aged children and youth. Int J Behav Nutr Phys Act. 2010;7:40.
Article
PubMed
PubMed Central
Google Scholar
Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT, et al. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012;380(9838):219–29.
Article
PubMed
PubMed Central
Google Scholar
Thornton JS, Fremont P, Khan K, Poirier P, Fowles J, Wells GD, et al. Physical activity prescription: a critical opportunity to address a modifiable risk factor for the prevention and management of chronic disease: a position statement by the Canadian academy of sport and exercise medicine. Br J Sports Med. 2016;50(18):1109–14.
Article
PubMed
Google Scholar
Torpy JMCA, Glass RM. Chronic diseases of children. JAMA. 2010;303(7):682.
Article
CAS
PubMed
Google Scholar
Corey M, Farewell V. Determinants of mortality from cystic fibrosis in Canada, 1970-1989. Am J Epidemiol. 1996;143(10):1007–17.
Article
CAS
PubMed
Google Scholar
Kosorok MR, Wei WH, Farrell PM. The incidence of cystic fibrosis. Stat Med. 1996;15(5):449–62.
Article
CAS
PubMed
Google Scholar
Burgel PR, Bellis G, Olesen HV, Viviani L, Zolin A, Blasi F, et al. Future trends in cystic fibrosis demography in 34 European countries. Eur Respir J. 2015;46(1):133–41.
Article
PubMed
Google Scholar
Cystic Fibrosis Canada. 2015 [Available from: http://www.cysticfibrosis.ca/about-cf/what-is-cystic-fibrosis/?lang=en.
Wilkes DL, Schneiderman JE, Nguyen T, Heale L, Moola F, Ratjen F, et al. Exercise and physical activity in children with cystic fibrosis. Paediatr Respir Rev. 2009;10(3):105–9.
Article
PubMed
Google Scholar
Klijn PH, van der Net J, Kimpen JL, Helders PJ, van der Ent CK. Longitudinal determinants of peak aerobic performance in children with cystic fibrosis. Chest. 2003;124(6):2215–9.
Article
PubMed
Google Scholar
Lands LC, Heigenhauser GJ, Jones NL. Analysis of factors limiting maximal exercise performance in cystic fibrosis. Clin Sci. 1992;83(4):391–7.
Article
CAS
Google Scholar
Coates AL, Boyce P, Muller D, Mearns M, Godfrey S. The role of nutritional status, airway obstruction, hypoxia, and abnormalities in serum lipid composition in limiting exercise tolerance in children with cystic fibrosis. Acta Paediatr Scand. 1980;69(3):353–8.
Article
CAS
PubMed
Google Scholar
Marcotte JE, Canny GJ, Grisdale R, Desmond K, Corey M, Zinman R, et al. Effects of nutritional status on exercise performance in advanced cystic fibrosis. Chest. 1986;90(3):375–9.
Article
CAS
PubMed
Google Scholar
Godfrey S, Mearns M. Pulmonary function and response to exercise in cystic fibrosis. Arch Dis Child. 1971;46(246):144–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Moorcroft AJ, Dodd ME, Morris J, Webb AK. Symptoms, lactate and exercise limitation at peak cycle ergometry in adults with cystic fibrosis. Eur Respir J. 2005;25(6):1050–6.
Article
CAS
PubMed
Google Scholar
Regnis JA, Donnelly PM, Robinson M, Alison JA, Bye PT. Ventilatory mechanics at rest and during exercise in patients with cystic fibrosis. Am J Respir Crit Care Med. 1996;154(5):1418–25.
Article
CAS
PubMed
Google Scholar
Bano-Rodrigo A, Salcedo-Posadas A, Villa-Asensi JR, Tamariz-Martel A, Lopez-Neyra A, Blanco-Iglesias E. Right ventricular dysfunction in adolescents with mild cystic fibrosis. J Cyst Fibros. 2012;11(4):274–80.
Article
PubMed
Google Scholar
Ionescu AA, Payne N, Obieta-Fresnedo I, Fraser AG, Shale DJ. Subclinical right ventricular dysfunction in cystic fibrosis. A study using tissue Doppler echocardiography. Am J Respir Crit Care Med. 2001;163(5):1212–8.
Article
CAS
PubMed
Google Scholar
Hull JH, Ansley L, Bolton CE, Sharman JE, Knight RK, Cockcroft JR, et al. The effect of exercise on large artery haemodynamics in cystic fibrosis. J Cyst Fibros. 2011;10(2):121–7.
Article
PubMed
Google Scholar
Poore S, Berry B, Eidson D, McKie KT, Harris RA. Evidence of vascular endothelial dysfunction in young patients with cystic fibrosis. Chest. 2013;143(4):939–45.
Article
CAS
PubMed
Google Scholar
Wells GD, Wilkes DL, Schneiderman JE, Rayner T, Elmi M, Selvadurai H, et al. Skeletal muscle metabolism in cystic fibrosis and primary ciliary dyskinesia. Pediatr Res. 2011;69(1):40–5.
Article
CAS
PubMed
Google Scholar
Dufresne V, Knoop C, Van Muylem A, Malfroot A, Lamotte M, Opdekamp C, et al. Effect of systemic inflammation on inspiratory and limb muscle strength and bulk in cystic fibrosis. Am J Respir Crit Care Med. 2009;180(2):153–8.
Article
PubMed
Google Scholar
Pinet C, Cassart M, Scillia P, Lamotte M, Knoop C, Casimir G, et al. Function and bulk of respiratory and limb muscles in patients with cystic fibrosis. Am J Respir Crit Care Med. 2003;168(8):989–94.
Article
PubMed
Google Scholar
Smidt N, de Vet HC, Bouter LM, Dekker J, Arendzen JH, de Bie RA, et al. Effectiveness of exercise therapy: a best-evidence summary of systematic reviews. Aust J Physiother. 2005;51(2):71–85.
Article
PubMed
Google Scholar
Orenstein DM, Hovell MF, Mulvihill M, Keating KK, Hofstetter CR, Kelsey S, et al. Strength vs aerobic training in children with cystic fibrosis: a randomized controlled trial. Chest. 2004;126(4):1204–14.
Article
PubMed
Google Scholar
Gulmans VA, de Meer K, Brackel HJ, Faber JA, Berger R, Helders PJ. Outpatient exercise training in children with cystic fibrosis: physiological effects, perceived competence, and acceptability. Pediatr Pulmonol. 1999;28(1):39–46.
Article
CAS
PubMed
Google Scholar
Turchetta A, Salerno T, Lucidi V, Libera F, Cutrera R, Bush A. Usefulness of a program of hospital-supervised physical training in patients with cystic fibrosis. Pediatr Pulmonol. 2004;38(2):115–8.
Article
PubMed
Google Scholar
Selvadurai HC, Blimkie CJ, Meyers N, Mellis CM, Cooper PJ, Van Asperen PP. Randomized controlled study of in-hospital exercise training programs in children with cystic fibrosis. Pediatr Pulmonol. 2002;33(3):194–200.
Article
CAS
PubMed
Google Scholar
Klijn PH, Oudshoorn A, van der Ent CK, van der Net J, Kimpen JL, Helders PJ. Effects of anaerobic training in children with cystic fibrosis: a randomized controlled study. Chest. 2004;125(4):1299–305.
Article
PubMed
Google Scholar
Barak A, Wexler ID, Efrati O, Bentur L, Augarten A, Mussaffi H, et al. Trampoline use as physiotherapy for cystic fibrosis patients. Pediatr Pulmonol. 2005;39(1):70–3.
Article
CAS
PubMed
Google Scholar
Oldenburg FA Jr, Dolovich MB, Montgomery JM, Newhouse MT. Effects of postural drainage, exercise, and cough on mucus clearance in chronic bronchitis. Am Rev Respir Dis. 1979;120(4):739–45.
PubMed
Google Scholar
Zach MS, Purrer B, Oberwaldner B. Effect of swimming on forced expiration and sputum clearance in cystic fibrosis. Lancet. 1981;2(8257):1201–3.
Article
CAS
PubMed
Google Scholar
Santana Sosa E, Groeneveld IF, Gonzalez-Saiz L, Lopez-Mojares LM, Villa-Asensi JR, Barrio Gonzalez MI, et al. Intrahospital weight and aerobic training in children with cystic fibrosis: a randomized controlled trial. Med Sci Sports Exerc. 2012;44(1):2–11.
Article
PubMed
Google Scholar
Santana-Sosa E, Gonzalez-Saiz L, Groeneveld IF, Villa-Asensi JR, Barrio Gomez de Aguero MI, Fleck SJ, et al. Benefits of combining inspiratory muscle with ‘whole muscle’ training in children with cystic fibrosis: a randomised controlled trial. Br J Sports Med. 2014;48(20):1513–7.
Article
PubMed
Google Scholar
Schneiderman-Walker J, Pollock SL, Corey M, Wilkes DD, Canny GJ, Pedder L, et al. A randomized controlled trial of a 3-year home exercise program in cystic fibrosis. J Pediatr. 2000;136(3):304–10.
Article
CAS
PubMed
Google Scholar
Hebestreit H, Arets HG, Aurora P, Boas S, Cerny F, Hulzebos EH, et al. Statement on exercise testing in cystic fibrosis. Respiration. 2015;90(4):332–51.
Article
PubMed
Google Scholar
Bar-Or O, Blimkie CJ, Hay JA, MacDougall JD, Ward DS, Wilson WM. Voluntary dehydration and heat intolerance in cystic fibrosis. Lancet. 1992;339(8795):696–9.
Article
CAS
PubMed
Google Scholar
Orenstein DM, Henke KG, Costill DL, Doershuk CF, Lemon PJ, Stern RC. Exercise and heat stress in cystic fibrosis patients. Pediatr Res. 1983;17(4):267–9.
Article
CAS
PubMed
Google Scholar
Durstine JL, American College of Sports Medicine. ACSM’s exercise management for persons with chronic diseases and disabilities. In: Human Kinetics, vol. xv. 3rd ed. Champaign: American College of Sports Medicine; 2009. p. 440.
Google Scholar
van Doorn N. Exercise programs for children with cystic fibrosis: a systematic review of randomized controlled trials. Disabil Rehabil. 2010;32(1):41–9.
Article
PubMed
Google Scholar
Swisher AK, Hebestreit H, Mejia-Downs A, Lowman JD, Bruber W, Nippins M, Alison J, Schneiderman J. Exercise and habitual physical activity for people with cystic fibrosis: Expert-consensus, evidence-based guide for advising patients. Cardiopulm Phys Ther J. 2015;26(4):85–98.
Article
Google Scholar
Global Strategy for Asthma Management and Prevention 2016 [Available from: http://ginasthma.org/gina-reports/.
The Global Asthma Report 2014 [Available from: http://www.globalasthmareport.org/2014/burden/burden.php
Wright AL, Stern DA, Kauffmann F, Martinez FD. Factors influencing gender differences in the diagnosis and treatment of asthma in childhood: the Tucson Children's respiratory study. Pediatr Pulmonol. 2006;41(4):318–25.
Article
PubMed
Google Scholar
Wilkerson LA. Exercise-induced asthma. J Am Osteopath Assoc. 1998;98(4):211–5.
CAS
PubMed
Google Scholar
Kippelen P, Anderson SD. Pathogenesis of exercise-induced bronchoconstriction. Immunol Allergy Clin N Am. 2013;33(3):299–312 vii.
Article
Google Scholar
Parsons JP, Hallstrand TS, Mastronarde JG, Kaminsky DA, Rundell KW, Hull JH, et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2013;187(9):1016–27.
Article
CAS
PubMed
Google Scholar
Walker TJ, Reznik M. In-school asthma management and physical activity: children's perspectives. J Asthma. 2014;51(8):808–13.
Article
PubMed
PubMed Central
Google Scholar
Stickland MK, Rowe BH, Spooner CH, Vandermeer B, Dryden DM. Effect of warm-up exercise on exercise-induced bronchoconstriction. Med Sci Sports Exerc. 2012;44(3):383–91.
Article
PubMed
Google Scholar
Driessen JM, van der Palen J, van Aalderen WM, de Jongh FH, Thio BJ. Inspiratory airflow limitation after exercise challenge in cold air in asthmatic children. Respir Med. 2012;106(10):1362–8.
Article
PubMed
Google Scholar
Cassim R, Koplin JJ, Dharmage SC, Senaratna BC, Lodge CJ, Lowe AJ, Russell MA. The difference in amount of physical activity performed by children with and without asthma: A systematic review and meta-analysis. J Asthma. 2016;53(9):882–92.
Article
PubMed
Google Scholar
Vahlkvist S, Pedersen S. Fitness, daily activity and body composition in children with newly diagnosed, untreated asthma. Allergy. 2009;64(11):1649–55.
Article
CAS
PubMed
Google Scholar
Lu KD, Manoukian K, Radom-Aizik S, Cooper DM, Galant SP. Obesity, Asthma, and Exercise in Child and Adolescent Health. Pediatr Exerc Sci. 2015;28(2):264–74.
Article
PubMed
PubMed Central
Google Scholar
Welsh L, Kemp JG, Roberts RG. Effects of physical conditioning on children and adolescents with asthma. Sports Med. 2005;35(2):127–41.
Article
PubMed
Google Scholar
Neder JA, Nery LE, Silva AC, Cabral AL, Fernandes AL. Short-term effects of aerobic training in the clinical management of moderate to severe asthma in children. Thorax. 1999;54(3):202–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bonsignore MR, La Grutta S, Cibella F, Scichilone N, Cuttitta G, Interrante A, et al. Effects of exercise training and montelukast in children with mild asthma. Med Sci Sports Exerc. 2008;40(3):405–12.
Article
PubMed
Google Scholar
Fanelli A, Cabral AL, Neder JA, Martins MA, Carvalho CR. Exercise training on disease control and quality of life in asthmatic children. Med Sci Sports Exerc. 2007;39(9):1474–80.
Article
PubMed
Google Scholar
Basaran S, Guler-Uysal F, Ergen N, Seydaoglu G, Bingol-Karakoc G, Ufuk AD. Effects of physical exercise on quality of life, exercise capacity and pulmonary function in children with asthma. J Rehabil Med. 2006;38(2):130–5.
Article
PubMed
Google Scholar
Ram FS, Robinson SM, Black PN. Effects of physical training in asthma: a systematic review. Br J Sports Med. 2000;34(3):162–7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bougault V, Boulet LP. Airways disorders and the swimming pool. Immunol Allergy Clin N Am. 2013;33(3):395–408 ix.
Article
Google Scholar
Counil FP, Varray A, Matecki S, Beurey A, Marchal P, Voisin M, et al. Training of aerobic and anaerobic fitness in children with asthma. J Pediatr. 2003;142(2):179–84.
Article
PubMed
Google Scholar
Eves ND, Davidson WJ. Evidence-based risk assessment and recommendations for physical activity clearance: respiratory disease. Appl Physiol Nutr Metab. 2011;36(Suppl 1):S80–100.
Article
PubMed
Google Scholar
Counil FP, Varray A, Karila C, Hayot M, Voisin M, Prefaut C. Wingate test performance in children with asthma: aerobic or anaerobic limitation? Med Sci Sports Exerc. 1997;29(4):430–5.
Article
CAS
PubMed
Google Scholar
Boas SR, Danduran MJ, McColley SA. Energy metabolism during anaerobic exercise in children with cystic fibrosis and asthma. Med Sci Sports Exerc. 1999;31(9):1242–9.
Article
CAS
PubMed
Google Scholar
Cramer H, Posadzki P, Dobos G, Langhorst J. Yoga for asthma: a systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2014;112(6):503–10 e5.
Article
PubMed
Google Scholar
Lucas SR, Platts-Mills TA. Physical activity and exercise in asthma: relevance to etiology and treatment. J Allergy Clin Immunol. 2005;115(5):928–34.
Article
PubMed
Google Scholar
Behm DG, Faigenbaum AD, Falk B, Klentrou P. Canadian Society for Exercise Physiology position paper: resistance training in children and adolescents. Appl Physiol Nutr Metab. 2008;33(3):547–61.
Article
PubMed
Google Scholar
Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002;39(12):1890–900.
Article
PubMed
Google Scholar
Ong L, Nolan R, Irvine J, Kovacs A. Parental overprotection and heart-focused anxiety in adults with congenital heart disease. Int J Behav Med. 2011;18(3):260–7.
Article
PubMed
Google Scholar
Longmuir PE, Brothers JA, de Ferranti SD, Hayman LL, Van Hare GF, Matherne GP, et al. Promotion of physical activity for children and adults with congenital heart disease: a scientific statement from the American Heart Association. Circulation. 2013;127(21):2147–59.
Article
PubMed
Google Scholar
Rhodes J, Ubeda Tikkanen A, Jenkins KJ. Exercise testing and training in children with congenital heart disease. Circulation. 2010;122(19):1957–67.
Article
PubMed
Google Scholar
Duppen N, Takken T, Hopman MT, ten Harkel AD, Dulfer K, Utens EM, et al. Systematic review of the effects of physical exercise training programmes in children and young adults with congenital heart disease. Int J Cardiol. 2013;168(3):1779–87.
Article
CAS
PubMed
Google Scholar
Brassard P, Poirier P, Martin J, Noel M, Nadreau E, Houde C, et al. Impact of exercise training on muscle function and ergoreflex in Fontan patients: a pilot study. Int J Cardiol. 2006;107(1):85–94.
Article
PubMed
Google Scholar
Opocher F, Varnier M, Sanders SP, Tosoni A, Zaccaria M, Stellin G, et al. Effects of aerobic exercise training in children after the Fontan operation. Am J Cardiol. 2005;95(1):150–2.
Article
PubMed
Google Scholar
Rhodes J, Curran TJ, Camil L, Rabideau N, Fulton DR, Gauthier NS, et al. Impact of cardiac rehabilitation on the exercise function of children with serious congenital heart disease. Pediatrics. 2005;116(6):1339–45.
Article
PubMed
Google Scholar
Morrison ML, Sands AJ, McCusker CG, McKeown PP, McMahon M, Gordon J, et al. Exercise training improves activity in adolescents with congenital heart disease. Heart. 2013;99(15):1122–8.
Article
CAS
PubMed
Google Scholar
Takken T, Giardini A, Reybrouck T, Gewillig M, Hovels-Gurich HH, Longmuir PE, et al. Recommendations for physical activity, recreation sport, and exercise training in paediatric patients with congenital heart disease: a report from the Exercise, Basic & Translational Research Section of the European Association of Cardiovascular Prevention and Rehabilitation, the European Congenital Heart and Lung Exercise Group, and the Association for European Paediatric Cardiology. Eur J Prev Cardiol. 2012;19(5):1034–65.
Article
CAS
PubMed
Google Scholar
Deanfield J, Thaulow E, Warnes C, Webb G, Kolbel F, Hoffman A, et al. Management of grown up congenital heart disease. Eur Heart J. 2003;24(11):1035–84.
Article
PubMed
Google Scholar
McBride MG, Binder TJ, Paridon SM. Safety and feasibility of inpatient exercise training in pediatric heart failure: a preliminary report. J Cardiopulm Rehabil Prev. 2007;27(4):219–22.
Article
PubMed
Google Scholar
Elisberg EI, Miller G, Weinberg SL, Katz LN. The effect of the Valsalva maneuver on the circulation. II. The role of the autonomic nervous system in the production of the overshoot. Am Heart J. 1953;45(2):227–36.
Article
CAS
PubMed
Google Scholar
Ortiz-Marron H, Ortiz-Pinto MA, Cuadrado-Gamarra JI, Esteban-Vasallo M, Cortes-Rico O, Rey-Gayo L, et al. Persistence and Variation in Overweight and Obesity Among the Pre-school Population of the Community of Madrid After 2 Years of Follow-up. The ELOIN Cohort. Rev Esp Cardiol (Engl ed). 2018;71(11):902–9.
Article
Google Scholar
Sjoberg A, Moraeus L, Yngve A, Poortvliet E, Al-Ansari U, Lissner L. Overweight and obesity in a representative sample of schoolchildren - exploring the urban-rural gradient in Sweden. Obes Rev. 2011;12(5):305–14.
Article
CAS
PubMed
Google Scholar
Liu JM, Ye R, Li S, Ren A, Li Z, Liu Y, et al. Prevalence of overweight/obesity in Chinese children. Arch Med Res. 2007;38(8):882–6.
Article
PubMed
Google Scholar
Bertoncello C, Cazzaro R, Ferraresso A, Mazzer R, Moretti G. Prevalence of overweight and obesity among school-aged children in urban, rural and mountain areas of the Veneto Region, Italy. Public Health Nutr. 2008;11(9):887–90.
Article
PubMed
Google Scholar
Malik M, Bakir A. Prevalence of overweight and obesity among children in the United Arab Emirates. Obes Rev. 2007;8(1):15–20.
Article
CAS
PubMed
Google Scholar
Hassapidou M, Daskalou E, Tsofliou F, Tziomalos K, Paschaleri A, Pagkalos I, et al. Prevalence of overweight and obesity in preschool children in Thessaloniki, Greece. Hormones (Athens). 2015;14(4):615–22.
Google Scholar
Kulaga Z, Gurzkowska B, Grajda A, Wojtylo M, Gozdz M, Litwin M. The prevalence of overweight and obesity among polish pre-school-aged children. Dev Period Med. 2016;20(2):143–9.
PubMed
Google Scholar
Statisteics Canada. [Available from: https://www.statcan.gc.ca/pub/82-625-x/2014001/article/14105-eng.htm.
American College of Sports Medicine. Resource Manual for Guidelines for Exercise Testing and Prescription. 6th ed. Philadelphia: Lippincott, Williams, Wilkens; 2010.
Google Scholar
Barlow SE, Expert C. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics. 2007;120(Suppl 4):S164–92.
Article
PubMed
Google Scholar
Pulgaron ER, Delamater AM. Obesity and type 2 diabetes in children: epidemiology and treatment. Curr Diab Rep. 2014;14(8):508.
Article
PubMed
PubMed Central
CAS
Google Scholar
McGavock J, Dart A, Wicklow B. Lifestyle therapy for the treatment of youth with type 2 diabetes. Curr Diab Rep. 2015;15(1):568.
Article
PubMed
CAS
Google Scholar
Liese AD, D'Agostino RB Jr, Hamman RF, Kilgo PD, Lawrence JM, et al. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for diabetes in youth study. Pediatrics. 2006;118(4):1510–8.
Article
PubMed
Google Scholar
Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, Imperatore G, Linder B, Marcovina S, Pettitt DJ, Pihoker C, Saydah S, Wagenknecht L. Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. N Engl J Med. 2017;376:1419–29.
Article
PubMed
PubMed Central
Google Scholar
Heinzmann-Filho JP, Vendrusculo FM, Woszezenki CT, Piva TC, Santos AN, Barcellos AB, et al. Inspiratory muscle function in asthmatic and healthy subjects: influence of age, nutrition and physical activity. J Asthma. 2016;53(9):893–9.
Article
CAS
PubMed
Google Scholar
Wearing SC, Hennig EM, Byrne NM, Steele JR, Hills AP. The impact of childhood obesity on musculoskeletal form. Obes Rev. 2006;7(2):209–18.
Article
CAS
PubMed
Google Scholar
Boden G. Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver. Curr Diab Rep. 2006;6(3):177–81.
Article
CAS
PubMed
Google Scholar
Schrauwen P. High-fat diet, muscular lipotoxicity and insulin resistance. Proc Nutr Soc. 2007;66(1):33–41.
Article
CAS
PubMed
Google Scholar
Gordon JW, Dolinsky VW, Mughal W, Gordon GR, McGavock J. Targeting skeletal muscle mitochondria to prevent type 2 diabetes in youth. Biochem Cell Biol. 2015;93:1–14.
Article
CAS
Google Scholar
Colley RC, Garriguet D, Janssen I, Craig CL, Clarke J, Tremblay MS. Physical activity of Canadian children and youth: accelerometer results from the 2007 to 2009 Canadian health measures survey. Health Rep. 2011;22(1):15–23.
PubMed
Google Scholar
Farpour-Lambert NJ, Aggoun Y, Marchand LM, Martin XE, Herrmann FR, Beghetti M. Physical activity reduces systemic blood pressure and improves early markers of atherosclerosis in pre-pubertal obese children. J Am Coll Cardiol. 2009;54(25):2396–406.
Article
CAS
PubMed
Google Scholar
Gidding SS. Cardiovascular risk factors in adolescents. Curr Treat Options Cardiovasc Med. 2006;8(4):269–75.
Article
PubMed
Google Scholar
Gidding SS, Barton BA, Dorgan JA, Kimm SY, Kwiterovich PO, Lasser NL, et al. Higher self-reported physical activity is associated with lower systolic blood pressure: the dietary intervention study in childhood (DISC). Pediatrics. 2006;118(6):2388–93.
Article
PubMed
Google Scholar
Moller NC, Groentved A, Wedderkopp N, Ried-Larsen M, Kristensen PL, Andersen LB, et al. Cardiovascular disease risk factors and blood pressure response during exercise in healthy children and adolescents: the European youth heart study. J Appl Physiol. 2010;109(4):1125–32.
Article
PubMed
Google Scholar
Kovacs VA, Fajcsak Z, Gabor A, Martos E. School-based exercise program improves fitness, body composition and cardiovascular risk profile in overweight/obese children. Acta Physiol Hung. 2009;96(3):337–47.
Article
PubMed
Google Scholar
Meyer AA, Kundt G, Lenschow U, Schuff-Werner P, Kienast W. Improvement of early vascular changes and cardiovascular risk factors in obese children after a six-month exercise program. J Am Coll Cardiol. 2006;48(9):1865–70.
Article
PubMed
Google Scholar
Riopel DA, Boerth RC, Coates TJ, Hennekens CH, Miller WW, Weidman WH. Coronary risk factor modification in children: exercise. A statement for physicians by the committee on atherosclerosis and hypertension in childhood of the council on cardiovascular disease in the young, American Heart Association. Circulation. 1986;74(5):1189A–91A.
CAS
PubMed
Google Scholar
Lazzer S, Boirie Y, Poissonnier C, Petit I, Duche P, Taillardat M, et al. Longitudinal changes in activity patterns, physical capacities, energy expenditure, and body composition in severely obese adolescents during a multidisciplinary weight-reduction program. Int J Obes. 2005;29(1):37–46.
Article
CAS
Google Scholar
Nemet D, Barkan S, Epstein Y, Friedland O, Kowen G, Eliakim A. Short- and long-term beneficial effects of a combined dietary-behavioral-physical activity intervention for the treatment of childhood obesity. Pediatrics. 2005;115(4):e443–9.
Article
PubMed
Google Scholar
Blaak EE, Westerterp KR, Bar-Or O, Wouters LJ, Saris WH. Total energy expenditure and spontaneous activity in relation to training in obese boys. Am J Clin Nutr. 1992;55(4):777–82.
Article
CAS
PubMed
Google Scholar
Huttunen NP, Knip M, Paavilainen T. Physical activity and fitness in obese children. Int J Obes. 1986;10(6):519–25.
CAS
PubMed
Google Scholar
Ingul CB, Tjonna AE, Stolen TO, Stoylen A, Wisloff U. Impaired cardiac function among obese adolescents: effect of aerobic interval training. Arch Pediatr Adolesc Med. 2010;164(9):852–9.
Article
PubMed
Google Scholar
da Silva PL, de Mello MT, Cheik NC, Sanches PL, Piano A, Corgosinho FC, et al. The role of pro-inflammatory and anti-inflammatory adipokines on exercise-induced bronchospasm in obese adolescents undergoing treatment. Respir Care. 2012;57(4):572–82.
Article
PubMed
Google Scholar
Lau PW, Wong DP, Ngo JK, Liang Y, Kim CG, Kim HS. Effects of high-intensity intermittent running exercise in overweight children. Eur J Sport Sci. 2015;15(2):182–90.
Article
PubMed
Google Scholar
Schranz N, Tomkinson G, Olds T. What is the effect of resistance training on the strength, body composition and psychosocial status of overweight and obese children and adolescents? A systematic review and meta-analysis. Sports Med. 2013;43(9):893–907.
Article
PubMed
Google Scholar
Shaibi GQ, Roberts CK, Goran MI. Exercise and insulin resistance in youth. Exerc Sport Sci Rev. 2008;36(1):5–11.
Article
PubMed
Google Scholar
Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metab Clin Exp. 2005;54(11):1472–9.
Article
CAS
PubMed
Google Scholar
Shaibi GQ, Cruz ML, Ball GD, Weigensberg MJ, Salem GJ, Crespo NC, et al. Effects of resistance training on insulin sensitivity in overweight Latino adolescent males. Med Sci Sports Exerc. 2006;38(7):1208–15.
Article
CAS
PubMed
Google Scholar
Fedewa MV, Gist NH, Evans EM, Dishman RK. Exercise and insulin resistance in youth: a meta-analysis. Pediatrics. 2014;133(1):e163–74.
Article
PubMed
Google Scholar
Marson EC, Delevatti RS, Prado AK, Netto N, Kruel LF. Effects of aerobic, resistance, and combined exercise training on insulin resistance markers in overweight or obese children and adolescents: A systematic review and meta-analysis. Prev Med. 2016;93:211–8.
Article
PubMed
Google Scholar
Franco RL, Bowen MK, Arena R, Privett SH, Acevedo EO, Wickham EP, et al. Sex differences in pulmonary oxygen uptake kinetics in obese adolescents. J Pediatr. 2014;165(6):1161–5.
Article
PubMed
PubMed Central
Google Scholar
Strutzenberger G, Richter A, Schneider M, Mundermann A, Schwameder H. Effects of obesity on the biomechanics of stair-walking in children. Gait Posture. 2011;34(1):119–25.
Article
CAS
PubMed
Google Scholar
Copeland KC, Silverstein J, Moore KR, Prazar GE, Raymer T, Shiffman RN, et al. Management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics. 2013;131(2):364–82.
Article
PubMed
Google Scholar
Garcia-Hermoso A, Cerrillo-Urbina AJ, Herrera-Valenzuela T, Cristi-Montero C, Saavedra JM, Martinez-Vizcaino V. Is high-intensity interval training more effective on improving cardiometabolic risk and aerobic capacity than other forms of exercise in overweight and obese youth? A meta-analysis. Obes Rev. 2016;17(6):531–40.
Article
CAS
PubMed
Google Scholar
Costigan SA, Eather N, Plotnikoff RC, Taaffe DR, Lubans DR. High-intensity interval training for improving health-related fitness in adolescents: a systematic review and meta-analysis. Br J Sports Med. 2015;49(19):1253–61.
Article
CAS
PubMed
Google Scholar
Gillen JB, Little JP, Punthakee Z, Tarnopolsky MA, Riddell MC, Gibala MJ. Acute high-intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes. Diabetes Obes Metab. 2012;14(6):575–7.
Article
CAS
PubMed
Google Scholar
American College of Sports medicine. ACSM's Resource Manual for Guidelines for Exercise Testing and Prescription. 7th ed; 2013. p. 896.
Google Scholar
Lee S, Bacha F, Hannon T, Kuk JL, Boesch C, Arslanian S. Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. Diabetes. 2012;61(11):2787–95.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bhave S, Pandit A, Yeravdekar R, Madkaikar V, Chinchwade T, Shaikh N, et al. Effectiveness of a 5-year school-based intervention programme to reduce adiposity and improve fitness and lifestyle in Indian children; the SYM-KEM study. Arch Dis Child. 2016;101(1):33–41.
Article
PubMed
Google Scholar
About Kids Health. 2015 [Available from: http://www.aboutkidshealth.ca/En/ResourceCentres/JuvenileIdiopathicArthritis/AboutJIA/Pages/WhatIsJIA.aspx.
Manners PJ, Bower C. Worldwide prevalence of juvenile arthritis why does it vary so much? J Rheumatol. 2002;29(7):1520–30.
PubMed
Google Scholar
Juvenile Arthritis: Arthritis Foundation; 2015 [Available from: http://www.aboutkidshealth.ca/En/ResourceCentres/JuvenileIdiopathicArthritis/AboutJIA/Pages/WhatIsJIA.aspx.
Dogru Apti M, Kasapcopur O, Mengi M, Ozturk G, Metin G. Regular aerobic training combined with range of motion exercises in juvenile idiopathic arthritis. Biomed Res Int. 2014;2014:748972.
Article
PubMed
PubMed Central
Google Scholar
Houghton K. Physical activity, physical fitness, and exercise therapy in children with juvenile idiopathic arthritis. Phys Sportsmed. 2012;40(3):77–82.
Article
PubMed
Google Scholar
Takken T, van der Net J, Helders PJ. Relationship between functional ability and physical fitness in juvenile idiopathic arthritis patients. Scand J Rheumatol. 2003;32(3):174–8.
Article
CAS
PubMed
Google Scholar
Philpott JF, Houghton K, Luke A. Physical activity recommendations for children with specific chronic health conditions: juvenile idiopathic arthritis, hemophilia, asthma, and cystic fibrosis. Clin J Sport Med. 2010;20(3):167–72.
Article
PubMed
Google Scholar
Takken T, Van Brussel M, Engelbert RH, Van Der Net J, Kuis W, Helders PJ. Exercise therapy in juvenile idiopathic arthritis: a Cochrane review. Eur J Phys Rehabil Med. 2008;44(3):287–97.
CAS
PubMed
Google Scholar
Armbrust W, Bos G, Wulffraat NM, van Brussel M, Cappon J, Dijkstra PU, et al. Internet program for physical activity and exercise capacity in children with juvenile idiopathic Arthritis: A multicenter randomized controlled trial. Arthritis Care Res (Hoboken). 2017;69(7):1040–9.
Article
Google Scholar
Van Oort C, Tupper SM, Rosenberg AM, Farthing JP, Baxter-Jones AD. Safety and feasibility of a home-based six week resistance training program in juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2013;11(1):46.
Article
PubMed
PubMed Central
Google Scholar
Tarakci E, Yeldan I, Baydogan SN, Olgar S, Kasapcopur O. Efficacy of a land-based home exercise programme for patients with juvenile idiopathic arthritis: a randomized, controlled, single-blind study. J Rehabil Med. 2012;44(11):962–7.
Article
PubMed
Google Scholar
Taxter A, Foss KB, Melson P, Ford KR, Shaffer M, Myer GD. Juvenile idiopathic arthritis and athletic participation: are we adequately preparing for sports integration? Phys Sportsmed. 2012;40(3):49–54.
Article
PubMed
Google Scholar
van Brussel M, van der Net J, Hulzebos E, Helders PJ, Takken T. The Utrecht approach to exercise in chronic childhood conditions: the decade in review. Pediatr Phys Ther. 2011;23(1):2–14.
Article
PubMed
Google Scholar
Singh-Grewal D, Wright V, Bar-Or O, Feldman BM. Pilot study of fitness training and exercise testing in polyarticular childhood arthritis. Arthritis Rheum. 2006;55(3):364–72.
Article
CAS
PubMed
Google Scholar
Sandstedt E, Fasth A, Fors H, Beckung E. Bone health in children and adolescents with juvenile idiopathic arthritis and the influence of short-term physical exercise. Pediatr Phys Ther. 2012;24(2):155–61 discussion 62.
Article
PubMed
Google Scholar
Singh-Grewal D, Schneiderman-Walker J, Wright V, Bar-Or O, Beyene J, Selvadurai H, et al. The effects of vigorous exercise training on physical function in children with arthritis: a randomized, controlled, single-blinded trial. Arthritis Rheum. 2007;57(7):1202–10.
Article
PubMed
Google Scholar
Takken T. Physical fitness, activity and training in children with juvenile idiopathic Arthritis. Pediatr Health. 2010;4(5):499–507.
Article
Google Scholar
Xu J, Murphy SL, Kochanek KD, Bastian BA. National Vital Statistics Reports. National Center for Health Statistics. 2016;64(2):1–119.
Google Scholar
Ellison L, Janz T. Childhood Cancer Incidence and Mortality in Canada. Ottawa: Statistics Canada; 2015. p. 82–624. -X
Google Scholar
Robison LL, Hudson MM. Survivors of childhood and adolescent cancer: life-long risks and responsibilities. Nat Rev Cancer. 2014;14(1):61–70.
Article
CAS
PubMed
Google Scholar
Hartman A, Hop W, Takken T, Pieters R, van den Heuvel-Eibrink M. Motor performance and functional exercise capacity in survivors of pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2013;60(3):494–9.
Article
PubMed
Google Scholar
West SL, Gassas A, Schechter T, Egeler RM, Nathan PC, Wells GD. Exercise intolerance and the impact of physical activity in children treated with hematopoietic stem cell transplantation. Pediatr Exerc Sci. 2014;26(3):358–64.
Article
PubMed
Google Scholar
Oeffinger K, Mertens AC, Sklar CA, Kawashima T, Hudson MM, Meadows AT, Friedman DL, Marina N, Hobbie W, Kadan-Lottick NS, Schwartz CL, Leisenring W, Robison LL. Chronic health conditions in adult survivors of childhood Cancer. N Engl J Med. 2006;355(15):1572–82.
Article
CAS
PubMed
Google Scholar
Hanahan D, Weinberg RA. The hallmarks of Cancer. Cell. 2000;100:57–70.
Article
CAS
PubMed
Google Scholar
Ness KK, Gurney JG. Adverse late effects of childhood cancer and its treatment on health and performance. Annu Rev Public Health. 2007;28:279–302.
Article
PubMed
Google Scholar
Huang TT, Ness KK. Exercise interventions in children with cancer: a review. Int J Pediatr. 2011;2011:461512.
Article
PubMed
PubMed Central
Google Scholar
Wolin KY, Ruiz JR, Tuchman H, Lucia A. Exercise in adult and pediatric hematological cancer survivors: an intervention review. Leukemia. 2010;24(6):1113–20.
Article
CAS
PubMed
Google Scholar
van Brussel M, Takken T, Lucia A, van der Net J, Helders PJ. Is physical fitness decreased in survivors of childhood leukemia? A systematic review. Leukemia. 2005;19(1):13–7.
Article
PubMed
Google Scholar
Ness KK, Morris EB, Nolan VG, Howell CR, Gilchrist LS, Stovall M, et al. Physical performance limitations among adult survivors of childhood brain tumors. Cancer. 2010;116(12):3034–44.
Article
PubMed
Google Scholar
Fairey AS, Courneya KS, Field CJ, Mackey JR. Physical exercise and immune system function in cancer survivors: a comprehensive review and future directions. Cancer. 2002;94(2):539–51.
Article
PubMed
Google Scholar
Hudson MM, Ness KK, Gurney JG, Mulrooney DA, Chemaitilly W, Krull KR, Green DM, Armstrong GT, Nottage KA, Jones KE, Sklar CA, Srivastava DK, Robison LL. Clinical ascertainment of health outcomes among adults treated for childhood Cancer. JAMA. 2013;309(22):2371–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mihlon F, Ray CE Jr, Messersmith W. Chemotherapy agents: a primer for the interventional radiologist. Semin Intervent Radiol. 2010;27(4):384–90.
Article
PubMed
PubMed Central
Google Scholar
van Brussel M, van Oorschot JW, Schmitz JP, Nicolay K, van Royen-Kerkhof A, Takken T, et al. Muscle metabolic responses during dynamic in-magnet exercise testing: A pilot study in children with an idiopathic inflammatory myopathy. Acad Radiol. 2015;22(11):1443–8.
Article
PubMed
PubMed Central
Google Scholar
Okada M, Meeske KA, Menteer J, Freyer DR. Exercise recommendations for childhood cancer survivors exposed to cardiotoxic therapies: an institutional clinical practice initiative. J Pediatr Oncol Nurs. 2012;29(5):246–52.
Article
PubMed
Google Scholar
Hauser M, Gibson B, Wilson N. Diagnosis of anthracycline-induced late cardiomyopathy by exercise-spiroergometry and stress-echocardiography. Eur J Pediatr. 2001;160(10):607–10.
Article
CAS
PubMed
Google Scholar
Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJ. Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane Database Syst Rev. 2016;3:CD008796.
PubMed
Google Scholar
Baumann FT, Bloch W, Beulertz J. Clinical exercise interventions in pediatric oncology: a systematic review. Pediatr Res. 2013;74(4):366–74.
Article
PubMed
Google Scholar
Moyer-Mileur LJ, Ransdell L, Bruggers CS. Fitness of children with standard-risk acute lymphoblastic leukemia during maintenance therapy response to a home-based exercise and nutrition program. J Pediatr Hematol Oncol. 2009;31(4):259–66.
Article
PubMed
Google Scholar
Takken T, van der Torre P, Zwerink M, Hulzebos EH, Bierings M, Helders PJ, et al. Development, feasibility and efficacy of a community-based exercise training program in pediatric cancer survivors. Psychooncology. 2009;18(4):440–8.
Article
PubMed
Google Scholar
Marchese VG, Chiarello LA, Lange BJ. Effects of physical therapy intervention for children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2004;42(2):127–33.
Article
PubMed
Google Scholar
Shore S, Shepard RJ. Immune responses to exercise in children treated for cancer. J Sports Med Phys Fitness. 1999;39:240–3.
CAS
PubMed
Google Scholar
San Juan AF, Chamorro-Vina C, Moral S, Fernandez del Valle M, Madero L, Ramirez M, et al. Benefits of intrahospital exercise training after pediatric bone marrow transplantation. Int J Sports Med. 2008;29(5):439–46.
Article
CAS
PubMed
Google Scholar
San Juan AF, Fleck SJ, Chamorro-Vina C, Mate-Munoz JL, Moral S, Garcia-Castro J, Ramirez M, Madero L, Lucia A. Early-phase adaptations to Intrahospital training in strength and functional mobility of children with leukemia. J Strength Cond Res. 2007;21(1):173–7.
Article
PubMed
Google Scholar