Table 1 The demographic, clinical and biochemical characteristics of the patient
From: The tortuous diagnosis of one case of neonatal hyperthyroidism
Age (Days) | 0 | 1 | 4 | 6 | 8 | 15 | 23 | 40 | 57 | 72 | 93 | 108 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Corrected gestational age (weeks) | 32+ 6 | 33 | 33+ 3 | 33+ 5 | 34 | 35 | 35+ 6 | 38+ 2 | 40+ 5 | 42+ 6 | 45+ 6 | 48 |
Weight (g)/%* | 2220(80) | 2200(77.8) | 2020(69.5) | 2090(46.1) | 2120(46.5) | 2060(23.3) | 2100(13.1%) | 2700(18.5) | NA | 3600(24.9) | NA | 5300(67.6) |
Height (cm)/%* | 47.5(97) | NA | NA | 48(95.1) | NA | 48(85.2) | 49.6(90%) | 50.1(69.7) | NA | 55.5(92.2) | NA | NA |
Head circumference (cm)/%* | 28.5(20) | NA | NA | NA | NA | NA | NA | 31.6(6.5) | NA | 34.2(0.0) | NA | NA |
NBNA | NA | NA | NA | NA | NA | NA | NA | 36 | NA | 38 | NA | NA |
Blood biochemical parameters | ||||||||||||
Leukocytes (3.5–9.5) 109/ L | 13.5 | 10.29 | 7.5 | 7.47 | 9 | 18.45 | 9.25 | NA | NA | NA | NA | NA |
Neutrophils (1.8–6.3) 109/ L | 10 | 6.29 | 3.94 | 3.2 | 3.89 | 7.97 | 3.37 | NA | NA | NA | NA | NA |
Hemoglobin (130–175 g/ L | 187 | 177 | 190 | 173 | 170 | 167 | 142 | NA | NA | NA | NA | NA |
Platelets (125–350) 109/ L | 53 | 63 | 92 | 144 | 195 | 251 | 164 | NA | NA | NA | NA | NA |
Alanine aminotransferase (9–50) U/ L | 86 | 95 | 80 | 94 | 137 | 212 | 175 | 105 | 77 | 93 | 21 | NA |
Aspartate aminotransferase (15–40) U/ L | 366 | 298 | 273 | 334 | 331 | 355 | 232 | 109 | 63 | 71 | 46 | NA |
Total bilirubin (2-20.4) µmol/ L | 149.3 | 177.1 | 279.1 | 326.4 | 315.6 | 258.5 | 173 | 108.7 | 42.3 | 22.2 | 6 | NA |
Direct bilirubin (2-20.4) µmol/ L | 121.7 | 128 | 222.9 | 247.9 | 252.1 | 215.6 | 146.6 | 93.4 | 35.6 | 15.1 | 5.2 | NA |
C-reactive protein (0-0.5) mg/ dL | 1.4 | 1.5 | 1.48 | 1.9 | 2.15 | <0.5 | <0.5 | |||||
TSH (0.27–4.2) uIU/mL | < 0.005 | < 0.005 | < 0.005 | 0.261 | 1.19 | 0.845 | 2.18 | |||||
FT3 (3.1–6.8) pmol/L | 6.2 | 5.92 | 2.68 | 3.07 | 3.26 | 4 | 3.92 | |||||
FT4 (12–22) pmol/L | 34.9 | 30.1 | 9.54 | 8.7 | 9.34 | 9.56 | 10 | |||||
Echocardiography | ||||||||||||
Transverse diameter of the right atrium (mm) | NA | 16 | 15 | NA | 17 | 16 | 16 | 12 | NA | NA | NA | NA |
Transverse diameter of the right ventricle (mm) NA | 16 | 16 | NA | 17 | 16 | 15 | 12 | NA | NA | NA | NA | |
Tricuspid regurgitation | NA | severe | severe | NA | severe | severe | severe | moderate | NA | NA | NA | NA |
Pulmonary artery pressure (mmHg) | NA | 64 | 64 | NA | 64 | 60 | 44 | 37 | NA | NA | NA | NA |
Patent ductus arteriosus (mm) | NA | 2.5 | 1.7 | NA | 1.7 | 1.4 | 1.6 | NA | NA | NA | NA | NA |
Patent foramen ovale (mm) | NA | 2.3 | 2 | NA | 2 | 2 | 2 | 3 | NA | NA | NA | |
Ejection fraction (%) | NA | 70 | 70 | NA | 64 | 67 | 67 | 70 | NA | NA | NA | |
Abdominal ultrasonography | ||||||||||||
Distance between the right inferior border of the liver and the subcostal margin of the right midclavicular line (cm) | NA | 4.7 | 4.8 | NA | 4.9 | 3.8 | 4.2 | 3.8 | NA | NA | NA | |
Spleen pachydiameter (cm) | NA | 1.5 | 1.6 | NA | 1.5 | 1.3 | 1.2 | 1.7 | NA | NA | NA | |
Biliary sludge | NA | Yes | Yes | NA | Yes | Yes | Yes | No | NA | NA | NA | |
Gallstone | NA | No | No | NA | No | No | Yes | Yes | NA | NA | NA | |
Treatment | ||||||||||||
Methimazole | → | → | → | |||||||||
Propranolol | → | → | → | |||||||||