Table 1 The Demographic and laboratory data of the three studied groups
From: The association of TMPRSS6 gene polymorphism with iron status in Egyptian children (a pilot study)
Variables | Group 1(Control) N = 40 (mean ± SD) | Group 2 (ID) N = 44 (mean ± SD) | Group 3 (IDA) N = 76 (mean ± SD) | P value |
|---|---|---|---|---|
Age (years) | 10.9 ± 1.3 | 10.2 ± 1.2 | 9.2 ± 1.5 | NS |
Sex (male/female) | 20/20 | 24/20 | 40/36 | NS |
BMI (Kg/m2) | 17.4 ± 14.5 | 18.5 ± 1.2 | 17.2 ± 1.5 | NS |
Retics (%) | 1.3 ± 0.4 | 1.2 ± 0.5 | 1.2 ± 0.6 | NS |
CRP (mg/L) | 0.42 ± 0.2 | 0.4 ± 0.1 | 0.33 ± 0.2 | NS |
HB (gm/L) | 12.9 ± 0.86 | 12.2 ± 0.74 | 9.5 ± 1.8 | P1 = 0.001 P2 = 0.001 P3 = 0.8 |
Hematocrit (%) | 36.7 ± 2.6 | 35.2 ± 2.6 | 30.1 ± 3.7 | P1 = 0.001 P2 = 0.001 P3 = 0.1 |
MCV (fl) | 77.8 ± 2.3 | 73.6 ± 3.9 | 66.7 ± 2.6 | P1 = 0.001 P2 = 0.001 P3 = 0.2 |
MCH (pg) | 26.8 ± 2.1 | 26.1 ± 1.6 | 22.1 ± 3.9 | P1 = 0.001 P2 = 0.001 P3 = 0.2 |
MCHC (g/dl) | 34.8 ± 1.5 | 31.5 ± 1.6 | 30.7 ± 2.4 | NS |
Serum Iron (ug/dl) | 92.48 ± 5.4 | 47.7 ± 1.7 | 41.3 ± 2.9 | P1 = 0.001 P2 = 0.6 P3 = 0.03 |
TIBC (ug/ml) | 316.07 ± 34.4 | 337.7 ± 5.04 | 351.03 ± 9.2 | NS |
Transferrin saturation % | 29.4 ± 3.85 | 15.9 ± 2.6 | 13.4 ± 3.08 | P1 = 0.001 P2 = 0.2 P3 = 0.001 |
Serum Ferritin (ng/ml) | 114.75 ± 16.57 | 27 .43 ± 6.05 | 20.49 ± 4.86 | P1 = 0.001 P2 = 0.9 P3 = 0.001 |
Serum human soluble transferrin receptor 1(mg/L) | 0.9 ± 0.1 | 0.16 ± 0.01 | 1.09 ± 0.2 | P1 = 0.4 P2 = 0.001 P3 = 0.002 |
Serum Ferroportin (ng/ ml) | 8.7 ± 1.7 | 3.04 ± 0.8 | 5.5 ± 0.8 | P1 = 0.05 P2 = 0.2 P3 = 0.006 |
Serum hepcidin (pg /ml) | 363.4 ± 16.3 | 285.5 ± 15.7 | 282.8 ± 13.4 | NS |
Hepcidin gene expression Fold change | 2.6 ± 0.3 | 0.97 ± 0.1 | 1.9 ± 0.2 | P1 = 0. 1 P2 = 0.07 P3 = 0.01 |
Body iron store (mg/kg) | 1.7 ± 0.2 | -5.4 ± 0.2 | -9.6 ± 0.9 | P1 = 0.001 P2 = 0.001 P3 = 0.001 |