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Table 3 Histological predictors for poor outcome

From: Development and post-Kasai procedure prognostic relevance of histological features for biliary atresia

Variable

Hazard ratio

95% CI of HR

p value

Univariate COX regression

  

Ishak/Metavir (4–6/3–4)

3.194

1.227–8.312

0.017

BA-specific (3–4)

4.110

1.687–10.016

0.002

Portal inflammation (Severe)

1.080

0.545–2.140

0.826

Intrahepatic cholestasis (Severe)

1.430

0.678–3.017

0.347

Ductal proliferation (Severe)

2.073

1.037–4.144

0.039

Age at PE (≥ 60)

1.646

0.817–3.315

0.163

Multivariable COX regression

Ishak/Metavir (4–6/3–4)

0.558

0.064–4.844

0.597

BA-specific (3–4)

5.774

0.781–42.676

0.086

Ductal proliferation (Severe)

1.621

0.794–3.308

0.185

  1. The COX proportional hazard regression model analysis includes histological characteristics (Ishak, Metavir, BA-specific stage and portal inflammation, intrahepatic cholestasis, ductal proliferation grade) and age at KP. Results with p-values < 0.05 were subjected to multivariate analysis after univariate analysis. P-values < 0.05 were considered statistically significant