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Table 2 Impact of fetal growth restriction in the global development quotient (GDQ) and in the different neurodevelopmental domains at 24 months of corrected age

From: Impact of early-onset fetal growth restriction on the neurodevelopmental outcome of very preterm infants at 24 months: a retrospective cohort study

 

Mean SD

βa (95% CI)

p value*

βadjustedb (95% CI)

Standardized βc

p value*

Global development quotient

FGR

96.39 ± 18.68

-7.625 (-12.758; -2.492)

0.004

-16.703 (-28.915; -4.492)

-0.525

0.009

AGA

104.01 ± 11.07

Ref

 

Ref

  

All infants

101.47 ± 14.46

     

Gross motor skills

FGR

95.61 ± 14.32

-3.432 (-7.746; 0.882)

0.118

-6.781 (-16.054; 2.491)

 

0.146

AGA

99.05 ± 10.35

Ref

 

Ref

  

All infants

97.90 ± 11.88

     

Personal–social–emotional skills

FGR

102.66 ± 21.52

-6.545 (-12.429; -0.662)

0.030

-11.065 (-22.782; 0.653)

 

0.063

AGA

109.20 ± 12.60

Ref

 

Ref

  

All infants

107.02 ± 16.34

     

Language and communication skills

FGR

88.61 ± 22.78

-11.670 (-18.292; -5.049)

0.001

-21.924 (-38.822; -5.025)

-0.546

0.013

AGA

100.28 ± 15.32

Ref

 

Ref

  

All infants

96.39 ± 18.88

     

Eye and hand coordination skills

FGR

102.07 ± 18.62

-5.318 (-10.442; -0.194)

0.042

-15.446 (-27.658; -3.234)

-0.480

0.015

AGA

107.39 ± 11.07

Ref

 

Ref

  

All infants

105.61 ± 14.20

     

Foundations of learning skills

FGR

98.18 ± 17.70

-6.068 (-10.995; -1.141)

0.016

-15.211 (-26.916; -3.506)

-0.481

0.013

AGA

104.25 ± 10.82

Ref

 

Ref

  

All infants

102.23 ± 13.74

     
  1. a Coefficients from unadjusted model. b Coefficients from model adjusted for maternal and perinatal factors. c Standardized coefficients from adjusted model. *p value comparing FGR infants and AGA infants. GDQ, global development quotient; Ref, reference; SD, standard deviation