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  1. Coronavirus disease 2019 (COVID-19) has impacted the provision of health services in all specialties. We aim to study the impact of COVID-19 on the utilization of pediatric hospital services including emergenc...

    Authors: Shu-Ling Chong, Jenifer Shui Lian Soo, John Carson Allen Jr, Sashikumar Ganapathy, Khai Pin Lee, Arif Tyebally, Chee Fu Yung, Koh Cheng Thoon, Yong Hong Ng, Jean Yin Oh, Oon Hoe Teoh, Yee Hui Mok and Yoke Hwee Chan

    Citation: BMC Pediatrics 2020 20:562

    Content type: Research article

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  2. Down syndrome (DS) is characterized by a series of immune dysregulations, of which interferon hyperreactivity is important, as it is responsible for surging antiviral responses and the possible initiation of a...

    Authors: Ahmad Kantar, Angelo Mazza, Ezio Bonanomi, Marta Odoni, Manuela Seminara, Ilaria Dalla Verde, Camillo Lovati, Stefania Bolognini and Lorenzo D’Antiga

    Citation: BMC Pediatrics 2020 20:561

    Content type: Case report

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  3. Children with a history of caustic or foreign body ingestion (FBI) seem to be presenting more frequently to emergency departments. This study aims to elucidate the clinical presentation, diagnostic procedures,...

    Authors: Arne Jorma Speidel, Lena Wölfle, Benjamin Mayer and Carsten Posovszky

    Citation: BMC Pediatrics 2020 20:560

    Content type: Research article

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  4. Pulmonary hypertension is a deadly complication of bronchopulmonary dysplasia, the most common pulmonary morbidity of prematurity. Despite these catastrophic consequences, no evidence-based therapies are avail...

    Authors: Simone Schneider, Mary Bailey, Tracy Spears, Charles R. Esther Jr, Matthew M. Laughon, Christoph P. Hornik and Wesley Jackson

    Citation: BMC Pediatrics 2020 20:559

    Content type: Study protocol

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  5. Bazett formula is frequently used in paediatric screening for the long QT syndrome (LQTS) and proposals exist that using standing rather than supine electrocardiograms (ECG) improves the sensitivity of LQTS di...

    Authors: Irena Andršová, Katerina Hnatkova, Kateřina Helánová, Martina Šišáková, Tomáš Novotný, Petr Kala and Marek Malik

    Citation: BMC Pediatrics 2020 20:558

    Content type: Research article

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  6. Previous research studies have demonstrated abnormalities in the metabolism of mothers of young children with autism.

    Authors: Kathryn Hollowood-Jones, James B. Adams, Devon M. Coleman, Sivapriya Ramamoorthy, Stepan Melnyk, S. Jill James, Bryan K. Woodruff, Elena L. Pollard, Christine L. Snozek, Uwe Kruger, Joshua Chuah and Juergen Hahn

    Citation: BMC Pediatrics 2020 20:557

    Content type: Research article

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  7. Nocturnal cough and wheeze are important symptoms when diagnosing any respiratory disease in a child, but objective measurements of these symptoms are not performed.

    Authors: Markus Lindenhofer, Lena Roth, Clemens Mädel, Florian Götzinger, Katharina Kainz, Christiane Lex, Thomas Frischer, Matthias Reinweber and Angela Zacharasiewicz

    Citation: BMC Pediatrics 2020 20:556

    Content type: Research article

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  8. Abundant clinical evidences indicate that the increased risk of cerebral palsy (CP) may be associated with the intrauterine exposure to maternal infection. Cytomegalovirus (CMV) is a common cause of CP. Howeve...

    Authors: H Xu, L Zhang, XY Xuan, M Zhu, J Tang and XK Zhao

    Citation: BMC Pediatrics 2020 20:555

    Content type: Research article

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  9. Children’s literacy and mathematical competencies are a critical platform for their successful functioning as individuals in society. However, many children, in particular those with low socio-economic status ...

    Authors: Frank Niklas, Efsun Annac and Astrid Wirth

    Citation: BMC Pediatrics 2020 20:554

    Content type: Study protocol

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  10. Necrotizing enterocolitis (NEC) is a devastating disease that is relatively frequently diagnosed in term infants with congenital heart disease (CHD), compared with term infants without CHD, in whom NEC is rare...

    Authors: Martin van der Heide, Mirthe J. Mebius, Arend F. Bos, Marcus T.R. Roofthooft, Rolf M.F. Berger, Jan B.F. Hulscher and Elisabeth M.W. Kooi

    Citation: BMC Pediatrics 2020 20:553

    Content type: Research article

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  11. In contrast to intoxications in toddlers which can be due to accidental ingestions, many intoxications in infants are due to medication errors. To our knowledge, this is the first case report of a citalopram into...

    Authors: Jo-Anne Janson, Arthur T. M. Wasylewicz, Marianne Eijkemans and Marieke Kerskes

    Citation: BMC Pediatrics 2020 20:552

    Content type: Case report

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  12. This study was conducted with the aim of developing a standard and valid questionnaire to evaluate the behavioral factors affecting musculoskeletal disorders among adolescent students based on the educational ...

    Authors: Mahin Nazari, Rokhsareh Beigi, Mahmood Salesi, Rosanna Cousins and Hamidreza Mokarami

    Citation: BMC Pediatrics 2020 20:551

    Content type: Research article

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  13. Previous studies have shown that changes in intestinal microfloras are associated with both gastrointestinal (GI) and non-GI tumors. It is not clear whether there is an association between GI microflora change...

    Authors: Xiaolin Gao, Ruixue Miao, Yiping Zhu, Chao Lin, Xue Yang, Ruizhen Jia, Kuang Linghan, Chaomin Wan and Jianjun Deng

    Citation: BMC Pediatrics 2020 20:290

    Content type: Research article

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  14. The developmental dysplasia of the hip (DDH) can cause a wide range of pathological changes, and often requires surgical treatment. Preoperative evaluation is very important for DDH. We aimed to assess the dia...

    Authors: Huihui Jia, Liang Wang, Yan Chang, Yongrui Song, Yuqi Liu, Fuyong Zhang, Jie Feng, Xiaodong Yang and Mao Sheng

    Citation: BMC Pediatrics 2020 20:550

    Content type: Research article

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  15. Medication Errors (MEs) are considered the most common type of error in pediatric critical care services. Moreover, the ME rate in pediatric patients is up to three times higher than the rate for adults. Never...

    Authors: Lorena Michele Brennan-Bourdon, Alan O. Vázquez-Alvarez, Jahaira Gallegos-Llamas, Manuel Koninckx-Cañada, José Luis Marco-Garbayo and Selene G. Huerta-Olvera

    Citation: BMC Pediatrics 2020 20:549

    Content type: Research article

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  16. To confirm the accuracy of transcutaneous bilirubin (TcB) in the neonatal intensive care unit both with and without phototherapy, and compare forehead and sternum as the TcB assessment site.

    Authors: Jaesung Jeon, Gina Lim, Ki Won Oh, Na Mi Lee, Hye Won Park and Mi Lim Chung

    Citation: BMC Pediatrics 2020 20:548

    Content type: Research article

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  17. Primary hyperparathyroidism may present in a myriad of manners, varying from an incidental asymptomatic biochemical finding to gastrointestinal, psychiatric, renal, and bone manifestations. While hyperparathyr...

    Authors: O. Legault, M. Inman, N. Moolman, S. Wiebe, A. Poulin and M. A. Nour

    Citation: BMC Pediatrics 2020 20:547

    Content type: Case report

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  18. Direct oral anticoagulants, such as apixaban, are increasingly used in everyday practice in order to treat or prevent thromboembolic diseases. To date, there is no available data about apixaban pharmacokinetic...

    Authors: Manon Launay, Yara Nasser, Isabelle Maubert, Anne-Cécile Chaux and Xavier Delavenne

    Citation: BMC Pediatrics 2020 20:546

    Content type: Case report

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  19. Autism spectrum disorder (ASD) is a developmental impairment characterized by persistent deficits in social communication and interactions, and over half of children with ASD possess below average intellectual...

    Authors: Yen Na Yum, Way Kwok-Wai Lau, Kean Poon and Fuk Chuen Ho

    Citation: BMC Pediatrics 2020 20:545

    Content type: Study protocol

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  20. Maternal iodine requirements increase during pregnancy to supply thyroid hormones essential for fetal brain development. Maternal iodine deficiency can lead to hypothyroxinemia, a reduced fetal supply of thyro...

    Authors: Kirsten Jade Cromie, Diane Erin Threapleton, Charles Jonathan Peter Snart, Elizabeth Taylor, Dan Mason, Barry Wright, Brian Kelly, Stephen Reid, Rafaq Azad, Claire Keeble, Amanda H. Waterman, Sarah Meadows, Amanda McKillion, Nisreen A. Alwan, Janet Elizabeth Cade, Nigel A. B. Simpson…

    Citation: BMC Pediatrics 2020 20:544

    Content type: Research article

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  21. To evaluate the efficacy of oral clonazepam versus oral lorazepam following initial parenteral benzodiazepine administration to control methamphetamine-induced agitation in children.

    Authors: Fariba Farnaghi, Razieh Rahmani, Hossein Hassanian-Moghaddam, Nasim Zamani, Rebecca McDonald, Narges Gholami and Latif Gachkar

    Citation: BMC Pediatrics 2020 20:543

    Content type: Research article

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  22. Living at high latitudes is one of the risk factors for vitamin D deficiency in children. However, evidence on vitamin D improvement for this pediatric population to date is limited. This study aims at evaluat...

    Authors: Xuguang Zhang, Yanping Chen, Shanshan Jin, Xinxin Bi, Dongkai Chen, Dongmei Zhang, Li Liu, Hong Jing and Lixin Na

    Citation: BMC Pediatrics 2020 20:542

    Content type: Research article

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  23. Kangaroo mother care (KMC) is an effective intervention for preterm and low birth weight infants. Effective implementation of KMC relies on a multidisciplinary team centering on the newborn’s caregiver, who de...

    Authors: Alinane Linda Nyondo-Mipando, Mai-Lei Woo Kinshella, Sangwani Salimu, Brandina Chiwaya, Felix Chikoti, Lusungu Chirambo, Ephrida Mwaungulu, Mwai Banda, Laura Newberry, Jenala Njirammadzi, Tamanda Hiwa, Marianne Vidler, Queen Dube, Elizabeth Molyneux, Joseph Mfutso-Bengo, David M. Goldfarb…

    Citation: BMC Pediatrics 2020 20:541

    Content type: Research article

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  24. X-linked agammaglobulinemia (XLA, OMIM#300,300), caused by mutations in the Bruton tyrosine kinase (BTK) gene, is a rare monogenic inheritable immunodeficiency disorder. Ecthyma gangrenosum is a cutaneous lesion ...

    Authors: Haixia Huang, Ke Bai, Yueqiang Fu, Jin Yan and Jing Li

    Citation: BMC Pediatrics 2020 20:540

    Content type: Case report

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  25. Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children, with various data linking rising atrial septal defect incidence (ASDI) with prenatal canna...

    Authors: Albert Stuart Reece and Gary Kenneth Hulse

    Citation: BMC Pediatrics 2020 20:539

    Content type: Research article

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  26. Early childhood is an age at risk of anaemia and its deleterious consequences. In Sudan, there is limited evidence on the prevalence and determinant of anaemia in under-five children. This study was conducted ...

    Authors: Khalid Abdelmutalab Elmardi, Ishag Adam, Elfatih Mohamed Malik, Abdalla Ahmed Ibrahim, Asma Hashim Elhassan, Hmooda Toto Kafy, Lubna Mohammed Nawai, Mujahid Sheikhedin Abdin and Stef Kremers

    Citation: BMC Pediatrics 2020 20:538

    Content type: Research article

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  27. Galectin-3 is a new biomarker, which plays an important role in tissue inflammation, cardiac remodeling, and fibrosis. It can be readily measured in the circulation to detect early heart failure (HF). This stu...

    Authors: Nagwan Saleh, Ahmed Khattab, Mohamed Rizk, Sherif Salem and Hany Abo-Haded

    Citation: BMC Pediatrics 2020 20:537

    Content type: Research article

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  28. Hemiscrotal agenesis (HSA) is an exceedingly rare congenital anomaly in scrotal development. It is characterized by unilateral absence of scrotal skin with intact midline raphe. In the English literature, only...

    Authors: Mohamed Mansy, Mostafa Kotb, Yasmine Abdelmeguid, Shaymaa Raafat and Marwa Abdelaziz

    Citation: BMC Pediatrics 2020 20:536

    Content type: Case report

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  29. Parents of infants in neonatal intensive care units (NICUs) are often unintentionally marginalized in pursuit of optimal clinical care. Family Integrated Care (FICare) was developed to support families as part...

    Authors: Karen M. Benzies, Khalid Aziz, Vibhuti Shah, Peter Faris, Wanrudee Isaranuwatchai, Jeanne Scotland, Jill Larocque, Kelly J. Mrklas, Christopher Naugler, H. Thomas Stelfox, Radha Chari, Amuchou Singh Soraisham, Albert Richard Akierman, Ernest Phillipos, Harish Amin, Jeffrey S. Hoch…

    Citation: BMC Pediatrics 2020 20:535

    Content type: Research article

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  30. This study assessed health workers’ adherence to neonatal health protocols before and during the implementation of a mobile health (mHealth) clinical decision-making support system (mCDMSS) that sought to brid...

    Authors: Hannah Brown Amoakoh, Kerstin Klipstein-Grobusch, Irene Akua Agyepong, Mary Amoakoh-Coleman, Gbenga A. Kayode, J. B. Reitsma, Diederick E. Grobbee and Evelyn K. Ansah

    Citation: BMC Pediatrics 2020 20:534

    Content type: Research article

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  31. Gestational weight gain has been associated with some adverse perinatal outcomes, but few studies have examined the association between gestational weight gain and offspring’s cognition and their conclusions a...

    Authors: Jose Alberto Martínez-Hortelano, Celia Álvarez-Bueno, Iván Cavero-Redondo, Ángel Herráiz-Adillo, Carlos Berlanga-Macías and Vicente Martínez-Vizcaíno

    Citation: BMC Pediatrics 2020 20:533

    Content type: Research article

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  32. The initialization of the neonatal gut microbiota (GM) is affected by diverse factors and is associated with infant development and health outcomes.

    Authors: Cheng Guo, Qian Zhou, Muxia Li, Letian Zhou, Lei Xu, Ying Zhang, Dongfang Li, Ye Wang, Wenkui Dai, Shuaicheng Li and Lin Zhang

    Citation: BMC Pediatrics 2020 20:532

    Content type: Research article

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  33. Early-onset sepsis (EOS) is a potentially life-threatening complication of birth. Clinical symptoms are often unspecific and biomarkers have low predictive values for EOS. Therefore, clinical suspicion often l...

    Authors: Johan Gyllensvärd, Fredrik Ingemansson, Elisabet Hentz, Marie Studahl and Anders Elfvin

    Citation: BMC Pediatrics 2020 20:531

    Content type: Research article

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  34. Parafunctional oral habits are known to cause deleterious effects on maxillofacial structures. One such effect is traumatic injuries secondary to chewing inanimate objects like pencils. Following trauma, the l...

    Authors: Anka Sharma, Vikrant O. Kasat, Amit R. Parate, Anirudh Upmanyu and Jaishri S. Pagare

    Citation: BMC Pediatrics 2020 20:530

    Content type: Case report

    Published on:

  35. As part of efforts to develop and implement a short course educational program on pediatric pain management, the current study sought to understand the culture and contextual factors that influence children’s ...

    Authors: Abigail Kusi Amponsah, Evans Oduro, Victoria Bam, Joana Kyei-Dompim, Collins Kwadwo Ahoto and Anna Axelin

    Citation: BMC Pediatrics 2020 20:529

    Content type: Research article

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  36. The aim of this paper was to investigate whether BMI and fat percentage classification criteria, would classify a sample of 7–13 year old boys from a rural background in similar nutritional categories.

    Authors: Maya van Gent, Anita Pienaar and Habib Noorbhai

    Citation: BMC Pediatrics 2020 20:527

    Content type: Research article

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  37. We describe the safety and efficacy of performing pediatric kidney transplantation with a modified extraperitoneal approach that includes mobilization of the native liver and kidney.

    Authors: Mahmoud Alameddine, Joshua S. Jue, Mahmoud Morsi, Javier Gonzalez, Marissa Defreitas, Jayanthi J. Chandar, Jeffrey J. Gaynor and Gaetano Ciancio

    Citation: BMC Pediatrics 2020 20:526

    Content type: Research article

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  38. This report summarizes the clinical characteristics of intractable anemia as part of the clinical presentation of Hirschsprung’s disease (HD) and aims to strengthen clinicians’ ability to recognize early signs...

    Authors: Xiaoang Sun, Jun Chu, Chenchen Li and Zhaohui Deng

    Citation: BMC Pediatrics 2020 20:525

    Content type: Case report

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  39. Children and adolescents are becoming the most prolific users of smart technology (ST) devices due to the numerous advantages presented by these devices. However, the overuse of ST devices can have detrimental...

    Authors: Ali Jasem Buabbas, Madawi Anwar Al-Mass, Basma Awad Al-Tawari and Mohammad Abbas Buabbas

    Citation: BMC Pediatrics 2020 20:524

    Content type: Research article

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  40. Human milk has potential protective effects against bronchopulmonary dysplasia (BPD). However, studies on the association between the dose of human milk and BPD in China are limited. This study aimed to evalua...

    Authors: Yan Xu, Zhangbin Yu, Qianqian Li, Jinjun Zhou, Xiaoguang Yin, Yuelan Ma, Yujie Yin, Shanyu Jiang, Rongping Zhu, Yue Wu, Liangrong Han, Yan Gao, Mei Xue, Yu Qiao, Lingling Zhu, Wenjuan Tu…

    Citation: BMC Pediatrics 2020 20:522

    Content type: Research article

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  41. In Uganda, childhood anemia remains a health challenge and is associated with malaria infection as well as iron deficiency. Iron deficiency is intertwined with nutritional status, age and other comorbidities i...

    Authors: Ambrose Mukisa, Denis Kasozi, Claire Aguttu, Peter C. Vuzi and Joseph Kyambadde

    Citation: BMC Pediatrics 2020 20:521

    Content type: Research article

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  42. Both bullying victimization and perpetration were associated with depression, social phobia, physical and psychological child abuse and Internet addiction in Lebanon. The prevalence of bullying in Lebanon is a...

    Authors: Diana Malaeb, Emmanuelle Awad, Chadia Haddad, Pascale Salameh, Hala Sacre, Marwan Akel, Michel Soufia, Rabih Hallit, Sahar Obeid and Souheil Hallit

    Citation: BMC Pediatrics 2020 20:520

    Content type: Research article

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  43. Childhood apraxia of speech (CAS) is a neurodevelopmental disorder with heterogeneous communication and other comorbid manifestations. While previous studies have characterized speech deficits associated with ...

    Authors: Catherine M. Stein, Penelope Benchek, Gabrielle Miller, Noémi B. Hall, Dhanya Menon, Lisa Freebairn, Jessica Tag, Jennell Vick, H. Gerry Taylor, Barbara A. Lewis and Sudha K. Iyengar

    Citation: BMC Pediatrics 2020 20:519

    Content type: Research article

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  44. Neonatal intrahepatic cholestasis caused by citrin deficiency (CD) is a rare inborn error of metabolism due to variants in the SLC25A13 gene encoding the calcium-binding protein citrin. Citrin is an aspartate-glu...

    Authors: S. C. Grünert, A. Schumann, P. Freisinger, S. Rosenbaum-Fabian, M. Schmidts, A. J. Mueller, S. Beck-Wödl, T. B. Haack, H. Schneider, H. Fuchs, U. Teufel, G. Gramer, L. Hannibal and U. Spiekerkoetter

    Citation: BMC Pediatrics 2020 20:518

    Content type: Case report

    Published on:

  45. Intraventricular hemorrhage during the early stage is a major complication in very low birth weight infants. Elevation of venous pressure is one of the contributing factors. The internal cerebral vein receives...

    Authors: Kenichi Tanaka, Rieko Sakamoto, Hiroko Imamura, Tetsuo Naramura, Shirou Matsumoto, Masanori Iwai, Hiroshi Mitsubuchi and Kimitoshi Nakamura

    Citation: BMC Pediatrics 2020 20:517

    Content type: Case report

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  46. Benign convulsions with mild gastroenteritis (BCWG) is a common condition in children in Asia and is generally not associated with pH or electrolyte imbalances. When BCWG is diagnosed, a lumbar puncture is usu...

    Authors: Xiao-sheng Hao, Jian-min Liang, Xue-mei Wu, Yun-peng Hao, Jiang-tao Wang and Song-yan Liu

    Citation: BMC Pediatrics 2020 20:516

    Content type: Research article

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  47. To study mean core to peripheral temperature difference (CPTD) and the mean lactate levels over the first 6 h of admission to hospital, as indicators of prognosis in critically ill children.

    Authors: Aashish Gupta, Jacob Puliyel, Bhawana Garg and Pramod Upadhyay

    Citation: BMC Pediatrics 2020 20:515

    Content type: Research article

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  48. Adults often have difficulty instilling eye drops in their own eyes, but little has been documented about the difficulties experienced by parents when administering eye drops to their young children, where the...

    Authors: Gloria C. Law, Alpaslan Bülbül, Christina J. Jones and Helen Smith

    Citation: BMC Pediatrics 2020 20:514

    Content type: Research article

    Published on: