Biochemical profiles and organ dysfunction in neonates with hypoxic-ischemic encephalopathy post-hoc analysis of the THIN trial

Table 2 Organ dysfunction and treatments by outcome at 18 months^a

Outcome	Good (n = 30)	Adverse (n = 17)	p-value	OR	CI (95%)
Anuria/oliguria 24–48 h, n/N (%)^b	1/27 (4)	5/16 (31)	0.02	11.82	1.23, 113.23
Vasopressors, n/N (%)	14/30 (46)	14/17 (82)	0.017	5.33	1.27, 22.48
Mechanical ventilation, n/N (%)	3/30 (10)	8/17 (47)	0.009	8.00	1.74, 36.81
≥ 2 anticonvulsants, n/N (%)	8/30 (27)	13/17 (77)	< 0.001	8.94	2.24, 35.61

^aAdverse outcome was defined as Bayley Scales of Infant and Toddler Development, third edition, cognitive and/or motor composite score < 85 (motor/cogn comp score), cerebral palsy with Gross Motor Function Classification System level 3–5, or death. 3 infants were lost to follow-up. ^bAnuria/oliguria was defined as urine output < 1 ml/kg/h

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