Using a new human milk fortifier to optimize human milk feeding among very preterm and/or very low birth weight infants: a multicenter study in China

Table 2 Body weight and weight gain velocity of infants in the nHMF group and cHMF group^*

Weight or weight gain	nHMF group (n = 95)	cHMF group (n = 148)	β (95%CI)^#	P-Value
Weight
D1, kg	1.53 ± 0.22	1.57 ± 0.26	-0.00(-0.05, 0.06)	0.88
D14, kg	1.86 ± 0.27	1.90 ± 0.33	-0.03(-0.05, 0.10)	0.49
D21, kg	2.04 ± 0.32	2.11 ± 0.36	-0.06(-0.03, 0.14)	0.19
Discharge, kg	2.39 ± 0.48	2.29 ± 0.45	0.11(-0.02, 0.24)	0.10
Weight for age z-score
D1	-0.87 ± 0.63	-1.07 ± 0.74	0.01 (-0.14, 0.14)	0.31
D14	-1.10 ± 0.65	-1.28 ± 0.86	0.08(-0.08, 0.24)	0.12
D21	-1.16 ± 0.71	-1.28 ± 0.92	0.10(-0.09, 0.29)	0.29
Discharge	-1.20 ± 0.97	-1.24 ± 0.87	0.18(-0.08, 0.30)	0.56
Weight gain from D1 to D21
Absolute weight gain, g	533 ± 165	540 ± 173	0.02(-0.03, 0.08)	0.38
Weight gain velocity, g/kg/d	14.0 ± 3.5	14.2 ± 3.8	0.42(-0.69, 1.52)	0.46
Change of z-score	-0.28 ± 0.43	-0.20 ± 0.44	0.09(-0.05, 0.22)	0.23
Weight gain from D1 to discharge
Absolute weight gain, g	878 ± 473	730 ± 372	-0.17(-0.29, -0.03)	0.01
Weight gain velocity, g/kg/d	13.5 ± 4.5	14.3 ± 6.3	0.83 (-1.1, 2.6)	0.40
Chang of z-score	-0.32 ± 0.77	-0.18 ± 0.45	0.18 (-0.01, 0.35)	0.09
Weight gain from D1 to D14
Absolute weight gain, g	338 ± 126	332 ± 137	0.01(-0.04, 0.04)	0.93
Weight gain velocity, g/kg/d	14.3 ± 4.6	13.6 ± 4.8	-0.20(-1.59, 1.20)	0.78
Change of z-score	-0.21 ± 0.33	-0.19 ± 0.36	0.03(-0.07, 0.13)	0.55

^* In the nHMF group, 2 infants were discharged before the end of the trial, we impute the body weight z-score at D21 as the same as the body weight z-score at discharge. Data was imputed using the mean of body weight z-score in nHMF group for the infant who died during study period
^# Linear mixed effect models were used to compare the difference of growth parameters between nHMF and cHMF group. Gestational age, birthweight, age of start using HMF, and days to achieve full enteral feeding were adjusted as covariates
D1, D14, D21, the 1st, 14th, and 21st day after full-strength fortification; nHMF, new human milk fortifier; cHMF, control human milk fortifier

ISSN: 1471-2431