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  1. The Rotavirus Efficacy and Safety Trial was a placebo-controlled Phase III study that evaluated the safety and efficacy of a three-dose pentavalent rotavirus vaccine (RV5) including its effect on healthcare ut...

    Authors: Robbin Itzler, Gary Koch, David O Matson, Leif Gothefors, Pierre Van Damme, Mark J DiNubile and Penny M Heaton
    Citation: BMC Pediatrics 2010 10:42
    Content type: Research article Published on:

  2. Acid suppression with a proton pump inhibitor is standard treatment for gastroesophageal reflux disease and erosive esophagitis in adults and increasingly is becoming first-line therapy for children aged 1-17 ...

    Authors: Vasundhara Tolia, Nader N Youssef, Mark A Gilger, Barry Traxler and Marta Illueca
    Citation: BMC Pediatrics 2010 10:41
    Content type: Research article Published on:

  3. Neonatal sepsis is a significant cause of morbidity and mortality in neonates. Appropriate clinical diagnosis and empirical treatment in a given setting is crucial as pathogens of bacterial sepsis and antibiot...

    Authors: Neema Kayange, Erasmus Kamugisha, Damas L Mwizamholya, Seni Jeremiah and Stephen E Mshana
    Citation: BMC Pediatrics 2010 10:39
    Content type: Research article Published on:

  4. Respiratory syncytial virus (RSV) is an important pathogen causing annual epidemics of bronchiolitis and pneumonia among infants worldwide. High-risk infants currently receive RSV prophylaxis with palivizumab,...

    Authors: Pilar Fernández, Adrian Trenholme, Katia Abarca, M Pamela Griffin, Micki Hultquist, Brian Harris and Genevieve A Losonsky
    Citation: BMC Pediatrics 2010 10:38
    Content type: Research article Published on:

  5. Bronchiolitis is the most common reason for admission of infants to hospital in developed countries. Fluid replacement therapy is required in about 30% of children admitted with bronchiolitis. There are curren...

    Authors: Ed Oakley, Franz E Babl, Jason Acworth, Meredith Borland, David Kreiser, Jocelyn Neutze, Theane Theophilos, Susan Donath, Mike South and Andrew Davidson
    Citation: BMC Pediatrics 2010 10:37
    Content type: Study protocol Published on:

  6. Worldwide, insulin-dependent type 1 diabetes is one of the most frequently diagnosed long-term endocrine disorders found in children and the incidences of this diseased is still increasing. In Sweden the routi...

    Authors: Lisbeth Jönsson, Inger Hallström and Anita Lundqvist
    Citation: BMC Pediatrics 2010 10:36
    Content type: Research article Published on:

  7. Over the past few years, great efforts have been made to screen duct-dependent congenital heart diseases in the newborn. Arterial pulse oximetry screening (foot and/or right hand) has been put forth as the mos...

    Authors: Christoph Rüegger, Hans Ulrich Bucher and Romaine Arlettaz Mieth
    Citation: BMC Pediatrics 2010 10:35
    Content type: Research article Published on:

  8. Systematic reviews (SRs) are considered an important tool for decision-making. There has been no recent comprehensive identification or description of child-relevant SRs. A description of existing child-releva...

    Authors: Simon Bow, Jeffrey Klassen, Annabritt Chisholm, Lisa Tjosvold, Denise Thomson, Terry P Klassen, David Moher and Lisa Hartling
    Citation: BMC Pediatrics 2010 10:34
    Content type: Research article Published on:

  9. Among children, early mortality following highly active antiretroviral therapy (HAART) remains high. It is important to define correlates of mortality in order to improve outcome.

    Authors: Dalton C Wamalwa, Elizabeth M Obimbo, Carey Farquhar, Barbra A Richardson, Dorothy A Mbori-Ngacha, Irene Inwani, Sara Benki-Nugent and Grace John-Stewart
    Citation: BMC Pediatrics 2010 10:33
    Content type: Research article Published on:

  10. The co-existence of two genetically distinct metabolic disorders in the same patient has rarely been reported. Phenylketonuria (PKU) is an inborn error of the metabolism resulting from a phenylalanine hydroxyl...

    Authors: Daniela Concolino, Maria Rapsomaniki, Eliana Disabella, Simona Sestito, Maria G Pascale, Maria T Moricca, Giuseppe Bonapace, Elisea Arbustini and Pietro Strisciuglio
    Citation: BMC Pediatrics 2010 10:32
    Content type: Case report Published on:

  11. Lactose intolerance is a common complication of diarrhoea in infants with malnutrition and a cause of treatment failure. A combination of nutritional injury and infectious insults in severe protein energy maln...

    Authors: Richard Nyeko, Israel Kalyesubula, Edison Mworozi and Hanifa Bachou
    Citation: BMC Pediatrics 2010 10:31
    Content type: Research article Published on:

  13. Non-invasive ventilation (NIV) may be useful after extubation in children. Our objective was to determine postextubation NIV characteristics and to identify risk factors of postextubation NIV failure.

    Authors: Juan Mayordomo-Colunga, Alberto Medina, Corsino Rey, Andrés Concha, Sergio Menéndez, Marta Los Arcos and Irene García
    Citation: BMC Pediatrics 2010 10:29
    Content type: Research article Published on:

  14. To determine the agents of poisoning and demographic distribution of children brought to Civil Hospital Karachi (CHK) with a history of accidental poison intake and to examine the factors associated with it.

    Authors: Nabeel Manzar, Syed Muhammad Ali Saad, Bushra Manzar and Syeda Shahzeen Fatima
    Citation: BMC Pediatrics 2010 10:28
    Content type: Research article Published on:

  15. This randomized controlled trial aims to evaluate the effects of an early developmental intervention program on the development of young children in low- and low-middle-income countries who are at risk for neu...

    Authors: Jan L Wallander, Elizabeth McClure, Fred Biasini, Shivaprasad S Goudar, Omrana Pasha, Elwyn Chomba, Darlene Shearer, Linda Wright, Vanessa Thorsten, Hrishikesh Chakraborty, Sangappa M Dhaded, Niranjana S Mahantshetti, Roopa M Bellad, Zahid Abbasi and Waldemar Carlo
    Citation: BMC Pediatrics 2010 10:27
    Content type: Study protocol Published on:

  16. The effects of intensive training for children with cerebral palsy (CP) remain uncertain. The aim of the study was to investigate the impact on motor function, quality of movements and everyday activities of t...

    Authors: Anne Brit Sorsdahl, Rolf Moe-Nilssen, Helga K Kaale, Jannike Rieber and Liv Inger Strand
    Citation: BMC Pediatrics 2010 10:26
    Content type: Research article Published on:

  17. Cow's milk is the most common food allergen in infants and the diagnosis of cow's milk allergy is difficult, even with the use of several diagnostic tests. Therefore, elimination diets and challenge tests are ...

    Authors: Mário C Vieira, Mauro B Morais, José VN Spolidoro, Mauro S Toporovski, Ary L Cardoso, Gabriela TB Araujo, Victor Nudelman and Marcelo CM Fonseca
    Citation: BMC Pediatrics 2010 10:25
    Content type: Research article Published on:

  18. Existing evidence indicates that once mature neonates with severe cardio-respiratory failure become eligible for Extra Corporeal Membrane Oxygenation (ECMO) their chances of intact survival are doubled if they...

    Authors: David J Field, Richard Firmin, Denis V Azzopardi, Frances Cowan, Edmund Juszczak and Peter Brocklehurst
    Citation: BMC Pediatrics 2010 10:24
    Content type: Study protocol Published on:

  19. Raised intracranial pressure (ICP) is known to complicate both traumatic and non-traumatic encephalopathies. It impairs cerebral perfusion and may cause death due to global ischaemia and intracranial herniatio...

    Authors: Samson Gwer, Hellen Gatakaa, Leah Mwai, Richard Idro and Charles R Newton
    Citation: BMC Pediatrics 2010 10:23
    Content type: Research article Published on:

  20. Diagnosis of neonatal infection is difficult, because of it's non-specific clinical presentation and the lack of reliable diagnostic tests. The purpose of this study was to examine the potential diagnostic val...

    Authors: J David M Edgar, Vanessa Gabriel, J Ruth Gallimore, Stanley A McMillan and Judith Grant
    Citation: BMC Pediatrics 2010 10:22
    Content type: Research article Published on:

  21. Robust data on the prevalence of childhood disability and the circumstances and characteristics of disabled children is crucial to understanding the relationship between impairment and social disadvantage. It ...

    Authors: Clare M Blackburn, Nick J Spencer and Janet M Read
    Citation: BMC Pediatrics 2010 10:21
    Content type: Research article Published on:

  23. Children at highest risk of developmental problems benefit from early identification and intervention. Investigating factors affecting child development at the time of transition to school may reveal opportuni...

    Authors: Suzanne C Tough, Jodi E Siever, Karen Benzies, Shirley Leew and David W Johnston
    Citation: BMC Pediatrics 2010 10:19
    Content type: Research article Published on:

  24. Ethnic differences in the prevalence of asthma among children in the UK are under-researched. We aimed to determine the ethnic differences in the prevalence of asthma and atopic asthma in children from the mai...

    Authors: Melissa J Whitrow and Seeromanie Harding
    Citation: BMC Pediatrics 2010 10:18
    Content type: Research article Published on:

  25. Muscle strength is important for young people with Down syndrome as they make the transition to adulthood, because their workplace activities typically emphasise physical rather than cognitive skills. Muscle s...

    Authors: Nora Shields, Nicholas F Taylor and Bo Fernhall
    Citation: BMC Pediatrics 2010 10:17
    Content type: Study protocol Published on:

  26. Research indicates that in the United States, children experience healthier BMI and fitness levels during school vs. summer, but research is limited. The primary goal of this pilot study was to assess where ch...

    Authors: Alison Tovar, Keith Lividini, Christina D Economos, Sara Folta, Jeanne Goldberg and Aviva Must
    Citation: BMC Pediatrics 2010 10:16
    Content type: Research article Published on:

  27. Preterm infants requiring assisted ventilation are at significant risk of both pulmonary and cerebral injury. Inhaled Nitric Oxide, an effective therapy for pulmonary hypertension and hypoxic respiratory failu...

    Authors: Lisa M Askie, Roberta A Ballard, Gary Cutter, Carlo Dani, Diana Elbourne, David Field, Jean-Michel Hascoet, Anna Maria Hibbs, John P Kinsella, Jean-Christophe Mercier, Wade Rich, Michael D Schreiber, Pimol Srisuparp, Nim V Subhedar, Krisa P Van Meurs, Merryn Voysey…
    Citation: BMC Pediatrics 2010 10:15
    Content type: Study protocol Published on:

  28. Previous studies have reported postpartum depression to be associated with both positive and negative effects on early infant growth. This study examined the hypothesis that maternal postnatal depression may b...

    Authors: Veit Grote, Torstein Vik, Rüdiger von Kries, Veronica Luque, Jerzy Socha, Elvira Verduci, Clotilde Carlier and Berthold Koletzko
    Citation: BMC Pediatrics 2010 10:14
    Content type: Research article Published on:

  29. Hypertension has been shown to start in early life and to track into adulthood. Detecting adolescents with hypertension and prehypertension will aid early intervention and reduce morbidity and mortality from t...

    Authors: Chukwunonso ECC Ejike, Chidiebere E Ugwu and Lawrence US Ezeanyika
    Citation: BMC Pediatrics 2010 10:13
    Content type: Research article Published on:

  30. Various perinatal factors influencing neuromotor development are known from cross sectional studies. Factors influencing the age at which distinct abilities are acquired are uncertain. We hypothesized that the...

    Authors: Christian Denne, Sarah Maag, Nicole Heussen and Martin Häusler
    Citation: BMC Pediatrics 2010 10:12
    Content type: Research article Published on:

  31. The prevalence of childhood obesity has increased dramatically in the last two decades and numerous efforts to understand, intervene on, and prevent this significant threat to children's health are underway fo...

    Authors: Carol Curtin, Sarah E Anderson, Aviva Must and Linda Bandini
    Citation: BMC Pediatrics 2010 10:11
    Content type: Research article Published on:

  32. The strongest causal evidence that customary spanking increases antisocial behavior is based on prospective studies that control statistically for initial antisocial differences. None of those studies have inv...

    Authors: Robert E Larzelere, Ronald B Cox Jr and Gail L Smith
    Citation: BMC Pediatrics 2010 10:10
    Content type: Correspondence Published on:

  33. Thyroid hormone treatment in children with congenital hypothyroidism can prevent intellectual disability. Guidelines recommend that children diagnosed with congenital hypothyroidism through newborn screening r...

    Authors: Alex R Kemper, Lijing Ouyang and Scott D Grosse
    Citation: BMC Pediatrics 2010 10:9
    Content type: Research article Published on:

  34. Endothelial dysfunction is a complication of both obesity and obstructive sleep apnea syndrome (OSAS), the latter being highly prevalent among obese children. It is unknown whether obesity causes endothelial d...

    Authors: Rakesh Bhattacharjee, Wadha H Alotaibi, Leila Kheirandish-Gozal, Oscar Sans Capdevila and David Gozal
    Citation: BMC Pediatrics 2010 10:8
    Content type: Research article Published on:

  36. There is very little evidence of the similarity of the mechanics of maternal and bottle feeding. We assessed the mechanics of sucking in exclusive breastfeeding, exclusive bottle feeding, and mixed feeding. Th...

    Authors: Angel Moral, Ignasi Bolibar, Gloria Seguranyes, Josep M Ustrell, Gloria Sebastiá, Cristina Martínez-Barba and Jose Ríos
    Citation: BMC Pediatrics 2010 10:6
    Content type: Research article Published on:

  37. There is increasing evidence that tight blood glucose (BG) control improves outcomes in critically ill adults. Children show similar hyperglycaemic responses to surgery or critical illness. However it is not k...

    Authors: Duncan Macrae, John Pappachan, Richard Grieve, Roger Parslow, Simon Nadel, Margrid Schindler, Paul Baines, Peter-Marc Fortune, Zdenek Slavik, Allan Goldman, Ann Truesdale, Helen Betts, Elizabeth Allen, Claire Snowdon, Deborah Percy, Michael Broadhead…
    Citation: BMC Pediatrics 2010 10:5
    Content type: Study protocol Published on:

  39. The UK has one of the lowest breastfeeding rates worldwide and in recent years the Government has made breastfeeding promotion one of its priorities. The UNICEF UK Baby Friendly Initiative is likely to increas...

    Authors: Gabriel Agboado, Elaine Michel, Elaine Jackson and Arpana Verma
    Citation: BMC Pediatrics 2010 10:3
    Content type: Research article Published on:

  40. Central adiposity is related to chronic disease risk in adolescents. Racial differences in waist circumference have been identified using cross-sectional data from this age group. We tested for racial differen...

    Authors: David J Tybor, Alice H Lichtenstein, Gerard E Dallal, Stephen R Daniels and Aviva Must
    Citation: BMC Pediatrics 2010 10:2
    Content type: Research article Published on:

  41. Infantile spasms represent a serious epileptic syndrome that occurs in the early infantile age. ACTH and Vigabatrin are actively investigated drugs in its treatment. This study describes the comparison of thei...

    Authors: Shahnaz Ibrahim, Shamshad Gulab, Sidra Ishaque and Taimur Saleem
    Citation: BMC Pediatrics 2010 10:1
    Content type: Research article Published on:

  42. Weight loss of greater than 7% from birth weight indicates possible feeding problems. Inadequate oral intake causes weight loss and increases the bilirubin enterohepatic circulation. The objective of this stud...

    Authors: Ariel A Salas, Jorge Salazar, Claudia V Burgoa, Carlos A De-Villegas, Valeria Quevedo and Amed Soliz
    Citation: BMC Pediatrics 2009 9:82
    Content type: Research article Published on:

  43. Parents are integral to the implementation of obesity prevention and management recommendations for children. Exploration of barriers to and facilitators of parental decisions to adopt obesity prevention recom...

    Authors: Kendrin R Sonneville, Nancy La Pelle, Elsie M Taveras, Matthew W Gillman and Lisa A Prosser
    Citation: BMC Pediatrics 2009 9:81
    Content type: Research article Published on:

  44. The HIV prevalence in Malawi is 12% and Kamuzu Central Hospital (KCH), in the capital Lilongwe, is the main provider of adult and paediatric HIV services in the central region. The Lighthouse at KCH offers opt...

    Authors: Ralf Weigel, Portia Kamthunzi, Charles Mwansambo, Sam Phiri and Peter N Kazembe
    Citation: BMC Pediatrics 2009 9:80
    Content type: Research article Published on:

  47. Decisions about interim analysis and early stopping of clinical trials, as based on recommendations of Data Monitoring Committees (DMCs), have far reaching consequences for the scientific validity and clinical...

    Authors: Ricardo M Fernandes, Johanna H van der Lee and Martin Offringa
    Citation: BMC Pediatrics 2009 9:77
    Content type: Research article Published on:

  48. Co-bedding, a developmental care strategy, is the practice of caring for diaper clad twins in one incubator (versus separating and caring for each infant in separate incubators), thus creating the opportunity ...

    Authors: Marsha L Campbell-Yeo, C Celeste Johnston, KS Joseph, Nancy L Feeley, Christine T Chambers and Keith J Barrington
    Citation: BMC Pediatrics 2009 9:76
    Content type: Study protocol Published on:

  49. Powdered infant formula (PIF) is not a sterile product, but this information appears to be poorly diffused among child caregivers. Parents and child care workers may behave in an unsafe manner when handling PIF.

    Authors: Giuseppe Calamusa, Rosalia Maria Valenti, Ivana Guida and Caterina Mammina
    Citation: BMC Pediatrics 2009 9:75
    Content type: Research article Published on:

  50. Individuals grow and accumulate central patterns of body fat into the diseases they will suffer from as older adults. The need to elicit the development and tracking of central patterns of body fat from younge...

    Authors: Kotsedi D Monyeki, Han CG Kemper and Phuti J Makgae
    Citation: BMC Pediatrics 2009 9:74
    Content type: Research article Published on:
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BMC Pediatrics

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