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The Vermont oxford neonatal encephalopathy registry: rationale, methods, and initial results
© Pfister et al.; licensee BioMed Central Ltd. 2012
Received: 9 February 2012
Accepted: 4 June 2012
Published: 22 June 2012
In 2006, the Vermont Oxford Network (VON) established the Neonatal Encephalopathy Registry (NER) to characterize infants born with neonatal encephalopathy, describe evaluations and medical treatments, monitor hypothermic therapy (HT) dissemination, define clinical research questions, and identify opportunities for improved care.
Eligible infants were ≥ 36 weeks with seizures, altered consciousness (stupor, coma) during the first 72 hours of life, a 5 minute Apgar score of ≤ 3, or receiving HT. Infants with central nervous system birth defects were excluded.
From 2006–2010, 95 centers registered 4232 infants. Of those, 59% suffered a seizure, 50% had a 5 minute Apgar score of ≤ 3, 38% received HT, and 18% had stupor/coma documented on neurologic exam. Some infants experienced more than one eligibility criterion. Only 53% had a cord gas obtained and only 63% had a blood gas obtained within 24 hours of birth, important components for determining HT eligibility. Sixty-four percent received ventilator support, 65% received anticonvulsants, 66% had a head MRI, 23% had a cranial CT, 67% had a full channel encephalogram (EEG) and 33% amplitude integrated EEG. Of all infants, 87% survived.
The VON NER describes the heterogeneous population of infants with NE, the subset that received HT, their patterns of care, and outcomes. The optimal routine care of infants with neonatal encephalopathy is unknown. The registry method is well suited to identify opportunities for improvement in the care of infants affected by NE and study interventions such as HT as they are implemented in clinical practice.
Neonatal encephalopathy (NE) in the term or late preterm infant is "a clinically defined syndrome of disturbed neurologic function in the earliest days of life manifested by difficulty with initiating and maintaining respiration, depression of tone and reflexes, subnormal level of consciousness, and often by seizures" . NE occurs in an estimated 2–5 per 1000 live term births of which up to one quarter experience moderate or severe cerebral injury [2–4]. Between 10-40% do not survive and as many as 30% exhibit significant long-term neurodevelopmental disability .
Randomized controlled trials (RCTs) demonstrated that hypothermic therapy (HT) may improve neurologic and developmental outcomes and reduce death and disability in term infants with NE [6–9]. As a result, many practitioners have lost equipoise [10, 11]. The National Institute of Child Health and Human Development and the American Academy of Pediatrics Committee on Fetus and Newborn caution that clinicians should follow published trial protocols, ensure systematic follow-up of survivors, and submit patient data to registries when using HT outside of a trial [12, 13]. Registries, by documenting the natural history of enrolled patients as they present for care, monitor clinical patterns and patient outcomes in rare disorders such as NE and track the “real world” dissemination of a novel therapy like HT .
The Vermont Oxford Network (VON) is a non-profit voluntary collaboration of health care professionals dedicated to improving the quality and safety of medical care for newborn infants and their families at over 850 neonatal intensive care units (NICU) around the world. The VON Neonatal Encephalopathy Registry (NER) was established in 2006.
The primary objective is to characterize infants born with NE, including perinatal and antenatal risk factors, how these infants are identified, the evaluations and treatments they receive, and their outcomes. Secondary objectives include monitoring the dissemination and uptake of the novel therapies such as HT and description of variation of care applied to NE infants. These data will help define clinical research questions and identify opportunities for improved care of NE. This manuscript describes the methods and basic demographic results of the VON NER.
Hospitals could enroll patients in the NER through participation in one of two databases maintained by VON. The very low birth weight (VLBW) database includes any infant born alive at a participating hospital with a birth weight 401–1500 grams or a gestational age of 22–29 weeks regardless of where the infant receives care, as well as any outborn infant meeting these criteria admitted to any location in the hospital within 28 days of birth without first having gone home. The Expanded database includes any infant regardless of birth weight or gestational age admitted to the hospital’s NICU by day 28.
In 2006 and 2007, only VON Expanded database centers could participate in the NER. Beginning in 2008, all VON database participating centers were eligible. Participation in the NER requires no additional fee. VON uses these data for research and reporting, but maintains the confidentiality of individual hospital data. Participating hospitals receive reports comparing their local data with the Registry as a whole. A participating NER center submitted data on one or more eligible infants.
The VON NER Steering Committee chose data items to characterize the population of all infants with NE, identify potential antecedents, evaluate variations in current practice, and monitor the dissemination of HT and adherence to the RCT efficacy standards. Data items include: patient identifiers, patient selection criteria, infant characteristics, treatments and tests, and outcomes at time of disposition. Where possible, data forms follow standards and terminology derived from existing studies to contribute to evolving medical knowledge. Participating centers receive explicit data definitions for each variable to ensure internal validity and uniform data acquisition. A complete catalogue of data items and definitions are in the manual of operations published on the VON website: http://www.vtoxford.org/tools/downloads.aspx.
Centers collect and submit data using freely provided VON eNICQ software, which provides easy to use on-screen data definitions, immediate feedback on issues such as missing or out-of-range values, and error checking for logical inconsistencies. VON staff members perform additional data assessment and contact hospitals about missing data items, unresolved records, out-of-range values, and appropriate modifications as indicated. Only de-identified data are submitted to VON.
The Registry does not dictate patient care, propose any interventions, or endorse any protocols for treatment. Each infant receives care according to the standards of that institution. There is no expected increased risk for participation of individual patients and only de-identified data are submitted. The University of Vermont and State Agricultural College Committee on Human Research in the Medical Sciences (CHRMS) Institutional Review Board (IRB) at the University of Vermont granted ethical approval for the methods of the NER (reference number CHRMS 06–100). Additionally, participating hospitals gained local IRB approval for the participation in the Registry. VON requires documentation of each participating center’s local IRB approval before participation in the Registry. Submitted data becomes the property of VON. The Network may use these data for research and reporting, but maintains the confidentiality of individual hospital data.
Outcomes of interest in the NER include death prior to hospital discharge, survivor disposition status, neurologic course, presence of seizures, common neonatal co-morbidities, and adverse events associated with HT including the following: arrhythmia, thrombosis, severe hypotension, seizure during re-warming, scalp edema, skin breakdown, sclerema neonatorum, thrombocytopenia, and infection. These outcomes will be addressed in future NER studies.
We summarized demographic and clinical characteristics with percentages for categorical variables, mean (and standard deviation) for normally distributed variables, and median (and interquartile range) for other continuous variables. Hospital characteristics come from the VON Annual Survey.
Growth of Vermont Oxford Network National Encephalopathy Registry: Participating centers and infants per year, 2006-2010
Year of birth
Number of centers
Number of infants
Hospitals registering infants in the Vermont Oxford Network Neonatal Encephalopathy Registry, 2006–2010
Cork University Maternity Hospital
National Maternity Hospital
Hospital de S. Joao
Hospital Sant Joan de Deu
United Arab Emirates
Arkansas Children's Hospital
UC Irvine Medical Center
Sharp Mary Birch Hospital for Women
Santa Clara Valley Medical Center
The Children's Hospital
Exempla St. Joseph Hospital
Poudre Valley Health System
Yale New Haven Children's Hospital
Christiana Care Health Services
Children's Hospital of SW Florida at Lee Memorial
Baptist Children's Hospital
Miami Children's Hospital
St. Joseph's Children's Hospital of Tampa
Tampa General Hospital
Medical Center at Columbus Regional, The
St. Luke's Regional Medical Center
Edward Hospital and Health Services
Advocate Lutheran General Hospital
Rockford Memorial Hospital
St. John's Hospital
Carle Foundation Hospital
Central DuPage Hospital
St. Luke's Hospital
Blank Children's Hospital
Overland Park Regional Medical Staff
Wesley Medical Center
Kosair Children's Hospital
Eastern Maine Medical Center
Barbara Bush Children's at Maine Medical
University of Maryland Division of Neonatology
Frederick Memorial Hospital
Massachusetts General Hospital for Children
UMass Memorial Healthcare
U. of MI, CS Mott Children's, Brandon NICU
Henry Ford Hospital
DeVos Children's, Spectrum Health
University of MN Children's Hospital, Fairview
North Memorial Medical Center
St. Cloud Hospital
St. Francis Medical Center, Cape Girardeau
Cardinal Glennon Children's Hospital
St. Louis Children's Hospital
St. Elizabeth Regional Medical Center
Alegent Health Bergen Mercy Medical Center
Nebraska Medical Center
Albany Medical Center
Weiler Hospital Montefiore
Winthrop University Hospital
Columbia University Medical Center
Golisano Children's Hospital at Strong
Mission Children's Hospital
Cape Fear Valley Medical Center
Women's Hospital of Greensboro
Pitt County Memorial Hospital
WAKEMED Faculty Physicians, Wake Medical Center
Brenner Children's Hospital at WFUBMC
Akron Children's Hospital
Children's Hospital Medical Center Cincinnati
Henry Zarrow Neonatal Intensive Care Unit
Rogue Valley Medical Center
Providence St. Vincent Medical Center
Randall Children's Hospital at Legacy Emanuel
Sacred Heart Medical Center
St. Luke's University Hospital
Geisinger Medical Center
Penn State Children's Hospital
Thomas Jefferson University Hospital
Magee Women's Hospital
Palmetto Health Richland
Children's Hospital of Greenville
University of Tennessee Medical Center
Baptist Memorial Hospital for Women
Monroe Carell Jr. Children's Hospital Vanderbilt
Cook Children's Medical Center
Christus Santa Rosa Healthcare
Methodist Children's Hospital
Vermont Children's at Fletcher Allen Health Care
Carilion Clinic Children's Hospital
Swedish Medical Center
West Virginia University School of Medicine
Gundersen Lutheran Medical Center
St. Mary's Hospital Medical Center
Wheaton Franciscan Healthcare at St. Joseph
Hospital Characteristics in Vermont Oxford Network Neonatal Encephalopathy Registry
Number of hospitals
Minority Serving Hospital
MRI Scanning Capability
AAP Level IIIA
AAP Level IIIB
AAP Level IIIC and IIID
AAP Level Unknown
VON classifies participating NICUs using a method based on the AAP Levels of Neonatal Care classification set forth by the Committee on Fetus and Newborn . The VON annual survey does not differentiate between Level IIIC (those that provide major surgical services excluding serious congenital heart anomalies that require cardiopulmonary bypass or extracorporeal membrane oxygenation (ECMO)) and Level IIID hospitals (those that do provide major surgery including surgical repair of serious congenital heart anomalies or ECMO). All NER hospitals classified themselves in the annual survey as subspecialty intensive care (level III) hospitals. The majority (52%) were level IIIB hospitals, which have no restrictions on the duration of mechanical ventilation but do not provide major surgery.
Of the 4232 eligible infants, 59% suffered a clinically apparent seizure within the first 72 hours of life, 50% had a 5 minute Apgar score of 3 or less, 38% had HT, 18% had stupor/coma, and 2% had neuromuscular blockade. HT as the sole eligibility criteria accounted for 8% of the entire sample. Many infants (39%) experienced more than one eligibility criterion. Among infants with multiple eligibility criteria, 30.7% received hypothermia, 28.1% had an Apgar score of 3 or less, 26.9% had a clinically apparent seizure, 17.2% had stupor or coma, and only 1.2% had neuromuscular blockade.
Characteristics of Infants in Vermont Oxford Network National Encephalopathy Registry, 2006-2010
Admission Time > 6hrs
Small for Gestational Age
Number of Births
Vaginal delivery using vacuum/forceps
Cesarean section before labor
Cesarean section after labor
Traumatic Birth Injury
Meconium Aspiration Syndrome
Cord Gas Obtained*
Evaluations and treatments
Evaluations and treatments received by infants in the Vermont Oxford Network National Encephalopathy Registry, 2006-2010
Anticonvulsant during hospital course
Blood gas obtained within 24 hours1
Blood gas obtained within first hour2
Full channel EEG
Amplitude integrated EEG (aEEG)
High flow nasal cannula (HFNC)
High frequency oscillatory ventilation (HFOV)
Extracorporeal membrane oxygenation (ECMO)
Inhaled nitrous oxide (iNO)
Outcomes at initial disposition of all infants in the Vermont Oxford Network National Encephalopathy Registry, 2006-2010
Anticonvulsants at discharge
Feeds at discharge
Enteral, all by mouth
Enteral, none by mouth
Some by mouth
No enteral feeding
Hearing screen passed
A patient registry is an organized system that uses observational study methods to collect uniform data and evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves a predetermined scientific, clinical, or policy purpose(s) . Registries can support clinical conditions, health care services, or products, and can address questions ranging from treatment effectiveness and safety to the quality of care delivered.
The VON NER captures data and characterizes infants with NE and a subset treated with HT. To increase external validity, inclusion criteria for the VON NER are intentionally few and simple: the presence of seizures and/or altered consciousness (stupor, coma) during the first 72 hours of life. Additional inclusion parameters capture all potentially encephalopathic infants treated with hypothermia independent of their neurologic status and infants whose neurologic status might be difficult to assess (e.g., paralyzed, mechanically ventilated, or sedated infants).
Historically, the presence of NE has been considered sine qua non of hypoxic-ischemic injury or birth asphyxia. However, the etiology of NE is not limited to hypoxic-ischemic injury and displays considerable diversity . Only a small proportion of infants in the NER had documented exposure to acute intrapartum asphyxia (“sentinel events”). These findings reflect previous research suggesting that a minority (25-35%) of cases of NE attributed to birth asphyxia have a clear contributing sentinel event in the intrapartum period [13, 19]. The VON NER is being used describe the frequency with which recognized antecedents of NE occurred in a large sample of encephalopathic term newborns. These findings will have implications for future studies of the etiology of NE.
Timely recognition of NE infants affected by HIE is crucial to the success of HT. Very few infants in the Registry were identified as having altered consciousness on neurologic exam. In fact, the most common route for entry was following a seizure. Among the subset of NE infants caused by HIE, by the time an infant suffers seizures it may be too late to achieve the full benefit of HT [20, 21]. Given that birth asphyxia is often presumed the etiology of NE, it is striking to note that umbilical cord blood gas examinations were obtained in just over half of the infants during their perinatal courses. Similarly, less than 40% of the infants had blood gas sampling performed following birth. Since neurologic exams and umbilical and cord blood gas examinations are commonly used tests to determine whether or not HT is appropriate, these data suggest there is room for improvement in the recognition and evaluation of NE.
Nearly four in ten (38%) NER infants were eligible due to exposure to HT. However the majority were also encephalopathic and in only a small percentage (8%) was HT the sole criteria for eligibility. One third of infants receiving HT were admitted after 6 hours of life when any neuroprotective benefit from HT may be diminished. Over 60% of NE infants required transport, which may be a significant contributing factor in the observed delay in admission. Identification of gaps between the conditions for implementation of HT in clinical trials and in what is observed in clinical practice and identification of areas of improvement are focused areas of ongoing NER research.
The optimal routine evaluation and treatments of infants with NE is unknown. The majority of infants were treated with anticonvulsants but significant variation was noted in the approach to electroencephalographic monitoring. Only 66% had optimal imaging (head MRI) and 23% underwent a suboptimal exam (head CT) according to accepted quality standards . Ongoing work of the NER will identify and document variation in the evaluations and medical treatments these infants receive, providing valuable information for future RCTs.
Variation in patient selection and adherence to established protocols contributes to differences in survival, adverse events, and long-term outcomes for treated infants [23, 24]. Among infants in the NER, 13% died, a proportion similar to the mortality rate of NE observed in a population based report by Badawi et al. (9%) despite different inclusion criteria . Of infants that survived to discharge, a significant proportion required ventilation, monitoring, and other medical care at home. These findings are consistent with previous observations of the medical burden and mortality associated with NE infants and underscores the need for improvement of the quality of care. The NER provides benchmarking data that member centers use while participating in VON multicenter quality improvement collaborations.
A large proportion of cerebral palsy, cognitive disability, and epilepsy arise in infants born at term or late preterm . In contrast to preterm infant births, the births of term and late preterm infants are scattered over a broad range of facilities, many of which care for relatively few infants each year with NE. NER hospitals may be the best representation of those caring for encephalopathic infants in the “real world” and represent a generalizable view of HT as it occurs outside the academic sector or in a research setting. VON NER centers are heterogeneous in terms of size and numbers of infant records submitted. However, the participating nurseries were largely non-profit tertiary referral centers. Slightly more than half were teaching hospitals.
The UK TOBY Cooling Register also captures data on neonatal HT [26, 27]. The TOBY Register started after the TOBY trial of HT closed enrollment, upon recognition that many physicians were offering HT out of the context of any trial [6, 28]. It is a phase 4 study of the specific methods of the trial, with a narrower set of inclusion criteria than the VON NER. Comparison of information in the VON and the TOBY registries will be useful in understanding dissemination of HT when implemented strictly in accordance with a previous trial (TOBY) versus in a more broad clinical setting (VON NER).
Registries have important limitations with respect to RCTs. RCTs have strong internal validity, but often are focused on a relatively homogeneous group of patients from whom significant numbers are excluded at the cost of external validity or widespread generalizability. Registries aim for greater generalizability with populations relevant to all clinical settings. The nature of registry data limits clinicians from applying registry data to clinical decision-making. However, careful data collection and analyses of the NER, with oversight by the Steering Committee, aim to limit the potential for bias and misinterpretation of data. Awareness and recognition of bias in registry data adds to its heuristic value for planning clinical research or guiding NICU policies.
A registry is well suited to the study of the heterogeneous population of NE infants and to the characterization of how interventions such as HT are implemented in clinical practice. This manuscript describes the methods and initial demographic results of the VON NER. Future manuscripts are planned on antecedents of NE, evaluation and treatment of neonatal seizure, optimal neuroimaging of NE infants, and hypothermia for HIE in routine practice.
Joe Carpenter – performed substantial contributions to Registry design, database construction, and statistical analysis.
- Nelson KB, Leviton A: How much of neonatal encephalopathy is due to birth asphyxia?. Am J Dis Child. 1991, 145 (11): 1325-1331.PubMedGoogle Scholar
- Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O'Sullivan F, Burton PR, Pemberton PJ, Stanley FJ: Intrapartum risk factors for newborn encephalopathy: the Western Australian case–control study. BMJ Clinical research ed. 1998, 317 (7172): 1554-1558. 10.1136/bmj.317.7172.1554.View ArticlePubMedPubMed CentralGoogle Scholar
- Badawi N, Kurinczuk JJ, Keogh JM, Alessandri LM, O'Sullivan F, Burton PR, Pemberton PJ, Stanley FJ: Antepartum risk factors for newborn encephalopathy: the Western Australian case–control study. BMJ Clinical research ed. 1998, 317 (7172): 1549-1553. 10.1136/bmj.317.7172.1549.View ArticlePubMedPubMed CentralGoogle Scholar
- Levene MI, Sands C, Grindulis H, Moore JR: Comparison of two methods of predicting outcome in perinatal asphyxia. Lancet. 1986, 1 (8472): 67-69.View ArticlePubMedGoogle Scholar
- Ellenberg JH, Nelson KB: Cluster of perinatal events identifying infants at high risk for death or disability. J Pediatr. 1988, 113 (3): 546-552. 10.1016/S0022-3476(88)80649-8.View ArticlePubMedGoogle Scholar
- Azzopardi DV, Strohm B, Edwards AD, Dyet L, Halliday HL, Juszczak E, Kapellou O, Levene M, Marlow N, Porter E, et al: Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med. 2009, 361 (14): 1349-1358. 10.1056/NEJMoa0900854.View ArticlePubMedGoogle Scholar
- Gluckman PD, Wyatt JS, Azzopardi D, Ballard R, Edwards AD, Ferriero DM, Polin RA, Robertson CM, Thoresen M, Whitelaw A, et al: Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet. 2005, 365 (9460): 663-670.View ArticlePubMedGoogle Scholar
- Jacobs S, Hunt R, Tarnow-Mordi W, Inder T, Davis P: Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane database of syst rev (Online). 2007, CD003311-4Google Scholar
- Shankaran S, Laptook A, Wright LL, Ehrenkranz RA, Donovan EF, Fanaroff AA, Stark AR, Tyson JE, Poole K, Carlo WA, et al: Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants. Pediatrics. 2002, 110 (2 Pt 1): 377-385.View ArticlePubMedGoogle Scholar
- Edwards AD, Azzopardi DV: Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child. 2006, 91 (2): F127-F131.View ArticleGoogle Scholar
- Kirpalani H, Barks J, Thorlund K, Guyatt G: Cooling for neonatal hypoxic ischemic encephalopathy: do we have the answer?. Pediatrics. 2007, 120 (5): 1126-1130. 10.1542/peds.2006-2776.View ArticlePubMedGoogle Scholar
- Blackmon LR, Stark AR: Hypothermia: a neuroprotective therapy for neonatal hypoxic-ischemic encephalopathy. Pediatrics. 2006, 117 (3): 942-948. 10.1542/peds.2005-2950.View ArticlePubMedGoogle Scholar
- Higgins RD, Raju TN, Perlman J, Azzopardi DV, Blackmon LR, Clark RH, Edwards AD, Ferriero DM, Gluckman PD, Gunn AJ, et al: Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop. J Pediatr. 2006, 148 (2): 170-175. 10.1016/j.jpeds.2005.12.009.View ArticlePubMedGoogle Scholar
- Gliklich RE, Dreyer NA: United States. Agency for Healthcare Research and Quality.: Registries for evaluating patient outcomes: a user's guide. 2007, Dept. of Health and Human Services, Public Health Service, Agency for Healthcare Research and Quality, Rockville, MD: U.SGoogle Scholar
- Morales LS, Staiger D, Horbar JD, Carpenter J, Kenny M, Geppert J, Rogowski J: Mortality among very low-birthweight infants in hospitals serving minority populations. Am J Public Health. 2005, 95 (12): 2206-2212. 10.2105/AJPH.2004.046730.View ArticlePubMedPubMed CentralGoogle Scholar
- Stark AR: Levels of neonatal care. Pediatrics. 2004, 114 (5): 1341-1347.View ArticlePubMedGoogle Scholar
- Dreyer NA, Garner S: Registries for robust evidence. Jama. 2009, 302 (7): 790-791. 10.1001/jama.2009.1092.View ArticlePubMedGoogle Scholar
- Edwards AD, Nelson KB: Neonatal encephalopathies. Time to reconsider the cause of encephalopathies. BMJ Clinical research ed. 1998, 317 (7172): 1537-1538. 10.1136/bmj.317.7172.1537.View ArticlePubMedPubMed CentralGoogle Scholar
- Volpe JJ: Neurology of the newborn. 2008, Saunders/Elsevier, Philadelphia, 5Google Scholar
- Gunn AJ, Bennet L, Gunning MI, Gluckman PD, Gunn TR: Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res. 1999, 46 (3): 274-280. 10.1203/00006450-199909000-00005.View ArticlePubMedGoogle Scholar
- Gunn AJ, Gunn TR, Gunning MI, Williams CE, Gluckman PD: Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep. Pediatrics. 1998, 102 (5): 1098-1106. 10.1542/peds.102.5.1098.View ArticlePubMedGoogle Scholar
- Ment LR, Bada HS, Barnes P, Grant PE, Hirtz D, Papile LA, Pinto-Martin J, Rivkin M, Slovis TL: Practice parameter: neuroimaging of the neonate: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2002, 58 (12): 1726-1738. 10.1212/WNL.58.12.1726.View ArticlePubMedGoogle Scholar
- Draper ES, Kurinczuk JJ, Lamming CR, Clarke M, James D, Field D: A confidential enquiry into cases of neonatal encephalopathy. Arch Dis Child. 2002, 87 (3): F176-F180.View ArticleGoogle Scholar
- Gressens P, Rogido M, Paindaveine B, Sola A: The impact of neonatal intensive care practices on the developing brain. J Pediatr. 2002, 140 (6): 646-653. 10.1067/mpd.2002.123214.View ArticlePubMedGoogle Scholar
- Himmelmann K, Hagberg G, Beckung E, Hagberg B, Uvebrant P: The changing panorama of cerebral palsy in Sweden. IX. Prevalence and origin in the birth-year period 1995–1998. Acta Paediatr. 2005, 94 (3): 287-294. 10.1111/j.1651-2227.2005.tb03071.x.View ArticlePubMedGoogle Scholar
- The TOBY Register. http://www.npeu.ox.ac.uk/tobyregister,
- Azzopardi D, Strohm B, Edwards AD, Halliday H, Juszczak E, Levene M, Thoresen M, Whitelaw A, Brocklehurst P: Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial. Arch Dis Child. 2009, 94 (4): F260-F264.View ArticleGoogle Scholar
- Azzopardi D, Brocklehurst P, Edwards D, Halliday H, Levene M, Thoresen M, Whitelaw A: The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. BMC Pediatr. 2008, 8: 17-10.1186/1471-2431-8-17.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2431/12/84/prepub
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