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Table 2 Changes in normal protein expression (NPX)-levels in 14 of 92 inflammatory proteins/cytokines in paired samples during medical treatment in 18 children with juvenile idiopathic arthritis (JIA)

From: An explorative study on proteomic analyses related to inflammation and pain in children with juvenile idiopathic arthritis

 

NPX levels at inclusiona

NPX levels at follow upa

P-values *

Increase ↑

Decrease ↓

IL-6

5.3 (4.6 – 5.9)

3.2 (2.9 – 3.6)

 < 0.001

↓

IL-20

1.0 (0.9 – 1.1)

0.9 (0.8 – 0.9)

0.008

↓

TNFSF14

4.9 (4.4 – 5.3)

4.3 (4.0 – 4.6)

0.008

↓

S100A12

4.3 (3.6 – 4.9)

3.1 (2.8 – 3.3)

0.008

↓

LIF

0.9 (0.8 – 1.0)

0.8 (0.7 – 0.9)

0.02

↓

CCL19

10.3 (9.9 – 10.8)

9.8 (9.6 – 10.1)

0.02

↓

NRTN

1.0 (1.0 – 1.2)

0.9 (0.8 – 1.0)

0.03

↓

TRANCE

5.8 (5.4 – 6.2)

6.3 (6.0 – 6.5)

0.008

↑

TRAIL

8.5 (8.3 – 8.7)

8.7 (8.6 – 8.9)

0.008

↑

TNFB

5.8 (5.6 – 6.0)

7.0 (6.4 – 7.5)

0.008

↑

CX3CL1

6.0 (5.8 – 6.2)

6.3 (6.1 – 6.4)

0.008

↑

Flt3L

9.1 (9.0 – 9.3)

9.5 (9.3 – 9.7)

0.01

↑

DNER

9.6 (9.5 – 9.8)

9.8 (9.7 – 9.9)

0.02

↑

LIF-R

4.3 (4.2 – 4.4)

4.5 (4.4 – 4.6)

0.03

↑

  1. *Paired T-test
  2. a NPX levels analyzed by Olink (Uppsala, Sweden) adjusted for multiple analyses using Benjamini–Hochberg method, presented as mean and confidence interval