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Table 4 Accuracy of CRP, FC, hBD2, and I-FABP prediction of NEC.

From: Values of serum intestinal fatty acid-binding protein, fecal calprotectin, and fecal human β-defensin 2 for predicting necrotizing enterocolitis

 

Cutoff value

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

AUC (95% CI)

CRP

0.575 (mg/dL)

63.3

52.5

50

65.7

0.656 (0.529–0.784)

FC

428.99 (ug/g)

76.7

67.5

63.9

79.4

0.787 (0.679–0.895)

hBD2

339.60 (ng/g)

63.3

50.0

48.7

35.5

0.633 (0.474–0.790)

I-FABP

2.54 (ng/mL)

76.7

87.5

82.1

83.3

0.897 (0.825–0.968)

  1. AUC: area under the receiver operating characteristic curve; CI: confidence interval; CRP: C-reactive protein; FC: fecal calprotectin; hBD2: human β-defensin 2; I-FABP: intestinal fatty acid-binding protein; NEC: necrotizing enterocolitis; NPV: negative predictive value; PPV: positive predictive value