While BMI is a simple and widely used screening tool for obesity, its ability to assess change in body composition over time is unknown. The index provides a common foundation for comparing individuals [11], but BMI cannot differentiate between fat and muscle. Thus, BMI has utility for screening and epidemiologic research however; there are limitations and increased risk for misclassifying growing children when using BMI and BMIz alone to define overweight and obesity [7]. This limitation may be due to the strong interaction between age and %FAT, where in children younger than 9 years, the BMIz is a weak predictor for both total fat mass and %FAT but BMIz is a stronger predictor of TFM in youth over the age of 9 years [4]. These results have strong implications for the use and reliance on the BMI for screening and monitoring weight-related changes in overweight and obese youth.
This study evaluated the relationship between BMIz and %FAT as determined by DXA before and after an intervention designed to improve body composition. The results confirmed that changes in %FAT cannot be predicted accurately by changes in BMIz alone. Likewise, Freedman (2009) examined if overweight and obese youth with excessive adiposity were also among those classified with a BMI-for-Age ≥ 85th percentile [12]. They found that nearly 77% of the children who had an obese BMI-for-Age (≥ 95th) percentile were classified as having elevated adiposity. However, those with a BMI-for-Age between the 85th and 94th percentiles (overweight) were variable with about 50% having moderate adiposity, 30% normal adiposity (median 10%) and only 20% have an elevated body fatness. They concluded that BMI is an appropriate screening tool to identify children who require further evaluation but is not a diagnostic method for assessing adiposity. The present analysis supports Freedman’s findings in that BMIz maintains an appropriate sensitivity to changes in adiposity over time but is unreliable due to poor specificity in predicting changes in %FAT [12].
While other studies have demonstrated BMI to have greater correlation with adiposity, our results discourage the use of BMI and BMIz for longitudinal monitoring of changes in adiposity among obese children and adolescents. There is growing evidence that the correlations between changes in BMI, BMIz and BMI-for-age percentiles and changes in adiposity (TFM, %FAT) are significantly lower than previously thought [13]. Accurately measuring changes in adiposity during childhood has vital implications for clinical management and treatment.
A strength of the current study was the large cohort (n = 515) of obese children whom were monitored over an extended period of time (3 years) with use of DXA. The present assessment is novel because it 1) utilizes DXA to establish the degree of adiposity in these subjects to evaluate these relationships in a large cohort (n = 515) of obese children whom were monitored over an extended period of time (3 years), 2) identifies the poor positive predictive value of BMIz relative to %FAT over time, and 3) supports our previous identification of the non-predictive nature of BMIz relative to TFM in younger children (4–9 years). A limitation of the present observational study is the large percentage of subjects loss to follow-up. The small sample sizes at follow-up assessment resulted in wide confidence intervals when evaluating the diagnostic properties of BMIz changes when predicting changes in %FAT. The primary objective of this study was not to evaluate changes from the baseline to the 2 or 3-year follow-up visit, but rather to evaluate the association between the BMI z-score (BMIz) and body fat percent (%FAT) trajectories over a 36-month follow-up period. Data from all initial patients (N = 515) at every visit was not required to provide robust and unbiased estimates of the trajectories. The trajectories were quantified by calculation and the regression slopes change linearly over time. While the prediction error at a particular time point is affected by the sample size at each time point, the standard error of the slope parameter estimate is constant. Therefore, we believe the present analysis is still accurate and pertinent to better understanding the relationship between BMIz and %FAT.
Another limitation and area of future investigation would be to identify the difference in correlations or associations by race-ethnicity, age, and pubertal status. Presently, no data was collected to classify pubertal status for the current study sample. It is well-established adiposity (%FAT) varies according to biological sex, maturation, pubertal status and race-ethnicity. Early maturation has been observed in overweight and obese girls, which has directly implications upon adiposity, visceral fat stores and overall body composition often leading to greater fat, lean and bone mass, although these vary by race-ethnicity [14, 15]. Overweight and obese status within boys may delay maturation and thus negatively impact body composition, inclusive of lean, fat and bone mass. The evidence regarding the exact mechanism and impact of maturation upon body composition remains mixed and is an opportunity for future investigations.
Finally, practicality and feasibility limit the use of DXA for monitoring changes in adiposity in obese youth and thus most clinicians utilize BMI with the supposition that an elevated BMI is equivalent to excess adiposity [16,17,18,19]. However, BMI is not indicative of the degree of adiposity in younger children [4, 5, 20, 21].
