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Table 3 Comparison of HMGB1, NLRP3, Capase-1, and cytokine levels in patients with different duration of seizure

From: Increased expression of NLRP3 associated with elevated levels of HMGB1 in children with febrile seizures: a case–control study

Variables

duration of seizure ≤ 5 min

(N = 22)a

duration of seizure > 5minnutes

(N = 8)a

P Value

HMGB1 (pg/ml)

411.9 (338.0–626.5)

357.8 (325.1–656.2)

0.798

NLRP3 (pg/ml)

2365 (1964–3187)

2071 (1625–3128)

0.440

Capase-1 (pg/ml)

2551 (1862–3571)

2498 (1801–3481)

0.977

IL-1β (pg/ml)

82.55 (73.92–131.97)

121.5 (76.4–164.7)

0.238

IL-6 (pg/ml)

40.87 (26.90–55.57)

37.72 (27.53–52.55)

0.842

TNF-α (pg/ml)

181.1 (146.6–284.4)

191.6 (135.9–234.4)

0.842

  1. FS febrile seizure, HMGB1 high mobility group box-1, IL-1β interleukin-1beta, N number, TNF-α tumor necrosis factor α. The P-value is for Mann–Whitney U-test
  2. aMedian (interquartile range)