Fig. 4

Sema7A mediates cytokine production of HCAECs by binding to integrin β1. a The mRNA expression levels and culture supernatant concentrations of TNF-α, IL-1β, IL-6 and IL-18 of HCAECs stimulated with different dosage of rhSema7A. b The mRNA expression levels of TNF-α, IL-1β, IL-6 and IL-18 of HCAECs pretreated with anti-plexin C1 antibody and anti-integrin β1 antibody, respectively, followed by 10 µg/ml rhSema7A stimulation. Data are expressed as M ± SEM from 3 separate experiments. *P < 0.05; **P < 0.01; n.s.:not significant. Sema7A: Semaphorin 7A; TNF: tumor necrosis factor; IL: interleukin