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Table 1 Clinical characteristics and laboratory findings of patients with hemolytic anemia in KD

From: Hemolytic anemia associated with intravenous immunoglobulin in Kawasaki disease

 

Case 1

Case 2

Case 3

Case 4

Case 5

Case 6

Case 7

Sex

Male

female

male

female

female

male

female

Age at diagnosis (months)

3

40

44

6

40

28

46

Height (centimeters)

65

80

100

71

98

93

96

Body Weight (kg)

7.8

18.0

17.2

9.3

16.5

13.6

14

Body Mass Index (kg/m2)

18.4

28.1

17.0

17.9

16.7

15.9

15.2

Initial fever duration (days)

3

4

5

5

4

7

7

Total fever duration (days)

8

7

9

8

7

10

9

WBC (/mm3)

17,300

11,300

8,800

9,700

14,200

8,020

10,300

ANC (/mm3)

12,802

8,972

5,830

7,207

13,374

6,600

7,750

Platelet (x103)

285

316

188

180

299

523

478

CRP (mg/dL)

6.3

3.6

8.4

8.6

8.2

5.03

7.8

AST (IU/L)

30

681

48

195

189

16

54

ALT (IU/L)

31

671

73

91

192

8

57

NT pro-BNP (pg/mL)

720

1,803

1,217

3,054

342

11,576

1,874

Initial Hb (mg/dL)

11.3

12.1

11.1

10.3

14.2

11.4

12.0

Lowest Hb (mg/dL)

9.6

9.0

8.1

8.3

7.4

8.5

9.0

Reticulocyte count (%)

10.8

3.3

13.2

10.0

13.0

1.8

3.0

LDH initial (IU/L)

754

551

694

381

526

548

645

Indirect bilirubin (mg/dL)

0.36

4.49

3.63

1.81

0.53

1.11

0.8

Indirect bilirubin (mg/dL) *

0.83

1.19

2.88

0.51

0.61

1.25

1.67

Haptoglobin (65-195 mg/dL)

118

96

105

238

89

345

265

Blood transfusion

none

none

none

none

none

none

none

Additional Treatment

MP

 

MP

PD

PD

PD

 

Coronary outcome

none

none

dilated

dilated

dilated

dilated

none

Blood group

A+

B+

A+

A+

A+

B+

A+

Antibody identified

IgG + C3d

IgG + C3d

IgG + C3d

IgG + C3d-

IgG + C3d-

IgG + C3d-

IgG + C3d-

  1. KD Kawasaki disease, WBC white blood cell count, ANC absolute neutrophil count, CRP C-reactive protein, AST aspartate aminotransferase, ALT alanine aminotransferase, NT pro-BNP nitrogen terminal, pro b-type natriuretic peptide, Hb hemoglobin, LDH lactate dehydrogenase, Indirect bilirubin (mg/dL) *, Indirect bilirubin blood level in follow-up, MP methylprednisolone 30 mg/kg/day for consecutive three days, PD prednisolone 2 mg/kg/day