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  1. Content type: Study protocol

    Much controversy exists about the optimal management of a patent ductus arteriosus (PDA) in preterm infants, especially in those born at a gestational age (GA) less than 28 weeks. No causal relationship has be...

    Authors: Tim Hundscheid, Wes Onland, Bart van Overmeire, Peter Dijk, Anton H. L. C. van Kaam, Koen P. Dijkman, Elisabeth M. W. Kooi, Eduardo Villamor, André A. Kroon, Remco Visser, Daniel C. Vijlbrief, Susanne M. de Tollenaer, Filip Cools, David van Laere, Anne-Britt Johansson, Catheline Hocq…

    Citation: BMC Pediatrics 2018 18:262

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  2. Content type: Study protocol

    The death of a child before or shortly after birth is frequently preceded by an end-of-life decision (ELD). Population-based studies of incidence and characteristics of ELDs in neonates and infants are rare, a...

    Authors: Laure Dombrecht, Kim Beernaert, Ellen Roets, Kenneth Chambaere, Filip Cools, Linde Goossens, Gunnar Naulaers, Luc De Catte, Joachim Cohen and Luc Deliens

    Citation: BMC Pediatrics 2018 18:260

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  3. Content type: Research article

    Universal HIV testing and treatment of infected children remain challenging in resource-limited settings (RLS), leading to undiagnosed children/adolescents and limited access to pediatric antiretroviral therap...

    Authors: Calixte Ida Penda, Carole Else Eboumbou Moukoko, Daniele Kedy Koum, Joseph Fokam, Cedric Anatole Zambo Meyong, Sandrine Talla and Paul Koki Ndombo

    Citation: BMC Pediatrics 2018 18:259

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  4. Content type: Study protocol

    Modified sport interventions run by physiotherapists have shown potential as cost-effective, engaging, and effective interventions to improve gross motor skills and support transition to real-world sports part...

    Authors: Georgina L. Clutterbuck, Megan L. Auld and Leanne M. Johnston

    Citation: BMC Pediatrics 2018 18:258

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  5. Content type: Study protocol

    Basic parenting research reveals that child mental health is associated with optimal parenting, which is composed of three key dimensions (structure, affiliation and autonomy support). The present study aims t...

    Authors: Mireille Joussemet, Geneviève A. Mageau, Marie-Pier Larose, Mélanie Briand and Frank Vitaro

    Citation: BMC Pediatrics 2018 18:257

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  6. Content type: Study protocol

    Twin-to-twin transfusion syndrome (TTTS) is a serious complication of 10–15% of twin or triplet pregnancies in which multiple fetuses share a single placenta. Communicating placental vessels allow one fetus (t...

    Authors: Christie Bolch, Michael Fahey, Dinah Reddihough, Katrina Williams, Susan Reid, Angela Guzys, Stephen Cole, Andrew Edwards, Alison Fung, Ryan Hodges, Ricardo Palma-Dias, Mark Teoh and Susan Walker

    Citation: BMC Pediatrics 2018 18:256

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  7. Content type: Study protocol

    Hypoxic-ischemic encephalopathy (HIE) is a rare neonatal condition affecting about 1‰ births. Despite a significant improvement in the management of this condition in the last ten years, HIE remains associated...

    Authors: Thierry Debillon, Nathalie Bednarek and Anne Ego

    Citation: BMC Pediatrics 2018 18:255

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  8. Content type: Case report

    Microphthalmia with linear skin defects (MLS) syndrome is a rare neurodevelopmental X-dominant disorder. It presents in females as it is normally lethal in males. Three causative genes for MLS syndrome (OMIM 3...

    Authors: Nina Prepeluh, Bojan Korpar, Andreja Zagorac, Boris Zagradišnik, Andreja Golub and Nadja Kokalj Vokač

    Citation: BMC Pediatrics 2018 18:254

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  9. Content type: Research article

    Sepsis is a leading cause of morbidity and mortality among newborns. C-reactive protein (CRP) and procalcitonin (PCT) have some limitations in the diagnosis of preterm neonatal sepsis. In this study, the cut-o...

    Authors: C. Aydemir, H. Aydemir, F. Kokturk, C. Kulah and A. G. Mungan

    Citation: BMC Pediatrics 2018 18:253

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  10. Content type: Study protocol

    Of children with hemiplegic cerebral palsy, 75% have impaired somatosensory function, which contributes to learned non-use of the affected upper limb. Currently, motor learning approaches are used to improve u...

    Authors: Belinda McLean, Misty Blakeman, Leeanne Carey, Roslyn Ward, Iona Novak, Jane Valentine, Eve Blair, Susan Taylor, Natasha Bear, Michael Bynevelt, Emma Basc, Stephen Rose, Lee Reid, Kerstin Pannek, Jennifer Angeli, Karen Harpster…

    Citation: BMC Pediatrics 2018 18:252

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  12. Content type: Study protocol

    Upper limb (UL) deficits in children with unilateral cerebral palsy (uCP) have traditionally been targeted with motor execution treatment models, such as modified Constraint-Induced Movement Therapy (mCIMT). H...

    Authors: Cristina Simon-Martinez, Lisa Mailleux, Els Ortibus, Anna Fehrenbach, Giuseppina Sgandurra, Giovanni Cioni, Kaat Desloovere, Nicole Wenderoth, Philippe Demaerel, Stefan Sunaert, Guy Molenaers, Hilde Feys and Katrijn Klingels

    Citation: BMC Pediatrics 2018 18:250

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  13. Content type: Study protocol

    Our aim was to design a study to evaluate the effectiveness and cost-effectiveness of adding physiotherapy to conventional treatment for children with functional constipation in primary care. Physiotherapy is ...

    Authors: Jojanneke J. G. T. van Summeren, Gea A. Holtman, Yvonne Lisman- van Leeuwen, Lisa E. A. M. Louer, Alice H. C. van Ulsen-Rust, Karin M. Vermeulen, Boudewijn J. Kollen, Janny H. Dekker and Marjolein Y. Berger

    Citation: BMC Pediatrics 2018 18:249

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  14. Content type: Research article

    Functional hand splinting is a common therapeutic intervention for children with neurological conditions. The aim of this study was to investigate the effectiveness of the Cognitive Orientation to daily Occupa...

    Authors: Michelle Jackman, Iona Novak, Natasha Lannin, Elspeth Froude, Laura Miller and Claire Galea

    Citation: BMC Pediatrics 2018 18:248

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  15. Content type: Case report

    Acetaminophen is a common cause of acute liver failure in pediatrics. Cerebral edema is a significant complication of acute hepatic failure and is associated with increased mortality.

    Authors: Emily B. Austin, Hailey Hobbs, Brian A. Crouse and Anna-Theresa Lobos

    Citation: BMC Pediatrics 2018 18:247

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  16. Content type: Study protocol

    Children commonly present to Emergency Departments (ED) with a non-blanching rash in the context of a feverish illness. While most have a self-limiting viral illness, this combination of features potentially r...

    Authors: Thomas Waterfield, Mark D. Lyttle, Derek Fairley, James Mckenna, Kerry Woolfall, Fiona Lynn, Julie-Ann Maney, Damian Roland, Aoife Weir and Michael D. Shields

    Citation: BMC Pediatrics 2018 18:246

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  17. Content type: Research article

    Childhood obesity is one of the most challenging public health issues of twenty-first century. While we know that there is an increase in prevalence of childhood and adolescence obesity, incidence studies must...

    Authors: Maryam Barzin, Shayan Aryannezhad, Sara Serahati, Akram Beikyazdi, Fereidoun Azizi, Majid Valizadeh, Maryam Ziadlou and Farhad Hosseinpanah

    Citation: BMC Pediatrics 2018 18:245

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  18. Content type: Study protocol

    In hospital, staff need to routinely monitor patients to identify those who are seriously ill, so that they receive timely treatment to improve their condition. A Paediatric Early Warning System is a multi-fac...

    Authors: Emma Thomas-Jones, Amy Lloyd, Damian Roland, Gerri Sefton, Lyvonne Tume, Kerry Hood, Chao Huang, Dawn Edwards, Alison Oliver, Richard Skone, David Lacy, Ian Sinha, Jenny Preston, Brendan Mason, Nina Jacob, Robert Trubey…

    Citation: BMC Pediatrics 2018 18:244

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  19. Content type: Research article

    Pediatric non-adherence to antiretroviral therapy (ART), loss to follow-up, and HIV drug resistance (HIVDR) are challenges to achieving UNAIDS’ targets of 90% of those diagnosed HIV-positive receiving treatmen...

    Authors: Nanlesta A. Pilgrim, Jerry Okal, James Matheka, Irene Mukui and Samuel Kalibala

    Citation: BMC Pediatrics 2018 18:243

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  20. Content type: Research article

    Unlicensed and off label drug use is an issue recognized worldwide in pediatric pharmacotherapy. The study was designed to assess the prevalence and predictors of unlicensed and off label drug use in neonatal ...

    Authors: Muhammad Aamir, Jamshaid Ali Khan, Faisal Shakeel, Rabeea Shareef and Nazia Shah

    Citation: BMC Pediatrics 2018 18:242

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  21. Content type: Research article

    Diarrhoeal disease is the second leading cause of death among children aged below 5 years. Even though, both preventable and treatable diseases, globally there are nearly 1.7 billion cases of childhood diarrho...

    Authors: Wondwossen Abebe, Alemu Earsido, Solomon Taye, Mesfin Assefa, Adane Eyasu and Girma Godebo

    Citation: BMC Pediatrics 2018 18:241

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  22. Content type: Research article

    Acute respiratory tract infections contribute significantly to morbidity and mortality among young children in resource-poor countries. However, studies on the viral aetiology of acute respiratory infections, ...

    Authors: Temitayo Famoroti, Wilbert Sibanda and Thumbi Ndung’u

    Citation: BMC Pediatrics 2018 18:240

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  23. Content type: Research article

    Early discharge of very low birth weight infant (VLBW) in low resource settings is inevitable but to minimize mortality of these infants after discharge we need to identify the death attributes.

    Authors: Yaser Abdallah, Flavia Namiiro, Jolly Nankunda, Jamiru Mugalu and Yvonne Vaucher

    Citation: BMC Pediatrics 2018 18:239

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  24. Content type: Study protocol

    Children initially hospitalized with severe anaemia in Africa are at high risk of readmission or death within 6 months after discharge. No intervention strategy specifically protects children during the post-d...

    Authors: Thandile Gondwe, Bjarne Robberstad, Mavuto Mukaka, Siri Lange, Bjørn Blomberg and Kamija Phiri

    Citation: BMC Pediatrics 2018 18:238

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  25. Content type: Research article

    There is increasing recognition of the value of “real-world evidence” in evaluating health care services. Registry-based, observational studies conducted in clinical settings represent a relevant model to achi...

    Authors: Katherine M. Morrison, Geoff D. C. Ball, Josephine Ho, Pam Mackie, Annick Buchholz, Jean-Pierre Chanoine, Jill Hamilton, Anne-Marie Laberge, Laurent Legault, Lehana Thabane, Mark Tremblay and Ian Zenlea

    Citation: BMC Pediatrics 2018 18:237

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  26. Content type: Study protocol

    Globally one out of four children under 5 years is affected by linear growth delay (stunting). This syndrome has severe long-term sequelae including increased risk of illness and mortality and delayed psychomotor...

    Authors: Pascale Vonaesch, Rindra Randremanana, Jean-Chrysostome Gody, Jean-Marc Collard, Tamara Giles-Vernick, Maria Doria, Inès Vigan-Womas, Pierre-Alain Rubbo, Aurélie Etienne, Emilson Jean Andriatahirintsoa, Nathalie Kapel, Eric Brown, Kelsey E. Huus, Darragh Duffy, B.Brett Finlay, Milena Hasan…

    Citation: BMC Pediatrics 2018 18:236

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  27. Content type: Study protocol

    Adolescents with chronic illness (CI) and parents of a child with CI are at risk for psychosocial problems. Psychosocial group interventions may prevent these problems. With the use of cognitive-behavioral the...

    Authors: Miriam Douma, Linde Scholten, Heleen Maurice-Stam and Martha A. Grootenhuis

    Citation: BMC Pediatrics 2018 18:235

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  28. Content type: Research article

    Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infan...

    Authors: Abhishek Chopra, Anup Thakur, Pankaj Garg, Neelam Kler and Kanwal Gujral

    Citation: BMC Pediatrics 2018 18:234

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  29. Content type: Study protocol

    Nutrition and environmental factors are essential for the education of the neonatal immune system. Epidemiological evidence has shown that malnutrition and allergic diseases that occur during early childhood s...

    Authors: Fui Chee Woon, Yit Siew Chin, Intan Hakimah Ismail, Yoke Mun Chan, Marijka Batterham, Amir Hamzah Abdul Latiff, Wan Ying Gan and Geeta Appannah

    Citation: BMC Pediatrics 2018 18:233

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  30. Content type: Study protocol

    A child’s first years of life are crucial for cognitive development and future health. Studies show that a varied diet with a high intake of vegetables is positive for both weight and cognitive development. Th...

    Authors: Eli Anne Myrvoll Blomkvist, Sissel Heidi Helland, Elisabet Rudjord Hillesund and Nina Cecilie Øverby

    Citation: BMC Pediatrics 2018 18:232

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  31. Content type: Case report

    Lesch-Nyhan syndrome is a rare inborn error of purine metabolism marked by a complete deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT). Inherited as an X-linked recessive genetic ...

    Authors: Lisa B. E. Shields, Dennis S. Peppas and Eran Rosenberg

    Citation: BMC Pediatrics 2018 18:231

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  32. Content type: Study protocol

    Children with congenital heart disease (CHD) are at increased risk for behavioral, emotional, and cognitive problems. They often have reduced exercise capacity and participate less in sports, which is associat...

    Authors: Malindi van der Mheen, Ingrid M. van Beynum, Karolijn Dulfer, Jan van der Ende, Eugène van Galen, Jorieke Duvekot, Lisette E. Rots, Tabitha P. L. van den Adel, Ad J. J. C. Bogers, Christopher G. McCusker, Frank A. Casey, Willem A. Helbing and Elisabeth M. W. J. Utens

    Citation: BMC Pediatrics 2018 18:230

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  33. Content type: Research article

    To investigate the unique features of inflammatory bowel disease (IBD) in children, we wanted to identify whether there might be a strong correlation between the disease phenotype and its prognosis at various ...

    Authors: Xin-Qiong Wang, Yuan Xiao, Xu Xu, Yi Yu, Cheng-Yan Shan, Yan Guo, Ling Gong, Tong Zhou, Shen-Shen Gao, Yao-Zong Yuan, Xiao-Jin Wang and Chun-Di Xu

    Citation: BMC Pediatrics 2018 18:229

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  34. Content type: Research article

    It was unclear how and to what extent the “Child Care” intervention (CCI) in rural Primary Health Care Program affected the prevalence of childhood diarrhea in rural western China.

    Authors: Wenlong Gao, Guirong Li, Xiaoning Liu and Hong Yan

    Citation: BMC Pediatrics 2018 18:228

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  35. Content type: Research article

    Measurement of transcutaneous bilirubin (TcB) is a quick, reliable and painless method to guide management of hyperbilirubinemia. Studies in term and late preterm infants have found that TcB measurements from ...

    Authors: Vidit Bhargava, Daniel Tawfik, Bruce Niebuhr and Sunil K. Jain

    Citation: BMC Pediatrics 2018 18:227

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  36. Content type: Correction

    After publication of the original article [1], the corresponding author noticed the given names and family names of the members included in the Swiss Neonatal End-of-Life Study Group were incorrectly reverted.

    Authors: Hans Ulrich Bucher, Sabine D. Klein, Manya J. Hendriks, Ruth Baumann-Hölzle, Thomas M. Berger, Jürg C. Streuli and Jean-Claude Fauchère

    Citation: BMC Pediatrics 2018 18:226

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    The original article was published in BMC Pediatrics 2018 18:81

  37. Content type: Study protocol

    The greatest opportunity for lifelong impact of genomic sequencing is during the newborn period. The “BabySeq Project” is a randomized trial that explores the medical, behavioral, and economic impacts of integ...

    Authors: Ingrid A. Holm, Pankaj B. Agrawal, Ozge Ceyhan-Birsoy, Kurt D. Christensen, Shawn Fayer, Leslie A. Frankel, Casie A. Genetti, Joel B. Krier, Rebecca C. LaMay, Harvey L. Levy, Amy L. McGuire, Richard B. Parad, Peter J. Park, Stacey Pereira, Heidi L. Rehm, Talia S. Schwartz…

    Citation: BMC Pediatrics 2018 18:225

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  39. Content type: Research article

    Various intervention programs exist for parents of preterm babies and some systematic reviews (SRs) have synthesised the evidence of their effectiveness. These reviews are, however, limited to specific interve...

    Authors: Shuby Puthussery, Muhammad Chutiyami, Pei-Ching Tseng, Lesley Kilby and Jogesh Kapadia

    Citation: BMC Pediatrics 2018 18:223

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  40. Content type: Study protocol

    HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) ...

    Authors: R. Chingono, H. Mebrahtu, Z. Mupambireyi, V. Simms, H. A. Weiss, P. Ndlovu, F. Charasika, M. Tomlinson, L.D. Cluver, F. M. Cowan and L. Sherr

    Citation: BMC Pediatrics 2018 18:222

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  41. Content type: Study protocol

    Initial studies suggest pharmaceutical grade cannabidiol (CBD) can reduce the frequency of convulsive seizures and lead to improvements in quality of life in children affected by epileptic encephalopathies. Wi...

    Authors: Darren Reithmeier, Richard Tang-Wai, Blair Seifert, Andrew W. Lyon, Jane Alcorn, Bryan Acton, Scott Corley, Erin Prosser-Loose, Darrell D. Mousseau, Hyun J. Lim, Jose Tellez-Zenteno, Linda Huh, Edward Leung, Lionel Carmant and Richard J. Huntsman

    Citation: BMC Pediatrics 2018 18:221

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  42. Content type: Study protocol

    Babies born at moderate-late preterm gestations account for > 80% of all preterm births. Although survival is excellent, these babies are at increased risk of adverse neurodevelopmental outcomes. They also are...

    Authors: Frank H. Bloomfield, Jane E. Harding, Michael P. Meyer, Jane M. Alsweiler, Yannan Jiang, Clare R. Wall and Tanith Alexander

    Citation: BMC Pediatrics 2018 18:220

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  44. Content type: Study protocol

    Bronchiolitis is the most common reason for admission to hospital for infants less than one year of age. Although management is well defined, there is substantial variation in practice, with infants receiving ...

    Authors: Libby Haskell, Emma J. Tavender, Catherine Wilson, Sharon O’Brien, Franz E. Babl, Meredith L. Borland, Liz Cotterell, Tibor Schuster, Francesca Orsini, Nicolette Sheridan, David Johnson, Ed Oakley and Stuart R. Dalziel

    Citation: BMC Pediatrics 2018 18:218

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  45. Content type: Case report

    Generalized Arterial Calcification of Infancy (GACI) is a heritable ectopic mineralization disorder resulting in diffuse arterial calcifications and/or stenosis, mostly caused by mutations in the ENPP1 gene. Here...

    Authors: Iole Brunod, Barthélémy Tosello, Sophie Hassid, Catherine Gire, Laurent Thomachot and Michel Panuel

    Citation: BMC Pediatrics 2018 18:217

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  46. Content type: Research article

    Acute respiratory infection (ARI) is the leading cause of morbidity and mortality in pediatric patients worldwide and imposes an intense pressure on health care facilities. Data on the epidemiology profiles of...

    Authors: Jiayi Chen, Pengwei Hu, Tao Zhou, Tianli Zheng, Lingxu Zhou, Chunping Jiang and Xiaofang Pei

    Citation: BMC Pediatrics 2018 18:216

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  47. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is complicated disease and increasing worldwide. Previously, many studies of NALFD prevalences have used alanine aminotransferase (ALT) of > 40 U/L to define NAFLD, al...

    Authors: Yunkoo Kang, Sowon Park, Seung Kim and Hong Koh

    Citation: BMC Pediatrics 2018 18:215

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  48. Content type: Case report

    Human milk is fundamental for its nutritional properties and to protect newborns, but it is not sterile and can sometime transmit bacteria. Few anecdotal cases suggest that breast milk could be a possible sour...

    Authors: Giangiacomo Nicolini, Martina Borellini, Vitaliana Loizzo, Roberta Creti, Luigi Memo and Alberto Berardi

    Citation: BMC Pediatrics 2018 18:214

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  49. Content type: Research article

    We previously reported that perinatal dioxin exposure increased autistic traits in children living in dioxin-contaminated areas of Vietnam. In the present study, we investigated the impact of dioxin exposure o...

    Authors: Anh Thi Nguyet Nguyen, Muneko Nishijo, Tai The Pham, Nghi Ngoc Tran, Anh Hai Tran, Luong Van Hoang, Hitomi Boda, Yuko Morikawa, Yoshikazu Nishino and Hisao Nishijo

    Citation: BMC Pediatrics 2018 18:213

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  50. Content type: Research article

    Exploring the osteogenic effect of different bone-loading sports is particular relevant to understand the interaction between skeletal muscle and bone health during growth. This study aimed to compare total an...

    Authors: João Valente-dos-Santos, Óscar M. Tavares, João P. Duarte, Paulo M. Sousa-e-Silva, Luís M. Rama, José M. Casanova, Carlos A. Fontes-Ribeiro, Elisa A. Marques, Daniel Courteix, Enio R. V. Ronque, Edilson S. Cyrino, Jorge Conde and Manuel J. Coelho-e-Silva

    Citation: BMC Pediatrics 2018 18:212

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