Skip to main content

Table 1 Biochemical data, organ dysfunction and treatment during admission

From: Biochemical profiles and organ dysfunction in neonates with hypoxic-ischemic encephalopathy post-hoc analysis of the THIN trial

Randomization

Therapeutic hypothermia (n = 25)

Standard care (n = 25)

Total (n = 50)

p-value

Biochemical data

 Max Creatinine (µmol/L), median (IQR), [range]

65 (54–82) [39–194]

73 (55–111) [31–314]

68 (55–87) [31–314]

0.35

 Max Urea (mmol/L), median (IQR), [range]

3.0 (2.5–4.3) [1.8–7.3]

3.8 (2.5–6.5) [1.5–11.3]

3.2 (2.5–5.0) [1.5–11.3]

0.17

 Max CRP (mg/dL), median (IQR) [range]a

8.6 (4.2–26.1) [0.0–80.1]

10.0 (5.3–17.9) [0.0–66.9]

8.6 (4.3–21.3) [0.0–80.1]

0.92

 Max Troponin T (pg/mL), median (IQR), [range]

170 (109–257) [59–841]

256 (126–345) [75–1180]

193 (126–310) [59–1180]

0.24

Platelets

 Minimum platelet count (× 109/L), median (IQR), [range]

153 (127–177) [54–252]

169 (110–219) [39–325]

160.5 (121–189) [39–325]

0.19

  < 100 000 per µl, n/N(%)b

4/25(16)

2/25(8)

6/50(12)

0.67

INR

 Max INR, median (IQR), [range]

1.9 (1.6–2.4) [1.4–4.9]

1.7 (1.5–2.5) [1.1–5.2]

1.8 (1.5–2.4) [1.1–5.2]

0.28

  > 1.8, n/N (%)

15/25 (60)

10/25 (40)

25/50 (50)

0.16

APTT

 Max APTT (sec), median (IQR), [range]

74 (63–85) [44–180]

61 (49–84) [34–179]

68 (58–85) [34–180]

0.097

  > 43 s, n/N (%)

25/25 (100)

23/25 (92)

48/50 (96)

0.49

Organ dysfunction and treatment

 Anuria/oliguria, n/N (%)c

  0–24 hoursd

7/25 (28)

16/23 (70)

23/48 (52)

0.004

  24–48 h

1/23 (4)

5/23 (22)

6/46 (13)

0.19

  48–72 h

0/22 (0)

1/19 (5)

1/41 (2)

0.46

   > 72 h

0/21 (0)

1/20 (5)

1/41 (2)

0.49

Number of vasopressors

   

0.38e

 0

11/25 (44)

8/25 (32)

19/50 (38)

 

 1

10/25 (40)

12/25 (48)

22/50 (44)

 

 2 or more

4/25 (16)

5/25 (20)

9/50 (18)

 

Intravenous bicarbonate, n/N(%)

5/25(20)

3/25 (12)

8/50(16)

0.70

Highest level of respiratory support, n/N (%)

   

0.53f

 Intermittent mandatory ventilation

5/25 (20)

7/25 (28)

12/50 (24)

 

 High frequency oscillation

1/25 (4)

1/25 (4)

2/50 (4)

 

Duration of antibiotics (days), median (IQR) [range]g

3 (3–5.75) [2–15]

3 (3–5) [2–7]

3 (3–5) [2–15]

0.501

Clinical seizures, n/N (%)

20/25 (80)

22/25 (88)

42/50 (84)

0.70

Number of anticonvulsants, n/N (%)

   

0.17

 0

6/25 (24)

3/25 (12)

9/50 (18)

 

 1

10/25 (40)

10/25 (40)

20/50 (40)

 

 2

6/25 (24)

6/25 (24)

12/50 (24)

 

 3

3/25 (12)

5/25 (20)

8/50 (16)

 

 4

0/25 (0)

1/25 (4)

1/50 (2)

 

Any blood products, n/N (%)

10/25 (40)

9/25(36)

19/50 (38)

0.77

  1. Abbreviations. INR International normalized ratio, APTT Activated partial thromboplastin time
  2. aData was unavailable for 1 infant in the TH-group and 1 in the SC-group. bOnly 1 infant had a platelet count < 50 000 per µl; this infant had a platelet count of 39 000 and platelet clumps seen in smear, but no active bleeding. cAnuria was defined as urine output < 0,5 ml/kg/h. Oliguria was defined as urine output < 1 ml/kg/h. dA minimum of 12 h within the first 24 h of life. eP-value based on Chi2-test on infants who received treatment with vasopressors vs. infants who did not. fP-value based on Chi2-test on infants who were treated with mechanical ventilation vs. infants not treated with mechanical ventilation. gData was unavailable for 1 infant in the TH-group and 1 in the SC-group. 1 infant in the SC-group was not treated with antibiotics and is not included in estimation of median and IQR
Back to article page

BMC Pediatrics

ISSN: 1471-2431

Contact us