Table 6 Characteristics of childhood B-cell ALL in different CNS statuses at diagnosis
Characteristics | Total | CNS1 | CNS2 | CNS3 | TLP+ | TLP- | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
165 | n | % | n | % | n | % | n | % | n | % | |||
Gender | Male/Female | 89 (53.94%) | 72/36 | 67/33 | 8 /15 | 35/65 | 3 /3 | 50/50 | 6 /4 | 60/40 | 6 /12 | 33/67 | 0.011 |
Age(< 10/≥10 years) | 149/16 | 99/9 | 92/8 | 22/1 | 96/4 | 6/0 | 100/0 | 9/1 | 90/10 | 13/5 | 72/28 | 0.1188 | |
WBC at diagnosis(< 100/≥100 × 109/L) | 151/14 | 99/9 | 92/8 | 20/3 | 87/13 | 5/1 | 83/17 | 9/1 | 90/10 | 18/0 | 100/0 | 0.3980 | |
WBC at LP(< 5/≥5 × 109/L) | 138/27 | 90/18 | 83/17 | 16/7 | 70/30 | 5/1 | 83/17 | 10/0 | 100/0 | 17/1 | 94/6 | 0.1569 | |
Risk group | LR/IR/HR | 72/91/2 | 51/55/2 | 71/60/100 | 13/10/0 | 18/11/0 | 0/6/0 | 0/7/0 | 2/8/0 | 3/9/0 | 6/12/0 | 8/13/0 | 0.1252 |
BCR::ABL1 | (Negative/Positive) | 160/5 | 105/3 | 97/3 | 22 /1 | 96/4 | 5 /1 | 83/17 | 10/0 | 100/0 | 18/0 | 100/0 | 0.303 |
TCF3::PBX1 | (Negative/Positive) | 155/10 | 101/7 | 94/6 | 23 /0 | 100/0 | 6/0 | 100/0 | 10/0 | 100/0 | 15/3 | 83/17 | 0.257 |
MLL-r | (Negative/Positive) | 155/10 | 102/6 | 94/6 | 21/2 | 91/9 | 5 /1 | 83/17 | 10/0 | 100/0 | 17/1 | 94/6 | 0.563 |
TEL::AML | (Negative/Positive) | 131 /34 | 85/23 | 79/21 | 19/4 | 83/17 | 6/0 | 100/0 | 8 /2 | 80/20 | 13/5 | 72/28 | 0.77 |
Relapse | No/Yes | 157/8 | 106/2 | 98/2 | 19/4 | 83/17 | 4/2 | 67/33 | 10/0 | 100/0 | 18/0 | 100/0 | 0.002 |