Increased expression of NLRP3 associated with elevated levels of HMGB1 in children with febrile seizures: a case–control study

Table 2 Comparison of HMGB1, NLRP3, Capase-1, and cytokine levels between the febrile seizures group and febrile control group

Variables	FS group^a (N = 30)	Control group^a (N = 30)	P-Value
HMGB1 (pg/ml)	399.84 (329.69–626.52)	304.56 (240.86–495.16)	0.023*
NLRP3 (pg/ml)	2330.15 (1956.64–3179.77)	1666.14 (1302.69–3231.45)	0.016*
Capase-1 (pg/ml)	2550.69 (1845.07–3560.79)	1504.81 (1134.57–2909.78)	0.001*
IL-1β (pg/ml)	87.90 (75.58–139.83)	65.31 (45.66–142.17)	0.007*
IL-6 (pg/ml)	40.87 (27.15–53.46)	25.06 (16.94–42.56)	0.003*
TNF-α (pg/ml)	181.05 (146.58–239.76)	134.39 (87.23–213.34)	0.026*

FS febrile seizure, HMGB1 high mobility group box-1, IL-1β interleukin-1beta, N number, TNF-α tumor necrosis factor α. The P-value is for Mann–Whitney U-test
^aMedian (interquartile range)
^*Indicates a significant difference

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