Table 4 The summary of the GRADE assessment for certainty evidence of each complication
Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Neurological complications | placebo | Relative (95% CI) | Absolute (95% CI) | ||
Pooled morbidity in intelligence (follow-up: range 5 years to ≥18 years) | ||||||||||||
6 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would reduce the effect | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||
Pooled morbidity in learning (follow-up: range 6 years to ≥18 years) | ||||||||||||
2 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would reduce the effect | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||
Pooled morbidity in motor (follow-up: range 5 years to 12 years) | ||||||||||||
7 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would reduce the effect | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||
Pooled morbidity in hearing (follow-up: range 5 years to ≥18 years) | ||||||||||||
3 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would suggest spurious effect, while no effect was observed | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||
Pooled morbidity in vision (follow-up: range 5 years to ≥18 years) | ||||||||||||
2 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would reduce the effect | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||
Pooled morbidity in cognitive (follow-up: mean 5.5 years) | ||||||||||||
2 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would reduce the effect | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||
Pooled morbidity in behavior (follow-up: mean 5 years) | ||||||||||||
1 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would reduce the effect | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||
Pooled morbidity in attention (follow-up: range 6 to ≥18 year) | ||||||||||||
4 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would reduce the effect | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||
Hearing morbidity in CDH (follow-up: range 5 to ≥18 year) | ||||||||||||
2 | observational studies | not serious | not serious | not serious | not serious | all plausible residual confounding would reduce the effect | not estimable | ⨁⨁⨁◯ Moderate | CRITICAL | |||