Table 2 Pharmacokinetic parameters after data adjustment for a model of two compartments for full population. Average ± standard deviation
From: Pharmacokinetics of ranitidine in preterm and term neonates with gastroesophageal reflux
AUC (Area under curve) | 1688.9 ± 562.6 ng/mL/h |
t½ of K10 | 1.69 ± 0.56 h |
t½ α (Half life distribution) | 0.3899 ± 0.129 h |
t½ el (Half life elimination) | 2.79 ± 0.93 h |
K10 (Velocity constant) | 0.9105 ± 0.34 h−1 |
K12 (Velocity of transference) | 0.5395 ± 0.176 h−1 |
K21 (Velocity of transference) | 1.76 ± 0.58 h−1 |
Vd (Volume of distribution) | 1.44 ± 0.48 L/Kg |
Cl (Clearance) | 5.9 ± 1.96 mL/Kg/h |