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Table 3 Comparison of baseline characteristics and treatment of patients witht different genetic backgrounds

From: The role of genetic factors in pediatric myelodysplastic syndromes with different outcomes

Characteristic

CSGMs (n = 8)

Only somatic mutation (n = 5)

Non-mutation* (n = 11)

Age at diagnosis, [years, median (range)]

6.37 (0.25−13)

7.8 (2–12)

4.8(0.75−11)

Diagnosis, no./total (%)

   

 RCC

4 (50%)

4 (80%)

7 (63.6%)

 Advanced MDS

4 (50%)

1 (20%)

4 (36.4%)

Hematological characteristics

   

 Hb level,median (range)

69 (44–101)

82 (54–100)

83 (46–125)

 PLT count,median (range)

53 (13–165)

45 (22–80)

62 (10–263)

 NE count, median (range)

1.6 (0.39–5.08)

1.7 (0.83–2.82)

0.98 (0.13–1.95)

 TD at diagnosis

6 (75%)

2 (40%)

2 (18.2%)

Treatment at diagnosis, no./total (%)

   

 Watch&wait / Support therapy

3 (50%)

2 (40%)

5 (45.4%)_

 IST (CsA)

1 (12.5%)

2 (40%)

4 (36.4%)

 HSCT

4 (50%)

1 (20%)

2 (18.2%)

Response, no./total (%)

   

 Hematological improvement(HI)

4 (50%)

2 (40%)

5 (45.4%)

 Stable disease (SD)

1(12.5%)

2 (40%)

5 (45.4%)

 Disease progression (PD)

3 (37.5%)

1 (20%)

1 (9.1%)

Outcomes, no./total (%)

   

 Survivl

6 (75%)

4 (80%)

10 (90.9%)

 Death

2 (25%)

1 (20%)

1 (9.1%)

  1. Abbreviations: CSGMs, co-occurrence of somatic and germline mutations; RCC, refractory cytopenia of childhood; Hb, hemoglobin; PLT, Platelet; NE, Neutrophil; TD, transfusion dependency; IST, immunosuppressive therapy; CsA, cyclosporine A; HSCT, hematopoietic stem cell transplantation; *Two patients with karyotypic abnormalities did not perform germline validation