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Echocardiography-guided percutaneous closure of perimembranous ventricular septal defects without arterial access and fluoroscopy
BMC Pediatrics volume 19, Article number: 302 (2019)
Traditional percutaneous device closure of perimembranous ventricular septal defects (PmVSDs) is a minimally invasive technique, but can result in high radiation exposure and can result in potential arterial complications. Here, we aimed to assess the safety and feasibility of device closure of PmVSDs via the femoral vein approach under transesophageal echocardiography (TEE) guidance in children.
From January 2014 to December 2017, a total of 46 PmVSD patients (mean age, 6.5 ± 2.3 years [range, 4.2–12.0 years]; mean body weight 22.1 ± 6.6 kg [range, 16.0–38.5 kg]; VSD diameter, 4.1 ± 0.6 mm [range, 3.2–5.0 mm]) underwent attempted transcatheter closure via the femoral vein approach under the guidance of TEE without fluoroscopy.
The transcatheter occlusion procedure under TEE guidance was successful in 44 (95.7%) patients. Surgery was necessary in 2 (4.3%) patients. The procedure duration was 28.2 ± 8.7 min (range, 12.0–42.0 min). One patient had immediate post-operative trivial residual shunt and three patients had immediate incomplete right bundle branch block (IRBBB) after operation; the new IRBBB in 1 case was noted in the first postoperative month. No residual shunt was noted at 3 months after the procedure, and no intervention related complications were detected at 1–24 months follow-up.
Percutaneous device closure of PmVSDs under TEE guidance solely by femoral vein approach is effective and safe, avoids radiation exposure, potential arterial complications and a surgical incision.
Perimembranous ventricular septal defect (PmVSD) is one of the most common congenital cardiac malformations. Since the first successful on-pump PmVSD closure, surgical repair through median sternotomy under cardiopulmonary bypass (CPB) has been considered the gold standard in pediatric cardiac surgery. As catheterization techniques develop and spread, traditional transcatheter VSD closure has been used to date, but result in radiation exposure  and potential arterial complications [2, 3]. In an effort to reduce injury related to fluoroscopy and angiography, another alternative technique is direct ventricular puncture using to close the VSD with a beating heart using an occluder recently came into practice. This method is widely used in China [4,5,6,7,8] and other countries [9,10,11,12]. However, there are still some disadvantages with this technique, including surgical trauma, incision, and scarring. In this study, we established a new method for transcatheter VSD closure through femoral venous route under the guidance of TEE, without accessing the femoral artery or the employment of fluoroscopy. This single-centered study aims to access the feasibility and safety of this new strategy.
We enrolled 46 patients with isolated PmVSDs at Second Xiangya Hospital between January 1, 2014, and December 31, 2017 which included 26 male and 20 female patients (mean age, 6.5 years (range 4.2–12.0 years); mean body weight 22.1 ± 6.6 kg [range, 16.0–38.5 kg]; VSD diameter, 4.1 ± 0.6 mm [range, 3.2–5.0 mm]) (Table 1). The PmVSD were detected by pre-operation transthoracic echocardiography (TTE) (Vivid™ E9; GE Healthcare, Little Chalfont, United Kingdom) with color and Doppler interrogation from sub-xyphoid, apical, and parasternal views.
The patient selection criteria were as follows: 1) a left-to-right shunt whose Qp/Qs was ≥1.5 due to isolated PmVSD; 2) patient age between 2.0 years and 13.0 years; 3) patient weight > 12.5 kg; 4) maximum PmVSD diameter of ≤6 mm and minimum PmVSD diameter of ≥3 mm; and 5) subaortic rim (distance from the defect to the aortic valve) of > 2 mm. Patients with the following conditions were excluded: 1) more than a mild degree of aortic valve prolapse or regurgitation; 2) malalignment PmVSD; and 3) coexisting cardiac anomalies requiring correction during the same procedure.
Informed consent was obtained from the parents of all participants, and the study was approved by the Committee on Clinical Applications at the Second Xiangya Hospital. All patients were followed up with clinical examination, TTE, and electrocardiography at 1, 3, and 6 months, and 1 and 2 years after the procedure.
Device and delivery system
The VSD occluder (Fig. 1a and b; Shanghai Shape Memory Alloy Co. Ltd., Shanghai, China) was described in previous report . In brief, this occluder is double-disk symmetrical concentric PmVSD occluder (S-pmVSO), and both discs were 2 mm larger than the waist. The waist was 4-14 mm long, with 3.5–4.5 mm diameter for its full length, corresponding to the size of the VSD in patients. The occluder size is selected according to the VSD diameter measured by TEE, with its diameter 2 mm larger than the VSD diameter.
The device is attached by a recessed microscrew to a delivery cable made of stainless steel (Fig. 1c). It is delivered through a 7F–8F long sheath. For introduction into the delivery sheath, the device is pulled into a special loader. The delivery system is also manufactured by Shanghai Shape Memory Alloy Co. Ltd., Shanghai, China.
The procedure was performed in a routine operating room under TEE guidance without fluoroscopy. All patients underwent general anesthesia with intubation in a supine position. TEE (Vivid E9 Dimension, bought from General Electric Company, Horten, Norway) was inserted into the middle esophagus. 9 T for patients less than 15 kg, 6 T for patients more than 15 kg. TEE studies were performed to evaluate the position, size, shape, direction of shunt flow, and the surrounding rims (particularly the subaortic rim) of the PmVSD prior to the procedure.
Femoral vein access was obtained using a 6-Fr sheath (Terumo Corporation, Tokyo, Japan). Heparinization was performed (125 U/kg) for anticoagulation. A 0.038inch bent stiff guide wire (provided by Terumo Medical Corporation, Somerset, New Jersey, USA) was advanced from the inferior vena cava (IVC) via the right atrium (RA) into the superior vena cava (SVC) under TEE guidance using the bicaval view. A 5Fr JR 4 diagnostic catheter (provided by Cordis Corporation, Miami Lakes, Florida, USA) was subsequently advanced into RA over the wire. Then the guidewire was withdrawn progressively and the tip of catheter was tracked by the TEE short-axis view (Fig. 2A1 and A2). It may be necessary to adjust the direction of the catheter tip to advance through the tricuspid valve (TV) towards right ventricle (RV). The guidewire was then advanced into RV through the catheter (Fig. 2B1 and B2). The catheter was advanced into the RV over the guidewire, and the guidewire was then removed. Guided by TEE, along with the wire, the catheter’s direction was adjusted again to go through the outflow tract of RV towards main pulmonary artery (Fig. 2C1 and C2). The catheter was then gradually withdrawn and with the guidance of TEE, to make its tip point to the defect and the catheter advanced into the left ventricle (LV) (Fig. 2D1 and D2). The guidewire was guided slowly and gently through the VSD into the LV via the TEE four-chamber view (Fig. 2E1 and E2). We removed the vascular sheath and the right coronary catheter. The long delivery sheath (7F–8F) loaded with the dilator was advanced into the LV over the guidewire, and the dilator was then removed along with the guidewire, leaving just the tip of the sheath adjacent to the cardiac apex (Fig. 2F1 and F2). Thereafter, the occluder device was delivered along the sheath. Under TEE guidance, the sheath was then gently withdrawn to deploy the left disc in the LV (Fig. 2G1 and G2) and then pulled back until the disc was against the interventricular septum wall. The right side of the device was deployed by retracting the delivery sheath while applying slight tension on the cable (Fig. 2H1 and H2). Before the device was unscrewed, its correct and stable position was confirmed by TEE. Then TEE (Fig. 3a and b) and TTE (Fig. 3c and d) were performed to ensure that there were no residual shunts or aortic regurgitation. Bundle branch block was evaluated by electrocardiography during the procedure. If no postoperative complications (aortic regurgitation, complete atrioventricular block, or residual shunt) were found, both the loader sheath and the cable were withdrawn. The femoral vein was compressed for 5–8 min to stop the bleeding. A prophylactic antibiotic was administered during the procedure and on the day after. Moreover, aspirin (3 mg/kg/day) was routinely administered for 6 months.
If complications (aortic regurgitation, complete atrioventricular block, or residual shunt) were detected, the patients underwent open heart repair under CPB.
Data are expressed as percentages for nominal variables and mean ± standard deviation for continuous variables. Statistical Program for Social Sciences (SPSS) for Windows, version 24.0 (IBM, Armonk, NY, USA), was used for statistical analysis.
All procedures were carried out in a standard theatre without fluoroscopy backup, but with a CPB unit standby. The transcatheter occlusion procedure under TEE guidance was successful in 44 (95.7%) patients (Additional file 1: Video S1). PmVSD occlusion failed because of a residual shunt (width > 2 mm; flow rate > 3 m/s) in 2 patients (VSD diameter, 4.5 mm and 4.6 mm; subaortic rim, 3 mm) with no improvement even after using a 6-mm, 7-mm, and 8-mm occluder, and then they underwent open heart surgery.
Symmetrical VSD occluder with a size (waist length) of 6 mm or 7 mm was used in this study. The mean procedural duration, post-operative mechanical ventilation duration, intensive care unit (ICU) residence, and in-hospital durations were 28.2 ± 8.7 min (range, 12.0–42.0 min), 65.2 ± 5.6 min (range, 56.0–78.0 min), 2.1 ± 0.1 h (mean, 2.0–2.4 h), and 2.7 ± 0.2 d (range, 2.5–3.0 d), respectively. There was no need for blood transfusion in any of our patients, who underwent percutaneous device closure (Table 1).
The patients were followed up by clinical examination, echocardiography, and electrocardiography at 1, 3, and 6 months, and 1 and 2 years postoperatively. All patients survived without any peripheral vascular injury, acute complications, or severe adverse events (death, valve injury, complete atrioventricular block or embolism) during the early period or follow-up.
Complete atrioventricular blocks were not detected, whereas IRBBB was observed in 3 patients. A new IRBBB was discovered in 1 case during the first postoperative month, and the IRBBB resolved spontaneously and changed to normal rhythm in 3 patients during the third month of follow-up. All patients showed sinus rhythm in the period of 12–24 months follow-up.
Tricuspid regurgitation had decreased in 1 patient, whereas no new atrioventricular regurgitation was detected in the other patients at the first month of follow-up.
A trivial residual shunt (width, 1 mm; flow rate < 2.0 m/s) was detected in 1 patient on discharge. Fortunately, the residual shunt disappeared at the third month of follow-up (Table 1).
No other complications such as device dislocation, thrombosis, or obstruction of the left or right ventricular outflow tract were observed in the present study.
PmVSD is the most common subtype of VSD, and responsible for > 85% of such defects. Although surgical repair through median sternotomy on CPB has been regarded as the gold standard for treatment of pmVSDs, complications such as bleeding, wound infection and cerebrovascular accidents have been reported. Interest has grown in the development of new techniques that can replace traditional open-heart surgery for treatment of PmVSD. The well-accepted guidance for transcatheter VSD closure has been X-ray angiography. However, two major concerns remain with the conventional techniques. One is the high exposure to radiation, especially for infants and children [13, 14]. The other one is the increased potential risks of vascular complications caused by femoral artery puncturing for angiography [15, 16]. Arterial access in children is reported to cause a high rate of complication, of which a significant proportion requires intervention [17, 18]. Moreover, complications such as arterial disruption, or acute occlusion, may be even limb-threatening .
In an effort to reduce injury related to fluoroscopy and angiography, TEE has been used for guidance during perventricular occlusion of VSD in recent years. Intraoperative device closure of PmVSDs without radiation and CPB under guidance of TEE was first reported by Amin and colleagues , and has become an accepted modality of treatment in many cardiac centers [4, 21, 22]. However, this approach still presents certain disadvantages such as surgical incision, surgical complications, and scarring.
Despite separate solutions being proposed to either reduce radiation exposure and avoid arterial access, or reduce surgical incision and complications, there is no reported method that deals with these problems at the same time. Our study is the first to report that echocardiography can be used as the only guidance for transcatheter VSD closure without arterial access, radiation exposure, surgical incision or surgical scarring. This novel technique is used as an alternative to surgical repair of PmVSD in our cardiac center.
Compared with the traditional interventional methods, the advantages of this technique is sole used of the femoral vein approach, the lack of need to establish the arterial-venous wire loop and no risk of femoral artery related complications. Second, the device can be easily controlled and adjusted during the procedure. Percutaneous device closure under TEE guidance just needs to establish a shorter transfer track that involves the right femoral vein, IVC, RA, TVs, RV, VSD, and LV. Third, the inclusion of TEE imaging is easier and safer [23, 24]. And compared with TTE, the advantages of TEE are no obstruction of the chest wall and lung, clearer image, stronger color Doppler signal, more cardiac anatomy information, and no interference in the monitoring operation. TEE provides a clear view of vessels and routes during surgical procedures . The vital part of percutaneous device closure is that the guidewire and delivery sheath should pass through the PmVSD under TEE imaging. TEE—performed immediately before, during, and after deployment of the occluder device—has been considered as a standard technique for this procedure . The site, size, and rims of the defect; suitability of the device; and guidance of the guidewire and sheath through the PmVSD can be precisely assessed via TEE during the procedure. Furthermore, once the device is released, TEE can provide beneficial information for occlusion; a repeat image can also be obtained to assess the effectiveness of PmVSD closure, including the device position, the presence of a residual shunt, and aortic valve regurgitation. Any dislocation or residual shunting is easy to find and further adjustments can be made immediately. In addition, there is no risk of radiation exposure, particularly for children and surgeons, and advanced equipment is not needed, such as the machine of digital subtraction angiography to identify and track the route, and no risk of allergy and renal failure.
Four types of VSD occluder were designed. The symmetric occluder that is suitable for single-rupture PmVSD and not easy to cause atrioventricular block, is concentric, and both discs are 2 mm larger than the waist. The left disc of the small waist big edge-type occluder, which is suitable for multi-rupture PmVSD, is 4 mm larger than the right disc, which is 4 mm larger than the waist. The asymmetric occluder is suitable for subaortic VSD and has a platinum marker guiding device in the left disc for orientation. In order to avoid aortic valve injury, the left disc of the occluder is an ellipse with 0 mm towards the aorta, and the right disc is a circle with 2 mm larger than the waist. The muscular occluder is suitable for muscular VSD and its waist height is 7 mm rather than 3.5–4.5 mm.
The procedure time for the fluoroscopyfree transcatheter VSD closure ranged from 12 to 42 min. The difference of the operator’s performance view may account for this. Unlike the traditional procedure, the performance view in the fluoroscopyfree technique is TEE, which only provides twodimensional (2D) views for operators. Although TEE has shown more advantages over fluoroscopy in the measurement of rims and dimensions of VSD, monitoring the deployment of the S-pmVSO and evaluation of the result of the implant, the biggest challenge for operators is to track the guidewire and sheath under the 2D view. Our initial experience confirms this. In our study, the device placement process was clearly visible using TEE for guidance, and welltimed placements can be precisely controlled by the operators. The main factors associated with procedure time include:1) the process to reach the defects, because there may be some difficulty to track the tip of the catheter and/ or guidewire with TEE; 2) the course of device deployment, as the angle between the sheath and ventricular septum may not be good enough, so that redeployment may be needed. Although a longer operating time was needed in certain cases, especially easy in our experience, the procedure time decreased remarkably as operators gained experience. The learning curve is very short for operators.
Residual shunt is the most frequent complication of percutaneous transcatheter closure of PmVSD. Proper selection of patient and device is mandatory for prevention of this inherent complication. In our study, all procedures were carried out in a standard theatre with a CPB unit standby. Thus, a patient could be converted to open heart surgery immediately in order to retrieve the device and repair the PmVSD.
Complete atrioventricular block is a significant problem for occlusion, particularly when using the Amplatzer occluder . No cases of complete atrioventricular block were detected in the present study. We believe that this observation was related to the procedure within the RV, which stimulated the right bundle branch block around the VSD. Care must be taken not to damage the tricuspid valve/chordae. In order to do so, clockwise torque on the catheter is occasionally required to obtain the right direction while advancing the tip of the catheter towards the right ventricle. If resistance is noted, the catheter should be turned clockwise and adjusted to avoid valve injury.
One possible disadvantage of this new technique is that the procedure is performed under general anaesthesia. However, we consider this only a minor drawback because general anaesthesia might also be needed for young children when performing traditional transcatheter closure or surgical repair of PmVSDs. Moreover, the data were from a single-centered study, the outcome and the superiority of this new strategy should be validated by prospective multi-centered randomized controlled trials.
Percutaneous device closure of PmVSDs under TEE guidance solely by femoral vein approach is effective and safe, avoids radiation exposure, potential arterial complications and a surgical incision.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Intensive care unit
Incomplete right bundle branch block
Perimembranous ventricular septal defects
Right ventricular outflow tract
Statistical Program for Social Sciences
Superior vena cava
Ventricular septal defect
Zhao Y, Wang N, Wen P, Ouyang WB, Zhang FW, Qiu X, Liu Y, Zhao GZ, Xie YQ, Pan XB. Safety and efficacy of percutaneous intervention for children with combined congenital heart abnormality solely guided by transthoracic echocardiography. Zhonghua Xin Xue Guan Bing Za Zhi. 2018;46(10):804–9.
Allen HD, Driscoll DJ, Fricker FJ, Herndon P, Mullins CE, Snider AR, Taubert KA. Guidelines for pediatric therapeutic cardiac catheterization. A statement for health professionals from the committee on congenital cardiac defects of the council on cardiovascular disease in the young, the American Heart Association. Circulation. 1991;84(5):2248–58.
Bacher K, Bogaert E, Lapere R, De Wolf D, Thierens H. Patient-specific dose and radiation risk estimation in pediatric cardiac catheterization. Circulation. 2005;111(1):83–9.
Hu S, Yang Y, Wu Q, Rwakaryebe M, Liu Z, Deng Y, Wei S, Zhao T. Results of two different approaches to closure of subaortic ventricular septal defects in children. Eur J Cardiothorac Surg. 2014;46(4):648–53.
Wu Q, Gao L, Xu X, Zhao T, Yang J, Wang X, Xie L, Xiong L, Yin N, Jin W, et al. Asymmetric occluder in minimal-invasive surgical device closure of ventricular septal defects. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38(5):490–8.
Hu S, Yang Y, Zhu Y, Wu Q, Muhoozi R, Wei S, Huang X, Zhao T. Experience with percardiac interventions for multiple congenital heart diseases in children. Interact Cardiovasc Thorac Surg. 2014;19(5):812–5.
Zhao T, Yang Y, Xu X, Wang X, Ying N, Wu Q, Naikho V, Gao N. Transesophageal echocardiographic guidance of percardiac device closure of intracardiac defects in patients weighing less than 10 kg. J Card Surg. 2012;27(6):740–4.
Yang Y, Gao L, Xu X, Zhao T, Yang J, Gao Z, Yin N, Xiong L, Xie L, Huang C, et al. Echocardiographic assessment and guidance in minimally invasive surgical device closure of perimembranous ventricular septal defects. Heart Surg Forum. 2014;17(4):E206–11.
Bai W, An Q, Tang H. Application of transesophageal echocardiography in minimally invasive surgical closure of ventricular septal defects. Tex Heart Inst J. 2012;39(2):211–4.
Omelchenko A, Gorbatykh Y, Voitov A, Zaitsev G, Bogachev-Prokophiev A, Karaskov A. Perventricular device closure of ventricular septal defects: results in patients less than 1 year of age. Interact Cardiovasc Thorac Surg. 2016;22(1):53–6.
Yin S, Zhu D, Lin K, An Q. Perventricular device closure of congenital ventricular septal defects. J Card Surg. 2014;29(3):390–400.
Liu H, Wang Z, Xia J, Hu R, Wu Z, Hu X, Ren W. Evaluation of different minimally invasive techniques in surgical treatment for ventricular septal defect. Heart Lung Circ. 2018;27(3):365–70.
Johnson JN, Hornik CP, Li JS, Benjamin DJ, Yoshizumi TT, Reiman RE, Frush DP, Hill KD. Cumulative radiation exposure and cancer risk estimation in children with heart disease. Circulation. 2014;130(2):161–7.
Andreassi MG, Ait-Ali L, Botto N, Manfredi S, Mottola G, Picano E. Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease. Eur Heart J. 2006;27(22):2703–8.
Vijayalakshmi IB, Chitra N, Praveen J, Prasanna SR. Challenges in device closure of a large patent ductus arteriosus in infants weighing less than 6 kg. J Interv Cardiol. 2013;26(1):69–76.
Kumar SM, Subramanian V, Bijulal S, Krishnamoorthy KM, Sivasankaran S, Tharakan JA. Percutaneous closure of a moderate to large tubular or elongated patent ductus arteriosus in children younger than 3 years: is the ADO II appropriate? Pediatr Cardiol. 2013;34(7):1661–7.
Vitiello R, McCrindle BW, Nykanen D, Freedom RM, Benson LN. Complications associated with pediatric cardiac catheterization. J Am Coll Cardiol. 1998;32(5):1433–40.
Kulkarni S, Naidu R. Vascular ultrasound imaging to study immediate postcatheterization vascular complications in children. Catheter Cardiovasc Interv. 2006;68(3):450–5.
Balaguru D, Dilawar M, Ruff P, Radtke WA. Early and late results of thrombolytic therapy using tissue-type plasminogen activator to restore arterial pulse after cardiac catheterization in infants and small children. Am J Cardiol. 2003;91(7):908–10.
Amin Z, Gu X, Berry JM, Titus JL, Gidding SS, Rocchini AP. Perventricular [correction of periventricular] closure of ventricular septal defects without cardiopulmonary bypass. Ann Thorac Surg. 1999;68(1):149–53 153-154.
Xing Q, Pan S, An Q, Zhang Z, Li J, Li F, Wu Q, Zhuang Z. Minimally invasive perventricular device closure of perimembranous ventricular septal defect without cardiopulmonary bypass: multicenter experience and mid-term follow-up. J Thorac Cardiovasc Surg. 2010;139(6):1409–15.
Hongxin L, Zhang N, Wenbin G, Zhang WL, Wang ZJ, Liang F, Zou CW. Peratrial device closure of perimembranous ventricular septal defects through a right parasternal approach. Ann Thorac Surg. 2014;98(2):668–74.
Yang Y, Zhang W, Wu Q, Gao L, Jin W, Zhao T. Transcatheter closure of atrial septal defects without fluoroscopy: a well-established procedure for alternative use in children. EuroIntervention. 2016;12(5):e652–7.
Bu H, Gao L, Zhang W, Wu Q, Jin W, Tang M, Zhao T. Application of perimembranous ventricular septal defects closure solely by femoral vein approach under transesophageal echocardiography guidance. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017;42(7):802–7.
Baykan A, Pamukcu O, Ozyurt A, Argun M, Onan SH, Sezer S, Uzum K, Narin N. Is it safe to close ASD with the guidance of transthoraxic echocardiography in pediatric population “ten years’ experience of a single center”. J Interv Cardiol. 2015;28(2):172–9.
Carminati M, Butera G, Chessa M, De Giovanni J, Fisher G, Gewillig M, Peuster M, Piechaud JF, Santoro G, Sievert H, et al. Transcatheter closure of congenital ventricular septal defects: results of the European registry. Eur Heart J. 2007;28(19):2361–8.
We thank all patients and their parents for participating in this study.
This study was supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (2014; grant no. 1685).
Ethics approval and consent to participate
Written informed consent to participate in the research was obtained from the patient’s parents in the case of participants under the age of 16 to the use of his/her all the related images and information for scientific purposes. The study was approved by the Committee on Clinical Trials and Applications at the Second Xiangya Hospital.
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Bu, H., Yang, Y., Wu, Q. et al. Echocardiography-guided percutaneous closure of perimembranous ventricular septal defects without arterial access and fluoroscopy. BMC Pediatr 19, 302 (2019) doi:10.1186/s12887-019-1687-0
- Percutaneous device closure
- Perimembranous ventricular septal defect
- Transesophageal echocardiography
- Femoral vein
- Radiation prevention