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  1. Content type: Case report

    X-linked recessive chondrodysplasia punctate (CDPX1) is a rare congenital disorder of bone and cartilage development, caused by a mutation in the arylsulfatase E (ARSE) gene located on chromosome Xp22.3. Altho...

    Authors: Guannan He, Yan Yin, Jing Zhao, Xueyan Wang, Jiaxiang Yang, Xi Chen, Li Ding and Yan Bai

    Citation: BMC Pediatrics 2019 19:250

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  2. Content type: Research article

    Human leukocyte antigen (HLA) molecules play a key role in the cellular immune system. They may be determinants of mother-to-child transmission which is the driving force in pediatric HIV infection. We intende...

    Authors: Linda Mouafo Mekue, Céline Nguefeu Nkenfou, Elvis Ndukong, Leaticia Yatchou, Beatrice Dambaya, Marie-Nicole Ngoufack, Joel Kadji Kameni, Jules-roger Kuiaté and Alexis Ndjolo

    Citation: BMC Pediatrics 2019 19:249

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  3. Content type: Research article

    Although child mortality has decreased over the last several decades, neonatal mortality has declined less substantially. In South Asia, neonatal deaths account for the majority of all under-five deaths, calli...

    Authors: Lindsay Mallick, Jennifer Yourkavitch and Courtney Allen

    Citation: BMC Pediatrics 2019 19:248

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  4. Content type: Study protocol

    Environmental Enteropathy (EE), characterized by alterations in intestinal structure, function, and immune activation, is believed to be an important contributor to childhood undernutrition and its associated ...

    Authors: Najeeha T. Iqbal, Sana Syed, Kamran Sadiq, Marium N. Khan, Junaid Iqbal, Jennie Z. Ma, Fayaz Umrani, Sheraz Ahmed, Elizabeth A. Maier, Lee A. Denson, Yael Haberman, Monica M. McNeal, Kenneth D. R. Setchell, Xueheng Zhao, Shahida Qureshi, Lanlan Shen…

    Citation: BMC Pediatrics 2019 19:247

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  5. Content type: Study protocol

    The microbial population of the human gut (the gut microbiome) is an integral cog in the bidirectional communication axis that exists between the gastrointestinal tract and the central nervous system. African ...

    Authors: Patricia A. Brennan, Anne L. Dunlop, Alicia K. Smith, Michael Kramer, Jennifer Mulle and Elizabeth J. Corwin

    Citation: BMC Pediatrics 2019 19:246

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  6. Content type: Case report

    This case follows a 14-month-old female, who despite multiple presentations to several physicians, continued to have recurrent febrile episodes with gross motor delay. Her case revealed an often missed diagnos...

    Authors: Tiziana Coppola, Bradford Becken, Heather Van Mater, Marie Theresa McDonald and Gabriela Maradiaga Panayotti

    Citation: BMC Pediatrics 2019 19:245

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  7. Content type: Research article

    Hypertension (AH) is an emerging disease that has rapidly increased in the last decades throughout the world. The increase in blood pressure (BP) is observed with growth and development and, although the manif...

    Authors: Fernando Rodrigues Peixoto Quaresma, Erika da Silva Maciel, Francisco Winter dos Santos Figueiredo and Fernando Adami

    Citation: BMC Pediatrics 2019 19:244

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  8. Content type: Research article

    Appropriate interpretation of a positive celiac antibody test by an ordering physician is important in order to institute proper management. We evaluated why children with an initial positive celiac serology w...

    Authors: Kathryn Potter, Lawrence de Koning, J. Decker Butzner and Dominica Gidrewicz

    Citation: BMC Pediatrics 2019 19:243

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  9. Content type: Research article

    Several studies have investigated heart rate variability (HRV) as a biomarker for acute brain injury in hypoxic ischemic encephalopathy (HIE). However, the current evidence is heterogeneous and needs further r...

    Authors: Mads Andersen, Ted C. K. Andelius, Mette V. Pedersen, Kasper J. Kyng and Tine B. Henriksen

    Citation: BMC Pediatrics 2019 19:242

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  10. Content type: Research article

    Adolescence is a critical phase of human development that lays the foundation for health in later life. Of the 1.8 billion adolescents in the world, roughly 90% live in low and middle-income countries. Yet mos...

    Authors: Sara K. Hanson, Richard J. Munthali, Lisa K. Micklesfield, Felipe Lobelo, Solveig A. Cunningham, Terryl J. Hartman, Shane A. Norris and Aryeh D. Stein

    Citation: BMC Pediatrics 2019 19:241

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  11. Content type: Research article

    In the pediatric population, infections by methicillin-resistant Staphylococcus aureus (MRSA) are associated with significant morbidity and hospital costs. Vancomycin is a glycopeptide antibiotic, widely used for...

    Authors: Talita Muniz Maloni, Talita Rantin Belucci, Sandra Regina Malagutti and Guilherme Henrique Campos Furtado

    Citation: BMC Pediatrics 2019 19:240

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  12. Content type: Research article

    Few prospective birth cohort studies are available on the effects of prenatal and early-life exposures on food allergy and eczema among Chinese children. The aim of this study was to evaluate the influence of ...

    Authors: Xiao Gao, Yan Yan, Guangyu Zeng, Tingting Sha, Shiping Liu, Qiong He, Cheng Chen, Ling Li, Shiting Xiang, Hongyan Li, Shan Tan and Qiang Yan

    Citation: BMC Pediatrics 2019 19:239

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  13. Content type: Study protocol

    Newborn screening (NBS) occupies a unique space at the intersection of translational science and public health. As the only truly population-based public health program in the United States, NBS offers the pro...

    Authors: Donald B. Bailey Jr, Lisa M. Gehtland, Megan A. Lewis, Holly Peay, Melissa Raspa, Scott M. Shone, Jennifer L. Taylor, Anne C. Wheeler, Michael Cotten, Nancy M. P. King, Cynthia M. Powell, Barbara Biesecker, Christine E. Bishop, Beth Lincoln Boyea, Martin Duparc, Blake A. Harper…

    Citation: BMC Pediatrics 2019 19:238

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  14. Content type: Research article

    There has been a growing interest in the non-skeletal roles of vitamin D particularly its immune-modulatory properties which has been shown to influence the susceptibility and severity to infections. There is ...

    Authors: Imran Hassam, Rodrick Kisenge, Said Aboud and Karim Manji

    Citation: BMC Pediatrics 2019 19:237

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  15. Content type: Research article

    The diagnosis of pertussis in clinical practice continues to be a challenge worldwide as the symptoms are variable. We aimed to determine the prevalence of pertussis in Chinese children irrespective of cough d...

    Authors: Dan-Xia Wu, Qiang Chen, Kai-Hu Yao, Lan Li, Wei Shi, Jiang-Wei Ke, Ai-Min Wu, Peng Huang and Kun-Ling Shen

    Citation: BMC Pediatrics 2019 19:236

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  16. Content type: Research article

    Unintentional child poisoning represents a significant public health problem across the globe, placing a substantial burden on health services emergency departments. Around the world, every year, thousands of ...

    Authors: Delba Fonseca Santos, Marysabel Pinto Telis Silveira, Aline Lins Camargo, Alicia Matijasevich, Iná Silva Santos, Aluísio J. D. Barros and Andréa Dâmaso Bertoldi

    Citation: BMC Pediatrics 2019 19:235

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  17. Content type: Research article

    During the first three months of pregnancy, the developing embryo may be susceptible to external and internal factors, which may lead to structural and functional congenital anomalies. The main objective of th...

    Authors: Molla Taye, Mekbeb Afework, Wondwossen Fantaye, Ermias Diro and Alemayehu Worku

    Citation: BMC Pediatrics 2019 19:234

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  18. Content type: Case report

    Thiamine-responsive megaloblastic anemia (TRMA) is a rare autosomal recessive inherited disease characterized by the clinical triad of megaloblastic anemia, sensorineural deafness, and diabetes mellitus. To da...

    Authors: Xin Li, Qing Cheng, Yu Ding, Qun Li, Ruen Yao, Jian Wang and Xiumin Wang

    Citation: BMC Pediatrics 2019 19:233

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  19. Content type: Research article

    Behçet’s disease (BD) is a rare vasculitic disorder affecting all sizes of vessels. Among BD patients, 4 to 25% of patients with diagnosed age younger than 16 years old are defined as juvenile BD (JBD). This s...

    Authors: Ya-Chiao Hu, Yao-Hsu Yang, Yu-Tsan Lin, Li-Chieh Wang, Hsin-Hui Yu, Jyh-Hong Lee and Bor-Luen Chiang

    Citation: BMC Pediatrics 2019 19:232

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  21. Content type: Research article

    Neonatal bloodspot screening (NBS) identifies conditions to offer early intervention and minimize irreversible damage. NBS policies guide a comprehensive system including processes for storage of neonatal drie...

    Authors: Marleen E. Jansen, Lion J. M. van den Bosch, Marjolein J. Hendriks, Mariska M. J. Scheffer, Marie-Louise Heijnen, Conor M. W. Douglas and Carla G. van El

    Citation: BMC Pediatrics 2019 19:230

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  22. Content type: Case report

    Manganese is a critical trace element that not only has antioxidant properties, but also is essential for various metabolic pathways and neurotransmitters production. However, it can be toxic at high levels, p...

    Authors: Azita Tavasoli, Khadije Arjmandi Rafsanjani, Saba Hemmati, Marziyeh Mojbafan, Elham Zarei and Soudabeh Hosseini

    Citation: BMC Pediatrics 2019 19:229

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  23. Content type: Case report

    Scurvy is one of the oldest diseases known to mankind. Although presently rare in the developed world, scurvy was a common potentially fatal disease. In recent times, the most common risk factors for scurvy in...

    Authors: Robin M. Lund, Mara L. Becker, Steven Shapiro, Tyler Allison and Julia G. Harris

    Citation: BMC Pediatrics 2019 19:228

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  24. Content type: Study protocol

    Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with pre...

    Authors: Gaston Ofman, Mauricio T. Caballero, Damian Alvarez Paggi, Jacqui Marzec, Florencia Nowogrodzki, Hye-Youn Cho, Mariana Sorgetti, Guillermo Colantonio, Alejandra Bianchi, Luis M. Prudent, Nestor Vain, Gonzalo Mariani, Jorge Digregorio, Elba Lopez Turconi, Cristina Osio, Fernanda Galletti…

    Citation: BMC Pediatrics 2019 19:227

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  25. Content type: Study protocol

    Sub-Saharan Africa (SSA) alone has nine out of every 10 children living with HIV globally and monitoring in this setting remains suboptimal, even as these children grow older. With scalability of antiretrovira...

    Authors: Joseph Fokam, Maria Mercedes Santoro, Desire Takou, Anne-Esther Njom-Nlend, Paul Koki Ndombo, Nelly Kamgaing, Cedric Kamta, Andre Essiane, Samuel Martin Sosso, Alexis Ndjolo, Vittorio Colizzi and Carlo-Federico Perno

    Citation: BMC Pediatrics 2019 19:226

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  26. Content type: Research article

    The prevalence of pediatric allergic diseases has increased rapidly in the United States over the past few decades. Recent studies suggest an association between the increase in allergic disease and early dist...

    Authors: Jeffrey Ni, Hannah Friedman, Bridget C. Boyd, Andrew McGurn, Piotr Babinski, Talar Markossian and Lara R. Dugas

    Citation: BMC Pediatrics 2019 19:225

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  27. Content type: Study protocol

    Responsive parenting interventions that shape parenting behaviors in the areas of sleep and soothing, appropriate and responsive feeding, and routines represent a promising approach to early obesity prevention...

    Authors: Justin A. Lavner, Brian K. Stansfield, Steven R. H. Beach, Gene H. Brody and Leann L. Birch

    Citation: BMC Pediatrics 2019 19:224

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  28. Content type: Research article

    We have limited information on families’ experiences during transition and after discharge from the neonatal intensive care unit.

    Authors: Ashwini Lakshmanan, Katrina Kubicek, Roberta Williams, Marisela Robles, Douglas L. Vanderbilt, Christine B. Mirzaian, Philippe S. Friedlich and Michele Kipke

    Citation: BMC Pediatrics 2019 19:223

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  29. Content type: Correction

    Following publication of the original article [1], the authors opted to revise the first paragraph of the section “Characteristics associated with maternal drinking in pregnancy”. Below is the updated version.

    Authors: Delyse Hutchinson, George J. Youssef, Clare McCormack, Judy Wilson, Steve Allsop, Jake Najman, Elizabeth Elliott, Lucinda Burns, Sue Jacobs, Ingrid Honan, Larissa Rossen, Hannah Fiedler, Samantha Teague, Joanne Ryan, Craig A. Olsson and Richard P. Mattick

    Citation: BMC Pediatrics 2019 19:222

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    The original article was published in BMC Pediatrics 2019 19:149

  30. Content type: Case report

    Cyanosis is usually associated with serious conditions requiring urgent treatment in the neonatal intensive care unit (NICU). Hemoglobin M (Hb M) disease is one type of congenital methemoglobinemia characteriz...

    Authors: Chungwoo Shin, Mee Hong, Myungshin Kim and Jung Hyun Lee

    Citation: BMC Pediatrics 2019 19:221

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  31. Content type: Research article

    Seeking healthcare in children is unique since parents decide upon the type and frequency of healthcare services accessed. Mothers/caregivers lower healthcare seeking behavior is one of the major reason for in...

    Authors: Nebiat Teshager Abegaz, Hailemariam Berhe and Gebremedhin Beedemariam Gebretekle

    Citation: BMC Pediatrics 2019 19:220

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  32. Content type: Research article

    Serious bacterial infections (SBI) are a significant cause of mortality worldwide. Parental concern and clinician’s gut feeling that there is something wrong has been associated with increased likelihood of de...

    Authors: Urzula Nora Urbane, Dita Gaidule-Logina, Dace Gardovska and Jana Pavare

    Citation: BMC Pediatrics 2019 19:219

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  34. Content type: Research article

    Payer-type (government-sponsored health coverage versus private health insurance) has been shown to influence a variety of cardiovascular disease outcomes in adults. However, it is unclear if the payer-type im...

    Authors: Jacob C. Hartz, Elizabeth Yellen, Annette Baker, Justin Zachariah, Heather Ryan, S. Skylar Griggs, Nirav K Desai, Ravi Yanumula, Samuel Vinci, Caroline Brantley, Jennifer Bachman, Ellen McAuliffe, Kimberlee Gauvreau, Michael Mendelson and Sarah de Ferranti

    Citation: BMC Pediatrics 2019 19:217

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  35. Content type: Case report

    Propranolol hydrochloride is the first-line agent recommended for the treatment of infantile hemangiomas (IH). Serious adverse effects of propranolol therapy for hemangiomas are infrequent.

    Authors: Ilirjana Bakalli, Elmira Kola, Robert Lluka, Ermela Celaj, Durim Sala, Inva Gjeta, Sashenka Sallabanda and Dea Klironomi

    Citation: BMC Pediatrics 2019 19:216

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  36. Content type: Research article

    Parents of children with chronic illness have reported decreased psychological and physical quality of life (QoL) relative to parents of children without such illness, which may be associated with the extent o...

    Authors: Alana Fairfax, Jamie Brehaut, Ian Colman, Lindsey Sikora, Alessia Kazakova, Pranesh Chakraborty and Beth K. Potter

    Citation: BMC Pediatrics 2019 19:215

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  37. Content type: Research article

    Globally, in every three preschool children one is affected by malnutrition. In Ethiopia, child undernutrition continues to be a serious public health problem. Data are scarce, especially in 24-59 months age c...

    Authors: Aweke Girma, Haile Woldie, Fantahun Ayenew Mekonnen, Kedir Abdela Gonete and Mekonnen Sisay

    Citation: BMC Pediatrics 2019 19:214

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  38. Content type: Research article

    Anemia is not only a major public health problem among children in developing countries, it is also an important predictor for their future growth and development. The objective of this study was to identify p...

    Authors: Abu Yusuf, A. S. M. A. Mamun, Md. Kamruzzaman, Aik Saw, Nagah M. Abo El-fetoh, Pete E. Lestrel and Md. Golam Hossain

    Citation: BMC Pediatrics 2019 19:213

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    The Correction to this article has been published in BMC Pediatrics 2019 19:258

  39. Content type: Research article

    It has been established that genetic factors play a substantial role in the development of neonatal hyperbilirubinemia. The population of Indonesia and other Southeast Asian countries has similar, yet differen...

    Authors: Radhian Amandito, Rinawati Rohsiswatmo, Michelle Halim, Vanessa Tirtatjahja and Amarila Malik

    Citation: BMC Pediatrics 2019 19:212

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  40. Content type: Research article

    Intussusception is a gastrointestinal condition in which early treatment is critical. Although its epidemiology and comorbidities have been studied, few studies have included the entire pediatric population of...

    Authors: Soojin Jo, In Seok Lim, Soo Ahn Chae, Sin Weon Yun, Na Mi Lee, Su Yeong Kim and Dae Yong Yi

    Citation: BMC Pediatrics 2019 19:211

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  41. Content type: Study protocol

    Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even ...

    Authors: Christian A. Maiwald, Kim V. Annink, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Hercilia Guimarães, Tom Stiris, Luigi Cattarossi, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela…

    Citation: BMC Pediatrics 2019 19:210

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  42. Content type: Research article

    The aim of this study was to investigate attitudes towards embryo donation and embryo donation families among professionals working in primary child healthcare, and their experiences of these families.

    Authors: Gabriela Armuand, Gunilla Sydsjö, Agneta Skoog Svanberg and Claudia Lampic

    Citation: BMC Pediatrics 2019 19:209

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  43. Content type: Research article

    Familial hypercholesterolemia (FH), the most frequent monogenetic hereditary disorder, is underdiagnosed and undertreated. Early identification of FH is essential because of the increased risk for premature ca...

    Authors: Alexandra Kreissl, Nina Walleczek, Pinky Rose Espina, Ulrike Hallwirth and Susanne Greber-Platzer

    Citation: BMC Pediatrics 2019 19:208

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  44. Content type: Research article

    Undernutrition among school age children has an impact on their health, cognition, and educational achievement. Therefore, this study aimed to assess the prevalence and associated factors of stunting and wasti...

    Authors: Zegeye Getaneh, Mulugeta Melku, Mekuanint Geta, Tadele Melak and Melkamu Tamir Hunegnaw

    Citation: BMC Pediatrics 2019 19:207

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  45. Content type: Case report

    Gorham-Stout disease is a rare condition characterized by unifocal and massive type IV osteolysis (variant of idiopathic nonhereditary osteolytic disease) with a slow progression, which is self-limiting for so...

    Authors: Mario Edgar Tena-Sanabria, Larisa Yarindy Jesús-Mejenes, Gabriela Fuentes-Herrera, Félix Alejandro Álvarez-Martínez, Nora Patricia Victorio-García and Juan Carlos Núñez-Enríquez

    Citation: BMC Pediatrics 2019 19:206

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  46. Content type: Research article

    Culture tests have demonstrated that once-daily administration of amoxicillin may be effective in the treatment of group A streptococcal (GAS) pharyngitis. However, culture methods do not allow accurate assess...

    Authors: Akihiro Nakao, Ken Hisata, Makoto Fujimori, Nobuaki Matsunaga, Mitsutaka Komatsu and Toshiaki Shimizu

    Citation: BMC Pediatrics 2019 19:205

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  48. Content type: Research article

    Pediatric ARDS still represents a difficult challenge in Pediatric Intensive Care Units (PICU). Among different treatments proposed, exogenous surfactant showed conflicting results. Aim of this multicenter ret...

    Authors: Andrea Wolfler, Marco Piastra, Angela Amigoni, Pierantonio Santuz, Eloisa Gitto, Emanuele Rossetti, Carmine Tinelli, Cinzia Montani, Fabio Savron, Simone Pizzi, Luigia D’amato, Maria Cristina Mondardini, Giorgio Conti and Annalisa De Silvestri

    Citation: BMC Pediatrics 2019 19:203

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  49. Content type: Case report

    The authors report a 1 month follow up of a neonate described as “miracle baby” because she was born Ebola virus disease-free and survived after her mother was infected with Ebola virus during the third trimes...

    Authors: N. Kasereka Baraka, Mupenzi Mumbere and Evie Ndombe

    Citation: BMC Pediatrics 2019 19:202

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  50. Content type: Case report

    Noma is a rare disease, which is characterized by rapid progression and a high rate of mortality; however, relatively few cases of noma infection accompanied by septic shock in children have been described. Fu...

    Authors: Lili Xu, Wanrui Wei, Xiaohua Ge, Sibei Wan, Jing Yu and Xiaodong Zhu

    Citation: BMC Pediatrics 2019 19:200

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