Table 4 Genotypes and allele frequencies of SNPs in the UGT1A1, SLCO1B1, SLCO1B3, BLVRA, and HMOX1 genes
Genotypes/Alleles | Case group (n = 144) n (%) | Control group (n = 50) n (%) | P value | OR (95%CI) |
|---|---|---|---|---|
UGT1A1-rs4148323 | ||||
GG | 73 (50.7) | 37 (74.0) | 1 | |
GA | 55 (38.2) | 13 (26.0) | 0.036 | 2.144 (1.041–4.416) |
AA | 16 (11.1) | 0 (0) | 0.003* | 0.820 (0.744–0.904) |
A allele | 87 (30.2) | 13 (13.0) | ||
G allele | 201 (69.8) | 87 (87.0) | 0.001 | 2.897 (1.535–5.465) |
UGT1A1-rs3771341 | ||||
GG | 134 (93.1) | 42 (84.0) | 1 | |
GA | 9 (6.2) | 7 (14.0) | 0.129* | 0.403 (0.141–1.148) |
AA | 1 (0.7) | 1 (2.0) | 0.426* | 0.313 (0.019–5.120) |
A allele | 11 (3.8) | 9 (9.0) | ||
G allele | 277 (96.2) | 91 (91.0) | 0.063 | 0.402 (0.161-1.000) |
UGT1A1-rs34946978 | ||||
CC | 136 (94.4) | 48 (96.0) | ||
CT | 8 (5.6) | 2 (4.0) | 1.000* | 1.412 (0.290–6.882) |
C allele | 280 (97.2) | 98 (98.0) | ||
T allele | 8 (2.8) | 2 (2.0) | 1.000* | 0.714 (0.149–3.421) |
UGT1A1-rs114982090 | ||||
CC | 138 (95.8) | 50 (100.0) | ||
CT | 6 (4.2) | 0 (0) | 0.342* | 0.958 (0.926–0.992) |
C allele | 282 (97.9) | 100 (100.0) | ||
T allele | 6 (2.1) | 0 (0) | 0.345* | 0.979 (0.963–0.996) |
SLCO1B1-rs4149056 | ||||
TT | 118 (81.9) | 41 (82.0) | 1 | |
CT | 25 (17.4) | 9 (18.0) | 0.934 | 0.965 (0.416–2.237) |
CC | 1 (0.7) | 0 (0) | 1.000* | 0.992 (0.975–1.008) |
C allele | 27 (9.4) | 9 (9.0) | ||
T allele | 261 (90.6) | 91 (91.0) | 0.911 | 1.046 (0.474–2.308) |
SLCO1B1-rs1564370 | ||||
CC | 89 (61.8) | 34 (68.0) | 1 | |
CG | 48 (33.3) | 13 (26.0) | 0.354 | 0.709 (0.342–1.470) |
GG | 7 (4.9) | 3 (6.0) | 1.000* | 1.122 (0.274–4.591) |
C allele | 226 (78.5) | 81 (81.0) | ||
G allele | 62 (21.5) | 19 (19.0) | 0.669 | 0.855 (0.482–1.517) |
SLCO1B3- rs2417940 | ||||
CC | 117 (81.3) | 29 (58.0) | 1 | |
CT | 27 (18.7) | 20 (40.0) | 0.002 | 2.989 (1.474–6.060) |
TT | 0 (0) | 1 (2.0) | 0.204* | 1.034 (0.968–1.106) |
C allele | 261 (90.6) | 78 (78.0) | ||
T allele | 27 (9.4) | 22 (22.0) | 0.001 | 2.726 (1.471–5.054) |
SLCO1B3-rs2117032 | ||||
CC | 23 (16.0) | 8 (16.0) | 1 | |
CT | 66 (45.8) | 30 (60.0) | 0.565 | 1.307 (0.524–3.256) |
TT | 55 (38.2) | 12 (24.0) | 0.367 | 0.627 (0.227–1.737) |
C allele | 112 (38.9) | 46 (46.0) | ||
T allele | 176 (61.1) | 54 (54.0) | 0.212 | 0.747 (0.472–1.182) |
BLVRA- rs699512 | ||||
AA | 73 (50.7) | 27 (54.0) | 1 | |
GA | 60 (41.7) | 18 (36.0) | 0.550 | 0.811 (0.408–1.613) |
GG | 11 (7.6) | 5 (10.0) | 0.766* | 1.229 (0.391–3.864) |
A allele | 206 (71.5) | 72 (72.0) | ||
G allele | 82 (28.5) | 28 (28.0) | 0.928 | 0.977 (0.589–1.620) |
HMOX1- rs2071747 | ||||
GC | 13 (9.0) | 2 (4.0) | ||
GG | 131 (91.0) | 48 (96.0) | 0.362* | 2.382 (0.518–10.944) |
C allele | 13 (4.5) | 2 (2.0) | ||
G allele | 275 (95.5) | 98 (98.0) | 0.372* | 2.316 (0.514–10.448) |