Table 4 GRADE evidence profiles for outcomes among the studies included in the meta-analysis
Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Nifedipine and Sildenafil | Nifedipine alone | Relative (95% CI) | Absolute (95% CI) | ||
Prolongation of pregnancy | ||||||||||||
4 | randomised trials | very seriousa | not serious | not serious | not serious | very strong association | 297 | 294 | - | MD 6.99 higher (5.32 higher to 8.65 higher) | ⨁⨁⨁⨁ High | CRITICAL |
Delivery rate in the 24–72 h after admission | ||||||||||||
5 | randomised trials | very seriousa | not serious | not serious | not serious | very strong association | 111/908 (12.2%) | 178/899 (19.8%) | RR 0.62 (0.50 to 0.76) | 75 fewer per 1,000 (from 99 to 48 fewer) | ⨁⨁⨁⨁ High | CRITICAL |
Neonatal birth weight | ||||||||||||
5 | randomised trials | very seriousa | seriousb | not serious | not serious | strong association | 328 | 325 | - | MD 252.48 higher (40.95 higher to 494.01 higher) | ⨁⨁◯◯ Low | IMPORTANT |
NICU admission | ||||||||||||
5 | randomised trials | very seriousa | not serious | not serious | not serious | very strong association | 88/360 (24.4%) | 141/357 (39.5%) | RR 0.62 (0.50 to 0.76) | 150 fewer per 1,000 (from 197 to 95 fewer) | ⨁⨁⨁⨁ High | IMPORTANT |