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  1. Content type: Research article

    Pacifier sucking habit has been associated in the literature with alterations of dental occlusion, and it could be a predisposing factor for other poor oral habits among children. Orthodontic pacifiers have be...

    Authors: Silvia Caruso, Alessandro Nota, Atanaz Darvizeh, Marco Severino, Roberto Gatto and Simona Tecco

    Citation: BMC Pediatrics 2019 19:294

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  2. Content type: Research article

    Given the limited information on parental health literacy measurements, the study aimed to develop and validate the Chinese Parental Health Literacy Questionnaire for caregivers of children 0 to 3 years old.

    Authors: Yan Zhang, Mu Li, Hong Jiang, Huijing Shi, Biao Xu, Salla Atkins and Xu Qian

    Citation: BMC Pediatrics 2019 19:293

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  3. Content type: Case report

    Fraser syndrome is a rare genetic disorder that often presents with ocular, renal, genital and limb’s congenital anomalies. The prognosis of this genetic disorder depends on the severity of the combination of ...

    Authors: Aimé Mbonda, Francky Teddy Endomba, Ulrick S. Kanmounye, Jan René Nkeck and Joel Noutakdie Tochie

    Citation: BMC Pediatrics 2019 19:292

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  4. Content type: Research article

    Cytomegalovirus [CMV] is a causative agent of congenital infection worldwide and often leads to neurological deficits and hearing loss in newborns. Infants born with symptomatic congenital Cytomegalovirus infe...

    Authors: Agniswar Sarkar, Dipanwita Das, Sabbir Ansari, Rajendra Prasad Chatterjee, Lopamudra Mishra, Biswanath Basu, Sanat Kumar Ghosh, Mala Bhattacharyay and Nilanjan Chakraborty

    Citation: BMC Pediatrics 2019 19:291

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  5. Content type: Research article

    Although stem cell transplantation has been successfully performed for cerebral palsy (CP) related to oxygen deprivation, clinical trials involving the use of stem cell transplantation for CP related to neonat...

    Authors: Liem Nguyen Thanh, Kien Nguyen Trung, Chinh Vu Duy, Doan Ngo Van, Phuong Nguyen Hoang, Anh Nguyen Thi Phuong, Minh Duy Ngo, Thinh Nguyen Thi and Anh Bui Viet

    Citation: BMC Pediatrics 2019 19:290

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  6. Content type: Case report

    POLR3-related leukodystrophy is an autosomal recessive neurodegenerative disorder characterized by onset time ranging from the neonatal period to late childhood, progressive motor decline that manifests as spa...

    Authors: Shuiyan Wu, Zhenjiang Bai, Xingqiang Dong, Daoping Yang, Hongmei Chen, Jun Hua, Libing Zhou and Haitao Lv

    Citation: BMC Pediatrics 2019 19:289

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  7. Content type: Research article

    Antiretroviral treatment (ART) has been shown to have a beneficial effect on the weight evolution but its effect on height remains unclear. We described patterns of height evolution and identified predictors o...

    Authors: Patrinee Traisathit, Saïk Urien, Sophie Le Coeur, Sakulrat Srirojana, Noppadon Akarathum, Suparat Kanjanavanit, Chaiwat Ngampiyaskul, Sawitree Krikajornkitti, Nicole Ngo-Giang-Huong, Marc Lallemant and Gonzague Jourdain

    Citation: BMC Pediatrics 2019 19:287

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  8. Content type: Research article

    Although infant media exposure has received attention for its implications on child development, upstream risk factors contributing to media exposure have rarely been explored. The study aim was to examine the...

    Authors: Ramkumar Aishworiya, Shirong Cai, Helen Y. Chen, Desiree Y. Phua, Birit F. P. Broekman, Lourdes Mary Daniel, Yap Seng Chong, Lynette P. Shek, Fabian Yap, Shiao-Yng Chan, Michael J. Meaney and Evelyn C. Law

    Citation: BMC Pediatrics 2019 19:286

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  9. Content type: Research article

    Functional constipation (FC) is a pediatric problem that is seen frequently. However, its prevalence in Asia remains undetermined. In this study we attempted to determine the prevalence, risk factors and thera...

    Authors: Anne Willemijn Walter, Anne Hovenkamp, Niranga Manjuri Devanarayana, Roshani Solanga, Shaman Rajindrajith and Marc Alexander Benninga

    Citation: BMC Pediatrics 2019 19:285

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  10. Content type: Research article

    In high syphilis prevalence settings, the syphilis testing and treatment strategy for mothers and newborns must be tailored to balance the risk of over treatment against the risk of missing infants at high-ris...

    Authors: Oluwakemi F. Ogundipe, Rafael Van den Bergh, Behounde Thierry, Kudakwashe C. Takarinda, Claude P. Muller, Collins Timire, Severine Caluwaerts, Pascale Chaillet and Isabel Zuniga

    Citation: BMC Pediatrics 2019 19:284

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  11. Content type: Research article

    Off-label drug use is widespread in pediatric drug treatment, and the implementation of guidelines on this topic remains challenging. The objective of this study was to evaluate current practice and awareness ...

    Authors: Mei Mei, Hong Xu, Libo Wang, Guoying Huang, Yonghao Gui and Xiaobo Zhang

    Citation: BMC Pediatrics 2019 19:281

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  12. Content type: Research article

    Community-acquired lower respiratory tract infections (CA-LRTIs) are the primary cause of hospitalization among children globally. A better understanding of the role of atypical pathogen infections in native c...

    Authors: Ai Chen, Liyao Song, Zhi Chen, Xiaomei Luo, Qing Jiang, Zhan Yang, Liangcai Hu, Jinhua He, Lifang Zhou and Hai Yu

    Citation: BMC Pediatrics 2019 19:280

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  13. Content type: Research article

    Early puberty is associated with higher risk of adverse health and behavioral outcomes throughout adolescence and adulthood. US girls are experiencing earlier puberty with substantial racial/ethnic differences...

    Authors: Sara Aghaee, Julianna Deardorff, Louise C. Greenspan, Charles P. Quesenberry Jr., Lawrence H. Kushi and Ai Kubo

    Citation: BMC Pediatrics 2019 19:277

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  14. Content type: Research article

    Growth and early development (ECD) are vital outcomes for children. This study aimed to examine the association between child growth and overall development in children aged 3 to 5 years in low- and middle-inc...

    Authors: Thach Duc Tran, Sara Holton, Hau Nguyen and Jane Fisher

    Citation: BMC Pediatrics 2019 19:276

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  15. Content type: Research article

    Oral diseases, such as dental caries, tooth wear, dental erosion and periodontal diseases are major health problems in many societies. The study aim was to explore the association between oral health related b...

    Authors: Lutango D. Simangwa, Anne N. Åstrøm, Anders Johansson, Irene K. Minja and Ann-Katrin Johansson

    Citation: BMC Pediatrics 2019 19:275

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  16. Content type: Research article

    High-risk patients in the pediatric intensive care unit (PICU) contribute substantially to PICU-mortality. Complex chronic conditions (CCCs) are associated with death. However, it is unknown whether CCCs also ...

    Authors: Carin W. Verlaat, Nina Wubben, Idse H. Visser, Jan A. Hazelzet, Johannes van der Hoeven, Joris Lemson and Mark van den Boogaard

    Citation: BMC Pediatrics 2019 19:274

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  17. Content type: Research article

    Plasma-free amino acid profiles have been reported to correlate with obesity and glucose metabolism, and have been studied as potentially useful biomarkers of lifestyle-related diseases affecting metabolism in...

    Authors: Yosuke Suzuki, Jun Kido, Shirou Matsumoto, Kie Shimizu and Kimitoshi Nakamura

    Citation: BMC Pediatrics 2019 19:273

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  18. Content type: Research article

    Children with medical complexity (CMC) account for an increasing proportion of pediatric intensive care unit (PICU) admissions across North America. Their risk of unscheduled PICU admission is threefold compar...

    Authors: Janet E. Rennick, Isabelle St-Sauveur, Alyssa M. Knox and Margaret Ruddy

    Citation: BMC Pediatrics 2019 19:272

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  19. Content type: Research article

    Research suggests that physical activity (PA) enhances cognitive performance and prevents stress-related impairments of higher order cognitive functions like working memory (WM) performance. The aim of the cur...

    Authors: Kathrin Wunsch, Maria Meier, Lea Ueberholz, Jana Strahler and Nadine Kasten

    Citation: BMC Pediatrics 2019 19:271

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  20. Content type: Research article

    The purpose of this study was to describe the demographic characteristics and prognosis of children admitted to the intensive care unit (ICU) after a pediatric emergency department (PED) return visit within 72 h.

    Authors: Charng-Yen Chiang, Fu-Jen Cheng, Yi-Syun Huang, Yu-Lun Chen, Kuan-Han Wu and I-Min Chiu

    Citation: BMC Pediatrics 2019 19:268

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  21. Content type: Case report

    Pulmonary interstitial emphysema (PIE) in very low birth weight infants is a rare but severe complication. Although most of these air leaks develop in mechanically ventilated infants, they have also been repor...

    Authors: Xiaoping Lei, Oliver Stangl, Christina Bösche, Kristina Stuchlik, Roland Czorba and Christian Wieg

    Citation: BMC Pediatrics 2019 19:267

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  22. Content type: Study protocol

    The start of complementary feeding in infancy plays an essential role in promoting healthy eating habits. Evidence shows that it is important what infants are offered during this first introduction of solid foods...

    Authors: S. M. C. van der Veek, C. de Graaf, J. H. M. de Vries, G. Jager, C. M. J. L. Vereijken, H. Weenen, N. van Winden, M. S. van Vliet, J. M. Schultink, V. W. T. de Wild, S. Janssen and J. Mesman

    Citation: BMC Pediatrics 2019 19:266

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  23. Content type: Case report

    Streptococcus pasteurianus is a rare cause of neonatal infection, with only 3 cases reported in the USA and 18 cases reported in other countries within the past decade. Neonatal S. pasteurianus infection typicall...

    Authors: Michelle T. Nguyen, Soha Idriss, Ernie Guzman and Elizabeth R. De Oliveira

    Citation: BMC Pediatrics 2019 19:265

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  24. Content type: Research article

    The relationship between birth weight and blood pressure has not been well explored in Chinese children and adolescents. The aim of this study was to investigate the relationship between birth weight and child...

    Authors: Chong Lai, Yiyan Hu, Di He, Li Liang, Feng Xiong, Geli Liu, Chunxiu Gong, Feihong Luo, Shaoke Chen, Chunlin Wang and Yimin Zhu

    Citation: BMC Pediatrics 2019 19:264

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  25. Content type: Research article

    Marfan syndrome (MFS) is a heritable connective tissue disease caused by a defect in FBN1. The diagnosis is based on the revised Ghent criteria. The main features involve the cardiovascular, musculoskeletal, opht...

    Authors: Jessica Warnink-Kavelaars, Anita Beelen, Sarah Dekker, Frans Nollet, Leonie A. Menke and Raoul H. H. Engelbert

    Citation: BMC Pediatrics 2019 19:262

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  26. Content type: Research article

    There are vast differences in prevalence rates of urinary tract infection (UTI) reported among malnourished children globally. We conducted a systematic review and meta-analysis to provide estimates of pooled ...

    Authors: Samuel N. Uwaezuoke, Ikenna K. Ndu and Ikenna C. Eze

    Citation: BMC Pediatrics 2019 19:261

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  27. Content type: Study protocol

    Education and health are crucial topics for public policies as both largely determine the future wellbeing of the society. Currently, several studies recognize that physical activity (PA) benefits brain health...

    Authors: Patricio Solis-Urra, Jorge Olivares-Arancibia, Ernesto Suarez-Cadenas, Javier Sanchez-Martinez, Fernando Rodríguez-Rodríguez, Francisco B. Ortega, Irene Esteban-Cornejo, Cristina Cadenas-Sanchez, Jose Castro-Piñero, Alejandro Veloz, Steren Chabert, Kabir P. Saradangani, Juan Pablo Zavala-Crichton, Jairo H. Migueles, Jose Mora-Gonzalez, Milton Quiroz-Escobar…

    Citation: BMC Pediatrics 2019 19:260

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  28. Content type: Research article

    Behavioural problems and psychopathology can present from as early as the preschool period. However there is evidence that behavioural difficulties may not be stable over this period. Therefore, the current st...

    Authors: Stephanie D’Souza, Lisa Underwood, Elizabeth R. Peterson, Susan M. B. Morton and Karen E. Waldie

    Citation: BMC Pediatrics 2019 19:259

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  29. Content type: Correction

    Following publication of the original article [1], the authors reported that name that appeared in published online version is incorrect.

    Authors: Abu Yusuf, A. S. M. A. Mamun, Md. Kamruzzaman, Aik Saw, Nagah M. Abo El-fetoh, Pete E. Lestrel and Md. Golam Hossain

    Citation: BMC Pediatrics 2019 19:258

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    The original article was published in BMC Pediatrics 2019 19:213

  30. Content type: Research article

    Infants infected during pregnancy or while breastfeeding requires early HIV diagnosis at 6 weeks after birth to identify HIV infection and timely treatment. The objective of this work was to determine the prev...

    Authors: Mulu Lemlem Desta, Muthupandian Saravanan, Haftamu Hilekiros, Atsebaha Gebrekidan Kahsay, Nesredin Futwi Mohamed, Alefech Addisu Gezahegn and Bruno S. Lopes

    Citation: BMC Pediatrics 2019 19:257

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  31. Content type: Study protocol

    Various noninvasive respiratory support modalities are available in neonatal critical care in order to minimize invasive ventilation. Continuous positive airway pressure (CPAP) is the more commonly used but no...

    Authors: Yuan Shi and Daniele De Luca

    Citation: BMC Pediatrics 2019 19:256

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  32. Content type: Research article

    The current standard treatment of neonates with intestinal perforation is surgery. However, the mortality rate after surgical treatment for intestinal perforation is very high for very low birth weight (VLBW) ...

    Authors: Nan Ye, Yurong Yuan, Lei Xu, Riccardo E. Pfister and Chuanzhong Yang

    Citation: BMC Pediatrics 2019 19:255

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  33. Content type: Research article

    Cleft lip and palate deformities are considered one of the most common birth defects of the head and neck that pose significant medical, psychosocial and financial burdens on the affected individuals and famil...

    Authors: Konjit K. Bekele, Peter E. Ekanem and Berhanu Meberate

    Citation: BMC Pediatrics 2019 19:254

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  34. Content type: Research article

    Clinical and laboratory parameters can aid in the early identification of neonates at risk for bacteremia before clinical deterioration occurs. However, current prediction models have poor diagnostic capabilit...

    Authors: Sandra A. N. Walker, Melanie Cormier, Marion Elligsen, Julie Choudhury, Asaph Rolnitsky, Carla Findlater and Dolores Iaboni

    Citation: BMC Pediatrics 2019 19:253

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  35. Content type: Research article

    Neonatal hypothermia plays a significant role in increasing neonatal death by 80% for every 1 degree Celsius decrease of body temperature, especially in sub Saharan countries. A global burden of neonatal hypot...

    Authors: Wubet Alebachew Bayih, Nega Assefa, Merga Dheresa, Biniam Minuye and Solomon Demis

    Citation: BMC Pediatrics 2019 19:252

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  36. Content type: Case report

    Reactivation of the Bacillus Calmette-Guérin (BCG), manifesting as erythema, induration, ulceration or crust formation at a previous BCG inoculation site, is a common and highly specific feature of Kawasaki di...

    Authors: Sobana Muthuvelu, Kev Shiau-Chong Lim, Ling-Yin Huang, Shi-Tying Chin and Anand Mohan

    Citation: BMC Pediatrics 2019 19:251

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  37. Content type: Case report

    X-linked recessive chondrodysplasia punctate (CDPX1) is a rare congenital disorder of bone and cartilage development, caused by a mutation in the arylsulfatase E (ARSE) gene located on chromosome Xp22.3. Altho...

    Authors: Guannan He, Yan Yin, Jing Zhao, Xueyan Wang, Jiaxiang Yang, Xi Chen, Li Ding and Yan Bai

    Citation: BMC Pediatrics 2019 19:250

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  38. Content type: Research article

    Human leukocyte antigen (HLA) molecules play a key role in the cellular immune system. They may be determinants of mother-to-child transmission which is the driving force in pediatric HIV infection. We intende...

    Authors: Linda Mouafo Mekue, Céline Nguefeu Nkenfou, Elvis Ndukong, Leaticia Yatchou, Beatrice Dambaya, Marie-Nicole Ngoufack, Joel Kadji Kameni, Jules-roger Kuiaté and Alexis Ndjolo

    Citation: BMC Pediatrics 2019 19:249

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  39. Content type: Research article

    Although child mortality has decreased over the last several decades, neonatal mortality has declined less substantially. In South Asia, neonatal deaths account for the majority of all under-five deaths, calli...

    Authors: Lindsay Mallick, Jennifer Yourkavitch and Courtney Allen

    Citation: BMC Pediatrics 2019 19:248

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  40. Content type: Study protocol

    Environmental Enteropathy (EE), characterized by alterations in intestinal structure, function, and immune activation, is believed to be an important contributor to childhood undernutrition and its associated ...

    Authors: Najeeha T. Iqbal, Sana Syed, Kamran Sadiq, Marium N. Khan, Junaid Iqbal, Jennie Z. Ma, Fayaz Umrani, Sheraz Ahmed, Elizabeth A. Maier, Lee A. Denson, Yael Haberman, Monica M. McNeal, Kenneth D. R. Setchell, Xueheng Zhao, Shahida Qureshi, Lanlan Shen…

    Citation: BMC Pediatrics 2019 19:247

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  41. Content type: Study protocol

    The microbial population of the human gut (the gut microbiome) is an integral cog in the bidirectional communication axis that exists between the gastrointestinal tract and the central nervous system. African ...

    Authors: Patricia A. Brennan, Anne L. Dunlop, Alicia K. Smith, Michael Kramer, Jennifer Mulle and Elizabeth J. Corwin

    Citation: BMC Pediatrics 2019 19:246

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  42. Content type: Case report

    This case follows a 14-month-old female, who despite multiple presentations to several physicians, continued to have recurrent febrile episodes with gross motor delay. Her case revealed an often missed diagnos...

    Authors: Tiziana Coppola, Bradford Becken, Heather Van Mater, Marie Theresa McDonald and Gabriela Maradiaga Panayotti

    Citation: BMC Pediatrics 2019 19:245

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  43. Content type: Research article

    Hypertension (AH) is an emerging disease that has rapidly increased in the last decades throughout the world. The increase in blood pressure (BP) is observed with growth and development and, although the manif...

    Authors: Fernando Rodrigues Peixoto Quaresma, Erika da Silva Maciel, Francisco Winter dos Santos Figueiredo and Fernando Adami

    Citation: BMC Pediatrics 2019 19:244

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