Table 4 Predictors of failure to enter clinical remission at 1 year after IBD diagnosis (n = 62)
From: Multicenter registry of pediatric inflammatory bowel disease from a developing country
Characteristics at diagnosis | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
OR (95%Cl) | P value | OR (95%Cl) | P value | |
Age | 0.90 (0.78, 1.04) | 0.15 | ||
Female | 0.74 (0.24, 2.23) | 0.59 | ||
Duration from onset to diagnosis | 1.02 (0.98, 1.05) | 0.37 | ||
Type of IBD (Crohn’s disease vs. ulcerative colitis) | 1.54 (0.52, 4.55) | 0.43 | ||
Abdominal pain | 1.11 (0.37, 3.33) | 0.85 | ||
Diarrhea | 12.96 (1.58, 106.1) | 0.02 | 9.32 (1.05, 82.76) | 0.045 |
Weight loss/failure to thrive | 6.33 (1.79, 22.41) | 0.004 | 4.92 (1.24, 19.49) | 0.02 |
Anemia | 4.10 (0.83, 20.28) | 0.08 | ||
Hypoalbuminemia | 4.73 (1.43, 15.59) | 0.01 | ||
Erythrocyte sedimentation rate > 20 mm/h | 0.55 (0.11, 2.73) | 0.46 | ||
C-reactive protein > 5 mg/L | 1.63 (0.45, 5.85) | 0.46 | ||
Moderate to severe disease (defined by disease activity score*) | 4.64 (1.17, 18.27) | 0.03 | ||
Corticosteroid use | 2.45 (0.69, 8.65) | 0.16 | ||
Immunomodulator use | 1.40 (0.48, 4.15) | 0.54 | ||
Infliximab use | 1.52 (0.58, 5.22) | 0.44 | ||