Characteristics of neonatal hypoxic-ischemic encephalopathy at high altitude and early results of therapeutic hypothermia

Table 2 Uni- and mult-ivariable regression analyses of the correlations of EEG and MRI abnormalities with demographic and clinical data in HIE patients undergoing hypothermia in 3 centers at high altitude in Multicenter Study

Variable	Background		Seizure time		Number of spikes/sharp waves		Number of delta brushes		Brain injury on MRI
Variable	Parameter estimate	P value	Parameter estimate	P value	Parameter estimate	P value	Parameter estimate	P value	Parameter estimate	P value
Univariate
Center	0.32	0.005	73.37	0.40	20.52	0.002	-7.96	0.16	0.54	<0.001
Sex	0.05	0.75	70.32	0.58	1.14	0.92	-1.49	0.72	0.49	<0.001
Gestational age	-0.17	0.0003	-36.51	0.33	2.69	0.45	-6.33	<0.0001	0.014	0.46
Birthweight	-0.0004	0.039	0.15	0.23	-0.004	0.72	-0.02	0.0004	-0.0005	<0.001
Ethnics	0.15	0.10	-68.53	0.31	11.22	0.08	-1.07	0.64	0.40	<0.001
HIE degree	0.36	0.004	154.11	0.10	17.50	0.044	4.85	0.09	0.034	<0.001
Initiation age of hypothermia	0.03	0.003	-5.21	0.49	1.14	0.11	-0.01	0.98	0.034	<0.001
Treatment time	0.004	<0.0001	Time -5.92	0.40	Time -0.44 Time² 0.01	<0.0001 <0.0001	Time -0.17 Time² 0.001	0.002 0.040
ScO₂	0.002	0.42	0.87	0.63	-0.13	0.88	-0.072	0.58	0.0016	0.59
Multivariate
Center	0.50	<0.0001			34.09	0.0003			0.04	<0.001
Sex									0.21	<0.001
Birthweight									-0.00046	<0.001
Ethnic							0.13	<0.0001	0.25	<0.001
HIE degree	0.22	0.050			6.18	0.013	6.18	0.013	0.30	<0.001
Initiation age of hypothermia									0.012	0.001
Treatment time	Time -0.001	<0.0001			Time -0.19 Time² 0.01	<0.0001 <0.0001	0.14	<0.0001
	Time² 0.0001	0.02			Time -0.19 Time² 0.01	<0.0001 <0.0001

Abbreviation: EEG Electroencephalography, MRI Magnetic resonance imaging, HIE Hypoxic-ischemic encephalopathy

ISSN: 1471-2431