Table 3 the comparison of frequency of primary and secondary outcome between two groups in term of birth weight and gestational age subgroups
Birth weight | Variables | Surfactant(n = 67) | Surfactant + Budesonide (n = 67) | P value | Gestational age | Surfactant(n = 67) | Surfactant + Budesonide (n = 67) | P value | |
|---|---|---|---|---|---|---|---|---|---|
Frequency (%) | Frequency (%) | Frequency (%) | Frequency (%) | ||||||
< 1500 gr N G1= 30 people N G2=40 people | Death | Yes | 17(42.5) | 9(30) | 0.284 Chi-square values = 1.14 | < 30 weeks N G1= 24 people N G2=16 | 17(70.8) | 5(31.3) | 0.014 Chi-square values = 6.07 |
**RR = 0.72, CI 95% (0.39, 1.33) | RR = 0.37, CI 95% (0.15, 0.87) | ||||||||
BPD | Yes | 10(25) | 8(26.7) | 0.875 Chi-square values = 0.02 | 5(20.8) | 7(43.8) | 0.166 Chi-square values = 2.40 | ||
RR = 1.05, CI 95% (0.57, 1.92) | RR = 1.81, CI 95% (0.88, 3.72) | ||||||||
Pulmonary Hemorrhage | Yes | 18(45) | 7(23.3) | 0.061 Chi-square values = 3.50 | 16(66.7) | 3(18.8) | 0.003 Chi-square values = 8.83 | ||
RR = 0.54, CI 95% (0.27, 1.09) | |||||||||
RR = 0.25, CI 95% (0.08, 0.76) | |||||||||
Pneumothorax | Yes | 5(12.5) | 7(23.3) | 0.234 Chi-square values = 1.41 | 5(20.8) | 4(25) | 1 Chi-square values = 0.09 | ||
RR = 1.47, CI 95% (0.82, 2.61) | |||||||||
RR = 1.14, CI 95% (0.48, 2.69) | |||||||||
Intraventricular Hemorrhage | Yes | 14(35) | 8(26.7) | 0.457 Chi-square values = 0.55 | 10(41.7) | 7(43.8) | 0.896 Chi-square values = 0.01 | ||
RR = 0.79, CI 95% (0.42, 1.49) | |||||||||
RR = 1.05, CI 95% (0.49, 2.25) | |||||||||
Second Dose Surfactant | Yes | 35(87.5) | 9(30) | 0.001 Chi-square values = 24.27 | 23(95.8) | 5(31.3) | 0.001 Chi-square values = 19.06 | ||
RR = 0.25, CI 95% (0.13, 0.46) | |||||||||
RR = 0.19, CI 95% (0.08, 0.43) | |||||||||
1500–2000 gr N G1= 22 people N G2=13 people | Death | Yes | 2(15.4) | 1(4.5) | 0.541 Chi-square values = 1.22 | people30-34 weeks N G1= 39 people N G2=32 people | 2(6.3) | 4(10.3) | 0.683 Chi-square values = 0.36 |
RR = 0.50, CI 95% (0.10, 2.56) | |||||||||
RR = 1.23, CI 95% (0.67, 2.27) | |||||||||
BPD | Yes | 0 | 0 | - | 5(15.6) | 1(2.6) | 0.084 Chi-square values = 3.87 | ||
RR = 0.28, CI 95% (0.04, 1.72) | |||||||||
Pulmonary Hemorrhage | Yes | 3(23.1) | 1(4.5) | 0.134 Chi-square values = 2.77 | 5(15.6) | 4(10.3 | 0.722 Chi-square values = 0.45 | ||
RR = 0.36, CI 95% (0.06, 2.05) | |||||||||
RR = 0.78, CI 95% (0.36, 1.68) | |||||||||
Pneumothorax | Yes | 1(7.7) | 0 | 0.371 Chi-square values = 1.74 | 1(3.1) | 3(7.7) | 0.746 Chi-square values = 0.69 | ||
RR = 1.39, CI 95% (0.76, 2.56) | |||||||||
Intraventricular Hemorrhage | Yes | 2(15.4) | 1(4.5) | 0.541 Chi-square values = 1.22 | 10(41.7) | 7(43.8) | 0.196 Chi-square values = 3.26 | ||
RR = 0.50, CI 95% (0.50, 2.56) | RR = 0.42, CI 95% (0.12, 1.42) | ||||||||
Second Dose Surfactant | Yes | 5(38.5) | 2(9.1) | 0.075 Chi-square values = 4.40 | 23(95.8) | 5(31.3) | 0.001 Chi-square values = 11.43 | ||
RR = 0.40, CI 95% (0.12, 1.32) | RR = 0.37, CI 95% (0.18, 0.77) | ||||||||
2000–2500 gr N G1= 15 people N G2=14 people | Death | Yes | 0 | 0 | 0 | 34–37 weeks N G1= 12 people N G2=11 people | 0 | 1(8.3) | 1 Chi-square values = 0.95 |
BPD | Yes | 0 | 0 | 0 | 0 | 0 | - | ||
Pulmonary Hemorrhage | Yes | 0 | 0 | 0 | 0 | 1(8.3) | 1 Chi-square values = 0.95 | ||
Pneumothorax | Yes | 0 | 0 | 0 | 0 | 0 | - | ||
Intraventricular Hemorrhage | Yes | 0 | 0 | 0 | 0 | 0 | - | ||
Second Dose Surfactant | Yes | 1(7.1) | 2(13.3) | 1 Chi-square values = 0.29 | 1(19.1) | 2(16.7) | 1 Chi-square values = 0.29 | ||
RR = 1.33, CI 95% (0.54, 3.23) | |||||||||
RR = 1.33, CI 95% (0.53, 3.32) | |||||||||