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Antibiotic surveillance on a paediatric intensive care unit: easy attainable strategy at low costs and resources
© Stocker et al.; licensee BioMed Central Ltd. 2012
Received: 23 September 2012
Accepted: 19 December 2012
Published: 21 December 2012
Antibiotic surveillance is mandatory to optimise antibiotic therapy. Our objectives were to evaluate antibiotic use in our pediatric intensive care unit (PICU) and to implement a simple achievable intervention aimed at improving antibiotic therapy.
Prospective, 3 months surveillance of antibiotic use on PICU (phase I) and evaluation according to the CDC 12-step campaign with development of an attainable intervention. 3 months surveillance (phase II) after implementation of intervention with comparison of antibiotic use.
Appropriate antibiotic use for culture-negative infection-like symptoms and targeted therapy for proven infections were the main areas for potential improvement. The intervention was a mandatory checklist requiring indication and recording likelihood of infection at start of antibiotic therapy and a review of the continuing need for therapy at 48 h and 5 days, reasons for continuation and possible target pathogen. The percentage of appropriate empiric antibiotic therapy courses for culture-negative infection-like symptoms increased from 18% (10/53) to 74% (42/57; p<0.0001), duration of therapy <3 days increased from 18% (10/53) to 35% (20/57; p=0.05) and correct targeting of pathogen increased from 58% (7/12) to 83% (20/24; p=0.21).
Antibiotic surveillance using the CDC 12-step campaign can help to evaluate institutional antibiotic therapy. Development of an attainable intervention using a checklist can show improved antibiotic use with minimal expense.
Antibiotic surveillance is mandatory to optimise antibiotic therapy and to prevent antimicrobial resistance [1–3]. Guidelines for developing an institutional program to enhance antimicrobial stewardship are published and contain several interventions with good impact but require a high level of organisational change, resources and acceptance . Only a small number of studies have focused on antibiotic surveillance on hospitalised newborns, infants and children [5–8]. In a recent published survey, Hersh et al. pointed out that lack of resources, including funding, time, and personnel were the major barriers to implementing an antimicrobial stewardship program in paediatrics .
The Center for Disease Control and Prevention (CDC) 12-step program to prevent antimicrobial resistance was launched in 2000 to educate clinicians about antimicrobial resistance and provide strategies to improve clinical practice . Patel and colleagues showed in a recent publication the possibility of using the CDC 12-Step Campaign to assess antibiotic prescribing and adherence to guidelines on a Neonatal Intensive Care Unit (NICU) .
In a recently published concise review, Newland and Hersh concluded that prospective audit with feedback was the most favourable and efficient strategy for antimicrobial stewardship programs in paediatrics . They asked for more publications on prospective audits and declared the most important challenge was to develop strategies to facilitate greater implementation of antimicrobial stewardship programs at low cost and low resource requirement. In line with these conditions our aim was to conduct an antibiotic surveillance audit on our Paediatric Intensive Care Unit (PICU) with a simple achievable strategy at low cost and low resource requirement.
We performed a prospective, single-centre interventional audit of antibiotic use on our PICU. Antibiotic therapy was assessed looking for adherence best practice recommendations of the CDC 12-step campaign. Basic data collection was carried out for 3 months (phase I). Interventions were then planned based on areas for potential improvement, that were simple and attainable, required minimal personnel resources and were low in cost (no funding available). Data collection was repeated after the intervention based on the power calculation (phase II). The audit was supervised by the departments of Paediatrics, Pharmacy and Microbiology at the Royal Brompton and Harefield NHS Foundation Trust. The results of phases I and II were reviewed as part of the clinical governance program. This audit with an implemented intervention that is part of standard care on our PICU without a change in policy didn't required ethical approval.
Site and subjects
This audit was conducted on the PICU at the Royal Brompton and Harefield NHS Foundation Trust in London, UK. Our unit is a specialised, tertiary unit for paediatric cardio-respiratory care with approximately 700 admissions per year. Newborns and children up to 16 years of age with a broad spectrum of cardiac malformations, cardiac diseases, rhythm disturbances, postoperative cardiorespiratory care and respiratory problems are treated in our facility. All admissions between 1st April 2010 and 31st June 2010 (91 days) were included in phase I, and then between 10th November 2010 and 28th February 2011 (110 days) in phase II.
Staff of the unit includes physicians (intensivists, cardiologists, respiratory physicians, anaesthesists, cardiothoracic and general paediatric surgeons) working as consultants, fellows and senior house officers; nursing staff working usually in 1:1 care (1 nurse / 1 patient), partially 1:2 if patients were stable and not invasively ventilated; pharmacists and allied health professionals. The group of physicians prescribing antibiotics remained unchanged in regard of number and level of expertise during both study periods: 5 consultant intensivists, 9 fellow intensivists and 9 senior house officers (Paediatrics). Infection control is part of our standard practises on our unit and two infection-focused care bundles are actively practised with prospective data collection: i) care bundle for prophylaxis of catheter-related infections, ii) care bundle for prophylaxis of ventilator-associated pneumonia. Both care bundles remained unchanged and there were no other stewardship interventions in place during the study phase.
Data collection in both phases was carried out using the electronic prescribing system for medication (ICIP), the electronic microbiology data system (EPR), the electronic system for nursing reports and all available medical reports. With the electronic medication and microbiology data system we were able to assess all doses of antibiotic therapy administered to patients on PICU, and results of all microbiologically tested samples (blood, cerebrospinal fluid, ascites, urine, tracheal aspirates). Indications for antibiotic therapy were obtained from medical and nursing reports in phase I, and additionally from the study intervention form during phase II.
Definitions and assessment of antibiotic use
The design of our study was an antibiotic surveillance audit, based on the CDC 12-step recommendations focused at the 2 strategies “Diagnose and treat infection effectively” (steps 3–5) and “Use antimicrobials wisely” (steps 6–10). The unit of antibiotic analysis was an antibiotic course, defined as one or more antibiotics given concurrently for one or more days. The possible reasons for therapy were categorised as 1) prophylaxis (post-surgery), 2) empiric therapy (clinical signs of possible infection with negative cultures) or 3) therapy for proven infection (clinical signs of infection with positive cultures from blood, cerebrospinal fluid, ascites, urine or tracheal aspirates). Appropriateness of antibiotic use was compared using institutional antimicrobial guidelines for prophylaxis and empiric therapy for suspected infections. Appropriate duration of empiric therapy for culture negative infection-like symptoms was defined as less than 3 days unless there were clear and reasonable documented reasons for continuing antibiotic therapy.
A checklist as a simple achievable intervention
A power calculation was done based on the aim of our primary intervention, which was to reduce inappropriate duration of empiric antibiotic therapy with culture negative results. In phase I, 18% (10/53) of patients on empiric therapy received it for an appropriate duration. We hypothesised, that it was possible to increase this to 36% (duplication) with the implemented intervention. With the definition of alpha=0.05 and a power of 80%, 42 courses of empiric therapy would be required to demonstrate a significant result. Calculating a possible compliance of 80% to the intervention our aim was to observe 52 courses of empiric antibiotic therapy during phase II. A Chi-squared test was calculated if all frequencies were equal to or greater than 5, otherwise a Fisher’s Exact two-tailed test was used.
Results of phase I (baseline period)
Assessing antibiotic use according to the CDC 12-step campaign revealed 2 main areas in phase I for potential improvement: i) Step 10: Empiric antibiotic therapy for < 3 days for unproven infections (culture negative); ii) Step 4: targeting of pathogens as therapy for proven infections (culture positive). 18% (10/53) of empiric antibiotic courses had a duration of < 3 days and there was no clear and reasonable documentation for courses of longer durations. In 58% (7/12) a cultured pathogen was targeted with a change of antibiotics unless antibiotics were already susceptible. The other CDC steps showed good results, i.e. 95% of all prophylactic courses complied with institutional guidelines and vancomycin, carbapenems and third generation cephalosporins were rarely used and did not appear in the top 5 most commonly used antibiotics (results not shown).
Results of phase II (intervention period)
Baseline demographics, overview of antibiotic courses, outcome variables
Phase I (91 days)
Phase II (110 days)
Hospitalisation days / admissiona
Infection-related fatal casualities
Sex (% male)
Age at admissionb
6 mt (0–16 yrs)
7 mt (0–16 yrs)
Antibiotic courses total
Non-proven infection courses
Proven infection courses
Secondary antibiotic courses total
Secondary courses for prophylaxis
Secondary courses for non-proven infection
Secondary courses for proven infection
Infection relapse rate (non-proven + proven)
Regarding possible adverse outcomes due to early discontinuation of antibiotic therapy there was no statistically significant difference in overall mortality, infection-related mortality and infection relapse rate (Tab 1). There was no case of death on our unit during the phase I of the study, whereas 3 children died during phase II, none of them infection related: i) cardiac failure in a newborn baby with critical aortic stenosis, ii) cardiac failure in a baby with unbalanced atrioventricular septum defect and complete AV-block III (palliative care), iii) ischemic necrotizing enterocolitis after cardiopulmonary bypass surgery (antibiotic therapy continued after surgery). Secondary courses of antibiotic therapy during the same hospitalisation after a first course of suspected or proven infection (possible relapses of infection) were even less frequent in phase II. The significantly higher rate of proven infections in phase II was due to an increased rate of pulmonary infections in the winter months November – February compared to phase I in April – June.
As with Patel et al. who evaluated antibiotic use according to the CDC 12-step program on a NICU, we used the CDC recommendations as the evaluation tool for our audit [8, 10]. Prolonged empiric antimicrobial treatment without clear evidence of infection, failure to narrow antimicrobial therapy when a causative organism is identified, and no clear documentation about indication and plan for therapy are reported to be common problems, and published data on general inappropriate use of antibiotics have similar findings to our results during phase I [12–16].
The first step in building an intervention for antibiotic surveillance/stewardship is to select the most appropriate strategy that leads to a sustained improvement in a defined area. In the guidelines for developing an institutional program to enhance antimicrobial stewardship there are two core strategies described: 1) prospective audit with feedback and 2) formulary restriction and pre-authorisation . Initiation of antibiotic therapy in the setting of a PICU patient is often empiric and based on apparently worsening clinical condition, with sepsis as a possible factor. During phase I of our audit vancomycin, carbapenems and third generation cephalosporins were not used regularly (not in our top 5 most commonly used antibiotics) and we concluded that the local formulary guidelines appeared to be respected without possible improvement with further formulary restriction and pre-authorisation [16–18]. We therefore selected prospective audit with feedback as a possible intervention, a strategy proposed in a recent review by Newland as the most favourable and efficient . The basis on an audit and feedback intervention is a review of every antibiotic course by a third party (typically an infectious disease physician or a clinical pharmacist) with the audit presented back to the prescriber. For implementation we faced the same barriers reported in other paediatric antibiotic stewardship programs: lack of resources, including funding, time, and personnel [9, 11]. We solved this challenge by developing a new strategy for audit and feedback. Instead of personnel audit and feedback by a third party, we created a checklist and used this as a way of audit and feedback (checklist as mandatory form for self-review and feedback by the treating physician). Recent publications about successful use of simple checklists guided us in developing our intervention [19–21]. Key elements for creating a successful checklist are short, clear and basic questions with reminders of routine care . With our checklist, we aimed to support the communication and documentation of indications for the initiation and continuation of antibiotic therapy, which served to remind the treating physician to review and potentially stop therapy or target the isolated pathogen. There are other publications regarding the use of mandatory prescription forms to start antibiotic therapy . The innovation of our approach is that the clinician is reviewing the prescription with help of a checklist at 2 points after start of antibiotic therapy (at 48 hours and 5 days).
The importance of a high compliance rate (power calculation aimed for a compliance rate of 80%) for a successful intervention is emphasised with the statistically not significant increase of antibiotic courses of empiric therapy < 3 days. In contrast to the aviation industry, there is still scepticism by some physicians about the use of checklists for the safe routine care and emergency situations in medicine, illustrated with a citation from A. Gawande in his recently published book “The Checklist Manifesto”: “It runs counter to deeply held beliefs about how the truly great among us – those we aspire to be – handle situations of high stakes and complexity” . A mandatory checklist in a computerised prescription system offers a possible way to improve compliance and impact of the intervention. Due to the potential risk of premature discontinuation of therapy a computerised checklist has to be mandatory but without an automatic antibiotic stop-order .
The limitations of our audit were the short surveillance time, the low compliance to the intervention (<80%) and the low numbers of proven infection with positive cultures (no conclusions regarding susceptibility patterns possible). The main strength of our audit was that it was a simple and achievable intervention which was low in cost (no additional funding) and resources. The construction of an easy attainable strategy is very important due to the fact that lack of resources and time are major barriers to implementing an antimicrobial stewardship program in paediatrics.
The 12 steps of the CDC campaign are a possible tool to evaluate institutional antibiotic therapy. A mandatory checklist as an audit-feedback-mechanism can be a simple achievable intervention with possible improvement in antibiotic use at minimal expense. Further studies with mandatory, computerised checklists within the prescribing system need to be carried out to show compliance and sustainable results over a longer period of time.
The authors thank the multidisciplinary team of the Paediatric Intensive Care Unit at the Royal Brompton and Harefield NHS Foundation Trust in London for help in data acquisition.
- Bradely JS: Commentary: antibiotic Stewardship in Paediatrics: a necessity. Pediatr Infect Dis J. 2007, 26: 538-539. 10.1097/INF.0b013e3180593184.View ArticleGoogle Scholar
- Davey P, Brown E, Fenelon L, Finch R, Gould I, Hartman G, et al: Interventions to improve antibiotic prescribing practises for hospital inpatients. Cochrane Database Syst Rev. 2005, 19 (4): CD003543-Google Scholar
- World Health Organization Global Strategy for Containment of Antimicrobial Resistance (WHO antimicrobial resistance website) 2001. Available at: http://www.who.int/drugresistance/guidance: Accessed December 10, 2010,
- Dellit TH, Owens RC, McGowen JE, Gerding DN, Weinstein RA, Burke JP, et al: Infectious Diseases Society of America and the Society of Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Inf Dis. 2007, 44: 159-177. 10.1086/510393.View ArticleGoogle Scholar
- DiPentima MC, Chan S: Impact of antimicrobial stewardship program on vancomycin use in a pediatric teaching hospital. Pediatr Infect Dis J. 2010, 29: 707-711. 10.1097/INF.0b013e3181d683f8.View ArticleGoogle Scholar
- Metjian TA, Prasad PA, Kogon A, Coffin SE, Zaoutis TE: Evaluation of antimicrobial stewardship program at a pediatric teaching hospital. Pediatr Infect Dis J. 2008, 27: 106-111.PubMedGoogle Scholar
- Patel SJ, Larson EL, Kubin CJ, Saiman L: A review of antimicrobial control strategies in hospitalized and ambulatory pediatric populations. Pediatr Infect Dis J. 2007, 26: 531-537. 10.1097/INF.0b013e3180593170.View ArticlePubMedGoogle Scholar
- Patel SJ, Oshodi A, Prasad PA, Delamora P, Larson E, Zaoutis TE, et al: Antibiotic use in neonatal intensive care units and adherence with Centers for Disease Control and Prevention 12-Step Campaign to prevent antimicrobial resistance. Pediatr Infect Dis J. 2009, 28: 1047-1051. 10.1097/INF.0b013e3181b12484.View ArticlePubMedPubMed CentralGoogle Scholar
- Hersh AL, Beekmann SE, Polgreen PM, Zaoutis TE, Newland JG: Anitmicrobial stewardship programs in pediatrics. Infect Control Hosp Epidemiol. 2009, 30 (12): 1211-1217. 10.1086/648088.View ArticlePubMedGoogle Scholar
- CDC 12-Step program to prevent antimicrobial resistance in health care settings (CDC antimicrobial resistance website) 2000. Available at: http://www.cdc.gov/drugresistance/healthcare/default.html,
- Newland JG, Hersh AL: Purpose and design of antimicrobial stewardship programs in pediatrics. Pediatr Infect Dis J. 2010, 29: 862-863. 10.1097/INF.0b013e3181ef2507.View ArticlePubMedGoogle Scholar
- Cuthbertson BH, Thompson M, Sherry A, Wright MM, Bellingan GJ, Intensive Care Society: Antibiotic-treated infections in intensive care patients in the UK. Anaesthesia. 2004, 59 (9): 885-890. 10.1111/j.1365-2044.2004.03742.x.View ArticlePubMedGoogle Scholar
- Erlandsson M, Burman LG, Cars O, Gill H, Nilsson LE, Walther SM, et al: Prescription of antibiotic agents in Swedish intensive care units is empiric and precise. Scan J Infect Dis. 2007, 39 (1): 63-69. 10.1080/00365540600740504.View ArticleGoogle Scholar
- Fischer JE, Ramser M, Altermatt S, Nadal D, Waldvogel K: Rational utilization of antibiotics in critically ill children. Schweiz Med wochenschr. 2000, 130 (42): 1564-1571.PubMedGoogle Scholar
- Leekha S, Terrell CL, Edson RS: General prinicples of antimicrobial therapy. Mayo Clin Proc. 2011, 86 (2): 156-167. 10.4065/mcp.2010.0639.View ArticlePubMedPubMed CentralGoogle Scholar
- Warren MM, Gibb AP, Walsh TS: Antibiotics prescription practice in an intensive care unit using twice-weekly collection of screening speciems: a prospective audit in a large UK teaching hospital. J Hosp Infect. 2005, 59 (2): 90-5. 10.1016/j.jhin.2004.09.014.View ArticlePubMedGoogle Scholar
- Fischer JE, Ramser M, Fanconi S: Use of antibiotics in paediatric intensive care and potential savings. Intensive Care Med. 2000, 26 (7): 959-966. 10.1007/s001340051288.View ArticlePubMedGoogle Scholar
- Potocki M, Goette J, Szucs TD, Nadal D: Prospective survey of antibiotic utilization in pediatric hospitalized patients to identify targets for improvement of prescription. Infection. 2003, 31 (6): 398-403.PubMedGoogle Scholar
- Gawande A: The hero in the age of checklists. The Checklist Manifesto. How to get things right. Edited by: Gawande A. 2010, Profile Books LTD, 158-186.Google Scholar
- Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat AH, Dellinger EP, et al: A surgical safety checklist to reduce morbidity and mortality in a global population. NEJM. 2009, 360: 491-499. 10.1056/NEJMsa0810119.View ArticlePubMedGoogle Scholar
- Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, et al: An intervention to decrease catheter-related bloodstream infections in the ICU. NEJM. 2006, 335: 2725-2732.View ArticleGoogle Scholar
- Evans RS, Pestotnik SL, Classen DC, et al: A computer-assisted management program for antibiotics and other aniinfective agents. N Engl J Med. 1998, 338: 232-238. 10.1056/NEJM199801223380406.View ArticlePubMedGoogle Scholar
- Brown EM: Interventions to optimise antibiotic prescribing in hospitals: the UK approach. Antibiotics policies: theory and practice. Edited by: Gould IM, Meer JWM. 2005, Kluwer Academic/Plenum Publisher, 159-183.View ArticleGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2431/12/196/prepub
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