Table 3 Multivariable LMM analyses of predictors associated with change of CD4 cell counts overtime who were on ART follow-up among HIV-infected children in Mekelle general hospital (2014–2016)
Covariate | Coefficient | (95% CI) | P-value | |
|---|---|---|---|---|
Lower | Upper | |||
Intercept | 19.1 | 17.9 | 20.18 | 0.000* |
Time | 0.022 | -0.005 | 0.048 | 0.113 |
WHO clinical stage (reff. = stage-I) | 1.00 | |||
Stage-II | -1.088 | -2.20 | 0.022 | 0.056 |
Stage-III | -0.59 | -1.91 | 0.732 | 0.385 |
Stage-IV | -1.30 | -2.37 | -0.23 | 0.018* |
Sex (reff. = male) | 1.00 | |||
Female | -0.46 | -1.16 | 0.241 | 0.200 |
Co-infection HIV/TB (reff. = no) | 1.00 | |||
Yes | -1.78 | -2.58 | -0.98 | 0.000* |
Education level (reff. = secondary and above) | 1.00 | |||
Elementary and below | -0.56 | -1.29 | 0.163 | 0.130 |
Residence (reff. = urban) | 1.00 | |||
Rural | 0.079 | -0.55 | 0.708 | 0.808 |
Functional status (reff. = ambulatory) | 1.00 | |||
Working | 0.602 | -0.151 | 1.357 | 0.119 |
Bedridden | -1.74 | -2.81 | -0.68 | 0.002* |
Opportunistic infection (reff. = yes) | 1.00 | |||
No | 1.33 | 0.51 | 2.14 | 0.002* |
Adverse drug events (reff. = no) | 1.00 | |||
Yes | 0.068 | -0.99 | 1.12 | 0.899 |
Age category (reff. = < 2 years) | 1.00 | |||
2–5 years | -0.43 | -0.82 | -0.04 | 0.033* |
6–14 years | -1.02 | -1.47 | -0.56 | 0.000* |
Adherence level (reff. = good) | 1.00 | |||
Fair | 0.211 | -0.75 | 1.17 | 0.667 |
Poor | 0.115 | -0.52 | 0.75 | 0.725 |