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Table 4 Adjusted associations between children’s exposure to environmental factors and BHgC by children’s genotypes for GST genes based on General Linear Models that include the interactions between GST genes and the main environmental exposures (n = 375)

From: Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children

Models

Environmental Factor

Categories compared

Gene

Genotypes

Ratio of Mean Hg* [Exposure Yes vs. No] (95% CI)

P value**

Interactive multivariable co-dominant model

Child’s age (months)

Age ≥ 72 vs. Age < 72

  

1.21 (1.03, 1.42)

0.02

Consumption

Saltwater fish

Yes vs. No

  

1.35 (1.15, 1.59)

 < 0.01

Pasta, macaroni, noodles

Yes vs. No

  

0.72 (0.58, 0.89)

 < 0.01

String beans

Yes vs. No

  

1.17 (1.01, 1.36)

0.04

Canned fish (sardine, mackerel) a

Yes vs. No

GSTP1b

Ile/Ile

1.59 (1.09, 2.32)

0.02

Ile/Val

1.46 (1.12, 1.91)

0.01

Val/Val

0.72 (0.47, 1.11)

0.14

Interactive multivariable recessive

model

Child’s age (months)

Age ≥ 72 vs. Age < 72

  

1.21 (1.03, 1.43)

0.02

Consumption

Saltwater fish

Yes vs. No

  

1.35 (1.15, 1.58)

 < 0.01

Pasta, macaroni, noodles

Yes vs. No

  

0.72 (0.58, 0.89)

 < 0.01

String beans

Yes vs. No

  

1.18 (1.01,1.37)

0.03

Canned fish (sardine, mackerel) c

Yes vs. No

GSTP1b

Val/Val

0.72 (0.46, 1.12)

0.14

Ile*

1.50 (1.20, 1.87)

 < 0.01

  1. *Ratio of mean Hg indicates geometric mean BHgC ratio = Exp [Mean (ln Hg) in Yes vs. No exposure groups calculated using SAS ESTIMATE statement for GLM. **P-values are for the comparison of geometric mean BHgC of children with environmental factors in comparison of exposed (Yes) vs. non-exposed (No). a Overall interaction P = 0.01. b GSTP1 was missing for 16 children. c Overall interaction P < 0.01. d Ile* includes Ile/Val or Ile/Ile genotypes of GSTP1 gene