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  1. Content type: Research article

    Physical activity (PA) is associated with changes in body composition that affect insulin sensitivity and leptin levels. Few studies have assessed the effect of lifestyle interventions on changes in objectivel...

    Authors: Lydia Morell-Azanza, Ana Ojeda-Rodríguez, Amaia Ochotorena-Elicegui, Nerea Martín-Calvo, María Chueca, Amelia Marti and Cristina Azcona-San Julian

    Citation: BMC Pediatrics 2019 19:90

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  2. Content type: Research article

    Despite being preventable, anaemia is a major public health problem that affects a sizable number of children under-five years globally and in Tanzania. This study examined the maternal factors associated with...

    Authors: Olaide O. Ojoniyi, Clifford O. Odimegwu, Emmanuel O. Olamijuwon and Joshua O. Akinyemi

    Citation: BMC Pediatrics 2019 19:89

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  3. Content type: Research article

    Series of biochemical and haematological changes occur during the course of dengue infection, which vary depending on the clinical disease. The patterns of change are not well documented and identifying these ...

    Authors: Grace Angeline Malarnangai Kularatnam, Eresha Jasinge, Sunethra Gunasena, Dulani Samaranayake, Manouri Prasanta Senanayake and Vithanage Pujitha Wickramasinghe

    Citation: BMC Pediatrics 2019 19:87

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  4. Content type: Case report

    Progressive lung involvement in Filamin A (FLNA)-related cerebral periventricular nodular heterotopia (PVNH) has been reported in a limited number of cases.

    Authors: Gloria Pelizzo, Mirella Collura, Aurora Puglisi, Maria Pia Pappalardo, Emanuele Agolini, Antonio Novelli, Maria Piccione, Caterina Cacace, Rossana Bussani, Giovanni Corsello and Valeria Calcaterra

    Citation: BMC Pediatrics 2019 19:86

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  5. Content type: Research article

    There is no gold standard in body composition measurement in pediatric patients with obesity. Therefore, the aim of this study was to investigate if there are any differences between two bioelectrical impedanc...

    Authors: Alexandra Kreissl, Anselm Jorda, Katharina Truschner, Gabriele Skacel and Susanne Greber-Platzer

    Citation: BMC Pediatrics 2019 19:84

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  6. Content type: Research article

    Nutritional status of children influences their health status, which is a key determinant of human development. In Ethiopia, 28% of child mortality is caused by under nutrition. There is also some controversia...

    Authors: Zufan Bitew Dessie, Melkitu Fentie, Zegeye Abebe, Tadesse Awoke Ayele and Kindie Fentahun Muchie

    Citation: BMC Pediatrics 2019 19:83

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  7. Content type: Study protocol

    Premature infants are at risk for abnormal sensory development due to brain immaturity at birth and atypical early sensory experiences in the Neonatal Intensive Care Unit. This altered sensory development can ...

    Authors: Mary Lauren Neel, Paul Yoder, Pawel J. Matusz, Micah M. Murray, Ashley Miller, Stephanie Burkhardt, Lelia Emery, Kaleigh Hague, Caitlin Pennington, Jessica Purnell, Megan Lightfoot and Nathalie L. Maitre

    Citation: BMC Pediatrics 2019 19:81

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  8. Content type: Research article

    Although dysmenorrhea is not a life-threatening condition, it can cause a substantial burden on individuals and communities. There is no data on the prevalence of dysmenorrhea in Kuwait. This study aimed to es...

    Authors: Sharefah Al-Matouq, Hessah Al-Mutairi, Ohood Al-Mutairi, Fatima Abdulaziz, Dana Al-Basri, Mona Al-Enzi and Abdullah Al-Taiar

    Citation: BMC Pediatrics 2019 19:80

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  9. Content type: Case report

    Maternofetal carnitine transport through the placenta is the main route of fetal carnitine uptake. Decreased free carnitine levels discovered by newborn screening has identified many asymptomatic adult women w...

    Authors: Si Chen, Yingying Hu, Yumei Huang, Yan Nan, Xiaojian Zhou, Shangqin Chen, Jin Lin and Zhenlang Lin

    Citation: BMC Pediatrics 2019 19:79

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  10. Content type: Case report

    Cholecystoduodenostomy is a surgical procedure that bypasses the extrahepatic biliary tree and connects the gallbladder directly to the duodenum. This case describes the successful use of this procedure in a n...

    Authors: Laura K. Fawcett, John Widger, Guy M. Henry and Chee Y. Ooi

    Citation: BMC Pediatrics 2019 19:78

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  11. Content type: Research article

    The present study investigates whether sensation seeking in pre-school-age children is associated with age, gender and socio-economic status, and how sensation seeking relates to behavioural difficulties.

    Authors: Myriam Haas, Andreas Hiemisch, Mandy Vogel, Oleg Wagner, Wieland Kiess and Tanja Poulain

    Citation: BMC Pediatrics 2019 19:77

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  12. Content type: Research article

    Children with cancer often suffer side effects from their treatment, for example nausea and vomiting, which can lead to malnutrition. If a child cannot eat orally, a percutaneous endoscopic gastrostomy (PEG) c...

    Authors: Margaretha Jenholt Nolbris, Ann-Louise Gustafsson, Carina Fondin, Karin Mellgren and Stefan Nilsson

    Citation: BMC Pediatrics 2019 19:76

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  13. Content type: Research article

    Obesity is one of the conditions that increases the risk of cardiovascular disease. Studies about obesity trajectory and cardio metabolic outcomes at adulthood are still scarce. Therefore, we aimed to assess t...

    Authors: Gabriela Callo Quinte, Fernando Barros, Denise Petrucci Gigante, Isabel Oliveira de Oliveira, Janaína Vieira dos Santos Motta and Bernardo Lessa Horta

    Citation: BMC Pediatrics 2019 19:75

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  14. Content type: Case report

    Numerous cases of scurvy secondary to diet limitations have been reported in the literature with most being boys with special needs. To date, the focus of the literature describing vitamin C deficiency has bee...

    Authors: Timothy Hahn, Whitney Adams and Keith Williams

    Citation: BMC Pediatrics 2019 19:74

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    The Correction to this article has been published in BMC Pediatrics 2019 19:151

  15. Content type: Case report

    Hemophagocytic Lymphohistiocytosis (HLH) is a rare, complex, life-threatening hyper-inflammatory condition due to over activation of lymphocytes mediated secretory cytokines in the body. It occurs as a primary...

    Authors: Jayesh Sheth, Akash Patel, Raju Shah, Riddhi Bhavsar, Sunil Trivedi and Frenny Sheth

    Citation: BMC Pediatrics 2019 19:73

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  16. Content type: Case report

    Total parenteral nutrition (TPN) and biliary atresia (BA) are common causes of cholestasis in infancy. The diagnosis of BA is time sensitive due to an inverse correlation between age at intervention (hepatic p...

    Authors: Atu Agawu, Andrew Wehrman, Jennifer Pogoriler, Natalie A. Terry and Henry C. Lin

    Citation: BMC Pediatrics 2019 19:72

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  17. Content type: Research article

    The incidence of type 1 diabetes mellitus (T1DM) in Kuwait is amongst the highest in the world. Vitamin D is considered to be involved in immune modulation and its deficiency contribute to autoimmune destructi...

    Authors: Majedah A. Rasoul, Mohammad Z. Haider, Maria Al-Mahdi, Hessa Al-Kandari and Gursev S. Dhaunsi

    Citation: BMC Pediatrics 2019 19:71

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  18. Content type: Research article

    The effects of prenatal maternal smoking have been studied extensively, however little research has examined the effects of prenatal exposure to maternal smoking on offspring sleep, particularly over several d...

    Authors: Frances O’Callaghan, Michael O’Callaghan, James G. Scott, Jake Najman and Abdullah Al Mamun

    Citation: BMC Pediatrics 2019 19:70

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  19. Content type: Research article

    Comprehensive data are needed to evaluate the burden of low birthweight. Analysis of routine data on health-care utilization during early childhood were used to test the hypothesis that infants with low birthw...

    Authors: Mario Rüdiger, Luise Heinrich, Katrin Arnold, Diana Druschke, Jörg Reichert and Jochen Schmitt

    Citation: BMC Pediatrics 2019 19:69

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  20. Content type: Case report

    Mutations in the PIGV, PIGO, PIGL, PIGY, PGAP2, PGAP3, and PIGW genes have recently been reported to cause hyperphosphatasia accompanied by mental retardation syndrome (HPMRS); the latter is an autosomal-recessiv...

    Authors: Li’na Fu, Yan Liu, Yu Chen, Yi Yuan and Wei Wei

    Citation: BMC Pediatrics 2019 19:68

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  21. Content type: Research article

    While intercenter variation (ICV) in anti-epileptic drug (AED) use in neonates with seizures has been previously reported, variation in AED practices across regional NICUs has not been specifically and systema...

    Authors: Maria L. V. Dizon, Rakesh Rao, Shannon E. Hamrick, Isabella Zaniletti, Robert DiGeronimo, Girija Natarajan, Jeffrey R. Kaiser, John Flibotte, Kyong-Soon Lee, Danielle Smith, Toby Yanowitz, Amit M. Mathur and An N. Massaro

    Citation: BMC Pediatrics 2019 19:67

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  22. Content type: Research article

    In Kawasaki disease (KD), a vasculitis of unknown etiology, the most serious complication is the development of coronary artery aneurysm (CAA). To date, the exact pathomechanism of KD is unknown. Both environm...

    Authors: K. Meyer, A. Volkmann, M. Hufnagel, E. Schachinger, S. Klau, J. Horstmann, R. Berner, M. Fischer, A. Lehner, N. Haas, S. Ulrich and A. Jakob

    Citation: BMC Pediatrics 2019 19:66

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  23. Content type: Research article

    Although renin-angiotensin II-aldosterone system inhibitor (RASI) use for renal protection is well-documented, adherence to RASI therapy in the pediatric population is unclear. This study aimed to evaluate pat...

    Authors: Chien-Ning Hsu, Shiou-Huei Huang and You-Lin Tain

    Citation: BMC Pediatrics 2019 19:64

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  24. Content type: Case report

    Primary lymphomas of the gastrointestinal tract are rare, accounting for only 1 to 4% of malignancies arising in the stomach, small intestine, or colon. The stomach is the most common extranodal site of lympho...

    Authors: Yu-Tang Chang, Ming-Yii Huang, Hsiang-Hung Shih, Chun-Chieh Wu, Tzu-Ying Lu and Pei-Chin Lin

    Citation: BMC Pediatrics 2019 19:63

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  25. Content type: Case report

    Hereditary spherocytosis (HS) is a type of hemolytic anemia caused by abnormal red cell membrane skeletal proteins with few unique clinical manifestations in the neonate and infant. An ANK1 gene mutation is the m...

    Authors: Ti-Long Huang, Bao-Hua Sang, Qing-Ling Lei, Chun-Yan Song, Yun-Bi Lin, Yu Lv, Chun-Hui Yang, Na Li, Yue-Huang Yang, Xian-Wen Zhang and Xin Tian

    Citation: BMC Pediatrics 2019 19:62

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  26. Content type: Case report

    Beta thalassemia (β-thal) is an inherited hemoglobin disorder characterized by reduced synthesis of the hemoglobin that results in microcytic hypochromic anemia. β-Thalassemia intermedia (TI) is a clinical ter...

    Authors: Faten Moassas, Mohamad Sayah Nweder and Hossam Murad

    Citation: BMC Pediatrics 2019 19:61

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  27. Content type: Research article

    Body composition in infancy plays a central role in the programming of metabolic diseases. Fat mass (FM) is determined by personal and environmental factors. Anthropometric measurements allow for estimations o...

    Authors: Ameyalli M. Rodríguez-Cano, Jennifer Mier-Cabrera, Cinthya Muñoz-Manrique, Arturo Cardona-Pérez, Gicela Villalobos-Alcázar and Otilia Perichart-Perera

    Citation: BMC Pediatrics 2019 19:60

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  28. Content type: Case report

    Hand, foot, and mouth disease (HFMD) is an acute viral infection occurring mostly in infants and children. Enterovirus 71 (EV71) infection mostly occurs in children < 5 years of age. Severe cases, however, are...

    Authors: Ying-Fu Chen, Lan Hu, Feng Xu, Cheng-jun Liu and Jing Li

    Citation: BMC Pediatrics 2019 19:59

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  29. Content type: Research article

    Donor human milk (DHM) is the best alternative for preterm infants when their own mother’s milk is unavailable. DHM should be pasteurized to guarantee microbiological safety; however, this process can influenc...

    Authors: Pasqua Piemontese, Domenica Mallardi, Nadia Liotto, Chiara Tabasso, Camilla Menis, Michela Perrone, Paola Roggero and Fabio Mosca

    Citation: BMC Pediatrics 2019 19:58

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  30. Content type: Research article

    Postoperative fluid management in critically ill neonates and infants with capillary leak syndrome (CLS) and extensive volume overload after cardiac surgery on cardiopulmonary bypass is challenging. CLS is oft...

    Authors: Anne Kerling, Okan Toka, André Rüffer, Hanna Müller, Sheeraz Habash, Christel Weiss, Sven Dittrich and Julia Moosmann

    Citation: BMC Pediatrics 2019 19:57

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  31. Content type: Research article

    Children with Sickle Cell Disease (SCD) show endocrine complications and metabolic alterations. The physiopathology of these conditions is not completely understood: iron overload due to chronic transfusions, ...

    Authors: V. Mandese, E. Bigi, P. Bruzzi, G. Palazzi, B. Predieri, L. Lucaccioni, M. Cellini and L. Iughetti

    Citation: BMC Pediatrics 2019 19:56

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  32. Content type: Case report

    Abernethy malformation is an extremely rare congenital malformation characterised by an extrahepatic portosystemic shunt. Children with Abernathy malformation can develop hepatopulmonary syndrome (HPS) with pu...

    Authors: Lijian Xie, Yun Li, Xunwei Jiang, Jian Zhao and Tingting Xiao

    Citation: BMC Pediatrics 2019 19:55

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  33. Content type: Research article

    The global incidence of overweight and obesity has increased dramatically among children and adolescents over the past decades. Insufficient sleep duration and physical inactivity are known risk factors for ov...

    Authors: Susanne Kobel, Olivia Wartha, Jens Dreyhaupt, Sarah Kettner and Jürgen M. Steinacker

    Citation: BMC Pediatrics 2019 19:54

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  34. Content type: Research article

    Prevalence of hemolytic neonatal hyperbilirubinemia (NHB) is not well characterized, and economic burden at the population level is poorly understood. This study evaluated the prevalence, clinical characterist...

    Authors: Tzy-Chyi Yu, Chi Nguyen, Nancy Ruiz, Siting Zhou, Xian Zhang, Elaine A. Böing and Hiangkiat Tan

    Citation: BMC Pediatrics 2019 19:53

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  35. Content type: Research article

    The literature suggests that 0.9 to 6% of infants who die unexpectedly may have had a metabolic disorder. At least 43 different inborn errors of metabolism (IEMs) have been associated with sudden death (SUDI)....

    Authors: F. H. de Bitencourt, I. V. D. Schwartz and F. S. L. Vianna

    Citation: BMC Pediatrics 2019 19:52

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  36. Content type: Research article

    Newborn resuscitation is a life-saving intervention for birth asphyxia, a leading cause of neonatal mortality. Improving provider newborn resuscitation skills is critical for delivering quality care, but the r...

    Authors: Mary Drake, Dunstan R. Bishanga, Akwila Temu, Mustafa Njozi, Erica Thomas, Victor Mponzi, Lauren Arlington, Georgina Msemo, Mary Azayo, Allan Kairuki, Amunga R. Meda, Kahabi G. Isangula and Brett D. Nelson

    Citation: BMC Pediatrics 2019 19:51

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  37. Content type: Research article

    A new formulation of the live-attenuated varicella vaccine Varilrix (GSK) produced without human serum albumin (HSA) was developed to minimize a theoretical risk of transmission of infectious diseases. A previous...

    Authors: Saul N. Faust, Maguelone Le Roy, Chitsanu Pancharoen, Miguel Angel Rodriguez Weber, Katrina Cathie, Ulrich Behre, Jolanta Bernatoniene, Matthew D. Snape, Klaus Helm, Carlos Eduardo Medina Pech, Ouzama Henry, Carmen Baccarini, Michael Povey and Paul Gillard

    Citation: BMC Pediatrics 2019 19:50

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  38. Content type: Research article

    The early recognition of meningococcal disease in children is vital. During the prodrome however, meningococcal infection presents similarly to many self-limiting viral infections. This mandates a cautious app...

    Authors: Thomas Waterfield, Derek Fairley, Bronagh Blackwood, James McKenna and Michael D. Shields

    Citation: BMC Pediatrics 2019 19:49

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  39. Content type: Research article

    In Senegal in 2015, an estimated 4800 children were living with HIV, with 1200 receiving ARV treatment, of whom half had follow-up care in decentralized sites outside Dakar.

    Authors: Abdoul-Magib Cissé, Gabrièle Laborde-Balen, Khady Kébé-Fall, Aboubacry Dramé, Halimatou Diop, Karim Diop, FatouNiasse-Traoré, Mohamed Coulibaly, Ndeye-Ngone Have, Nicole Vidal, Safiatou Thiam, Abdoulaye S. Wade, Martine Peeters, Bernard Taverne, Philippe Msellati and Coumba Touré-Kane

    Citation: BMC Pediatrics 2019 19:47

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  40. Content type: Research article

    Excessive and inappropriate antimicrobial use in the community is one risk factor that can result in the spread of antimicrobial resistance. Upper respiratory tract infections are most frequently reported amon...

    Authors: Hani Saleh Faidah, Abdul Haseeb, Majd Yousuf Lamfon, Malak Mohammad Almatrafi, Imtinan Abdullah Almasoudi, Ejaz Cheema, Waleed Hassan Almalki, Mahmoud E Elrggal, Mahmoud M.A. Mohamed, Fahad Saleem, Manal Mansour Al-Gethamy, Beenish Pervaiz, Tahir Mehmood Khan and Mohamed Azmi Hassali

    Citation: BMC Pediatrics 2019 19:46

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  41. Content type: Research article

    Data on the prevalence of suicidal ideation, suicide attempts, and direct self-injurious behavior in adolescents with a migration background are scarce. There are hints that this population is at risk. The aim...

    Authors: Carolin Donath, Marie Christine Bergmann, Sören Kliem, Thomas Hillemacher and Dirk Baier

    Citation: BMC Pediatrics 2019 19:45

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  42. Content type: Research article

    A number of region-specific validated triage systems exist; however very little is known about their performance in resource limited settings. We compare the local triage tool and internationally validated too...

    Authors: Nafsa R. Marombwa, Hendry R. Sawe, Upendo George, Said S. Kilindimo, Nanyori J. Lucumay, Kilalo M. Mjema, Juma A. Mfinanga and Ellen J. Weber

    Citation: BMC Pediatrics 2019 19:44

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  43. Content type: Research article

    Kawasaki disease (KD) is an acute febrile vasculitis that primarily affects children. Previous studies have shown that both innate and adapt immune systems are involved in the immunopathogenesis of KD. The fol...

    Authors: Meng Xu, Yanfang Jiang, Jinghua Wang, Deying Liu, Shaofeng Wang, Huanfa Yi and Sirui Yang

    Citation: BMC Pediatrics 2019 19:43

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