Fig. 1

Time course and scatterplots of alanine aminotransferase (ALT) and nutritional parameters during hospitalization. A, B. Time course of nutritional indicators and the patient’s test results. A Changes in total daily calories (kcal) served to the patient (top), body weight (BW, kg) (bottom, grey solid line), albumin (Alb, g/dL) (bottom, grey dotted line), and ALT(U/L) (bottom, black solid line). B The time course of BW (solid black line) and hematocrit-adjusted Alb (Alb/HCT, solid grey line). We divided Alb by HCT to adjust for concomitant dehydration C, D. Scatterplots and nonparametric test results of BW versus ALT or Alb/HCT. Figures C and D indicate the relationship between BW and ALT and between BW and Alb/HCT, respectively. The box plots on the X and Y axes show the data distribution. The box indicates the interquartile range (IQR), and the solid horizontal line represents the median. Whiskers are expanded to the most extreme data point of no more than 1.5 × IQR from the edge of the box. Open circles reveal outliers. Nonparametric test results are shown below each scatterplot. For the statistical analysis, we used free statistical software R version 4.2.1 (The R Foundation for Statistical Computing Platform, https://www.r-project.org)