Table 3 Diagnostic criteria for central nervous system leukemia according to CCCG-ALL-2015

CNS1

CSF detection showed no leukemic cells and no abnormal clinical and imaging changes.

CNS2

a. Cerebrospinal fluid leukocytes < 5 cells/µl, blasts identified through CM in the centrifuged specimen;

b. Flow cytometry detected immature cells in the cerebrospinal fluid.

CNS3/CNSL

a. Cerebrospinal fluid leukocytes ≥ 5 cells/µL and blasts were found through CM in the centrifuged specimen;

b. Have definite symptoms and signs of central nervous system involvement, such as cranial nerve paralysis that other causes cannot explain;

c. Imaging evidence of central nervous system infiltration.

TLP

Bloody cerebrospinal fluid or cerebrospinal fluid red blood cells ≥ 10/µL.