Table 2 Vital signs and laboratory values during the study period^a

Heart rate, (beats/min; mean ± SD)

161 ± 3

162 ± 5

0.358

MBP, (mmHg; mean ± SD)

45 ± 3

44 ± 2

0.065

Breathing frequency, mean ± SD

45 ± 9

48 ± 7

0.272

FiO₂, mean ± SD

0.39 ± 0.13

0.40 ± 0.14

0.803

VT (mL/kg; mean ± SD)

6.8 ± 1.8

6.3 ± 1.7

0.368

PIP (cmH₂O; mean ± SD)

22.4 ± 3.6

19.1 ± 2.9

 < 0.001

MAP (cmH₂O; mean ± SD)

10.9 ± 2.7

9.1 ± 1.8

0.002

pH, mean ± SD

7.41 ± 0.03

7.41 ± 0.06

0.539

PaO₂, (mmHg; mean ± SD)

85.3 ± 16.0

94.0 ± 11.7

0.031

PaCO₂, (mmHg; mean ± SD)

48.1 ± 7.3

47.4 ± 6.5

0.924

PaO₂/FiO₂ ratio, median (IQR)

232 (186–290)

265 (220–322)

0.025

Lactates, (mmol/l; mean ± SD)

1.1 ± 0.5

1.2 ± 0.4

0.542

Midazolam (ug/kg.min; mean ± SD)

1.5 ± 0.5

1.1 ± 0.3

 < 0.001