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Table 1 Demographic Characteristics of Pregnant Women and their Children in Project Viva

From: Associations of prenatal maternal depressive symptoms with cord blood glucocorticoids and child hair cortisol levels in the project viva and the generation R cohorts: a prospective cohort study

 

Overalla

EPDS < 13

EPDS ≥ 13

 

n = 925

n = 747 (92%)

n = 65 (8%)

Mother

   

Age at enrollment (years) (mean (SD))

33.1 (4.5)

33.2 (4.3)

31.8 (4.9)

Pre-pregnancy BMI (kg/m2) (mean (SD))

24.3 (4.8)

24.1 (4.7)

24.4 (5.0)

Education (N (%))

   

 Not a college graduate

214 (23.1)

160 (21.4)

19 (29.2)

 College graduate

711 (76.9)

587 (78.6)

46 (70.8)

Pregnancy smoking status (N (%))

   

 Never

646 (70.1)

512 (68.8)

49 (75.4)

 Former

202 (21.9)

176 (23.7)

8 (12.3)

 Smoked during pregnancy

73 (7.9)

56 (7.5)

8 (12.3)

Marital Status (N (%))

   

 Not married or cohabiting

38 (4.1)

18 (2.4)

11 (16.9)

 Married or cohabitating

887 (95.9)

729 (97.6)

54 (83.1)

Annual household income (N (%))

   

 ≤$40,000

63 (7.1)

39 (5.4)

11 (18.6)

 >$40,000

820 (92.9)

685 (94.6)

48 (81.4)

Friends/family social support (points) (mean (SD))

13.6 (2.1)

13.7 (2.0)

12.5 (3.0)

Child at birth

   

Sex (N (%))

   

 Male

450 (48.6)

355 (47.5)

29 (44.6)

 Female

475 (51.4)

392 (52.5)

36 (55.4)

Race/ethnicity (N (%))

   

 Black

45 (4.9)

27 (3.6)

10 (15.4)

 Hispanic

22 (2.4)

13 (1.7)

2 (3.1)

 Asian

11 (1.2)

9 (1.2)

2 (3.1)

 White

805 (87.0)

667 (89.3)

49 (75.4)

 More than one race/ethnicity

42 (4.5)

31 (4.1)

2 (3.1)

Gestational age (weeks) at birth (mean (SD))

39.7 (1.6)

39.7 (1.6)

39.5 (1.5)

Cord blood cortisol (nmol/L) (mean (SD)) [min, max]

340.3 (182.5) [33.1, 1076.0]

341.1 (190.4) [33.1, 1076.0]

355.1 (164.8) [137.9, 838.7]

Cord blood cortisone (nmol/L) (mean (SD)) [min, max]

241.4 (80.4) [56.0, 577.2]

240.2 (80.4) [56.0, 577.2]

251.6 (82.3) [110.5, 508.3]

Cortisol to cortisone ratio (units) (mean (SD)) [min, max]

1.43 (0.62) [0.15, 4.25]

1.43 (0.62) [0.15, 4.25]

1.52 (0.66) [0.50, 3.04]

Child at mid-childhood

   

Age at mid-childhood hair cortisol measurement (years) (mean (SD))

7.8 (0.8)

7.8 (0.7)

7.9 (0.9)

Hair cortisol at mid-childhood (pg/mg) (median (IQR)) [min, max] b

0.97 (0.50, 2.37) [0.01, 236.19]

0.97 (0.48, 2.35) [0.01, 236.19]

0.92 (0.52, 2.57) [0.01, 74.55]

Child at early adolescence

   

Age at early adolescent hair cortisol measurement (years) (mean (SD))

13.2 (0.9)

13.2 (0.9)

13.1 (0.9)

Hair cortisol at early adolescence (pg/mg) (median (IQR)) [min, max] b

2.19 (1.12, 4.42) [0.01, 200.96]

2.10 (1.12, 4.15) [0.01, 200.96]

2.89 (1.36, 6.80) [0.01, 48.69]

Change in hair cortisol from mid-childhood to early adolescence (pg/mg) (median (IQR)) [min, max] b

0.75 (-0.51, 2.65) [-234.71, 194.70]

0.73 (-0.60, 2.63) [-234.71, 194.70]

0.98 (-0.13, 4.57) [-60.32, 44.80]

  1. a The “Overall” column includes participants with missing EPDS scores. For these participants, we imputed the missing EPDS score using multiple imputation in all analyses
  2. b Tabulations only include white children