Table 2 the comparison of primary and secondary outcome between two groups
Variables | Surfactant Group (n = 67) | Surfactant + Budesonide Group (n = 67) | P value* | Variables | Surfactant Group (n = 67) | Surfactant + Budesonide Group (n = 67) | P value** | |
|---|---|---|---|---|---|---|---|---|
Mean (SD) | Mean (SD) | Frequency (%) | Frequency (%) | |||||
Ventilation use length (day) | 4.37 ± 2.81 | 2.85 ± 3.64 | 0.008 T value= -2.70 | Death † | Yes | 19(28.4) | 10(14.9) | 0.059 Chi-square values = 3.56 ***RR = 0.63, CI95% (0.37, 1.09) |
Mean diff = − 1.62, CI 95% (-2.63, − 0.41) | ||||||||
Hospital stay (day) | 16.21 ± 12.40 | 16.15 ± 15 | 0.679 T value= -0.02 | No | 48(71.6) | 57(85.1) | ||
Mean diff= -0.06, CI 95% (-4.76, 4.64) | ||||||||
First -day- MAP (mmHg) | 16.81 ± 1.64 | 15.48 ± 2.43 | 0.001 T value= -3.70 | BPD † | Yes | 10 (14.9) | 8 (11.9) | 0.612 Chi-square values = 0.257 RR = 0.87, CI95% (0.50, 1.50) |
Mean diff= -1.32, CI 95% (-2.03, -0.61) | ||||||||
Third -day – MAP (mmHg) | 11.05 ± 4.29 | 7.73 ± 2.86 | 0.001 T value= -5.22 | No | 57(85.1) | 59(88.1) | ||
Mean diff= -3.31, CI 95% (-4.57, -2.06) | ||||||||
First -day- oxygen index (%) | 15.09 ± 7.24 | 12.70 ± 7.01 | 0.055 T value= -1.94 | Pulmonary Hemorrhage | Yes | 21(31.3) | 8(11.9) | 0.006 Chi-square values = 7.43 RR = 0.49, CI95% (0.26, 0.90) |
Mean diff= -2.38, CI95% (-4.82, 0.04) | ||||||||
Third -day- oxygen index (%) | 4.87 ± 4.25 | 3.69 ± 4.13 | 0.111 T value=-1.60 | No | 46(68.7) | 59(88.1) | ||
Mean diff=-1.17, CI 95% (-2.62, 0.27) | ||||||||
First -day- Blood Sugar (mg/dL) | 86.93 ± 20.78 | 84.73 ± 21.25 | 0.547 T value=-0.60 | Pneumothorax | Yes | 6 [9] | 7(10.4) | 0.770 Chi-square values = 0.08 RR = 1.08, CI95% (0.63, 1.85) |
Mean diff=- 2.19, CI 95% (-9.37, 4.98) | ||||||||
Third -day- Blood Sugar (mg/dL) | 98.18 ± 21.46 | 95.27 ± 17.06 | 0.175 T value=-0.86 | No | 61(91) | 60(89.6) | ||
Mean diff=-2.91, CI 95% (-9.57, 3.74) | ||||||||
First -day- Mean Blood Pressure (mm Hg) | 36.04 ± 7.78 | 38.07 ± 4.95 | 0.010 T value = 2.41 | Intraventricular Hemorrhage | Yes | 16(23.9) | 9(13.4) | 0.121 Chi-square values = 2.41 RR = 0.67, CI95% (0.39, 1.17) |
Mean diff = 2.03, CI95% (0.36, 3.69) | ||||||||
Third -day- Mean Blood Pressure (mm Hg) | 38.17 ± 4.33 | 39.52 ± 4.04 | 0.064 T value = 1.86 | No | 51(76.1) | 58(86.6) | ||
Mean diff = 1.35, CI 95% (-0.08, 2.79) | ||||||||
* Independent t-test, **chi-square test, ***Risk Ratio (RR) † Primary Outcome | Second Dose Surfactant | Yes | 41(61.2) | 13(19.4) | 0.001 Chi-square values = 24.31 RR = 0.35, CI 95% (0.21, 0. 58) | |||
No | 26(38.8) | 54(80.6) | ||||||