Table 2 Renal function parameters before and after administration of ifosfamide and acute changes during chemotherapy cycles
Pre-chemotherapy | 24 h-post-chemotherapy | Acute change* (%) | |||
|---|---|---|---|---|---|
n | Median (min-max) | n | Median (min-max) | Median (min-max) | |
Glomerular parameters | |||||
eGFR (ml/min/1.73m2) | 89 | 126 (54–171) | 81 | 136 (81–206) | 8 (-25-66) |
Plasma creatinine (µmol/L) | 89 | 45 (29–113) | 81 | 42 (28–75) | -7.3 (-39.7-33.3) |
Plasma cystatin C (mg/L) | 68 | 0.7 (0.5–1.1) | 61 | 0.8 (0.3–1.1) | 5.5 (-23.0-34.8) |
Urine albumin/creatinine (mg/mmol) | 90 | 1.2 (0.1–8.4) | 89 | 0.1 (0.1–18.3) | 0.0 (-99.4-15008.7) |
Tubular parameters | |||||
Plasma sodium (mmol/l) | 89 | 139 (134–145) | 81 | 137 (132–143) | -1.4 (-6.3-1.5) |
Plasma potassium (mmol/l) | 89 | 3.8 (3.1–4.7) | 81 | 3.7 (2.9–6.9) | -2.4 (-38.3-76.9) |
Plasma bicarbonate (mmol/l) | 89 | 25.5 (18.1–30.3) | 81 | 24.5 (19.4–30.3) | -2.7 (-27.7-28.2) |
Plasma protein (mg/l) | 89 | 70 (60–83) | 81 | 69 (60–82) | 0.0 (-13.3-13.0) |
Plasma calcium (mmol/l) | 89 | 2.3 (2.1–2.6) | 81 | 2.3 (2.0-2.6) | 0.4 (-9.2-12.6) |
Plasma magnesium (mmol/l) | 89 | 0.8 (0.6-1.0) | 81 | 0.8 (0.6–1.1) | 1.3 (-19.2-21.3) |
Plasma phosphate (mmol/l) | 89 | 1.4 (0.8–1.7) | 81 | 1.1 (0.7–1.5) | -13.7 (-48.3-32.3) |
Fractional excretion of phosphate (%) | 89 | 9.5 (3.6–19.1) | 81 | 18.8 (8.3–37.0) | 120.9 (-20.7-351.3) |
Tmp/GFR (mmol/l) | 89 | 1.2 (0.6–1.6) | 81 | 0.9 (0.4–1.3) | -22.5 (-62.7-18.1) |
Plasma uric acid (µmol/L) | 89 | 184 (105–410) | 81 | 136 (72–287) | -27.7 (-56.1-4.5) |
Fractional excretion of uric acid (%) | 89 | 8.6 (2.7–19.0) | 81 | 24.8 (9.3–41.7) | 193.0 (12.7-513.8) |
Fractional excretion of glucose (%) | 89 | 0.1 (0.0-0.4) | 86 | 0.1 (0.0–23.0) | 75.4 (-87.1-229843.1) |
Urine calcium/creatinine (mmol/mmol) | 90 | 0.5 (0.1–1.9) | 88 | 0.9 (0.1–2.1) | 70.3 (-56.4-858.2) |
Urine β2-microglobulin/creatinine (mg/mol) | 90 | 6.0 (4.6-115.3) | 89 | 417.2 (6.0-2743.8) | 4704.8 (-74.6-45630.7) |
Urine glycine/creatinine | 63 | 0.2 (0.0-2.1) | 61 | 0.9 (0.0-4.6) | 293.1 (-74.5-3225.6) |
Urine betaine/creatinine | 62 | 0.0 (0.0-0.5) | 62 | 0.3 (0.0-1.1) | 802.7 (-59.3-5991.0) |