Table 1 Baseline characteristics and laboratory findings by hypoxic-ischaemic encephalopathy (HIE) grading
HIE Grade I (n = 54) | HIE Grade II (n = 116) | HIE Grade III (n = 25) | p | |
|---|---|---|---|---|
Gestational age (weeks), mean ± SD | 38.6 ± 1.7 | 38.5 ± 2 | 37.6.±2.4 | 0.143* |
Birthweight (gram), mean ± SD | 3157 ± 566 | 3199 ± 448 | 3080 ± 763 | 0.662* |
Maternal Age, mean ± SD | 25 ± 5.7 | 27 ± 6 | 29.5 ± 6.2 | 0.01 |
Gestational diabetes, n(%) | 2 (0.03) | 8 (0.06) | 1 (0.04) | 0.75 |
Cord blood pH, mean ± SD | 7.05 ± 0.1 | 6.90 ± 0.1 | 6.79 ± 0.26 | 0.075* |
Cord blood base deficit, mmol/L, mean ± SD | 14.4 ± 3.5 | 18.8 ± 5.3 | 23.6 ± 7.2 | 0.001* |
5th min. APGAR score Median(IQR) | 8 (4–9) | 7 (2–9) | 3 (0–7) | 0.009¥ |
Cardiac compression in delivery room, n (%) | 1 (0.5) | 4 (3.4) | 18 (72) | 0.0001¶ |
Inotrope requirement, n (%) | - | 13 (11) | 15 (60) | 0.0001¶ |
Seizure, n (%) | - | 36 (30) | 20 (80) | 0.001¶ |
Therapeutic hypothermia, n(%) | 2 (3.8) | 116 (100) | 25 (100) | 0.001¶ |
Mortality, n(%) | - | - | 18 (72) | 0.001¶ |
CK-MB, ng/ml median (IQR) | 40.1 (15.3–290) | 75.9 (31–300) | 98.8 (51–300) | 0.004* |
Troponin I, ng/ml median (IQR) | 0.12 (0.01–0.73) | 0.17(0.01–1.01) | 0.42 (0.02-3) | < 0.01* |
IS median (IQR) | - | 5 (5–10) | 20 (5-120) | < 0.01¥ |