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Table 3 Differences in neonatal morbidity and care practices of VP-born infants from the LOLLIPOP and POPS cohorts

From: Changes in neonatal morbidity, neonatal care practices, and length of hospital stay of surviving infants born very preterm in the Netherlands in the 1980s and in the 2000s: a comparison analysis with identical characteristics definitions

 

LOLLIPOP (2002-03)

N = 549

POPS (1983)

N = 679

Effect of cohort (LOLLIPOP vs. POPS)

     

Model 1

Model 2

Model 3

Model 4

 

N

%

N

%

OR (CI 95%)

OR (CI 95%)

OR (CI 95%)

OR (CI 95%)

Morbidity

        

IVH grade III-IV

18

3.6

47

9.3

0.36 (0.21–0.33)***

0.15 (0.04–0.50)**

0.15 (0.04–0.55)**

0.26 (0.06–1.12)(*)

sepsis

135

27.7

246

36.3

0.67 (0.52–0.87)**

0.59 (0-40-0.86)**

0.63 (0.42–0.96)*

0.53 (0.32–0.88)*

proven NEC

12

2.3

11

1.6

1.42 (0.62–3.23)

1.37 (0.38–5.04)

1.56 (0.36–6.76)

2.22 (0.45–11.10)

apnea

465

90.8

453

66.9

4.89 (3.48–6.87)***

6.02 (3.47–10.46)***

6.50 (3.65–11.57)***

10.52 (5.18–21.34)***

Care practices

        

Surfactant therapy

191

34.8

      

mechanical ventilation

291

55.7

302

47.0

1.42 (1.13-1-79)**

1.22 (0.88–1.72)

1.40 (0.97–2.03)(*)

1.52 (0.96–2.42)(*)

CPAP

438

83.9

305

46.9

5.90 (4.46–7.80)***

6.99 (4.50-10.86)***

8.36 (5.22–13.37)***

7.88 (4.64–13.37)***

caffeine therapy

452

89.3

402

64.1

4.68 (3.38–6.49)***

5.07 (3.07–8.36)***

5.62 (3.33–9.48)***

7.93 (4.26–14.77)***

postnatal corticosteroids

28

5.5

49

7.2

0.76 (0.45–1.20)

0.46 (0.20–1.07)(*)

0.49 (0.20–1.18)

0.54 (0.18–1.57)

 

Median

Range

Median

Range

Model 1

IRR (CI 95%)

Model 2

IRR (CI 95%)

Model 3

IRR (CI 95%)

Model 4

IRR (CI 95%)

length of mechanical ventilation, days

1

0–84

0

0–78

1.15 (0.91–1.46)

1.10 (0.76–1.61)

1.16 (0.76–1.78)

0.92 (0.57–1.46)

length of NICU stay, days

16

0-143

38

0-380

0.48 (0.44–0.54)***

0.44 (0.38–0.51)***

0.41 (0.35–0.48)***

0.39 (0.33–0.46)***

length of hospital stay, days

54

10–339

65

12–380

0.86 (0.82–0.90)***

0.86 (0.81–0.92)***

0.83 (0.78–0.90)***

0.89 (0.83–0.94)***

  1. OR: odds ratio IRR: incidence rate ratio *** p < 0.001 **p < 0.01 *p < 0.05 (*)p < 0.1
  2. Model 1: unadjusted
  3. Model 2: adjusted for sociodemographic characteristics (maternal age at birth, parental education)
  4. Model 3 Model 2 + adjusted for prenatal characteristics (maternal smoking during pregnancy, previous pregnancy)
  5. Model 4: Model 3 + adjusted for infant characteristics (gestational age, small for gestation, multiple birth, sex, meconium, PPROM, breech presentation, low APGAR, cesarean section)
  6. In POPS, complete data ranged from N = 627 to N = 679, but IVH comprised N = 505 complete data, and length of NICU stay N = 454. In LOLLIPOP, complete data ranged from N = 462 to N = 526
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BMC Pediatrics

ISSN: 1471-2431

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