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Table 3 Comparison of plasma I-FABP, FC, hBD2, and CRP levels among NEC neonates according to modified bell’s system stages and the control set

From: Values of serum intestinal fatty acid-binding protein, fecal calprotectin, and fecal human β-defensin 2 for predicting necrotizing enterocolitis

 

CRP (mg/L)

FC (ug/g)

hBD2 (ng/g)

I-FABP (ng/mL)

Stage II NEC

(n = 18)

0.57

(0.50–14.87)

482.99

(113.55–1552.18)

376.44

(352.27–391.46)

3.36

(1.245–6.745)

Stage III NEC

(n = 12)

14.24

(0.46–93.4)

818.06

(328.40–4358.23)

336.87

(316.33–372.67)

9.28

(5.085–13.238)

Control

(n = 40)

0.53

(0.30–31.53)

213.34

(32.15–1036.29)

339.86

(319.57–368.45)

1.38

(0.083–4.961)

p value

0.016a

0.000 a

0.000 a

0.000 a

 

0.204b

0.101 b

0.000 b

0.017 b

 

1.0c

0.014 c

0.000 c

0.002 c

 

0.012d

0.000 d

0.474 d

0.000 d

  1. a Kruskal–Wallis test for comparison among three groups.
  2. b Stage II NEC vs. stage 3 NEC for dual comparison by Mann–Whitney U-test.
  3. c Stage II NEC vs. control for dual comparison by Mann–Whitney U-test.
  4. d Stage III NEC vs. control for dual comparison by Mann–Whitney U-test.
  5. CRP: C-reactive protein; FC: fecal calprotectin; hBD2: human β-defensin 2; I-FABP: intestinal fatty acid-binding protein; NEC: necrotizing enterocolitis.