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Table 1 The characteristics of included RCTs

From: Milrinone for the treatment of heart failure caused by severe Pneumonia in children with congenital heart disease: a meta-analysis

RCT

Sample size

 

Age

 

Interventions

Outcomes

Milrinone group

Control group

 

Milrinone group

Control group

 

Milrinone group

Control group

Chen 2015

25

25

 

1.7 ± 0.5

1.5 ± 0.3

 

Routine treatment + milrinone injection intravenous drip at 0.5 pg/µg/(kg-min).

Routine treatment

①⑤

Huang 2017

55

55

 

1.78 ± 0.41

1.74 ± 0.42

 

Routine treatment + milrinone injection intravenous drip at 0.5 pg/µg/(kg-min).

Routine treatment

①②③⑤

Lin 2021

48

46

 

4.5 ± 0.7

4.7 ± 0.8

 

Routine treatment + milrinone injection intravenous drip at 0.25 ~ 1 Âµg/(kg-min).

Routine treatment

①⑤

Ma 2020

39

39

 

2.84 ± 0.43

2.91 ± 0.46

 

Routine treatment + milrinone injection intravenous drip at 0.05 Âµg/(kg-min).

Routine treatment

①②③⑤

Tang 2018

43

43

 

1.4 ± 0.3

1.3 ± 0.2

 

Routine treatment + milrinone injection intravenous drip at 0.25 ~ 0.75 Âµg/(kg-min).

Routine treatment

①②③④⑤

Wang 2020

31

31

 

0.41 ± 0.02

0.40 ± 0.02

 

Routine treatment + milrinone injection intravenous drip at 0.5 pg/µg/(kg-min).

Routine treatment

①⑤

Wu 2016

50

50

 

7.28 ± 1.39

7.2 ± 1.3

 

Routine treatment + milrinone injection intravenous drip at 0.25 ~ 0.75 Âµg/(kg-min).

Routine treatment

①④⑤

Wu 2017

50

50

 

7.28 ± 1.39

7. 2 ± 1. 3

 

Routine treatment + milrinone injection intravenous drip at 0.25 ~ 0.75 Âµg/(kg-min).

Routine treatment

①⑤

  1. Notes: RCT, randomized controlled trial; ①, the total effective rate; ②, the time to stable heart rate; ③, the time to stable respiration; ④, LVEF; ⑤, the incidence of adverse reactions