From: The role of genetic factors in pediatric myelodysplastic syndromes with different outcomes
Characteristic | CSGMs (n = 8) | Only somatic mutation (n = 5) | Non-mutation* (n = 11) |
---|---|---|---|
Age at diagnosis, [years, median (range)] | 6.37 (0.25−13) | 7.8 (2–12) | 4.8(0.75−11) |
Diagnosis, no./total (%) | Â | Â | Â |
 RCC | 4 (50%) | 4 (80%) | 7 (63.6%) |
 Advanced MDS | 4 (50%) | 1 (20%) | 4 (36.4%) |
Hematological characteristics | Â | Â | Â |
 Hb level,median (range) | 69 (44–101) | 82 (54–100) | 83 (46–125) |
 PLT count,median (range) | 53 (13–165) | 45 (22–80) | 62 (10–263) |
 NE count, median (range) | 1.6 (0.39–5.08) | 1.7 (0.83–2.82) | 0.98 (0.13–1.95) |
 TD at diagnosis | 6 (75%) | 2 (40%) | 2 (18.2%) |
Treatment at diagnosis, no./total (%) | Â | Â | Â |
 Watch&wait / Support therapy | 3 (50%) | 2 (40%) | 5 (45.4%)_ |
 IST (CsA) | 1 (12.5%) | 2 (40%) | 4 (36.4%) |
 HSCT | 4 (50%) | 1 (20%) | 2 (18.2%) |
Response, no./total (%) | Â | Â | Â |
 Hematological improvement(HI) | 4 (50%) | 2 (40%) | 5 (45.4%) |
 Stable disease (SD) | 1(12.5%) | 2 (40%) | 5 (45.4%) |
 Disease progression (PD) | 3 (37.5%) | 1 (20%) | 1 (9.1%) |
Outcomes, no./total (%) | Â | Â | Â |
 Survivl | 6 (75%) | 4 (80%) | 10 (90.9%) |
 Death | 2 (25%) | 1 (20%) | 1 (9.1%) |