Table 5 Characteristics of iron status of the studied children stratified by the studied genotypes
From: The association of TMPRSS6 gene polymorphism with iron status in Egyptian children (a pilot study)
| Â | rs4820268 | rs855791 | rs11704654 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Variables | AA | AG | GG | P | AA | AG | GG | P | CC | CT | P |
Number | 50 | 80 | 30 | 0.1 | 22 | 132 | 6 | Â | 104 | 56 | Â |
HB (gm/dl) | 11.6 ± 2 | 11 ± 1.4 | 10.8 ± 2.2 | 0.8 | 11.15 ± 0.6 | 11.17 ± 0.1 | 10.8 ± 0.4 | 0.9 | 10.8 ± 0.2 | 11.6 ± 0.2 | 0.01 |
S. iron (ug/dl) | 57.7 ± 4.3 | 56.3 ± 3.8 | 53.2 ± 5.3 | 0.3 | 50.1 ± 4.2 | 57.4 ± 2.7 | 49.3 ± 5.7 | 0.5 | 53.3 ± 2.8 | 57.3 ± 4.1 | 0.4 |
S. ferritin (ng/dl) | 34.4 ± 3 | 39.6 ± 3.7 | 30.1 ± 4.1 | 0.3 | 45.3 ± 53.2 | 34.9 ± 2.6 | 34.8 ± 7.3 | 0.04 | 31.2 ± 2.8 | 42 ± 4.5 | 0.01 |
S. sTfR1 (mg/L) | 0.73 ± 0.15 | 0.53 ± .15 | 0.94 ± 0.3 | 0.05 | 0.13 ± 0.01 | 0.7 ± 0.1 | 1.6 ± 0.01 | 0.1 | 0.8 ± 0.14 | 0.5 ± 0.11 | 0.2 |
S. Ferroportin (ng/ml) | 6.4 ± 1.4 | 6.4 ± 0.8 | 2.5 ± 0.8 | 0.7 | 4.8 ± 1.9 | 5.5 ± 0.7 | 6.8 ± 1.3 | 0.7 | 5.6 ± 0.8 | 5.2 ± 0.9 | 0.7 |
S. hepcidin (pg/ml) | 345.3 ± 36.7 | 290.9 ± 30.3 | 277.3 ± 23.9 | 0.05 | 211.4 ± 36.6 | 287.75 ± 30.2 | 569.2 ± 118.4 | 0.01 | 247.3 ± 29.5 | 375 ± 49.9 | 0.02 |
Hepcidin gene expression fold | 0.87 ± 0.15 | 1.98 ± 0.23 | 2 ± 0.35 | 0.03 | 1.9 ± 0.4 | 1.7 ± 0.2 | 2.7 ± 0.6 | 0.3 | 1.9 ± 0.2 | 1.6 ± 0.3 | 0.4 |
Body iron store (mg/kg) | -6.6 ± 0.8 | -5.3 ± 0.7 | -9.4 ± 1.2 | 0.1 | -4.3 ± 1.8 | -6.6 ± 0.5 | -12.3 ± 1.7 | 0.04 | -7.3 ± 0.7 | -5.6 ± 0.8 | 0.1 |