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Table 2 Predictors of poor jaundice clearance

From: Development and post-Kasai procedure prognostic relevance of histological features for biliary atresia

 

Good JC (n = 23)

Poor JC (n = 45)

Odd ratio

95% confidence interval

p value

Univariate analysis

Ishak/Metavir

     

 1–3/1–2 (n = 22)

13

9

5.2

1.73–15.64

0.002

 4–6/3–4 (n = 46)

10

36

   

BA-specific

  

6.29

2.08–19.02

0.001

 1–2 (n = 28)

16

12

   

 3–4 (n = 40)

7

33

   

Portal inflammation

  

1.78

0.64–4.94

0.268

 Mild and moderate (n = 35)

14

21

   

 Severe (n = 33)

9

24

   

Intrahepatic cholestasis

  

1.93

0.55–6.78

0.3

 Mild and moderate (n = 51)

19

32

   

 Severe (n = 17)

4

13

   

Ductal proliferation

  

0.95

0.34–2.62

0.92

 Mild and moderate (n = 39)

13

26

   

 Severe (n = 29)

10

19

   

Age at PE

  

2.57

0.91–7.28

0.073

 < 60 (n = 34)

15

19

   

 ≥ 60 (n = 34)

8

26

   

Cholangitis

  

1.17

0.41–3.28

0.77

 No (n = 25)

9

16

   

 Yes (n = 43)

14

29

   

Multivariate analysis

Ishak/Metavir

  

0.94

0.13–6.64

0.953

BA-specific

  

6.05

0.93–39.44

0.060

Age at PE

  

2.16

0.65–7.19

0.211

  1. The data is tabulated for number of patients according to good or poor jaundice clearance (JC) by those with or without cholangitis; age at Kasai of ≥ 60 days or < 60 days; Ishak/Metavir stage 1–3/1–2 vs. 4–6/3–4; BA-specific stage 1–2 vs. 3–4; portal inflammation, intrahepatic cholestasis, and ductal proliferation severe vs. mild/moderate. Univariate and multivariate analysis showing odd ratio and 95% confidence interval for poor JC. Results with p-values < 0.1 were subjected to multivariate analysis after univariate analysis. P-values < 0.05 were considered statistically significant
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BMC Pediatrics

ISSN: 1471-2431

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